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The finding that overexpression of HIF-1alpha (show HIF1A Proteins) increased the activity of the CYP7A1 (show CYP7A1 Proteins) promoter suggested that hypoxia decreased the expression of CYP7A1 (show CYP7A1 Proteins) in a HIF-1 (show HIF1A Proteins)-independent manner.
Results demonstrated a detrimental effect of Bcl2 (show BCL2 Proteins) and H19 (show NCKAP1 Proteins) associated with cholestatic liver fibrosis and an indispensable role of Shp (show LAMC1 Proteins) to maintain normal liver function.
These findings show that POD-1/TCF21 (show TCF21 Proteins) regulates SF-1 (show NR5A1 Proteins) and LRH-1 (show NR5A2 Proteins) by distinct mechanisms, contributing to the understanding of POD-1 (show TCF21 Proteins) involvement and its mechanisms of action in adrenal and liver tumorigenesis.
Overexpression of SHP (show LAMC1 Proteins) and activation of AMPK (show PRKAA1 Proteins) reverses profibrogenic features of HCV-infected cells by decreasing TGF-beta (show TGFB1 Proteins) and fibrotic gene expression.
Data suggest that LRH1/NR5A2 (show NR5A2 Proteins) (liver receptor homologue-1) exhibits phospholipid-mediated allosteric control of protein-protein binding interface in interactions with TIF2 (show NCOA2 Proteins) (co-activator; transcription intermediary factor 2) and SHP (show LAMC1 Proteins).
At the molecular level, estrogen upregulated hepatic SHP (show LAMC1 Proteins) expression through binding to its proximal promoter. In addition, the roles of estrogen were largely blunted in mice with SHP (show LAMC1 Proteins) deficiency.
These data are suggestive of a role for SHP (show LAMC1 Proteins) in controlling NLRP3 (show NLRP3 Proteins) inflammasome activation through a mechanism involving interaction with NLRP3 (show NLRP3 Proteins) and maintenance of mitochondrial homeostasis.
These results establish SHP (show LAMC1 Proteins) as a novel antihypertrophic regulator that acts by interfering with GATA6 (show GATA6 Proteins) signaling.
E2F1 transcription factor (show E2F1 Proteins) activates early growth response (Egr)-1 (show EGR1 Proteins) promoter which is repressed by SHP (show LAMC1 Proteins) and EIA-like inhibitor of differentiation (EID)1 (show EID1 Proteins).
SHP (show LAMC1 Proteins) regulates PDCD5 (show PDCD5 Proteins)-mediated apoptosis in cancer cells
Six novel SNPs, five in ME1 (show ME1 Proteins) and one in NR0B2, were identified as candidates that have effects on meat and carcass quality traits.
Mortality of SHP (show LAMC1 Proteins)-/- mice after ethanol binge feeding was significantly reduced and Aldh2 (show ALDH2 Proteins) mRNA level was higher. After an intoxicating dose of ethanol, SHP (show LAMC1 Proteins)-/- mice exhibited faster blood ethanol clearance.
This study reveals SHP (show LAMC1 Proteins) as a global transcriptional partner of SREBP-2 (show SREBF2 Proteins) in regulation of sterol biosynthetic gene networks and provides a potential mechanism for cholesterol-lowering action of FGF19 (show FGF19 Proteins).
Our results suggest that SHP (show LAMC1 Proteins) is required for both antidiabetic and hypolipidemic effects of TZDs in ob/ob mice through regulation of PPARgamma (show PPARG Proteins) expression.
LSD1 (show KDM1A Proteins) is a novel histone-modifying enzyme in the orchestrated regulation mediated by the farnesoid X receptor (show xpr1 Proteins) and small heterodimer partner that reduces hepatic bile acid levels and protects the liver against bile acid toxicity.
SHP (show LAMC1 Proteins) ablation creates a proinflammatory phenotype which is exacerbated after sleeve gastrectomy despite weight loss. These inflammatory alterations are possibly related to factors extrinsic to a direct manifestation of Non-alcoholic fatty liver.
Data indicate that EE2-induced cholestasis increases SHP (show LAMC1 Proteins) and represses CYP2D6 (show CYP2D6 Proteins) expression in Tg-CYP2D6 (show CYP2D6 Proteins) mice in part through ERa transactivation of Shp (show LAMC1 Proteins) promoter.
Neonatal exposure to diethylstilbestrol alters adult hepatic physiology in an SHP (show LAMC1 Proteins)-dependent manner.
Disruption of Shp (show LAMC1 Proteins) in mice alters timing of expression of genes that regulate homocysteine metabolism and the liver responses to ethanol and homocysteine. SHP (show LAMC1 Proteins) inhibits the transcriptional activation of Bhmt (show BHMT Proteins) and cystathionine gamma-lyase (show CTH Proteins) by FOXA1 (show FOXA1 Proteins).
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
short heterodimer partner
, nuclear receptor subfamily 0 group B member 2
, nuclear receptor SHP
, orphan nuclear receptor SHP
, small heterodimer partner
, small heterodimer partner homologue