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Browse our Nuclear Receptor Subfamily 1, Group I, Member 2 Proteins (NR1I2)

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Nuclear Receptor Subfamily 1, Group I, Member 2 Proteins (NR1I2)
On www.antibodies-online.com are 12 Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Proteins from 7 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group I, Member 2 Antibodies (150) and Nuclear Receptor Subfamily 1, Group I, Member 2 Kits (28) and many more products for this protein. A total of 201 Nuclear Receptor Subfamily 1, Group I, Member 2 products are currently listed.
Synonyms:
BXR, mPXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, PXR.1, PXR.2, PXR1, SAR, SXR
list all proteins Gene Name GeneID UniProt
NR1I2 8856 O75469
NR1I2 18171 O54915
NR1I2 84385 Q9R1A7

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Nuclear Receptor Subfamily 1, Group I, Member 2 Proteins (NR1I2) by Origin

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More Proteins for Nuclear Receptor Subfamily 1, Group I, Member 2 Interaction Partners

Human Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. Extracellular granzyme K (show GZMK Proteins) mediates endothelial activation through the cleavage of PAR-1 (show MARK2 Proteins).

  2. Pregnane X receptor interacts with liver X receptor to regulate expression of SMPDL3A in primary hepatocytes.

  3. 66034T/C polymorphism of the human pregnane X receptor (hPXR) is potential risk factor for drug-resistant epilepsy.

  4. The data suggest that some of the natural PXR variants may have adverse physiological consequences owing to its influence on the expression levels and functional output of drug-metabolizing enzymes and transporters.

  5. miR (show MLXIP Proteins)-30c-1-3p was shown to alter the expression of CYP3A4 (show CYP3A4 Proteins), a prototypical target gene of PXR.

  6. The nuclear receptor PXR regulates hepatic energy metabolism. (Review)

  7. Novel functions of PXR in cardiometabolic disease development have been described. (Review)

  8. Acetylation of lysine 109 modulates PXR DNA binding and transcriptional activity; PXR acetylation status and transcriptional activity are modulated by E1A binding protein (p300 (show EP300 Proteins)) and SIRT1 (show SIRT1 Proteins).

  9. Genome-wide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARalpha (show PPARA Proteins) in primary human hepatocytes has been presented.

  10. PXR regulates the intestinal epithelial barrier during inflammation by modulating cytokine-induced MLCK (show MYLK Proteins) expression and JNK1 (show MAPK8 Proteins)/2 activation

Pig (Porcine) Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. The regulatory effect of IFN-gamma (show IFNG Proteins) on CYP3A29 expression is mediated via PXR.

  2. Pregnane X receptor is required for interferon-alpha-mediated CYP3A29 expression, and its expression before CYP3A29.

  3. In conclusion, PXR and FXR (show NR1H4 Proteins) both responded to ligands that activated their human orthologs, and some of the alternatively spliced variants significantly altered PXR and FXR (show NR1H4 Proteins) transactivation at in vivo expression levels.

  4. the PXR gene revealed multiple splice variants in the ligand-binding domain

Mouse (Murine) Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) interaction partners

  1. Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT.

  2. The present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands.

  3. FGF21 (show FGF21 Proteins)-PXR signaling pathway may be involved in decreased hepatic CYP3A4 (show CYP3A4 Proteins) metabolic activity in Nonalcoholic fatty liver disease.

  4. Pregnenolone 16alpha-carbonitrile has immunosuppressive activity independent of PXR activation to protect mice from immune-mediated liver injury induced by Con (show KITLG Proteins) A.

  5. carcinogens might trigger PXR in epidermal cells, particularly in Langerhans cells, leading to DNA damage

  6. PXR activation stimulates EGF (show EGF Proteins)-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 (show FOXO3 Proteins) from accelerating cell-cycle progression.

  7. The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia.

  8. modulation of vemurafenib bioavailability through pregnane X receptor-mediated regulation of drug transporters has the potential to markedly influence systemic exposure and thereby therapeutic outcomes.

  9. results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging.

  10. Suggest a novel role for PXR signaling in the maintenance of intestinal homeostasis and may help to elucidate additional mechanisms through which PXR signaling is protective in inflammatory bowel disease.

Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2) Protein Profile

Protein Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2)

  • nuclear receptor subfamily 1, group I, member 2 (NR1I2)
  • nuclear receptor subfamily 1, group I, member 2 (Nr1i2)
  • pregnane x receptor (PXR)
  • BXR protein
  • mPXR protein
  • ONR1 protein
  • PAR protein
  • PAR1 protein
  • PAR2 protein
  • PARq protein
  • PRR protein
  • PXR protein
  • PXR.1 protein
  • PXR.2 protein
  • PXR1 protein
  • SAR protein
  • SXR protein

Protein level used designations for NR1I2

nuclear receptor subfamily 1 group I member 2 , orphan nuclear receptor PAR1 , orphan nuclear receptor PXR , pregnane X nuclear receptor variant 2 , pregnane X receptor , steroid and xenobiotic receptor , Pregnane X receptor , nuclear receptor subfamily 1, group 1, member 2 , pregnane X receptor (nuclear receptor sub family 1, group I, member 2)

GENE ID SPECIES
8856 Homo sapiens
403482 Canis lupus familiaris
397228 Sus scrofa
493713 Bos taurus
18171 Mus musculus
84385 Rattus norvegicus
574226 Macaca mulatta
100008739 Oryctolagus cuniculus
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