Browse our Nuclear Receptor Subfamily 1, Group H, Member 4 Proteins (NR1H4)

On www.antibodies-online.com are 12 Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) Proteins from 6 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group H, Member 4 Antibodies (135) and Nuclear Receptor Subfamily 1, Group H, Member 4 Kits (22) and many more products for this protein. A total of 176 Nuclear Receptor Subfamily 1, Group H, Member 4 products are currently listed.
Synonyms:
AI957360, BAR, Fxr, HRR-1, HRR1, NR1H4, RIP14, Rxrip14, zgc:92742, zgc:110190
list all proteins Gene Name GeneID UniProt
NR1H4 9971 Q96RI1
NR1H4 20186 Q60641
NR1H4 60351 Q62735

Nuclear Receptor Subfamily 1, Group H, Member 4 Proteins (NR1H4) by Origin

More Proteins for Nuclear Receptor Subfamily 1, Group H, Member 4 Interaction Partners

Human Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) interaction partners

  1. we conclude that FXR-Gank (show PSMD10 Proteins)-TSPs-Stem cells pathway is a key determinant of liver cancer in animal models and in pediatric liver cancer. Our data provide a strong basis for development of FXR-Gank (show PSMD10 Proteins)-based therapy for treatment of patients with hepatoblastoma

  2. PPARalpha (show PPARA Proteins) and FXR function coordinately to integrate liver energy balance.

  3. These studies investigated in differentiated HepaRG cells and in primary human hepatocytes (PHHs) effects of FXR activation on HBV replication and of infection on the FXR pathway.

  4. Treatment with LXR (show NR1H3 Proteins) and FXR ligands initiates coated platelet formation, which is thought to support coagulation but results in desensitization to platelet stimuli through inhibition of alphaIIbbeta3 consistent with their ability to inhibit platelet function and stable thrombus formation in vivo.

  5. FXR ligands to inhibit platelet activation.

  6. Taken together, our data provide the first evidence that FXR suppresses proliferation of human liver cancer cells via the inhibition of the mTOR (show FRAP1 Proteins)/S6K (show RPS6KB1 Proteins) signaling pathway. FXR expression can be used as a biomarker of personalized mTOR (show FRAP1 Proteins) inhibitor treatment assessment for liver cancer patients.

  7. Activated FXR inhibits leptin (show LEP Proteins) signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy.

  8. FXR may promote the proliferation of tumor cells and the hepatocytes in the process of liver regeneration by activating the PDK4 (show PDK4 Proteins)-mediated metabolic reprogramming to generate glycolytic intermediates essential for rapid biomass generation, establishing a mechanistic link between cell proliferation and metabolic switch.

  9. this is the first report of bile acid derivatives able to antagonize GPBAR1 (show GPBAR1 Proteins) and and farnesoid X receptor (show xpr1 Proteins) (FXR) modulatory activity.

  10. induction of SOCS3 (show SOCS3 Proteins) may be a novel mechanism by which FXR exerts its anti-hepatocellular carcinoma effects

Rabbit Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) interaction partners

  1. results suggest that hypothyroidism induces a moderate non-alcoholic steatohepatitis, alllowing the hepatic regeneration. The FXRalpha may be involved in the development of non-alcoholic steatohepatitis in hypothyroid subjects.

  2. FXR is expressed in the ovary, in all regions of the oviduct, and all portions of the vagina of rabbits.

Mouse (Murine) Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) interaction partners

  1. FXR activation ameliorated central nervous system autoimmunity in an IL-10 (show IL10 Proteins)-dependent fashion and even suppressed advanced clinical disease upon therapeutic administration

  2. In livers of mice, FXR regulates amino acid catabolism and detoxification of ammonium via ureagenesis and glutamine synthesis.

  3. Data suggest that FXR and TGR5 (show GPBAR1 Proteins) expression is down-regulated in aging kidney; caloric restriction prevents these age-related changes. Additionally, in long-lived Ames dwarf (show PROP1 Proteins) mice, renal FXR and TGR5 (show GPBAR1 Proteins) expression is up-regulated. Treatment of aged mice with dual FXR/TGR5 (show GPBAR1 Proteins) agonist reverses age-related changes in kidney structure/function. (FXR = farnesoid X activated receptor; TGR5 (show GPBAR1 Proteins) = G protein-coupled bile acid receptor 1 (show GPBAR1 Proteins))

  4. this study provides evidence for roles of FXR as an important regulator of placental inflammation

  5. These findings suggest that bile acids and FXR play pivotal roles in sepsis via controlling the NLRP3 (show NLRP3 Proteins) inflammasome.

  6. Our results indicate that the gut (show GUSB Proteins) microbiota promotes diet-induced obesity and associated phenotypes through FXR, and that FXR may contribute to increased adiposity by altering the microbiota composition.

  7. findings uncovered a novel mechanism in which INT-767 activation of FXR induces Tgr5 (show GPBAR1 Proteins) gene expression and increases Ca(2 (show CA2 Proteins)+) levels and cAMP activity to stimulate GLP-1 (show GCG Proteins) secretion and improve hepatic glucose and lipid metabolism in high-fat diet-induced obese mice.

  8. In mice, we found transintestinal cholesterol excretion to be regulated by intestinal FXR via induction of its target gene Fgf15.

  9. FXR ligands to inhibit platelet activation.

  10. FXR could be a target molecule for reducing portal hypertension during hepatic fibrosis.

Pig (Porcine) Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) interaction partners

  1. alterations in bile acid composition may have contributed to the observed disturbance in FXR-mediated signalling pathways in short bowel syndrome-associated liver disease

  2. FXR splice variant has a dominant positive effect on wild type FXR.

  3. In conclusion, PXR (show NR1I2 Proteins) and FXR both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR (show NR1I2 Proteins) and FXR transactivation at in vivo expression levels.

Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) Protein Profile

Protein Summary

This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4)

  • nuclear receptor subfamily 1, group H, member 4 (nr1h4)
  • nuclear receptor subfamily 1, group H, member 4 (NR1H4)
  • nuclear receptor subfamily 1, group H, member 4 (LOC100219563)
  • nuclear receptor subfamily 1, group H, member 4 (Nr1h4)
  • AI957360 protein
  • BAR protein
  • Fxr protein
  • HRR-1 protein
  • HRR1 protein
  • NR1H4 protein
  • RIP14 protein
  • Rxrip14 protein
  • zgc:92742 protein
  • zgc:110190 protein

Protein level used designations for NR1H4

nuclear receptor subfamily 1, group H, member 4 , orphan nuclear receptor FOR2 , FXRalpha , bile acid receptor , farnesoid X activated receptor , bile acid receptor-like , RXR-interacting protein 14 , farnesoid X nuclear receptor , farnesoid X-activated receptor , farnesol receptor HRR-1 , retinoid X receptor-interacting protein 14 , nuclear receptor subfamily 1 group H member 4

GENE ID SPECIES
398316 Xenopus laevis
436847 Danio rerio
452162 Pan troglodytes
695618 Macaca mulatta
100019526 Monodelphis domestica
100052821 Equus caballus
100219563 Taeniopygia guttata
100391012 Callithrix jacchus
100587301 Nomascus leucogenys
9971 Homo sapiens
373902 Gallus gallus
612928 Canis lupus familiaris
540528 Bos taurus
100009485 Oryctolagus cuniculus
20186 Mus musculus
60351 Rattus norvegicus
100153960 Sus scrofa
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