Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
Report shows that sensitivity to the anti-proliferative effects of tamoxifen in some ER-positive breast cancer cells expressing the hormone-binding hotspot ESR1 mutations is dependent on cross-talk with the IGF1R (show IGF1R Proteins) signaling pathway.
breast tumors that highly express ZEB1 exhibit ER-alpha promoter hypermethylation.
Study reports that ligand induces rapid interchromosomal interactions among subsets of estrogen receptor alpha-bound transcription units.
ESR1 can be a potential target for Ppituitary adenoma.
Genetic polymorphisms in VDR (show CYP27B1 Proteins), ESR1 and ESR2 (show ESR2 Proteins) genes may contribute to increased risks for Parkinson's disease. (Meta-analysis)
Data show that Cyclin D1 (show CCND1 Proteins), a major target of ERalpha, is transcriptionally up-regulated by IKKepsilon (show IKBKE Proteins) in a phospho-ERalpha-Ser (show SIGLEC1 Proteins)-167-dependent manner.
miR (show MLXIP Proteins)-221 and miR (show MLXIP Proteins)-222 play a significant role in the regulation of ERalpha expression at the protein level and could be potential targets for restoring ERalpha expression and responding to antiestrogen therapy in a subset of breast cancers.
our data suggest that HRG (show NRG1 Proteins)-beta1, bound to the ErbB2 (show ERBB2 Proteins) ErbB3 (show ERBB3 Proteins) heterodimer, in the presence of membrane ER-alpha, interacts with and activates PI 3 (show PI3 Proteins)-K/Akt (show AKT1 Proteins).
Thus, these findings suggest that Hsc70 (show HSPA8 Proteins) associates with unliganded hERalpha, and thereby deters hERalpha from recruiting transcriptional coregulators, presumably as a component of chaperone complexes.
Rare polymorphisms at codons 119 and 432 of CYP1B1 (show CYP1B1 Proteins) gene have higher risk for endometrial cancer, and positive correlations with ERalpha and ERbeta (show ESR2 Proteins) expressions in endometrial cancer.
Comprehensive genetic analysis for differential functions of esr1, esr2a, and esr2b in fish reproduction.
Data suggest that endocrine disruptor, 17alpha-ethinylestradiol, disrupts primordial germ cell migration and distribution in embryonic zebrafish; this effect appears to be mediated through estrogen receptor Esr2a (not Esr1 or Esr2b).
This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.
It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.
Involvement of maternal esr2a mRNA, presumably transactivated by maternal 17beta-estradiol stored in the oocyte from enveloping granulosa cells, in the epigenetic programming of zebrafish development.
during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase
show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.
Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta (show ESR2 Proteins) after a 21-day exposure to endocrine-disrupting chemicals.
Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b (show ESR2 Proteins), ERbeta1; and esr2a, ERbeta2 ).
Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.
ESR1 inhibits the expression of Pitx2 (show PITX2 Proteins) gene by binding to a left side-specific enhancer region in Pitx2 (show PITX2 Proteins) gene and recruiting histone deacetylase 1 (show HDAC1 Proteins) to this region, leading to the suppression of Pitx2 (show PITX2 Proteins) gene in the left lateral plate mesoderm.
Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.
Lupus-prone ERalpha -/- mice are not protected from lupus disease expression if ovariectomized.
Taken together, the above results clearly demonstrated an mTORC2 (show CRTC2 Proteins)-dependent regulation of actin polymerization that contributed to the effects of ERalpha and ERbeta (show ESR2 Proteins) on spatial learning, which may provide a novel target for the prevention and treatment of E2-related dementia in the aged population
These findings suggest that RASD1 (show RASD1 Proteins) acts as a novel signaling molecule and plays an important role in regulating dynamic uterine remodeling during the estrous cycle in the uterus.
Truncating mutations of Prlr (show PRLR Proteins) promote tumor growth in a model of human ERalpha+ breast cancer.
This comparative study documented the complexity of ERalpha genes, mRNAs, and proteins, and further determined the underlying structural basis of ligand-independent activation by C-terminally-truncated ERalpha variants.
E2-ERs system was functional in maintaining oocyte meiotic arrest by regulating the expression of natriuretic peptide C (show NPPC Proteins) and natriuretic peptide receptor 2 (NPPC (show NPPC Proteins)/NPR2 (show NPRL2 Proteins))
Ventromedial hypothalamus neurons expressing Esr1 are indispensable for female aggression.
Increased DNA methylation (show HELLS Proteins) accompanied this pattern, particularly at CpG dinucleotides located within binding or flanking regions for the transcriptional regulator CCCTC-binding factor (show CTCF Proteins) of ESR1 and ESR2 (show ESR2 Proteins), consistent with sustained transcriptional activation of ERa and ERb (show ESR2 Proteins)
Ciliary length and beat frequency of the oviductal epithelial cells are regulated through ESR1.
Loss of endothelial ERalpha reduces vascular stiffness in male mice fed a Western Diet with an associated outward hypertrophic remodeling of resistance arteries.
The mRNA expression of ER-alpha and ER-beta (show ESR2 Proteins) in the hypothalamus of developing male and female bovines, is reported.
Distribution of estrogen receptor alpha and progesterone receptor (show PGR Proteins) B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
ER-alpha is detected predominantly in the soma whereas ER-beta (show ESR2 Proteins) is only present in the nucleus of a few cells in the frontal cortex.
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
fetal ovary of cattle has the steroidogenic enzyme aromatase (show CYP19A1 Proteins) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
there are different levels of ERalpha, ERbeta (show ESR2 Proteins) and PR in bovine oviducts at different cycle stages in vivo
estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (show SNRPB Proteins)) and a comparison of these with normal ovarian structures are reported.
These data indicate that PGF2alpha, TNFalpha (show TNF Proteins) and IFNgamma regulate ERalpha and ERbeta (show ESR2 Proteins) mRNA expressions in bovine luteal cells.
The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.
Results showed that the effects of FSHb (show FSHB Proteins), ESR, and PRLR (show PRLR Proteins) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.
The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.
ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII (show COX8A Proteins) and stage I of the seminiferous epithelial cycle, but not in other cells.
positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta (show ESR2 Proteins) stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells
The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 (show ESR2 Proteins)) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.
These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta (show ESR2 Proteins) activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.
Pig ejaculated spermatozoa express estrogen receptor.
The expression of mRNAs for ERalpha, ERbeta (show ESR2 Proteins) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.
The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.
The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.
expression of estrogen receptor alpha and beta and progesterone receptor (show PGR Proteins) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function
synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
, ERA-like GTPase
, ERA-like protein 1
, GTP-binding protein era homolog
, GTPase Era, mitochondrial
, conserved ERA-like GTPase
, estrogen receptor alpha 1
, estradiol receptor
, estrogen receptor
, nuclear receptor subfamily 3 group A member 1
, estrogen receptor alpha
, estrogen receptor, alpha
, estrogen nuclear receptor alpha
, estrogen receptor alpha 3*,4,5,6,7*/822 isoform
, estrogen receptor alpha E1-E2-1-2
, estrogen receptor alpha E1-N2-E2-1-2
, estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform
, estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform
, estrogen receptor alpha delta 4 +49 isoform
, estrogen receptor alpha delta 4*,5,6,7*/654 isoform
, estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform
, Er alpha
, estrogen receptor 1 (alpha)
, estrogen receptor alpha variant delta 4
, estrogen receptor protein
, estrogen receptor 1
, nuclear receptor
, Estradiol receptor
, Nuclear receptor subfamily 3 group A member 1
, estrogen alpha receptor