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Browse our Nuclear Receptor Subfamily 1, Group D, Member 2 Proteins (NR1D2)

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Nuclear Receptor Subfamily 1, Group D, Member 2 Proteins (NR1D2)
On www.antibodies-online.com are 4 Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) Proteins from 3 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group D, Member 2 Antibodies (70) and Nuclear Receptor Subfamily 1, Group D, Member 2 Kits (3) and many more products for this protein. A total of 84 Nuclear Receptor Subfamily 1, Group D, Member 2 products are currently listed.
Synonyms:
BD73, EAR-1R, hs.37288, HZF-2, hzf2, NR1D2, Rev-erb, REV-ERBB, RVR
list all proteins Gene Name GeneID UniProt
NR1D2 9975 Q14995
NR1D2 353187 Q60674
Rat NR1D2 NR1D2 259241  

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Nuclear Receptor Subfamily 1, Group D, Member 2 Proteins (NR1D2) by Origin

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More Proteins for Nuclear Receptor Subfamily 1, Group D, Member 2 Interaction Partners

Human Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) interaction partners

  1. heme is involved in regulating the degradation of Rev-erbbeta in a manner consistent with its role in circadian rhythm maintenance

  2. Together, the findings demonstrate an anti-inflammatory effect, downregulating of MMP-9 (show MMP9 Proteins) and CCL2 (show CCL2 Proteins) transcription, of astroglial REV-ERBs activation through HDAC3 (show HDAC3 Proteins)-dependent and HDAC3 (show HDAC3 Proteins)-independent mechanisms.

  3. REV-ERBbeta plays a role in supporting cancer cell viability when autophagy is compromised.

  4. REV-ERB-ALPHA (show NR1D1 Proteins) circadian gene variant associates with obesity in two independent populations: Mediterranean and North American.

  5. Cobalt protoporphyrin IX (CoPP) and zinc protoporphyrin IX (ZnPP) are ligands that bind directly to the REV-ERBs. However, instead of mimicking the agonist action of heme, CoPP and ZnPP function as antagonists of REV-ERB function.

  6. Our results suggest that the REV-ERBalpha (show NR1D1 Proteins) rs2071427 polymorphism modulates body fat mass in both adult and young people.

  7. oxidative stress leads to oxidation of cysteine(s), thus releasing heme from Rev-erbbeta and altering its transcriptional activity.

  8. Nuclear receptor rev-erb-{alpha (show NR1D1 Proteins)} circadian gene variants have a role in response to lithium carbonate in bipolar affective disorder

  9. Rev-erbbeta modulates the apoCIII (show APOC3 Proteins) gene expression by recruiting different transcription co-activator or co-repressor.

  10. heme regulation of REV-ERBs may link the control of metabolism and the mammalian clock

Mouse (Murine) Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) interaction partners

  1. Loss of REV-ERB-BETA leads to de-repression of orexinergic genes.

  2. In conclusion, the present study demonstrates that KK-S6 functions as a novel modulator of the amplitude of molecular circadian rhythms by influencing RORE-mediated BMAL1 (show ARNTL Proteins) expression.

  3. Genetic deletion of the Rev-erbalpha (show NR1D1 Proteins) gene or pharmacological inhibition of REV-ERBalpha (show NR1D1 Proteins) activity in the ventral midbrain induced mania-like behavior in association with a central hyperdopaminergic state.

  4. data now unite REV-ERB-alpha and REV-ERB-beta with PER, CRY and other components of the principal feedback loop that drives circadian expression and indicate a more integral mechanism for the coordination of circadian rhythm and metabolism

  5. In mouse livers, Rev-erbbeta mRNA and protein levels oscillate with a diurnal pattern similar to that of Rev-erbalpha, and both Rev-erbs are recruited to a remarkably similar set of binding sites across the genome, enriched near metabolic genes

  6. The results suggest that heme, functioning as a REV-ERB ligand, is an important signaling molecule for induction of adipogenesis. Synthetic small molecule ligands for REV-ERB are effective modulators of adipogenesis.

  7. oscillation of p21WAF1/CIP1 gene transcription is regulated by the antagonistic activities of the orphan nuclear receptors REV-ERBalpha (show NR1D1 Proteins)/beta and RORalpha4/gamma, which are core clock regulators

  8. examined cell-autonomous circadian oscillations using combined gene knockout and RNA interference and demonstrated that REV-ERBalpha (show NR1D1 Proteins) and beta are functionally redundant and are required for rhythmic Bmal1 (show ARNTL Proteins) expression

  9. These data suggest that Rev-erb beta has the potential to activate gene expression, and is a positive regulator of Srebp-1c (show SREBF1 Proteins), a regulator of lipogenesis.

Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2) Protein Profile

Protein Summary

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group D, Member 2 (NR1D2)

  • nuclear receptor subfamily 1, group D, member 2 (NR1D2)
  • nuclear receptor subfamily 1, group D, member 2 (nr1d2)
  • nuclear receptor subfamily 1, group D, member 2 (LOC100218788)
  • nuclear receptor subfamily 1, group D, member 2 (Nr1d2)
  • BD73 protein
  • EAR-1R protein
  • hs.37288 protein
  • HZF-2 protein
  • hzf2 protein
  • NR1D2 protein
  • Rev-erb protein
  • REV-ERBB protein
  • RVR protein

Protein level used designations for NR1D2

nuclear receptor subfamily 1, group D, member 2 , V-erbA-related protein 1-related , nuclear receptor Rev-ErbA beta variant 1 , nuclear receptor Rev-ErbA beta variant 2 , nuclear receptor subfamily 1 group D member 2 , orphan nuclear hormone receptor BD73 , rev-erb-beta , rev-erba-alpha-related receptor , Rev-erb beta , orphan nuclear receptor RVR , EAR4 , Rev-ErbA-beta , Rev-erb-Beta2 , orphan nuclear receptor HZF-2 , orphan receptor , Rev-erb-beta

GENE ID SPECIES
460230 Pan troglodytes
701624 Macaca mulatta
100101761 Xenopus (Silurana) tropicalis
100218788 Taeniopygia guttata
9975 Homo sapiens
353187 Mus musculus
259241 Rattus norvegicus
396125 Gallus gallus
485643 Canis lupus familiaris
532076 Bos taurus
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