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Browse our Estrogen Receptor alpha Proteins (ESR1)

Full name:
Estrogen Receptor 1 Proteins (ESR1)
On www.antibodies-online.com are 36 Estrogen Receptor 1 (ESR1) Proteins from 12 different suppliers available. Additionally we are shipping Estrogen Receptor alpha Antibodies (1164) and Estrogen Receptor alpha Kits (97) and many more products for this protein. A total of 1328 Estrogen Receptor alpha products are currently listed.
Synonyms:
2610524P08Rik, 9130407C09Rik, AA420328, ACT1GP1, ACTGP1, AU019798, AU041214, ER, ER-alpha, ERa, ERAL1A, eralpha, ERbeta, ER[a], ER[b]2, ER[b]a, Esr, ESR1, ESRA, Estr, Estra, ESTRR, H-ERA, HERA-A, HERA-B, HY-psi-gamma-AC6, LOC398733, LOC398734, M-ERA, MERA-S, MERA-W, Nr3a1, RNESTROR, XER, xesr-1, xlERalpha1, xlERalpha2, zfER-beta2, zfER[a], zfER[b]2
list all proteins Gene Name GeneID UniProt
ESR1 73  
ESR1 57837 Q9CZU4
ESR1 24890 P06211

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Estrogen Receptor alpha Proteins (ESR1) by Origin

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More Proteins for Estrogen Receptor alpha Interaction Partners

Human Estrogen Receptor 1 (ESR1) interaction partners

  1. Review of the role of estrogen receptor alpha in obesity and diabetes.

  2. IKKalpha (show CHUK Proteins) is an important determinant of poor outcome in patients with ER-positive invasive ductal breast cancer and thus may represent a potential therapeutic target

  3. PHB (show PHB Proteins) promotes AR activation in ER-positive breast cancer.

  4. Lymph node involvement is more common with lack of ERalpha expression, and may be able to help triage which patients should undergo lymphadenectomy. Mutations in ESR1 might explain why some low risk women with low BMI develop endometrial cancer.

  5. We found an approximately approximately 3 fold increased rate of high RS among BRCA1 and 2 carriers with ER positive breast cancer (BC)compared with the general BC population

  6. we are lacking prospective studies to confirm these results and to determine the optimal treatment combinations for patients with the ESR1 mutations. In addition, the clinical development of novel agents to overcome resistance engendered by these mutations is also needed

  7. Estradiol induced the expression of ABCG2 through ERalpha and the over-expressed ABCG2 made MCF7 more tolerant to methotrexate.

  8. Associations in women between recognition of identity through vocal sounds and variation in ESR1.

  9. Association study investigated the ESR1, ESR2 (show ESR2 Proteins), and CYP19A1 (show CYP19A1 Proteins) gene polymorphisms in Chinese migraine patients, data suggested that ESR1 rs2234693 plays a potential role in migraine susceptibility in a Chinese population, especially for menstrually related migraine

  10. Estrogen receptor 1 (ESR1) single nucleotide polymorphism (SNP) rs1062577 A allele is significantly associated with the elevated risk and greater stages of breast cancer.

Zebrafish Estrogen Receptor 1 (ESR1) interaction partners

  1. Data suggest that endocrine disruptor, 17alpha-ethinylestradiol, disrupts primordial germ cell migration and distribution in embryonic zebrafish; this effect appears to be mediated through estrogen receptor Esr2a (not Esr1 or Esr2b).

  2. This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.

  3. It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.

  4. Involvement of maternal esr2a mRNA, presumably transactivated by maternal 17beta-estradiol stored in the oocyte from enveloping granulosa cells, in the epigenetic programming of zebrafish development.

  5. during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase

  6. show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.

  7. Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta (show ESR2 Proteins) after a 21-day exposure to endocrine-disrupting chemicals.

  8. Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b (show ESR2 Proteins), ERbeta1; and esr2a, ERbeta2 ).

  9. Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.

  10. genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A (show ESR2 Proteins) and ERbeta-B and induces apoptosis in an ER-independent manner

Xenopus laevis Estrogen Receptor 1 (ESR1) interaction partners

  1. ESR1 inhibits the expression of Pitx2 (show PITX2 Proteins) gene by binding to a left side-specific enhancer region in Pitx2 (show PITX2 Proteins) gene and recruiting histone deacetylase 1 (show HDAC1 Proteins) to this region, leading to the suppression of Pitx2 (show PITX2 Proteins) gene in the left lateral plate mesoderm.

  2. Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.

Mouse (Murine) Estrogen Receptor 1 (ESR1) interaction partners

  1. Triptorelin and cetrorelix induce immune responses and affect uterine development and expressions of genes and proteins of ESR1, LHR (show LHCGR Proteins), and FSHR (show FSHR Proteins)

  2. the augmentation of endogenous MTA1 (show MTA1 Proteins) expression during neuronal ischemic injury acts additionally to an endocrinous cascade orchestrating intimate interactions between ERalpha and BCL2 (show BCL2 Proteins) pathways.

  3. BMP4 (show BMP4 Proteins) inhibited ERalpha signaling by increasing the degradation of ERalpha, and that the expression of BMP4 (show BMP4 Proteins) itself was suppressed by estrogens.

  4. Suggest that insulin (show INS Proteins) promotes the expression of DNA methyltransferases, induces methylation of ER-alpha second exon region and decreases the expression of ER-alpha, thereby interfering with estrogen regulation of VSMCs proliferation, resulting in atherosclerosis.

  5. ER-alpha plays a more critical role in promoting adipose-derived stem cells proliferation and migration while ER-beta (show ESR2 Proteins) is more potent in suppressing adipose-derived stem cells brown adipose tissue differentiation mediated by decreased UCP-1 (show UCP1 Proteins), PGC-1alpha and PPAR (show PPARA Proteins)-x03B3; expression.

  6. Data indicate bacterial metabolic and other pathway differences in the seminal fluid of wildtype vs. estrogen receptor-alpha (ESR1) knockout (KO) mice.

  7. suppression of AKT (show AKT1 Proteins) by hyperactivation of mTORC1, inhibition on nuclear ERalpha signaling, and down-regulation of cell-cycle-driving proteins play important roles in the retarded mammary development induced by Tsc1 (show TSC1 Proteins) deletion.

  8. Results indicate that estrogen receptor alpha (ERalpha) might affect embryo cavitation by regulating trophectoderm (TE) lineage differentiation.

  9. These findings indicate the retention of dysfunctional mitochondria in MERKO muscle and implicate ERalpha in the preservation of mitochondrial health and insulin (show INS Proteins) sensitivity as a defense against metabolic disease in women.

  10. a specific interaction with liver X receptor alpha (LXRalpha (show NR1H3 Proteins)) mediates the broad effects of ERalpha on the hepatic lipid metabolism.

Rainbow Trout (Oncorhynchus mykiss) Estrogen Receptor 1 (ESR1) interaction partners

Cow (Bovine) Estrogen Receptor 1 (ESR1) interaction partners

  1. The mRNA expression of ER-alpha and ER-beta (show ESR2 Proteins) in the hypothalamus of developing male and female bovines, is reported.

  2. Distribution of estrogen receptor alpha and progesterone receptor (show PGR Proteins) B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study

  3. ER-alpha is detected predominantly in the soma whereas ER-beta (show ESR2 Proteins) is only present in the nucleus of a few cells in the frontal cortex.

  4. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1

  5. fetal ovary of cattle has the steroidogenic enzyme aromatase (show CYP19A1 Proteins) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary

  6. there are different levels of ERalpha, ERbeta (show ESR2 Proteins) and PR in bovine oviducts at different cycle stages in vivo

  7. estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period

  8. The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (show SNRPB Proteins)) and a comparison of these with normal ovarian structures are reported.

  9. These data indicate that PGF2alpha, TNFalpha (show TNF Proteins) and IFNgamma regulate ERalpha and ERbeta (show ESR2 Proteins) mRNA expressions in bovine luteal cells.

  10. The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.

Pig (Porcine) Estrogen Receptor 1 (ESR1) interaction partners

  1. These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.

  2. Results showed that the effects of FSHb (show FSHB Proteins), ESR, and PRLR (show PRLR Proteins) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.

  3. The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.

  4. ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII (show COX8A Proteins) and stage I of the seminiferous epithelial cycle, but not in other cells.

  5. positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta (show ESR2 Proteins) stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells

  6. The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 (show ESR2 Proteins)) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.

  7. These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta (show ESR2 Proteins) activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.

  8. Pig ejaculated spermatozoa express estrogen receptor.

  9. The expression of mRNAs for ERalpha, ERbeta (show ESR2 Proteins) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.

Horse (Equine) Estrogen Receptor 1 (ESR1) interaction partners

  1. The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.

  2. The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.

  3. expression of estrogen receptor alpha and beta and progesterone receptor (show PGR Proteins) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function

Rhesus Monkey Estrogen Receptor 1 (ESR1) interaction partners

  1. synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance

Estrogen Receptor alpha (ESR1) Protein Profile

Protein Summary

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Alternative names and synonyms associated with Estrogen Receptor alpha (ESR1)

  • actin, gamma 1 pseudogene 1 (ACTG1P1)
  • estrogen receptor 2a (esr2a)
  • estrogen receptor 1 (esr1)
  • estrogen receptor alpha 2 (LOC398733)
  • estrogen receptor alpha 1 (LOC398734)
  • Era (G-protein)-like 1 (E. coli) (Eral1)
  • Era-like 12S mitochondrial rRNA chaperone 1 (ERAL1)
  • estrogen receptor (er)
  • estrogen receptor 1 (ESR1)
  • estrogen receptor 1 (Esr1)
  • estrogen receptor 1 (alpha) (Esr1)
  • estrogen receptor alpha-like (LOC100351261)
  • 2610524P08Rik protein
  • 9130407C09Rik protein
  • AA420328 protein
  • ACT1GP1 protein
  • ACTGP1 protein
  • AU019798 protein
  • AU041214 protein
  • ER protein
  • ER-alpha protein
  • ERa protein
  • ERAL1A protein
  • eralpha protein
  • ERbeta protein
  • ER[a] protein
  • ER[b]2 protein
  • ER[b]a protein
  • Esr protein
  • ESR1 protein
  • ESRA protein
  • Estr protein
  • Estra protein
  • ESTRR protein
  • H-ERA protein
  • HERA-A protein
  • HERA-B protein
  • HY-psi-gamma-AC6 protein
  • LOC398733 protein
  • LOC398734 protein
  • M-ERA protein
  • MERA-S protein
  • MERA-W protein
  • Nr3a1 protein
  • RNESTROR protein
  • XER protein
  • xesr-1 protein
  • xlERalpha1 protein
  • xlERalpha2 protein
  • zfER-beta2 protein
  • zfER[a] protein
  • zfER[b]2 protein

Protein level used designations for Estrogen Receptor 1 Proteins (ESR1)

ERbeta-B , NR3A2-B , estrogen receptor beta2 , estrogen receptor 1 , estrogen receptor alpha , estrogen receptor alpha 2 , bER alpha1 , gER alpha1 , brain estrogen receptor alpha1 , gonad estrogen receptor alpha1 , estrogen receptor alpha 1 , CEGA , ERA-W , ERA-like GTPase , ERA-like protein 1 , GTP-binding protein era homolog , GTPase Era, mitochondrial , conserved ERA-like GTPase , Era G-protein-like 1 , GTPase, human homolog of E. coli essential cell cycle protein Era , era (E. coli G-protein homolog)-like 1 , hERA , estrogen receptor , ER-alpha , estradiol receptor , estrogen nuclear receptor alpha , estrogen receptor alpha 3*,4,5,6,7*/822 isoform , estrogen receptor alpha E1-E2-1-2 , estrogen receptor alpha E1-N2-E2-1-2 , estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform , estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform , estrogen receptor alpha delta 4 +49 isoform , estrogen receptor alpha delta 4*,5,6,7*/654 isoform , estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform , nuclear receptor subfamily 3 group A member 1 , Er alpha , estrogen receptor 1 (alpha) , estrogen receptor alpha variant delta 4 , estrogen receptor protein , ER , estrogen receptor, alpha , nuclear receptor , Estradiol receptor , Nuclear receptor subfamily 3 group A member 1

GENE ID SPECIES
73 Homo sapiens
317734 Danio rerio
394461 Xenopus (Silurana) tropicalis
398733 Xenopus laevis
398734 Xenopus laevis
57837 Mus musculus
26284 Homo sapiens
100136026 Oncorhynchus mykiss
2099 Homo sapiens
24890 Rattus norvegicus
407238 Bos taurus
397435 Sus scrofa
396099 Gallus gallus
443228 Ovis aries
100860768 Capra hircus
403640 Canis lupus familiaris
552888 Felis catus
791249 Equus caballus
613025 Macaca mulatta
100713276 Cavia porcellus
100136461 Salmo salar
259252 Danio rerio
751998 Taeniopygia guttata
101825539 Mesocricetus auratus
13982 Mus musculus
100351261 Oryctolagus cuniculus
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