Browse our NR1D1 Proteins (NR1D1)

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Nuclear Receptor Subfamily 1, Group D, Member 1 Proteins (NR1D1)
On are 5 Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) Proteins from 3 different suppliers available. Additionally we are shipping NR1D1 Antibodies (78) and NR1D1 Kits (2) and many more products for this protein. A total of 88 NR1D1 products are currently listed.
A530070C09Rik, ear-1, EAR1, Eip75B, hRev, MGC82865, MGC82881, R75201, REV-ERBAALPHA, THRA1, THRAL
list all proteins Gene Name GeneID UniProt
NR1D1 9572 P20393
NR1D1 217166 Q3UV55
Rat NR1D1 NR1D1 252917 Q63503

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NR1D1 Proteins (NR1D1) by Origin

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More Proteins for NR1D1 Interaction Partners

Zebrafish Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) interaction partners

  1. Two differentially active alternative promoters control the expression of the zebrafish orphan nuclear receptor (show ESRRA Proteins) gene Rev-erbalpha.

Human Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) interaction partners

  1. Highly quantitative fluorescence anisotropy assays in competition mode revealed that the rev-erbA-alpha specificity for the NCoR (show NCOR1 Proteins) corepressor lies in the first two residues of the beta-strand in Interaction Domain 1 of NCoR (show NCOR1 Proteins).

  2. Data show that ubiquitin E3 ligase Siah2 (show SIAH2 Proteins) depletion delays circadian degradation of nuclear hormone receptor (show NR0B1 Proteins) RevErbalpha (Nr1d1) and lengthens period length.

  3. the role of NR1D1 polymorphisms in the regulation of Nuclear receptor REV-ERBalpha and circadian rhythms regulation

  4. associations between NR1D1, RORA (show RORA Proteins) and RORB (show RORB Proteins) genes and bipolar disorder.(

  5. CRY2 (show CRY2 Proteins) and REV-ERB ALPHA as the clock genes upregulated in obesity during the 24 h period and that REV-ERB ALPHA is an important gene associated with MS.

  6. Our results suggest that the REV-ERB ALPHA rs939347 polymorphism could modulate body fat mass in men. The present work supports the role of REV-ERB ALPHA in the development of obesity as well as a potential target for the treatment of obesity

  7. Using free-energy simulations, the study shows that rev-erbA-alpha-induced DNA deformation preferentially occurs by induced fit rather than by conformational selection, even though the DNA is only slightly distorted in the complex.

  8. Rev-erbalpha is a novel regulator of hepatic stellate cell transdifferentation

  9. apoA-IV (show APOA4 Proteins) inhibits hepatic gluconeogenesis by decreasing Glc-6-Pase (show G6PC Proteins) and PEPCK (show PEPCK Proteins) gene expression through NR1D1.

  10. Rev-erbalpha bestows protection against mycobacterial infection by direct gene repression of IL10 (show IL10 Proteins) and thus provide a novel target in modulating macrophage microbicidal properties.

Mouse (Murine) Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) interaction partners

  1. SHP (show LAMC1 Proteins) and REV-ERBalpha play a critical role in controlling rhythmic CHOP (show DDIT3 Proteins) expression in alcoholic fatty liver.

  2. REV-ERBalpha binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (show HSP90AA2 Proteins) and HSP90beta (show HSP90AB1 Proteins), a chaperone responsible for the activation of proteins to ensure survival of a cell.

  3. Our findings may throw light on the function of ApoA4 (show APOA4 Proteins) in inflammatory responses and acute-phase reactions, as well as the development of SERPINA3 (show SERPINA3 Proteins) relative diseases.

  4. Using circular chromosome conformation capture sequencing, we systematically examined the interacting loci of a Bmal1 (show ARNTL Proteins)-bound super-enhancer upstream of a clock gene Nr1d1 in mouse liver. Global analysis showed that cohesin-CTCF (show CTCF Proteins) co-binding sites tend to insulate the phases of circadian oscillating genes while cohesin-non-CTCF (show CTCF Proteins) sites are associated with high circadian rhythmicity of transcription.

  5. Nr1d1 gene mutant mice, in which the DNA-binding domain (exons 3 and 4) was deleted (Nr1d1 Deltaex3/4) was used in this study. The Nr1d1 Deltaex3/4 mice showed enhanced hepatic steatosis after being challenged with an high-fat diet, but not with a low-fat diet, indicating an interaction between diet and genotype for this phenotypic change.

  6. Study identifies a REV-ERBalpha post-translational regulatory circuit in which cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins)) phosphorylation of REV-ERBalpha is recognized by the F-box protein (show FBXO30 Proteins), FBXW7alpha, to direct REV-ERBalpha degradation via the proteasome. Disruption of this CDK1 (show CDK1 Proteins)-FBXW7 (show FBXW7 Proteins)-mediated REV-ERBalpha degradation pathway in mouse liver alters circadian rhythmicity, in particular amplitude, and whole-body lipid/glucose home...

  7. lack of Rev-erbalpha increased Bmal1 (show ARNTL Proteins), Npas2 (show NPAS2 Proteins), Clock, and Fabp7 (show FABP7 Proteins) expression, confirming the direct regulation of these genes by REV-ERBalpha also in the brain; results add further proof to the notion that clock genes are involved in sleep homeostasis

  8. These observations establish a mechanistic link between the metabolic functions of Rev-erbalpha(Nr1d1) with mitochondrial homeostasis and protection against oxidative stress.

  9. REV-ERBalpha-mediated inhibition of CCL2 (show CCL2 Proteins) expression during viral-induced encephalitis may have a protective effect.

  10. These findings establish Rev-erbalpha as a specific modulator of FGF21 (show FGF21 Proteins) signaling in adipose tissue.

Cow (Bovine) Nuclear Receptor Subfamily 1, Group D, Member 1 (NR1D1) interaction partners

  1. results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha) plays an inhibitory role in the expression of prostaglandin G/H synthetase(PTGS2 (show PTGS2 Proteins)) in both bovine uterine stromal and epithelial cells treated with ovarian steroids

  2. Rev-ErbAalpha is highly expressed in articular chondrocytes

NR1D1 Protein Profile

Protein Summary

This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes.

Alternative names and synonyms associated with NR1D1

  • nuclear receptor subfamily 1, group D, member 1 (nr1d1)
  • nuclear receptor subfamily 1, group d, member 1 (nr1d1)
  • nuclear receptor subfamily 1, group D, member 1 (NR1D1)
  • nuclear receptor subfamily 1, group D, member 1 (Nr1d1)
  • A530070C09Rik protein
  • ear-1 protein
  • EAR1 protein
  • Eip75B protein
  • hRev protein
  • MGC82865 protein
  • MGC82881 protein
  • R75201 protein
  • REV-ERBAALPHA protein
  • THRA1 protein
  • THRAL protein

Protein level used designations for NR1D1

nuclear receptor subfamily 1, group D, member 1 , Reverbalpha , ear1 , nuclear receptor subfamily 1 group D member 1 , Rev-ErbAalpha , V-erbA-related protein 1 , nuclear receptor Rev-ErbA-alpha , rev-erbA-alpha , EAR-1 , REV-ERBalpha , Rev-ErbA-alpha protein , nuclear receptor protein , orphan nuclear receptor , rev-erb alpha , rev-erbA alpha , rev-erbA(alpha) , V-erbA-related protein EAR-1 , Rev-erbA-alpha

444369 Xenopus laevis
494487 Danio rerio
9572 Homo sapiens
217166 Mus musculus
100688236 Canis lupus familiaris
768225 Bos taurus
252917 Rattus norvegicus
641342 Sus scrofa
100174903 Ovis aries
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