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these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.
Intestinal activation of LXR (show NR1H3 Antibodies) reduces the production of chylomicrons by a mechanism dependent on the apical localization of SR-B1 (show SCARB1 Antibodies).
Suggest that blocking cholesterol deposition and inhibiting the LXRalpha (show NR1H3 Antibodies) pathway-induced inflammatory response might be one of the main mechanisms by which anthocyanins exert their protective effects in diabetic nephropathy.
LXR-alpha (show NR1H3 Antibodies) might downregulate S1PR2 (show S1PR2 Antibodies) expression via miR (show MLXIP Antibodies)-130a-3p in quiescent HUVECs. Stimulation of TNF-alpha (show TNF Antibodies) attenuates the activity of LXR-alpha (show NR1H3 Antibodies) and results in enhanced S1PR2 (show S1PR2 Antibodies) expression.
Lipoxin A4 increases ABCA1 (show ABCA1 Antibodies) expression and promotes cholesterol efflux through LXRalpha (show NR1H3 Antibodies) pathway in THP-1 (show GLI2 Antibodies) macrophage-derived foam cells.
These results identify LXRalpha (show NR1H3 Antibodies) as a key cardiac transcriptional regulator that helps orchestrate an adaptive metabolic response to chronic cardiac stress.
Studied the role of LXRalpha (show NR1H3 Antibodies) with Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in adipogenesis of MSCs.
In conclusion, our data indicate that HNF-4alpha (show HNF4A Antibodies) may have a wider role in cell and plasma cholesterol homeostasis by controlling the expression of LXRalpha (show NR1H3 Antibodies) in hepatic cells.
Propofol up-regulates expression of ABCA1 (show ABCA1 Antibodies), ABCG1 (show ABCG1 Antibodies), and SR-B1 (show SCARB1 Antibodies) through the PPARgamma (show PPARG Antibodies)/LXRalpha (show NR1H3 Antibodies) pathway in THP-1 (show GLI2 Antibodies) macrophage-derived foam cells.
The rs12221497 polymorphism in the LXRalpha gene was associated with the susceptibility to stroke in a Han Chinese population.
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha