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anti-Human NR2E3 Antibodies:
anti-Mouse (Murine) NR2E3 Antibodies:
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Human Polyclonal NR2E3 Primary Antibody for WB - ABIN523375
Qin, Knapinska, Dobri, Madoux, Chase, Hodder, Petrukhin: In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3. in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2013
Cow (Bovine) Polyclonal NR2E3 Primary Antibody for WB - ABIN2780915
Hayashi, Gekka, Goto-Omoto, Takeuchi, Kubo, Kitahara: Novel NR2E3 mutations (R104Q, R334G) associated with a mild form of enhanced S-cone syndrome demonstrate compound heterozygosity. in Ophthalmology 2005
The frameshift mutation found in patient 1, p.I307LfsX33, is a new causative mutation for ESCS; it is located in exon 6. This mutation truncates the 410 amino acids in the normal NR2E3 protein into 306 amino acids and causes the synthesis of a protein lacking more than half of the ligand-binding domain.
Autosomal dominant retinitis pigmentosa due to p.Gly56Arg mutation in the NR2E3 gene
The murine and human TAAR5 (show TAAR5 Antibodies) (hTAAR5) display significant basal activity in the Gq/11 pathway.
NR2E3 is a novel epigenetic regulator that helps to maintain a normal epigenetic status in response to benzo(a)pyrene mediated toxic injury. NR2E3 may be a potential target for cancer prevention.
Study presents evidence that PNR could promote ERalpha (show ESR1 Antibodies)-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway.
Direct sequencing of NR2E3 identified 3 previously described mutations and 4 novel mutations in Enhanced S-cone syndrome (ESCS) forms
Molecular genetic studies helped to identify a novel p.D406G mutation in NR2E3 of the Goldmann-Favre syndrome (GFS) and vasoproliferative tumors of the retina affected members.
Genetic screening confirmed the presence of two disease-causing mutations in the NR2E3 gene in each study patient, as well as identified a novel mutation (202 A > G, S68G).
PNR/NR2E3 and related NRs (show SPNS1 Antibodies) such as TLX (show CD46 Antibodies) and COUPTFs can selectively associate with the developmental corepressor BCL11A (show BCL11A Antibodies) via a conserved motif F/YSXXLXXL/Y within the RID1 domain.
Human trace amine-associated receptor TAAR5 (show TAAR5 Antibodies) can be activated by trimethylamine.
Chemical compounds identified as modulators of Nr2e3 activity may be useful for the treatment of RP through their effects on expression of disease-causing mutant genes.
Modifier genes as therapeutics: the nuclear hormone receptor (show NR0B1 Antibodies) Rev Erb alpha (Nr1d1 (show NR1D1 Antibodies)) rescues Nr2e3 associated retinal disease.
PNR/NR2E3 and related NRs (show SPNS1 Antibodies) such as TLX (show NR2E1 Antibodies) and COUPTFs can selectively associate with the developmental corepressor BCL11A (show BCL11A Antibodies) via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains.
These studies further support the 'transcriptional dominance' model of photoreceptor cell fate determination and provide insights into the pathogenesis of retinal disease phenotypes caused by NR2E3 mutations.
These studies reveal a novel role for Nr1d1 (show NR1D1 Antibodies), in conjunction with its cofactor Nr2e3, in regulating transcriptional networks critical for photoreceptor development and function.
These experiments show that in mature vertebrate retina Nr2e3 is expressed exclusively in rods and that Nr2e3 functions as a repressor of cone-specific genes in rod photoreceptor cells.
Our studies reveal a critical role of NR2E3 in establishing functional specificity of NRL (show NRL Antibodies)-expressing photoreceptor precursors during retinal neurogenesis.
NR2E3 acts simultaneously in different cell types: in late mitotic progenitors, newly differentiating post mitotic cells, and mature rods and cones.
Orphan receptor. Ligands are likely small molecules, either sharing some similarities with trace amine as, e.g. derivatives of indolamines (such as 5-methoxytryptamine) or of phenylethylamines (such as phenylethanolamine) or being any kind of metabolite of amino acids or biogenic amine neurotransmitters.
nuclear receptor subfamily 2, group E, member 3
, photoreceptor-specific nuclear receptor
, retina-specific nuclear receptor
, nuclear receptor subfamily 2 group E member 3
, retinal degeneration 7
, putative neurotransmitter receptor
, trace amine receptor 5
, trace amine-associated receptor 5