You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3)

Full name:
Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3)
On www.antibodies-online.com are 14 Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) Proteins from 7 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group H, Member 3 Antibodies (125) and Nuclear Receptor Subfamily 1, Group H, Member 3 Kits (18) and many more products for this protein. A total of 168 Nuclear Receptor Subfamily 1, Group H, Member 3 products are currently listed.
Synonyms:
AU018371, im:7141239, LXR, LXR-a, LXR-alpha, LXRA, LXRalpha, NR1H3, RLD-1, RLD1, Unr1, wu:fd59b01, zgc:113339, zgc:158542
list all proteins Gene Name GeneID UniProt
NR1H3 10062 Q13133
NR1H3 22259 Q9Z0Y9
NR1H3 58852  

Show all synonyms

Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3) by Origin

Select your origin of interest

Top referenced Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins

  1. Human NR1H3 Protein expressed in HEK-293 Cells - ABIN2727545 : Tian, Goldstein, Brown: Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex. in Proceedings of the National Academy of Sciences of the United States of America 2016 (PubMed)

More Proteins for Nuclear Receptor Subfamily 1, Group H, Member 3 Interaction Partners

Rhesus Monkey Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.

Human Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. Collectively, these findings demonstrate that LXRalpha activation induces 17beta-HSD13 expression in a SREBP-1c (show SREBF1 Proteins)-dependent manner.

  2. mutant NR1H3 (LXRA) alters gene expression profiles, suggesting a disruption in transcriptional regulation as one of the mechanisms underlying Multiple Sclerosis pathogenesis.

  3. Data show that the synthetic liver X receptors (LXRs) agonist T0901317 promoted cytokines IL-1beta (show IL1B Proteins), IL-6 (show IL6 Proteins) and TNFalpha (show TNF Proteins) mRNA degradation, destabilized TNFalpha (show TNF Proteins) mRNA through its 3'-untranslated region, and increased the expression of tristetraprolin (TTP (show ZFP36 Proteins)).

  4. RXRalpha (show RXRA Proteins) negatively regulates the transcription and expression by directly binding to the RARE in the promoter of Cx43 (show GJA1 Proteins)

  5. Serum and placental LXR-alpha and endoglin (show ENG Proteins) levels were significantly higher in patients with preeclampsia than those in control group (P<0.05, each).

  6. this study shows that the anti-inflammatory effect of platycodin D in IL-1beta (show IL1B Proteins)-stimulated chondrocytes is mediated by activating LXR-a

  7. results indicated that down-regulation of LXRalpha was shown to suppress invasion and EMT (show ITK Proteins) of gastric cancer cells

  8. this study shows that show that H2O2 exerts a dual regulation on mRNA expression of LXRalpha and its target genes

  9. combined PPARgamma (show PPARG Proteins) C1431T, PGC-1alpha G482S, and LXRalpha -115G/A polymorphisms increase the risk of coronary artery disease and predicted the severity of coronary atherosclerosis in Thais

  10. Distinct gene regulatory programs define the inhibitory effects of liver X receptors, NR1H2 (show NR1H2 Proteins)/NR1H3 and PPARG (show PPARG Proteins) on cancer cell proliferation.

Mouse (Murine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. EEPD1 is a novel LXR-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1 (show ABCA1 Proteins).

  2. luteolin can abolish lipid accumulation induced by LXR-SREBP-1c (show SREBF1 Proteins) activation both in vivo and in vitro

  3. induction of ABCG1 expression by MEK1/2 inhibitors was associated with activation of SIRT1, a positive regulator of LXR activity, and inactivation of SULT2B1 and RIP140, two negative regulators of LXR activity

  4. geranylgeranyl pyrophosphate may act as an endogenous regulator of adipocyte differentiation and maturation through a mechanism partially dependent on the LXR pathway.

  5. these data demonstrate that O3-derived oxysterols have pro-inflammatory functions and form lipid-protein adducts with LXR, thus leading to suppressed cholesterol regulatory gene expression and providing a biochemical mechanism mediating O3-derived formation of oxidized lipids in the airways and subsequent adverse health effects.

  6. Overall, our results suggest that LXR agonist pretreatment could protect against DEX-induced deficits in cerebellar development in postnatal mice and may thus be perspective recruited to counteract such GC side effects.

  7. ABCG1 (show ABCG1 Proteins) expression was down-regulated by TLR4 (show TLR4 Proteins), which induces inflammation and lipid accumulation in vascular smooth muscle cells via PPARgamma (show PPARG Proteins)/LXRalpha signaling.

  8. LXRalpha(-/-) myocardial infarction (MI) murine hearts demonstrated significantly increased infarct size, reduced ejection fraction , aggravated left ventricular (LV) chamber dilation, enhanced fibrosis and reduced angiogenesis. In addition, LXRalpha(-/-) mice had increased mortality compared with Wild-type (WT) mice. LXRalpha deficiency increases mortality, aggravates pathological injury and LV remodeling induced by MI.

  9. this study shows that suggest that activated LXRalpha competes with IRF3 (show IRF3 Proteins) for GRIP1 (show NCOA2 Proteins) binding, thus repressing IRF3 (show IRF3 Proteins) and NF-kappaB (show NFKB1 Proteins) transcriptional activity and inhibiting the inflammatory response initiated by LPS (show TLR4 Proteins) in Kupffer cells

  10. HDAC5 inhibits hepatic lipogenic genes expression by attenuating the transcriptional activity of liver X receptor.

Cow (Bovine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD (show SCD Proteins)), Fatty acid synthase (FASN (show FASN Proteins)), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.

  2. LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.

Zebrafish Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.

  2. Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis

  3. Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.

Pig (Porcine) Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) interaction partners

  1. Allele A of the exon5-A201C in NR1H3 promotes a reduction in backfat thicknes.NR1H3 plays role in lipid deposition.

  2. discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB (show NR1H2 Proteins) Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]

Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3)

  • nuclear receptor subfamily 1, group H, member 3 (NR1H3)
  • nuclear receptor subfamily 1, group H, member 3 (nr1h3)
  • nuclear receptor subfamily 1, group H, member 3 (Nr1h3)
  • nuclear receptor subfamily 1, group H, member 3 (LOC100352900)
  • AU018371 protein
  • im:7141239 protein
  • LXR protein
  • LXR-a protein
  • LXR-alpha protein
  • LXRA protein
  • LXRalpha protein
  • NR1H3 protein
  • RLD-1 protein
  • RLD1 protein
  • Unr1 protein
  • wu:fd59b01 protein
  • zgc:113339 protein
  • zgc:158542 protein

Protein level used designations for NR1H3

nuclear receptor subfamily 1, group H, member 3 , oxysterols receptor LXR-alpha-like , liver X nuclear receptor alpha variant 1 , oxysterols receptor LXR-alpha , LXR alpha , liver X receptor alpha , ubiquitously-expressed nuclear receptor 1 , nuclear orphan receptor LXR-alpha , nuclear receptor subfamily 1 group H member 3 , LXRalpha , liver X receptor , lxr , nuclear oxysterol receptor LxR-alpha , RLD-1

GENE ID SPECIES
466507 Pan troglodytes
713679 Macaca mulatta
100224796 Taeniopygia guttata
100388967 Callithrix jacchus
100453246 Pongo abelii
100567692 Anolis carolinensis
100605954 Nomascus leucogenys
10062 Homo sapiens
22259 Mus musculus
483625 Canis lupus familiaris
507176 Bos taurus
100352900 Oryctolagus cuniculus
548341 Danio rerio
395221 Gallus gallus
397553 Sus scrofa
58852 Rattus norvegicus
Selected quality suppliers for Nuclear Receptor Subfamily 1, Group H, Member 3 Proteins (NR1H3)
Did you look for something else?