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Findings indicate that the Gata6 (show GATA6 ELISA Kits) promoter is activated by Esrrb in association with Ncoa3 (show NCOA3 ELISA Kits), and Dax1 (show NR0B1 ELISA Kits) inhibited activities of Esrrb and Ncoa3 (show NCOA3 ELISA Kits), resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.
mitotic Esrrb binding is highly dynamic, driven by specific recognition of its DNA-binding motif and is associated with early transcriptional activation of target genes after completion of mitosis
JARID2 (show JARID2 ELISA Kits) physically interacts with ESRRB, SALL4A (show SALL4 ELISA Kits), and PRDM14 (show PRDM14 ELISA Kits)
interacts in trophoblast stem cells with the histone demethylase Lsd1 and with the RNA Polymerase II-associated Integrator complex
The forced expression of Essrb (and Nanog (show NANOG ELISA Kits)) resulted in the dispensability of nucleostemin (show E2IG3 ELISA Kits) expression in embryonic stem cells.
Daily regulation of Esrrb in photoreceptor cells may contribute to their adaptation to 24-h changes in metabolic demands.
Loss of Errbeta affects body composition, neuropeptide levels, stress hormones, and centrally-modulated startle responses of mice.
Esrrb selective deletion in the hindbrain alters neuropeptide Y (show NPY ELISA Kits) expression, whole-body energy level and ingestive behavior.
Esrrb forms a heterodimer complex with Sox2 (show SOX2 ELISA Kits) in ES cells to regulate transcriptional differences between mouse embryonic and epiblast stem cells.
Dax1 (show NR0B1 ELISA Kits) functions as a negative regulator of Esrrb and Oct3/4 (show POU5F1 ELISA Kits), and these molecules form a regulatory loop for controlling the pluripotency and self-renewal capacity of embryonic stem cells.
SNP (rs61742642; C to T, P386S) in the ligand-binding domain of human estrogen-related receptor beta is associated with audiometric temporary threshold shift.
The rs1676303 TT (P=0.02) and rs6574293 GG (P=0.04) genotypes of ESRRB were associated with RCD (show BCL10 ELISA Kits) and TMD (show TTN ELISA Kits), respectively.
analysis of Esrrb target genes indicates Esrrb may be an important factor in regulating cell proliferation
ERRbeta has a role in estrogen-dependent cellular function including cancer cell proliferation
The significant association and the presence of high-risk haplotypes identified in the ESRRB gene confirm the association of variants in ESRRB and rotator cuff disease.
study concludes ESRRB, a gene when mutated causes a form of hearing impairment, also contributes to dental decay likely by influencing the formation of an enamel surface more susceptible to demineralization under acidic conditions
ERRbeta signalling leads to BCAS2-mediated blockage of the G1/S transition and inhibition of the epithelial to mesenchymal transition through FST (show FST ELISA Kits)-mediated regulation of E-cadherin (show CDH1 ELISA Kits)
This is the first report of DFNB35 mutations in the Czech Republic and it seems to be a rare cause of non-syndromic hearing loss.
A novel missense mutation in the ESRRB gene causes DFNB35 hearing loss in a Tunisian family.
Data confirm the up-regulation of ER-beta (show ESR2 ELISA Kits) as the principal receptor involved in the progression of human endometriosis.
ESRRB is a crucial transcription factor to improve the self-renewal of porcine induced pluripotent stem cells.
ERbeta (show ESR2 ELISA Kits) is expressed in the cotyledon of the placenta and suggest a role of ER beta (show ESR2 ELISA Kits) primarily in trophoblast cell differentiation and placental angiogenesis and/or vascular functions.
This gene encodes a protein with similarity to the estrogen receptor. Its function is unknown; however, a similar protein in mouse plays an essential role in placental development.
, estrogen-related receptor beta
, steroid hormone receptor ERR2-like
, estrogen receptor related 2
, estrogen receptor-like 2
, nuclear receptor subfamily 3 group B member 2
, steroid hormone receptor ERR2
, ERR beta-2
, estrogen-related nuclear receptor beta
, nuclear receptor ERRB2
, orphan nuclear receptor
, estrogen-related receptor, beta