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Browse our Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3)

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Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3)
On www.antibodies-online.com are 8 Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) Proteins from 6 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group H, Member 3 Antibodies (125) and Nuclear Receptor Subfamily 1, Group H, Member 3 Kits (13) and many more products for this protein. A total of 157 Nuclear Receptor Subfamily 1, Group H, Member 3 products are currently listed.
Synonyms:
AU018371, im:7141239, LXR, LXR-a, LXR-alpha, LXRA, LXRalpha, NR1H3, RLD-1, RLD1, Unr1, wu:fd59b01, zgc:113339, zgc:158542
list all proteins Gene Name GeneID UniProt
NR1H3 10062 Q13133
NR1H3 22259 Q9Z0Y9
NR1H3 58852  

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Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3) by Origin

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More Proteins for Nuclear Receptor Subfamily 1, Group H, Member 3 Interaction Partners

Rhesus Monkey Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.

Human Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.

  2. Intestinal activation of LXR reduces the production of chylomicrons by a mechanism dependent on the apical localization of SR-B1 (show SCARB1 Proteins).

  3. Suggest that blocking cholesterol deposition and inhibiting the LXRalpha pathway-induced inflammatory response might be one of the main mechanisms by which anthocyanins exert their protective effects in diabetic nephropathy.

  4. LXR-alpha might downregulate S1PR2 (show S1PR2 Proteins) expression via miR (show MLXIP Proteins)-130a-3p in quiescent HUVECs. Stimulation of TNF-alpha (show TNF Proteins) attenuates the activity of LXR-alpha and results in enhanced S1PR2 (show S1PR2 Proteins) expression.

  5. Lipoxin A4 increases ABCA1 expression and promotes cholesterol efflux through LXRalpha pathway in THP-1 macrophage-derived foam cells.

  6. These results identify LXRalpha as a key cardiac transcriptional regulator that helps orchestrate an adaptive metabolic response to chronic cardiac stress.

  7. Studied the role of LXRalpha with Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in adipogenesis of MSCs.

  8. In conclusion, our data indicate that HNF-4alpha (show HNF4A Proteins) may have a wider role in cell and plasma cholesterol homeostasis by controlling the expression of LXRalpha in hepatic cells.

  9. Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARgamma/LXRalpha pathway in THP-1 macrophage-derived foam cells.

  10. The rs12221497 polymorphism in the LXRalpha gene was associated with the susceptibility to stroke in a Han Chinese population.

Mouse (Murine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. These studies demonstrate that SOAT2 is a negative regulator of LXR-stimulated fecal neutral sterol loss in mice.

  2. Bone marrow-AT2 (show AGTR2 Proteins) deficiency aggravates atherosclerosis, at least in part, by eliminating the anti-atherogenic properties of macrophages elicited by LXRbeta (show NR1H2 Proteins) activation.

  3. LXR activation reduces the growth of xenograft tumour of Human oral squamous cell carcinoma cells in mice accompanied by the upregulation of ABCA1 (show ABCA1 Proteins) expression and the decline of cholesterol levels in the tumour.

  4. these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.

  5. LXRalpha is a determinant of sexually dimorphic circadian patterns of key physiological parameters

  6. Promoting Liver X receptor-alpha expression inhibits lipopolysaccharide induced inflammation in Kupffer cells through elevating NOR-1 (show NR4A3 Proteins) expression.

  7. Intestinal activation of LXR reduces the production of chylomicrons by a mechanism dependent on the apical localization of SR-B1 (show SCARB1 Proteins).

  8. Data (including data from studies in knockout/transgenic mice) suggest INS (show INS Proteins) is required for lipogenic effects of activation of LXRalpha in liver; INS (show INS Proteins) is not required to down-regulate gene expression in ER stress or inflammation (as seen in diabetes).

  9. Our findings suggest that the previously reported anti-atherogenic effects of sesamol and sesame oil could be attributed to enhanced PPARgamma1 and LXRalpha expression and transcriptional activity leading to improved macrophage cholesterol efflux.

  10. Our data suggest that GLP-1 (show GCG Proteins)-based therapy modulate ABCA1 (show ABCA1 Proteins)/ABCG1 (show ABCG1 Proteins) expression in adipocytes potentially through an LXR-alpha mediated process.

Cow (Bovine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD (show SCD Proteins)), Fatty acid synthase (FASN (show FASN Proteins)), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.

  2. LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.

Zebrafish Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.

  2. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

  3. Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.

Pig (Porcine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB (show NR1H2 Proteins) Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]

Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3)

  • nuclear receptor subfamily 1, group H, member 3 (NR1H3)
  • nuclear receptor subfamily 1, group H, member 3 (nr1h3)
  • nuclear receptor subfamily 1, group H, member 3 (Nr1h3)
  • nuclear receptor subfamily 1, group H, member 3 (LOC100352900)
  • AU018371 protein
  • im:7141239 protein
  • LXR protein
  • LXR-a protein
  • LXR-alpha protein
  • LXRA protein
  • LXRalpha protein
  • NR1H3 protein
  • RLD-1 protein
  • RLD1 protein
  • Unr1 protein
  • wu:fd59b01 protein
  • zgc:113339 protein
  • zgc:158542 protein

Protein level used designations for NR1H3

nuclear receptor subfamily 1, group H, member 3 , oxysterols receptor LXR-alpha-like , liver X nuclear receptor alpha variant 1 , oxysterols receptor LXR-alpha , LXR alpha , liver X receptor alpha , ubiquitously-expressed nuclear receptor 1 , nuclear orphan receptor LXR-alpha , nuclear receptor subfamily 1 group H member 3 , LXRalpha , liver X receptor , lxr , nuclear oxysterol receptor LxR-alpha , RLD-1

GENE ID SPECIES
466507 Pan troglodytes
713679 Macaca mulatta
100224796 Taeniopygia guttata
100388967 Callithrix jacchus
100453246 Pongo abelii
100567692 Anolis carolinensis
100605954 Nomascus leucogenys
10062 Homo sapiens
22259 Mus musculus
483625 Canis lupus familiaris
507176 Bos taurus
100352900 Oryctolagus cuniculus
548341 Danio rerio
395221 Gallus gallus
397553 Sus scrofa
58852 Rattus norvegicus
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