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Browse our Nuclear Receptor Subfamily 1, Group I, Member 3 Proteins (NR1I3)

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Nuclear Receptor Subfamily 1, Group I, Member 3 Proteins (NR1I3)
On www.antibodies-online.com are 13 Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) Proteins from 6 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 1, Group I, Member 3 Antibodies (109) and Nuclear Receptor Subfamily 1, Group I, Member 3 Kits (11) and many more products for this protein. A total of 146 Nuclear Receptor Subfamily 1, Group I, Member 3 products are currently listed.
Synonyms:
AA209988, AI551208, CAR, CAR-beta, CAR1, Care2, CXR, ESTM32, MB67
list all proteins Gene Name GeneID UniProt
NR1I3 12355 O35627
NR1I3 65035 Q9QUS1
NR1I3 9970 Q14994

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Nuclear Receptor Subfamily 1, Group I, Member 3 Proteins (NR1I3) by Origin

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More Proteins for Nuclear Receptor Subfamily 1, Group I, Member 3 Interaction Partners

Pig (Porcine) Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) interaction partners

  1. characterized activity profile of CAR and compared with hCAR (show CXADR Proteins) and mCAR (show CXADR Proteins); related this to structural homology among the 3 orthologues; 5 alternative splice variants identified and sequenced each of which generated a truncated protein product

Mouse (Murine) Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) interaction partners

  1. Combining CAR activation with limited beta-catenin (show CTNNB1 Proteins) activation induces tumorigenesis, and the tumours share a conserved gene expression signature with beta-catenin (show CTNNB1 Proteins)-positive human hepatocellular carcinoma.

  2. Constitutive androstane receptor is the main mediator of liver hypertrophy induced by cyproconazole and fluconazole, but not tebuconazole; constitutive androstane receptor played a crucial role in liver tumor development induced by all three triazoles.

  3. CAR activation decreases miR (show MLXIP Proteins)-122 levels through suppression of HNF4alpha (show HNF4A Proteins) transcriptional activity and indirectly regulates the promitogenic protein cMyc (show MYC Proteins).

  4. The induction of CYP2B by PB or CFA (show TBCA Proteins) was comparable to nuclear CAR levels. CAR nuclear translocation was induced by CFA (show TBCA Proteins) in both rat strains.

  5. The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor beta and contributes to the development of experimental dermal fibrosis.

  6. ubiquitin-proteasomal regulation of CCRP (show DNAJC7 Proteins) and HSP70 (show HSP70 Proteins) are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers

  7. These results suggest that in vivo deletion of CAR resulted in higher bone mass, which appears to be a result from reduced metabolism of testosterone due to down-regulation of Cyp2b.

  8. Studies indicate that phenobarbital binding to EGFR inhibits distal signaling to derepress RACK1-facilitated dephosphorylation of constitutive active androstane receptor (CAR) by PP2A, and activates the transcription of Cyp2B10.

  9. Data indicate that the phosphorylation status of constitutive active androstane receptor (CAR) and EGFR (show EGFR Proteins) in response to phenobarbital and EGF (show EGF Proteins) was confirmed in hepatocytes.

  10. Xenobiotic-induced hepatocyte proliferation mediated by CAR or PPARalpha (show PPARA Proteins) is enhanced by PXR (show NR1I2 Proteins) co-activation despite the fact that PXR (show NR1I2 Proteins) activation alone does not cause the cell proliferation in mouse livers.

Human Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) interaction partners

  1. These results reveal both novel and known targets of hCAR (show CXADR Proteins) and support the role of hCAR (show CXADR Proteins) in maintaining the homeostasis of metabolism and cell proliferation in the liver.

  2. Around 42.5% of the overall interindividual variability in warfarin dose requirements was explained : VKORC1 (show VKORC1 Proteins) genotype accounted for 29.6%, CYP2C9 (show CYP2C9 Proteins) genotype for 4.3%, age for 3.6%, the CYP4F2 genotype for 3.3%, and CAR/HNF4alpha (show HNF4A Proteins) (rs2501873/rs3212198) for 1.7%

  3. It is suggested that the functions of PXR (show NR1I2 Proteins), CAR and AhR (show AHR Proteins) may be closely implicated in the pathogeneses of metabolic vascular diseases, such as hyperlipidemia, atherogenesis, and hypertension.

  4. Suggest that PXR and CAR double humanized mice are more sensitive rifampcin induction of cytochrome P450 and UDP-glucuronosyltransferases.

  5. PRMT5 (show PRMT5 Proteins) enhances transcriptional activity of constitutive androstane receptor.PRMT5 is a gene-selective co-activator for CAR.

  6. The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor beta and contributes to the development of experimental dermal fibrosis.

  7. Donor CYP3A5 (show CYP3A5 Proteins), NR1I3 gene polymorphisms.

  8. ubiquitin-proteasomal regulation of CCRP (show DNAJC7 Proteins) and HSP70 (show HSP70 Proteins) are important contributors to the regulation of cytoplasmic CAR levels, and hence the ability of CAR to respond to PB or PB-like inducers

  9. The polymorphisms investigated in PPARA (show PPARA Proteins) (rs1800206), RXRA (show RXRA Proteins) (rs11381416), and NR1I2 (show NR1I2 Proteins) (rs1523130) did not influence the lipid-lowering efficacy and safety of statin and our results show the possible influence of NR1I3 genetic variant on the safety of statin.

  10. miR (show MLXIP Proteins)-137 is a crucial regulator of cancer response to doxorubicin treatment

Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3) Protein Profile

Protein Summary

This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Nuclear Receptor Subfamily 1, Group I, Member 3 (NR1I3)

  • constitutive androstane receptor (CAR)
  • constitutive androstane receptor (LOC100346291)
  • nuclear receptor subfamily 1, group I, member 3 (Nr1i3)
  • nuclear receptor subfamily 1, group I, member 3 (NR1I3)
  • AA209988 protein
  • AI551208 protein
  • CAR protein
  • CAR-beta protein
  • CAR1 protein
  • Care2 protein
  • CXR protein
  • ESTM32 protein
  • MB67 protein

Protein level used designations for NR1I3

constitutive androstane receptor , constitutively transactivates RAREs , nuclear receptor subfamily 1 group I member 3 , orphan nuclear receptor MB67 , constitutive androstane receptor NR1I3 , nuclear receptor constitutive active receptor , strain Fischer nuclear receptor (CAR) , constitutive activator of retinoid response , constitutive active receptor , constitutive active response , constitutive androstane nuclear receptor variant 2 , constitutive androstane nuclear receptor variant 3 , constitutive androstane nuclear receptor variant 4 , constitutive androstane nuclear receptor variant 5 , orphan nuclear hormone receptor , xenobiotic receptor

GENE ID SPECIES
654317 Sus scrofa
100346291 Oryctolagus cuniculus
12355 Mus musculus
488653 Canis lupus familiaris
493711 Bos taurus
65035 Rattus norvegicus
9970 Homo sapiens
395439 Gallus gallus
574249 Macaca mulatta
458014 Pan troglodytes
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