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Human NR1H3 Protein expressed in HEK-293 Cells - ABIN2727545
Tian, Goldstein, Brown: Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex. in Proceedings of the National Academy of Sciences of the United States of America 2016
Liver x receptor modulation of gene expression leads to proluteolytic effects in primate luteal cells. LXR activation causes increased cholesterol efflux and decreased extracellular cholesterol uptake.
AMPK (show PRKAA1 Proteins) activates LXRalpha and ABCA1 (show ABCA1 Proteins) expression in human macrophages
PPARalpha (show PPARA Proteins) and LXRalpha may be mediators by which omega3PUFA attenuate bile acid-induced hepatocellular injury
Inhibition of Pancreatic Cancer Cell-Induced Paracrine Hedgehog Signaling by Liver X Receptor Agonists and Oxy16, a Naturally Occurring Oxysterol
Data identify LXR as an important factor in early-pregnancy lipogenesis that is also necessary to protect against abnormalities in fetoplacental lipid homeostasis.
data suggest that ASXL3 is another corepressor of LXRalpha, promoting to the regulation of lipid homeostasis
results indicated that LXRalpha plays a specific and important role in activation of TH by regulating D1, and that LXRalpha binds to and regulates the hDIO1 promoter, competing with TRbeta (show TXNRD2 Proteins) on specific sequences within the promoter.
GW3965 significantly increases the expression of liver X nuclear receptor beta (show NR1H2 Proteins) (LXRbeta (show NR1H2 Proteins)) mRNA, while the liver X nuclear receptor alpha (LXRalpha( mRNA expression did not change a lot, and sensitizes gefitinib by inhibiting NF-kappa B (NF-kappaB (show NFKB1 Proteins)) activation.
Transactivation assays showed that MCFA activated LXRa, whereas long-chain FA caused no effect. Our results suggest that LXRa functions as a receptor for saturated FA or acyl-CoA of C10 and C12 in length.
We demonstrated that LXR stimulation decreases mRNA and protein expression of FLOT2 (show FLOT2 Proteins) and DHHC5 in MCF-7 cells. LXR stimulation also reduces Akt (show AKT1 Proteins) phosphorylation and its localization at the plasma membrane
The effects of LXR agonist on interleukin-8 (IL-8 (show IL8 Proteins)) secretion and nuclear factor-kappa B (NF-kappaB (show NFKB1 Proteins)) activation in human umbilical vein endothelial cells (HUVECs), is reported.
Data indicate a functional circuit linking PTEN and LXRs, and highlights LXRs as metabolic gatekeepers that are able to constrain prostate cancer (PCa (show ENPP1 Proteins)) progression.
LXR activation impairs adipose expansion by increasing adipocyte apoptosis, lipolysis and antagonising PPARgamma (show PPARG Proteins)-mediated transcriptional activity, which contributes to decreased insulin (show INS Proteins) sensitivity in whole body.
The present study indicates a requirement for C/EBPbeta (show CEBPB Proteins) in the insulin (show INS Proteins)-mediated induction of SREBP-1c (show SREBF1 Proteins) mRNA expression in rodent liver. Coupled with previous data showing that this induction requires LXRalpha, our data reported herein indicate a requirement for both transcription factors.
The deletion of Srebf-2 (show SREBF2 Proteins) and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR activity and SREBP-1c (show SREBF1 Proteins) expression.
Wild-type mice and transgenic mice deficient for both alpha and beta Liver X Receptor isoforms were fed a control or an oleate enriched diet; results suggests that dietary oleic acid reduces cholesterolemia while promoting LXR-dependent hepatic lipogenesis without detrimental effects to the liver.
treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR-ABCA1 (show ABCA1 Proteins)/ABCG1 (show ABCG1 Proteins) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (show HSD11B1 Proteins)-C levels observed in patients receiving both medications
We describe a molecular pathway comprising miR-155 and its epigenetic LXRalpha target that when deregulated enables pathogenic pulmonary fibrosis. Manipulation of the miR-155/LXR pathway may have therapeutic potential for idiopathic pulmonary fibrosis.
27OH is not an important regulator of Srebp- or LXR regulated genes under basal conditions in mouse liver
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD (show SCD Proteins)), Fatty acid synthase (FASN (show FASN Proteins)), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers.
LXRalpha V133I polymorphism had a significant effect on linoleic acid composition in intramuscular fat.
Intestinal nr1h3 activation delays transport of absorbed neutral lipids, with accumulation of neutral lipids in enterocyte cytoplasmic droplets.
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Results describe transcriptional activity and developmental expression of liver X receptor (lxr) in zebrafish.
Allele A of the exon5-A201C in NR1H3 promotes a reduction in backfat thicknes.NR1H3 plays role in lipid deposition.
discovery and examination of two polymorphisms in LXRA (LXRA Bsl in exon 2, and LXRA HpyCH4 III in intron 8) and one polymorphism in LXRB (LXRB (show NR1H2 Proteins) Aci I in exon 5) for genetic linkage and association analyses in fat content or leanness in pigs [LXRA & LRRB]
The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
nuclear receptor subfamily 1, group H, member 3
, oxysterols receptor LXR-alpha-like
, liver X nuclear receptor alpha variant 1
, oxysterols receptor LXR-alpha
, LXR alpha
, liver X receptor alpha
, ubiquitously-expressed nuclear receptor 1
, nuclear orphan receptor LXR-alpha
, nuclear receptor subfamily 1 group H member 3
, liver X receptor
, nuclear oxysterol receptor LxR-alpha