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Browse our Nuclear Receptor Subfamily 1, Group I, Member 2 Proteins (NR1I2)

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Nuclear Receptor Subfamily 1, Group I, Member 2 Proteins (NR1I2)
On www.antibodies-online.com are 12 Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Proteins from 7 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group I, Member 2 Antibodies (124) and Nuclear Receptor Subfamily 1, Group I, Member 2 Kits (17) and many more products for this protein. A total of 164 Nuclear Receptor Subfamily 1, Group I, Member 2 products are currently listed.
Synonyms:
BXR, mPXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, PXR.1, PXR.2, PXR1, SAR, SXR
list all proteins Gene Name GeneID UniProt
NR1I2 8856 O75469
NR1I2 18171 O54915
NR1I2 84385 Q9R1A7

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Nuclear Receptor Subfamily 1, Group I, Member 2 Proteins (NR1I2) by Origin

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More Proteins for Nuclear Receptor Subfamily 1, Group I, Member 2 Interaction Partners

Human Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. We found that ARRDC3 is required for ALIX (show PDCD6IP Proteins) ubiquitination induced by activation of PAR1 (show MARK2 Proteins)

  2. SUMOylation at specific sites on PXR protein are involved in enhancement of transcription function of this receptor.

  3. hPXR is regulated through its phosphorylation at threonine-408 by PKC, CHIP/chaperone-dependent stability check, and autophagic degradation pathway.

  4. we have identified novel PXR dependent pathways in human de novo lipogenesis, which may participate in hepatic steatosis and pathogenesis of steatohepatitis

  5. Role of NR1I2 polymorphisms in head and neck squamous cell carcinoma

  6. Our results revealed that PXR could be a determinant of stable warfarin doses.

  7. Carriers of two copies of the ATG haplotypes of NR1I2-rs1523130, rs3814055 and rs1523127 were less sensitive to thrombocytopenia than those harboring other haplotypes

  8. Genotyping of CYP3A4 (show CYP3A4 Proteins)/MDR1/NR1I2 polymorphisms may be helpful for better guiding tacrolimus dosing in CYP3A5 (show CYP3A5 Proteins) nonexpressers.

  9. Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.

  10. PSC is characterized by disease-specific impairment of SULT2A1 (show SULT2A1 Proteins) expression following PXR activation, a phenomenon which is not noted in PBC (show DLAT Proteins), and may account for the impaired hepatoprotection in PSC.

Pig (Porcine) Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. The regulatory effect of IFN-gamma (show IFNG Proteins) on CYP3A29 expression is mediated via PXR.

  2. Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.

  3. In conclusion, PXR and FXR (show NR1H4 Proteins) both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR (show NR1H4 Proteins) transactivation at in vivo expression levels.

  4. the PXR gene revealed multiple splice variants in the ligand-binding domain

Mouse (Murine) Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. PXR activation stimulates EGF (show EGF Proteins)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (show FOXO3 Proteins) from accelerating cell-cycle progression.

  2. The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia.

  3. modulation of vemurafenib bioavailability through pregnane X receptor-mediated regulation of drug transporters has the potential to markedly influence systemic exposure and thereby therapeutic outcomes.

  4. results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging.

  5. Suggest a novel role for PXR signaling in the maintenance of intestinal homeostasis and may help to elucidate additional mechanisms through which PXR signaling is protective in inflammatory bowel disease.

  6. a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4 (show TLR4 Proteins).

  7. Role of pregnane X receptor in obesity and glucose homeostasis

  8. Xenobiotic-induced hepatocyte proliferation mediated by CAR or PPARalpha (show PPARA Proteins) is enhanced by PXR co-activation despite the fact that PXR activation alone does not cause the cell proliferation in mouse livers.

  9. Results indicate that pregnane X receptor (PXR) represents a flow-activated detoxification system to protect endothelial cells (ECs) against damage by xeno- and endobiotics.

  10. Study reveals that alpha-tocopherol is a partial agonist of PXR and that PXR is necessary for Cyp3a induction by alpha-tocopherol in Pxr-null and PXR-humanized mice.

Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Protein Profile

Protein Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2)

  • nuclear receptor subfamily 1, group I, member 2 (NR1I2)
  • nuclear receptor subfamily 1, group I, member 2 (Nr1i2)
  • pregnane x receptor (PXR)
  • BXR protein
  • mPXR protein
  • ONR1 protein
  • PAR protein
  • PAR1 protein
  • PAR2 protein
  • PARq protein
  • PRR protein
  • PXR protein
  • PXR.1 protein
  • PXR.2 protein
  • PXR1 protein
  • SAR protein
  • SXR protein

Protein level used designations for NR1I2

nuclear receptor subfamily 1 group I member 2 , orphan nuclear receptor PAR1 , orphan nuclear receptor PXR , pregnane X nuclear receptor variant 2 , pregnane X receptor , steroid and xenobiotic receptor , Pregnane X receptor , nuclear receptor subfamily 1, group 1, member 2 , pregnane X receptor (nuclear receptor sub family 1, group I, member 2)

GENE ID SPECIES
8856 Homo sapiens
403482 Canis lupus familiaris
397228 Sus scrofa
493713 Bos taurus
18171 Mus musculus
84385 Rattus norvegicus
574226 Macaca mulatta
100008739 Oryctolagus cuniculus
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