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Browse our Nuclear Receptor Subfamily 2, Group F, Member 6 Proteins (NR2F6)

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Nuclear Receptor Subfamily 2, Group F, Member 6 Proteins (NR2F6)
On www.antibodies-online.com are 6 Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6) Proteins from 4 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 2, Group F, Member 6 Antibodies (82) and Nuclear Receptor Subfamily 2, Group F, Member 6 Kits (3) and many more products for this protein. A total of 101 Nuclear Receptor Subfamily 2, Group F, Member 6 products are currently listed.
Synonyms:
AV090102, COUP(II), COUP-TF3, couptf2, EAR-2, EAR2, Erbal2, fc94g11, NR2F6, wu:fc94g11, zgc:77259
list all proteins Gene Name GeneID UniProt
NR2F6 2063 P10588
NR2F6 13864 P43136
NR2F6 245980 O09017

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Nuclear Receptor Subfamily 2, Group F, Member 6 Proteins (NR2F6) by Origin

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More Proteins for Nuclear Receptor Subfamily 2, Group F, Member 6 Interaction Partners

Human Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6) interaction partners

  1. Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI (show NR2F1 Proteins), COUP-TFII (show NR2F2 Proteins), EAR2 and TLX (show CD46 Proteins) requires a F/YSXXLXXL/Y motif. NSD1 interaction with liganded NRs (show SPNS1 Proteins)is mediated by an overlapping LXXLL motif.

  2. study demonstrated that expression of EAR2 was elevated in colorectal cancer and knockdown of EAR2 reduced survivability and tumor growth of colon cancer cells

  3. Ear2 ligand binding domain is required for Rasd1 (show RASD1 Proteins) to alleviate Ear2-mediated repression of renin (show REN Proteins) transcription.

Mouse (Murine) Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6) interaction partners

  1. NR2F6 is a central checkpoint for cancer immune surveillance.

  2. Snail (show SNAI1 Proteins) inhibits adipogenesis through a down-regulation of Nr2f6, which in turn facilitates the expression of IL-17 (show IL17A Proteins), an anti-adipogenic cytokine.

  3. The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development.

  4. Interaction of NSD1 with the NR2E/F subfamily including COUP-TFI (show NR2F1 Proteins), COUP-TFII (show NR2F2 Proteins), EAR2 and TLX (show NR2E1 Proteins) requires a F/YSXXLXXL/Y motif. NSD1 interaction with liganded NRs (show SPNS1 Proteins) is mediated by an overlapping LXXLL motif.

  5. Nuclear orphan receptor (show NR1D2 Proteins) NR2F6 directly antagonizes NFAT (show NFATC1 Proteins) and RORgammat binding to the Il17a (show IL17A Proteins) promoter.

  6. It was concluded that both Nr2f2 (show NR2F2 Proteins) and Nr2f6 negatively regulate renin (show REN Proteins) promoter activity, but may do so by divergent mechanisms.

  7. Our study establishes NR2F6 as a transcriptional repressor of IL-17 (show IL17A Proteins) expression in Th17-differentiated CD4 (show CD4 Proteins)(+) T cells in vitro and in vivo.

Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6) Protein Profile

Protein Summary

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock\; is required early in the development of the locus coeruleus (LC).

Alternative names and synonyms associated with Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6)

  • nuclear receptor subfamily 2, group F, member 6 (nr2f6)
  • nuclear receptor subfamily 2, group F, member 6 (NR2F6)
  • nuclear receptor subfamily 2, group F, member 6 (Nr2f6)
  • nuclear receptor subfamily 2, group F, member 6a (nr2f6a)
  • AV090102 protein
  • COUP(II) protein
  • COUP-TF3 protein
  • couptf2 protein
  • EAR-2 protein
  • EAR2 protein
  • Erbal2 protein
  • fc94g11 protein
  • NR2F6 protein
  • wu:fc94g11 protein
  • zgc:77259 protein

Protein level used designations for NR2F6

nuclear receptor subfamily 2, group F, member 6 , nuclear receptor subfamily 2 group F member 6 , ERBA-related gene-2 , V-erbA-related protein 2 , nuclear receptor V-erbA-related , v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2 , COUP transcription factor 3 , EAR-2 , avian erythroblastic leukemia viral (v-erb-a) oncogene homolog-like 2 , COUPg , V-erbA-related protein EAR-2 , orphan nuclear receptor EAR-2 , ovalbumin upstream promoter gamma nuclear receptor rCOUPg , EAR2-A , chicken ovalbumin upstream promoter transcription factor 2

GENE ID SPECIES
448119 Xenopus (Silurana) tropicalis
474359 Gallus gallus
748739 Pan troglodytes
2063 Homo sapiens
609720 Canis lupus familiaris
13864 Mus musculus
245980 Rattus norvegicus
379873 Xenopus laevis
325637 Danio rerio
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