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Browse our Estrogen Receptor alpha Proteins (ESR1)

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Estrogen Receptor 1 Proteins (ESR1)
On are 25 Estrogen Receptor 1 (ESR1) Proteins from 11 different suppliers available. Additionally we are shipping Estrogen Receptor alpha Antibodies (855) and Estrogen Receptor alpha Kits (122) and many more products for this protein. A total of 1033 Estrogen Receptor alpha products are currently listed.
2610524P08Rik, 9130407C09Rik, AA420328, ACT1GP1, ACTGP1, AU019798, AU041214, ER, ER-alpha, ERa, ERAL1A, eralpha, ERbeta, ER[a], ER[b]2, ER[b]a, Esr, ESR1, ESRA, Estr, Estra, ESTRR, H-ERA, HERA-A, HERA-B, HY-psi-gamma-AC6, LOC398733, LOC398734, M-ERA, MERA-S, MERA-W, Nr3a1, RNESTROR, XER, xesr-1, xlERalpha1, xlERalpha2, zfER-beta2, zfER[a], zfER[b]2
list all proteins Gene Name GeneID UniProt
ESR1 73  
ESR1 57837 Q9CZU4
ESR1 24890 P06211

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Estrogen Receptor alpha Proteins (ESR1) by Origin

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More Proteins for Estrogen Receptor alpha Interaction Partners

Human Estrogen Receptor 1 (ESR1) interaction partners

  1. For key genes ERBB2 (show ERBB2 Proteins) and ESR1, we demonstrate that overexpression is linked to the production of highly modified and truncated splice variants in tumours, but not controls, correlated with tumour subtype

  2. The ESR1 ubiquitin binding surface contributes to the modulation of estradiol-induced ESR1-mediated cell proliferation.

  3. ESR1 mutations can be robustly identified with circulating DNA analysis and predict for resistance to aromatase (show CYP19A1 Proteins) inhibitors therapy.

  4. ESR1 may be associated with low mineral osseous densitometry, while CYP17 (show CYP17A1 Proteins) and COMT (show COMT Proteins) gene polymorphisms were not associated with mineral osseous densitometry.

  5. Data suggest 17beta-estradiol stimulates odontoblastic differentiation of dental pulp via coordinated regulation of estrogen receptor alpha, c-Src (show SRC Proteins), and MAP kinase (show MAPK1 Proteins) signaling pathways, which may play key role in calcification/regeneration of dentin.

  6. Enhanced KLF17 (show KLF17 Proteins) expression sensitizes ERalpha-positive breast cancer cells to endocrine therapy.KLF17-ERalpha interaction plays a potential role in inhibition of ERalpha-dependent breast cancer progression.

  7. Among the proteins reported here, some well-known breast cancer markers (e.g., annexin A1 (show ANXA1 Proteins), annexin A2 (show ANXA2 Proteins) and vimentin (show VIM Proteins)) were identified in the MDA-MB-231 cell line and thus we were able to distinguish both cell lines sufficiently.

  8. homozygote (XX) genotype of ER-alpha gene XbaI polymorphism, but not PvuII mutation, may increase the risk of chronic periodontitis, specifically in the Chinese Han female population.

  9. Cells traditionally considered as being deprived of estrogen receptor are able to respond to hormonal stimulation via the ERalpha36 receptor. [Review]

  10. SERD- or SSH-palbociclib combination has therapeutic potential in breast tumors resistant to endocrine therapies or those expressing ESR1 mutations

Zebrafish Estrogen Receptor 1 (ESR1) interaction partners

  1. Data suggest that endocrine disruptor, 17alpha-ethinylestradiol, disrupts primordial germ cell migration and distribution in embryonic zebrafish; this effect appears to be mediated through estrogen receptor Esr2a (not Esr1 or Esr2b).

  2. This study revealed similar patterns of transcript abundance across reproductive morphs for ERbeta1, ERbeta2, ERalpha, and aromatase in the forebrain and saccule.

  3. It was concluded that morpholino (MO) oligonucleotid technology in zebrafish embryos is an good approach for investigating the interplay of estrogen receptor subtypes in a true physiological context.

  4. Involvement of maternal esr2a mRNA, presumably transactivated by maternal 17beta-estradiol stored in the oocyte from enveloping granulosa cells, in the epigenetic programming of zebrafish development.

  5. during embryogenesis two of the three 17beta-estradiol receptor genes, esr1 and esr2b are expressed, and in presence of ligand the mRNA levels of these two genes increase

  6. show that inactivation of the estrogen receptor ESR1 results in ectopic expression of cxcr4b throughout the primordium, whereas ESR1 overexpression results in a reciprocal reduction in the domain of cxcr4b expression.

  7. Data show that temperature and photoperiod significantly influence the transcription of the estrogen-responsive genes, Vtg1, Vtg2, ER alpha and ER beta (show ESR2 Proteins) after a 21-day exposure to endocrine-disrupting chemicals.

  8. Cloning of the cDNAs corresponding to three oestrogen receptors (esr1, ERalpha; esr2b (show ESR2 Proteins), ERbeta1; and esr2a, ERbeta2 ).

  9. Data show that the hepatic expression of estrogen receptor alpha, beta1 and beta2 genes responds differently to estradiol.

  10. genistein binds and activates the three zebrafish estrogen receptors ERalpha, ERbeta-A (show ESR2 Proteins) and ERbeta-B and induces apoptosis in an ER-independent manner

Xenopus laevis Estrogen Receptor 1 (ESR1) interaction partners

  1. ESR1 inhibits the expression of Pitx2 (show PITX2 Proteins) gene by binding to a left side-specific enhancer region in Pitx2 (show PITX2 Proteins) gene and recruiting histone deacetylase 1 (show HDAC1 Proteins) to this region, leading to the suppression of Pitx2 (show PITX2 Proteins) gene in the left lateral plate mesoderm.

  2. Data suggest a dual regulation in which XESR5 produces a competent area for mesoderm formation by suppressing the gene expression of XESR1, while XESR1 sharpens the boundary of Xbra expression.

Mouse (Murine) Estrogen Receptor 1 (ESR1) interaction partners

  1. Results indicate that green fluorescent protein visualizes a sex difference of estrogen receptor-alpha expressing neurons.

  2. After ERbeta interference, beta-catenin, p-Gsk3beta (Ser9) and CyclinDl were strongly expressed compared with expressions in the blank control group

  3. ERalpha responses E2-induced ERRalpha (show ESRRA Proteins) activation, while ERbeta (show ESR2 Proteins) responses the basal expression

  4. Thus, suppression of oviductal protease (show OVCH2 Proteins) activity mediated by estrogen-epithelial estrogen receptor alpha signaling is required for fertilization and preimplantation embryo development.

  5. Data show that ablation of estrogen receptor alpha (ERalpha) in endothelial cell (EC) reduced Western diet (WD)-induced vascular stiffness and improved endothelial-dependent dilation.

  6. Data show that estrogen receptor alpha (ERalpha) in tachykinin 2 (show TAC1 Proteins) protein (Tac2 (show TAC1 Proteins)) neurons typically restrains pubertal onset and hypothalamic reproductive drive.

  7. Data show that estradiol has no effect on kisspeptin (Kiss1 (show KISS1 Proteins)) mRNA expression in prepubertal Kiss1 (show KISS1 Proteins) cell-specific estrogen receptoralpha knockout (KERalphaKO) mice.

  8. These data suggest that ERalpha mediates the neurite outgrowth promoting effects of estradiol in olfactory epithelium cultures.

  9. we generated a novel ERalpha-ZsGreen reporter mouse line in which expression of a green fluorescent reporter protein, ZsGreen, is driven by a 241kb ERalpha gene promoter

  10. This is the first study to estimate protein expression changes in urethras from ERalpha(-/-) female mice. These changes could be related to the molecular mechanism of ERalpha in SUI.

Rainbow Trout (Oncorhynchus mykiss) Estrogen Receptor 1 (ESR1) interaction partners

Cow (Bovine) Estrogen Receptor 1 (ESR1) interaction partners

  1. The mRNA expression of ER-alpha and ER-beta (show ESR2 Proteins) in the hypothalamus of developing male and female bovines, is reported.

  2. Distribution of estrogen receptor alpha and progesterone receptor (show PGR Proteins) B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study

  3. ER-alpha is detected predominantly in the soma whereas ER-beta (show ESR2 Proteins) is only present in the nucleus of a few cells in the frontal cortex.

  4. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1

  5. fetal ovary of cattle has the steroidogenic enzyme aromatase (show CYP19A1 Proteins) to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary

  6. there are different levels of ERalpha, ERbeta (show ESR2 Proteins) and PR in bovine oviducts at different cycle stages in vivo

  7. estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period

  8. The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD (show SNRPB Proteins)) and a comparison of these with normal ovarian structures are reported.

  9. These data indicate that PGF2alpha, TNFalpha (show TNF Proteins) and IFNgamma regulate ERalpha and ERbeta (show ESR2 Proteins) mRNA expressions in bovine luteal cells.

  10. The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.

Pig (Porcine) Estrogen Receptor 1 (ESR1) interaction partners

  1. These results will improve the understanding of the functions of the ESR1 in spermatogenesis within the reproductive tract and will shed light on ESR1 as a candidate in the selection of boar with good sperm quality and fertility.

  2. Results showed that the effects of FSHb (show FSHB Proteins), ESR, and PRLR (show PRLR Proteins) genes were significant in the Tibet pig population, and the effective genotypes of the three genes for reproductive traits were BB, BB, and AA, respectively.

  3. The aim of this work was to study the effects on litter size of variants of the porcine genes RBP4, ESR1 and IGF2, currently used in genetic tests for different purposes.

  4. ERalpha mRNA was present in type A and type B spermatogonia up to mid-pachytene primary spermatocytes in stage V-VIII (show COX8A Proteins) and stage I of the seminiferous epithelial cycle, but not in other cells.

  5. positive staining for ERalpha in the nuclei of skeletal muscle cells, while the ERbeta (show ESR2 Proteins) stain showed positive signals in nuclei and cytoplasm of skeletal myofibers and myoblasts derived from satellite cells

  6. The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 (show ESR2 Proteins)) and to analyze the effects of these variants and the well known intronic ESR1 PvuII polymorphism on litter size.

  7. These data demonstrate novel and differential mechanisms by which ERalpha and ERbeta (show ESR2 Proteins) activation control coronary artery vasoreactivity in males and females and regulate vascular NO and O(2)(-) formation.

  8. Pig ejaculated spermatozoa express estrogen receptor.

  9. The expression of mRNAs for ERalpha, ERbeta (show ESR2 Proteins) and PR in the sow uterus differed between endometrium and myometrium as well as with stages of the estrous cycle and early pregnancy.

Horse (Equine) Estrogen Receptor 1 (ESR1) interaction partners

  1. The presence of a single isoform of ESR1 (66kDa) and ESR2 (61kDa) was found by Western-blot analysis in samples from seven stallions and the expression of the seven transmembrane estradiol binding receptor GPER in colt testis.

  2. The spatial arrangement of estrogen receptor alpha during early pregnancy showed cytoplasmic staining of endometrial epithelia and in the nuclei of occasional stromal cells.

  3. expression of estrogen receptor alpha and beta and progesterone receptor (show PGR Proteins) in equine microplacentomes gives evidence for a role of placental steroids as regulators of placental function

Rhesus Monkey Estrogen Receptor 1 (ESR1) interaction partners

  1. synaptic abundance of ER-alpha in prefronal cortex is correlated with individual cognitive performance

Estrogen Receptor alpha (ESR1) Protein Profile

Protein Summary

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.

Alternative names and synonyms associated with Estrogen Receptor alpha (ESR1)

  • actin, gamma 1 pseudogene 1 (ACTG1P1)
  • estrogen receptor 2a (esr2a)
  • estrogen receptor 1 (esr1)
  • estrogen receptor alpha 2 (LOC398733)
  • estrogen receptor alpha 1 (LOC398734)
  • Era (G-protein)-like 1 (E. coli) (Eral1)
  • Era-like 12S mitochondrial rRNA chaperone 1 (ERAL1)
  • estrogen receptor (er)
  • estrogen receptor 1 (ESR1)
  • estrogen receptor 1 (Esr1)
  • estrogen receptor 1 (alpha) (Esr1)
  • estrogen receptor alpha-like (LOC100351261)
  • 2610524P08Rik protein
  • 9130407C09Rik protein
  • AA420328 protein
  • ACT1GP1 protein
  • ACTGP1 protein
  • AU019798 protein
  • AU041214 protein
  • ER protein
  • ER-alpha protein
  • ERa protein
  • ERAL1A protein
  • eralpha protein
  • ERbeta protein
  • ER[a] protein
  • ER[b]2 protein
  • ER[b]a protein
  • Esr protein
  • ESR1 protein
  • ESRA protein
  • Estr protein
  • Estra protein
  • ESTRR protein
  • H-ERA protein
  • HERA-A protein
  • HERA-B protein
  • HY-psi-gamma-AC6 protein
  • LOC398733 protein
  • LOC398734 protein
  • M-ERA protein
  • MERA-S protein
  • MERA-W protein
  • Nr3a1 protein
  • RNESTROR protein
  • XER protein
  • xesr-1 protein
  • xlERalpha1 protein
  • xlERalpha2 protein
  • zfER-beta2 protein
  • zfER[a] protein
  • zfER[b]2 protein

Protein level used designations for Estrogen Receptor 1 Proteins (ESR1)

ERbeta-B , NR3A2-B , estrogen receptor beta2 , estrogen receptor 1 , estrogen receptor alpha , estrogen receptor alpha 2 , bER alpha1 , gER alpha1 , brain estrogen receptor alpha1 , gonad estrogen receptor alpha1 , estrogen receptor alpha 1 , CEGA , ERA-W , ERA-like GTPase , ERA-like protein 1 , GTP-binding protein era homolog , GTPase Era, mitochondrial , conserved ERA-like GTPase , Era G-protein-like 1 , GTPase, human homolog of E. coli essential cell cycle protein Era , era (E. coli G-protein homolog)-like 1 , hERA , estrogen receptor , ER-alpha , estradiol receptor , estrogen nuclear receptor alpha , estrogen receptor alpha 3*,4,5,6,7*/822 isoform , estrogen receptor alpha E1-E2-1-2 , estrogen receptor alpha E1-N2-E2-1-2 , estrogen receptor alpha delta 3*,4,5,6,7*,8*/941 isoform , estrogen receptor alpha delta 3*,4,5,6,7*/819-2 isoform , estrogen receptor alpha delta 4 +49 isoform , estrogen receptor alpha delta 4*,5,6,7*/654 isoform , estrogen receptor alpha delta 4*,5,6,7,8*/901 isoform , nuclear receptor subfamily 3 group A member 1 , Er alpha , estrogen receptor 1 (alpha) , estrogen receptor alpha variant delta 4 , estrogen receptor protein , ER , estrogen receptor, alpha , nuclear receptor , Estradiol receptor , Nuclear receptor subfamily 3 group A member 1

73 Homo sapiens
317734 Danio rerio
394461 Xenopus (Silurana) tropicalis
398733 Xenopus laevis
398734 Xenopus laevis
57837 Mus musculus
26284 Homo sapiens
100136026 Oncorhynchus mykiss
2099 Homo sapiens
24890 Rattus norvegicus
407238 Bos taurus
397435 Sus scrofa
396099 Gallus gallus
443228 Ovis aries
100860768 Capra hircus
403640 Canis lupus familiaris
552888 Felis catus
791249 Equus caballus
613025 Macaca mulatta
100713276 Cavia porcellus
100136461 Salmo salar
259252 Danio rerio
751998 Taeniopygia guttata
101825539 Mesocricetus auratus
13982 Mus musculus
100351261 Oryctolagus cuniculus
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