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Human Polyclonal NR1H2/3 Primary Antibody for ELISA, WB - ABIN250297
Tangirala, Bischoff, Joseph, Wagner, Walczak, Laffitte, Daige, Thomas, Heyman, Mangelsdorf, Wang, Lusis, Tontonoz, Schulman: Identification of macrophage liver X receptors as inhibitors of atherosclerosis. in Proceedings of the National Academy of Sciences of the United States of America 2002
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Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha (show NR1H3 Antibodies), promoting to the regulation of lipid homeostasis
results indicated that LXRalpha (show NR1H3 Antibodies) plays a specific and important role in activation of TH by regulating D1, and that LXRalpha (show NR1H3 Antibodies) binds to and regulates the hDIO1 promoter, competing with TRbeta (show TXNRD2 Antibodies) on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (show NR1H2 Antibodies) (LXRbeta (show NR1H2 Antibodies)) mRNA, while the liver X nuclear receptor alpha (LXRalpha (show NR1H3 Antibodies)( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB (show NFKB1 Antibodies)) activation.
Transactivation assays showed that MCFA activated LXRa, whereas long-chain FA caused no effect. Our results suggest that LXRa functions as a receptor for saturated FA or acyl-CoA of C10 and C12 in length.
We demonstrated that LXR (show NR1H3 Antibodies) stimulation decreases mRNA and protein expression of FLOT2 (show FLOT2 Antibodies) and DHHC5 (show ZDHHC5 Antibodies) in MCF-7 cells. LXR (show NR1H3 Antibodies) stimulation also reduces Akt (show AKT1 Antibodies) phosphorylation and its localization at the plasma membrane
The effects of LXR (show NR1H3 Antibodies) agonist on interleukin-8 (IL-8 (show IL8 Antibodies)) secretion and nuclear factor-kappa B (NF-kappaB (show NFKB1 Antibodies)) activation in human umbilical vein endothelial cells (HUVECs), is reported.
Collectively, these findings demonstrate that LXRalpha (show NR1H3 Antibodies) activation induces 17beta-HSD13 expression in a SREBP-1c (show SREBF1 Antibodies)-dependent manner.
mutant NR1H3 (LXRA (show NR1H3 Antibodies)) alters gene expression profiles, suggesting a disruption in transcriptional regulation as one of the mechanisms underlying Multiple Sclerosis pathogenesis.
Data show that the synthetic liver X receptors (LXRs) agonist T0901317 promoted cytokines IL-1beta (show IL1B Antibodies), IL-6 (show IL6 Antibodies) and TNFalpha (show TNF Antibodies) mRNA degradation, destabilized TNFalpha (show TNF Antibodies) mRNA through its 3'-untranslated region, and increased the expression of tristetraprolin (TTP (show ZFP36 Antibodies)).
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha