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Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor (show ESRRA Proteins) gene Rev-erbalpha.
To determine the impact of REV-ERBalpha activation in the cigarette smoke (CS)-induced lung inflammatory response, we treated primary small airway epithelial cells with CS extract or lipopolysaccharide in the absence or presence of pre-treatment with the REV-ERBalpha agonist GSK 4112.
Downregulation of NR1D1 in MCF7 cells resulted in resistance to doxorubicin, both in vitro and in vivo Analysis of four public patient data sets indicated that NR1D1 expression correlates positively with clinical outcome in breast cancer patients who received chemotherapy. Our findings suggest that NR1D1 and its ligands provide therapeutic options that could enhance the outcomes of chemotherapy in breast cancer patients
Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha specificity for the NCoR (show NCOR1 Proteins) corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR (show NCOR1 Proteins).
Data show that ubiquitin E3 ligase Siah2 (show SIAH2 Proteins) depletion delays circadian degradation of nuclear hormone receptor (show NR0B1 Proteins) RevErbalpha (Nr1d1) and lengthens period length.
the role of NR1D1 polymorphisms in the regulation of Nuclear receptor REV-ERBalpha and circadian rhythms regulation
associations between NR1D1, RORA (show RORA Proteins) and RORB (show RORB Proteins) genes and bipolar disorder.(
CRY2 (show CRY2 Proteins) and REV-ERB ALPHA as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA is an important gene associated with MS.
Our results suggest that the REV-ERB ALPHA rs939347 polymorphism could modulate body fat mass in men. The present work supports the role of REV-ERB ALPHA in the development of obesity as well as a potential target for the treatment of obesity
Using free-energy simulations, the study shows that rev-erbA-alpha-induced DNA deformation preferentially occurs by induced fit rather than by conformational selection, even though the DNA is only slightly distorted in the complex.
Rev-erbalpha is a novel regulator of hepatic stellate cell transdifferentation
Data demonstrated that the circadian rhythm of testosterone synthesis in TM3 (show TPM1 Proteins) cells was disturbed following Fen treatment as evidenced by changes in the circadian rhythmicity of core clock genes (Bmal1 (show ARNTL Proteins), Rev-erbalpha, Roralpha).
REV-ERBalpha KO mice show a greater inflammatory response to 10 and 30 days of cigarette smoke, including increased neutrophil lung influx, pro-inflammatory cytokine release, and pro-senescence marker when compared to WT mice.
that REV-ERBalpha plays a major role in retinal information processing
A significant proportion of circadian lncRNAs are expressed at enhancer regions, mostly bound by two key circadian transcription factors, BMAL1 (show ARNTL Proteins) and REV-ERBalpha.
SHP (show LAMC1 Proteins) and REV-ERBalpha play a critical role in controlling rhythmic CHOP (show DDIT3 Proteins) expression in alcoholic fatty liver.
REV-ERBalpha binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (show HSP90AA2 Proteins) and HSP90beta (show HSP90AB1 Proteins), a chaperone responsible for the activation of proteins to ensure survival of a cell.
Our findings may throw light on the function of ApoA4 (show APOA4 Proteins) in inflammatory responses and acute-phase reactions, as well as the development of SERPINA3 (show SERPINA3 Proteins) relative diseases.
Using circular chromosome conformation capture sequencing, we systematically examined the interacting loci of a Bmal1 (show ARNTL Proteins)-bound super-enhancer upstream of a clock gene Nr1d1 in mouse liver. Global analysis showed that cohesin-CTCF (show CTCF Proteins) co-binding sites tend to insulate the phases of circadian oscillating genes while cohesin-non-CTCF (show CTCF Proteins) sites are associated with high circadian rhythmicity of transcription.
Nr1d1 gene mutant mice, in which the DNA-binding domain (exons 3 and 4) was deleted (Nr1d1 Deltaex3/4) was used in this study. The Nr1d1 Deltaex3/4 mice showed enhanced hepatic steatosis after being challenged with an high-fat diet, but not with a low-fat diet, indicating an interaction between diet and genotype for this phenotypic change.
Study identifies a REV-ERBalpha post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins)) phosphorylation of REV-ERBalpha is recognized by the F-box protein (show FBXO30 Proteins), FBXW7alpha, to direct REV-ERBalpha degradation via the proteasome. Disruption of this CDK1 (show CDK1 Proteins)-FBXW7 (show FBXW7 Proteins)-mediated REV-ERBalpha degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...
results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha) plays an inhibitory role in the expression of prostaglandin G/H synthetase(PTGS2 (show PTGS2 Proteins)) in both bovine uterine stromal and epithelial cells treated with ovarian steroids
Rev-ErbAalpha is highly expressed in articular chondrocytes
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes.
nuclear receptor subfamily 1, group D, member 1
, nuclear receptor subfamily 1 group D member 1
, V-erbA-related protein 1
, nuclear receptor Rev-ErbA-alpha
, Rev-ErbA-alpha protein
, nuclear receptor protein
, orphan nuclear receptor
, rev-erb alpha
, rev-erbA alpha
, V-erbA-related protein EAR-1