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Results show reduced Tob2 expression in primary hepatocellular Carcinoma cells (HCC (show FAM126A ELISA Kits)) and that dysregulation of miR (show MLXIP ELISA Kits)-362 and Tob2 may contribute to HCC (show FAM126A ELISA Kits) malignancy.
The antiproliferative and the mRNA deadenylation/decay-promoting effects of TOB1 and TOB2 proteins are linked.
study identifies miR-378-TOB2-cyclin D1 as a functional module to mediate the cross talk between Myc and Ras signaling in cellular transformation
TNFalpha (show TNF ELISA Kits) is able to transactivate ErbB-2 (show ERBB2 ELISA Kits) and use it as an obligatory downstream signaling molecule in the generation of mitogenic signals.
Haploinsufficiency of the MLL (show MLL ELISA Kits) and TOB2 genes in lymphoid malignancy.
Antiproliferative proteins of the BTG/Tob (show TDO2 ELISA Kits) family are degraded by the ubiquitin-proteasome system. the C-terminal regions are necessary and sufficient to control the stabilities of BTG1 (show BTG1 ELISA Kits), BTG2 (show BTG2 ELISA Kits), Tob (show TDO2 ELISA Kits), and Tob2 proteins.
Tob1(-/-), Tob2(-/-), and Tob1/2 double knockout (DKO, Tob1(-/-) & Tob2(-/-)) embryonic stem cells (ESCs (show NR2E3 ELISA Kits)) grew faster than wild type (WT) ESCs (show NR2E3 ELISA Kits) without losing pluripotency.
miR (show MLXIP ELISA Kits)-322 and its target protein Tob2 modulate Osx (show SP7 ELISA Kits) mRNA stability
Tob2 protein suppresses PPARgamma2 (show PPARG ELISA Kits) transcription by inhibiting BMP2 (show BMP2 ELISA Kits)-induced Smad1 (show SMAD1 ELISA Kits)/5 phosphorylation through its interaction with Smad6 (show SMAD6 ELISA Kits) and by sequestering C/EBPalpha (show CEBPA ELISA Kits) from the PPARgamma2 (show PPARG ELISA Kits) promoter.
Tob2 negatively regulates formation of osteoclasts by suppressing RANKL (show TNFSF11 ELISA Kits) expression through its interaction with vitamin D receptor (show VDR ELISA Kits)
TOB2 belongs to the TOB (see TOB1\; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.
, transducer of ERBB2, 2
, protein Tob4
, transducer of erbB-2 2