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Browse our Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3)

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Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3)
On www.antibodies-online.com are 14 Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) Proteins from 7 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group H, Member 3 Antibodies (127) and Nuclear Receptor Subfamily 1, Group H, Member 3 Kits (16) and many more products for this protein. A total of 168 Nuclear Receptor Subfamily 1, Group H, Member 3 products are currently listed.
Synonyms:
AU018371, im:7141239, LXR, LXR-a, LXR-alpha, LXRA, LXRalpha, NR1H3, RLD-1, RLD1, Unr1, wu:fd59b01, zgc:113339, zgc:158542
list all proteins Gene Name GeneID UniProt
NR1H3 10062 Q13133
NR1H3 22259 Q9Z0Y9
NR1H3 58852  

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Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3) by Origin

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More Proteins for Nuclear Receptor Subfamily 1, Group H, Member 3 Interaction Partners

Rhesus Monkey Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.

Human Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. this study shows that the anti-inflammatory effect of platycodin D in IL-1beta (show IL1B Proteins)-stimulated chondrocytes is mediated by activating LXR-a

  2. results indicated that down-regulation of LXRalpha was shown to suppress invasion and EMT (show ITK Proteins) of gastric cancer cells

  3. this study shows that show that H2O2 exerts a dual regulation on mRNA expression of LXRalpha and its target genes

  4. combined PPARgamma (show PPARG Proteins) C1431T, PGC-1alpha G482S, and LXRalpha -115G/A polymorphisms increase the risk of coronary artery disease and predicted the severity of coronary atherosclerosis in Thais

  5. Distinct gene regulatory programs define the inhibitory effects of liver X receptors, NR1H2 (show NR1H2 Proteins)/NR1H3 and PPARG (show PPARG Proteins) on cancer cell proliferation.

  6. these data show that YXS is effective in mitigating MI/R injury by suppressing mitochondrial mediated apoptosis and oxidative stress and by upregulating LXRalpha, thereby providing a rationale for future clinical trials and clinical applications

  7. decreased expression of miR (show MLXIP Proteins)-155 in the peripheral blood may be utilized as a potential novel biomarker for non-alcoholic fatty liver disease screening mainly by targeting LXRalpha.

  8. HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor.

  9. The anti-inflammatory effects of platelet-derived microparticles in human plasmacytoid dendritic cells involve liver X receptor activation.

  10. these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.

Mouse (Murine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. LXRalpha(-/-) myocardial infarction (MI) murine hearts demonstrated significantly increased infarct size, reduced ejection fraction , aggravated left ventricular (LV) chamber dilation, enhanced fibrosis and reduced angiogenesis. In addition, LXRalpha(-/-) mice had increased mortality compared with Wild-type (WT) mice. LXRalpha deficiency increases mortality, aggravates pathological injury and LV remodeling induced by MI.

  2. this study shows that suggest that activated LXRalpha competes with IRF3 (show IRF3 Proteins) for GRIP1 (show NCOA2 Proteins) binding, thus repressing IRF3 (show IRF3 Proteins) and NF-kappaB (show NFKB1 Proteins) transcriptional activity and inhibiting the inflammatory response initiated by LPS (show TLR4 Proteins) in Kupffer cells

  3. HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor.

  4. findings suggest that LXRalpha, by restoring the differentiation of LSECs, may be critical for the regression of liver fibrosis.

  5. This study showed that although a certain redundancy exists in the functions of liver X receptor alpha and beta, some physiological processes are more under the influence of only one of them.

  6. These studies demonstrate that SOAT2 is a negative regulator of LXR-stimulated fecal neutral sterol loss in mice.

  7. Bone marrow-AT2 (show AGTR2 Proteins) deficiency aggravates atherosclerosis, at least in part, by eliminating the anti-atherogenic properties of macrophages elicited by LXRbeta (show NR1H2 Proteins) activation.

  8. LXR activation reduces the growth of xenograft tumour of Human oral squamous cell carcinoma cells in mice accompanied by the upregulation of ABCA1 (show ABCA1 Proteins) expression and the decline of cholesterol levels in the tumour.

  9. these data identify a new mechanism of LXR regulation that involves TIPARP, ADP-ribosylation and MACROD1.

  10. LXRalpha is a determinant of sexually dimorphic circadian patterns of key physiological parameters

Cow (Bovine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD (show SCD Proteins)), Fatty acid synthase (FASN (show FASN Proteins)), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.

  2. LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.

Zebrafish Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.

  2. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

  3. Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.

Pig (Porcine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB (show NR1H2 Proteins) Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]

Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3)

  • nuclear receptor subfamily 1, group H, member 3 (NR1H3)
  • nuclear receptor subfamily 1, group H, member 3 (nr1h3)
  • nuclear receptor subfamily 1, group H, member 3 (Nr1h3)
  • nuclear receptor subfamily 1, group H, member 3 (LOC100352900)
  • AU018371 protein
  • im:7141239 protein
  • LXR protein
  • LXR-a protein
  • LXR-alpha protein
  • LXRA protein
  • LXRalpha protein
  • NR1H3 protein
  • RLD-1 protein
  • RLD1 protein
  • Unr1 protein
  • wu:fd59b01 protein
  • zgc:113339 protein
  • zgc:158542 protein

Protein level used designations for NR1H3

nuclear receptor subfamily 1, group H, member 3 , oxysterols receptor LXR-alpha-like , liver X nuclear receptor alpha variant 1 , oxysterols receptor LXR-alpha , LXR alpha , liver X receptor alpha , ubiquitously-expressed nuclear receptor 1 , nuclear orphan receptor LXR-alpha , nuclear receptor subfamily 1 group H member 3 , LXRalpha , liver X receptor , lxr , nuclear oxysterol receptor LxR-alpha , RLD-1

GENE ID SPECIES
466507 Pan troglodytes
713679 Macaca mulatta
100224796 Taeniopygia guttata
100388967 Callithrix jacchus
100453246 Pongo abelii
100567692 Anolis carolinensis
100605954 Nomascus leucogenys
10062 Homo sapiens
22259 Mus musculus
483625 Canis lupus familiaris
507176 Bos taurus
100352900 Oryctolagus cuniculus
548341 Danio rerio
395221 Gallus gallus
397553 Sus scrofa
58852 Rattus norvegicus
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