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PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway.
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
Wild-type mice and transgenic mice deficient for both alpha and beta Liver X Receptor isoforms were fed a control or an oleate enriched diet; results suggests that dietary oleic acid reduces cholesterolemia while promoting LXR-dependent hepatic lipogenesis without detrimental effects to the liver.
Ativation of LXRbeta increases AQP2 (show AQP2 Proteins) protein levels in the renal collecting ducts via a posttranscriptional mechanism top regulate water electrolyte balance.
EEPD1 is a novel LXR (show NR1H3 Proteins)-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1 (show ABCA1 Proteins).
Saponin-enriched sea cucumber extracts up-regulation hepatic LCR-beta signaling, preventing obesity in mice fed a high-fat diet.
This study showed that although a certain redundancy exists in the functions of liver X receptor alpha (show NR1H3 Proteins) and beta, some physiological processes are more under the influence of only one of them.
these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.
Intestinal activation of LXR (show NR1H3 Proteins) reduces the production of chylomicrons by a mechanism dependent on the apical localization of SR-B1 (show SCARB1 Proteins).
LXRB in Sertoli cells plays a role in the blood-testis barrier, germ cell epithelium integrity, paracrine action on Leydig cells modulating testosterone synthesis, paratubular smooth muscle function and metabolism, and lipid homeostasis.
These data suggest that high doses of insulin (show INS Proteins) downregulate apoA-I (show APOA1 Proteins) gene expression in HepG2 cells through redistribution of FOXO1 (show FOXO1 Proteins)/LXRbeta complex, FOXA2 (show FOXA2 Proteins), and LXRalpha (show NR1H3 Proteins) on hepatic enhancer of apoA-I (show APOA1 Proteins) gene.
Expression of some LXR-dependent genes of cholesterol trafficking is related to breast tumor characteristics, but not time to recurrence.
a positive association of placental PPARgamma (show PPARG Proteins) mRNA levels and placental DHA levels with baby weight
GW3965 significantly increases the expression of liver X nuclear receptor beta (LXRbeta) mRNA, while the liver X nuclear receptor alpha (LXRalpha (show NR1H3 Proteins)( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB (show NFKB1 Proteins)) activation.
The effects of LXR (show NR1H3 Proteins) agonist on interleukin-8 (IL-8 (show IL8 Proteins)) secretion and nuclear factor-kappa B (NF-kappaB (show NFKB1 Proteins)) activation in human umbilical vein endothelial cells (HUVECs), is reported.
Interactions among SNPs in nucleotide excision repair (NER) genes.
we demonstrate that joint deletion of two short conserved motifs that bind UNR and DDX6 relieves repression of 4E-T-bound mRNA, in part reliant on the 4E-T-DDX6-CNOT1 axis.
These results suggested that 25-HC promoted ADC cell migration and invasion in an LXR-dependent manner in the monoculture system but that in the coculture system, the 25-HC-induced IL-1beta secretion enhanced the effect of 25-HC in an LXR-independent manner.
Protein level of LXRbeta protein was markedly reduced in focal cortical dysplasia.
Distinct gene regulatory programs define the inhibitory effects of liver X receptors, NR1H2/NR1H3 (show NR1H3 Proteins) and PPARG (show PPARG Proteins) on cancer cell proliferation.
The liver X receptors, LXRA (NR1H3\; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs\; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009
nuclear receptor subfamily 1, group H, member 2
, LXR beta
, liver X receptor beta
, oxysterols receptor LXR-beta
, retinoid X receptor-interacting protein No.15
, ubiquitously-expressed nuclear receptor 2
, nuclear orphan receptor LXR-beta
, orphan nuclear receptor OR-1
, ubiquitous receptor
, ubiquitously-expressed nuclear receptor
, LX receptor beta
, liver X nuclear receptor beta
, nuclear receptor NER
, steroid hormone-nuclear receptor NER
, nuclear receptor subfamily 1 group H member 2