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Guinea Pig Monoclonal NR3C1 Primary Antibody for BP, ChIP - ABIN268501
Lambert, Nordeen: CBP recruitment and histone acetylation in differential gene induction by glucocorticoids and progestins. in Molecular endocrinology (Baltimore, Md.) 2003
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Human Monoclonal NR3C1 Primary Antibody for WB - ABIN1882199
Wang, Shen, Thiyagarajan, Lin, Palm, Horvath, Klopstock, Cutler, Pique, Schrijver, Davis, Mindrinos, Speed, Scharfe: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing. in Nucleic acids research 2011
Show all 4 Pubmed References
Human Monoclonal NR3C1 Primary Antibody for BI, IF - ABIN968431
Beato, Herrlich, Schütz: Steroid hormone receptors: many actors in search of a plot. in Cell 1996
Show all 3 Pubmed References
Human Monoclonal NR3C1 Primary Antibody for ICC, FACS - ABIN969321
Charmandari, Ichijo, Jubiz, Baid, Zachman, Chrousos, Kino: A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. in The Journal of clinical endocrinology and metabolism 2008
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Human Monoclonal NR3C1 Primary Antibody for BI, IF - ABIN968430
Hollenberg, Weinberger, Ong, Cerelli, Oro, Lebo, Thompson, Rosenfeld, Evans: Primary structure and expression of a functional human glucocorticoid receptor cDNA. in Nature 1986
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Human Monoclonal NR3C1 Primary Antibody for ELISA, WB - ABIN2473809
Harris, Kerns, St Clair: RNA sulfurtransferase activity in rat liver and chemically induced hepatomas. in Cancer research 1976
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Human Polyclonal NR3C1 Primary Antibody for FACS, IF (p) - ABIN726875
Takigawa, Miyazaki, Kinoshita, Kawarabayashi, Nishiyama, Hatsuse, Ono, Saitoh, Seki, Yamamoto: Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice. in American journal of physiology. Gastrointestinal and liver physiology 2013
Human Polyclonal NR3C1 Primary Antibody for IF (p), IHC (p) - ABIN685138
Ding, Shi, Han, Cui: Regulation of glucocorticoid-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction filial rats. in Life sciences 2016
Cow (Bovine) Polyclonal NR3C1 Primary Antibody for ChIP, ICC - ABIN152763
He, Simons: STAMP, a novel predicted factor assisting TIF2 actions in glucocorticoid receptor-mediated induction and repression. in Molecular and cellular biology 2007
The potentiation of RANKL (show TNFSF11 Antibodies) induced CTX release by dexamethasone was significantly less in bone marrow macrophage cells from mice with conditional knockout of the osteoclastic glucocorticoid receptor and completely absent in cells from GR(dim) mice, which carry a point mutation in one dimerizing interface of the GC receptor.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (show HSP90 Antibodies) cochaperone activity of FKBP51 (show FKBP5 Antibodies) with a functional impact on GR signaling in a neuronal context.
These results together suggested that ERK1 (show MAPK3 Antibodies) phosphorylation plays a critical role in regulating GR beta expression and hydrocortisone-induce GR phosphorylation at Ser220, which is critical for the anti-apoptotic effects hydrocortisone on hepatic ischemia-reperfusion injury.
a significant protein-protein interaction between GR and CHOP (show DDIT3 Antibodies), (GR-CHOP (show DDIT3 Antibodies) heterocomplex formation) under endoplasmic reticulum stress conditions, is reported.
This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha (show PPARA Antibodies) in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (show CDK5R1 Antibodies); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (show CDK5R1 Antibodies)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90 (show HSP90 Antibodies)-p23 (show CDK5R1 Antibodies) client protein, we investigated glucocorticoid signaling.
REV-ERBalpha (show NR1D1 Antibodies) binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (show HSP90AA2 Antibodies) and HSP90beta (show HSP90AB1 Antibodies), a chaperone responsible for the activation of proteins to ensure survival of a cell.
Phospho-AMPK (show PRKAA1 Antibodies) is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha (show PPARA Antibodies) at the chromatin level, a novel adaptation mechanism to prolonged fasting.
GR signaling decreases NRF2 (show NFE2L2 Antibodies) transcriptional activation through reducing the NRF2 (show NFE2L2 Antibodies)-dependent histone acetylation. Consistent with these observations, GR signaling blocked NRF2 (show NFE2L2 Antibodies)-mediated cytoprotection from oxidative stress.
GRbeta antagonizes the GC-induced signaling during fasting via GRalpha and the PPARalpha (show PPARA Antibodies)-FGF21 (show FGF21 Antibodies) axis that reduces fat burning. Furthermore, hepatic GRbeta increases inflammation, which leads to hepatic lipid accumulation.
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (show HSP90 Antibodies) complex that favor FKBP51 (show FKBP5 Antibodies) repression over FKBP52 (show FKBP4 Antibodies) potentiation.
Association between suicide and altered NR3C1 gene expression in the prefrontal cortex.
Results identified three novel heterozygous missense NR3C1 mutations causing glucocorticoid resistance in patients with adrenal incidentalomas without Cushing's syndrome. p.R477S and p.Y478C are located in the DNA binding domain (DBD) of the glucocorticoid receptor (GR) while p.L67P is located in the ligand binding domain of GR.
Data show that the 3' UTR (show UTS2R Antibodies) of glucocorticoid receptor beta (GRbeta) is regulated by miR144.
Except for a slightly higher risk of bronchopulmonary dysplasia (BPD (show MOD(MDG4) Antibodies)) in carriers of the GRBclI variant, the glucocorticoid receptor gene polymorphisms BclI, N363S, and R23K did not affect neonatal outcome parameters in this large multicenter cohort of Very-Low-Birth-Weight preterm infants.
A woman with glucocorticoid resistance and her mother had a novel p.Arg477Cys (c.1429C>T) mutation in exon 4 of NR3C1, in the 2dzinc finger of the DNA-binding domain. Its 'in silico' functional effect was assessed using pathogenicity prediction software, being characterized as pathogenic. An unrelated patient had a novel p.His588Leufs*5 (c.1762_1763insTTAC) mutation, in exon 6, in the ligand binding domain.
NR3C1 as an important gene of the hypothalamic-pituitary-adrenal axis seems to be particularly relevant for the pathophysiology of ADHD combined with comorbid CD.
The impact of AKT1 (show AKT1 Antibodies) on glucocorticoid receptor (GR)-induced transcriptional activity in cooperation with phospho-serine/threonine-binding protein 14-3-3 (show YWHAQ Antibodies), was examined.
Childhood Maltreatment and MDD are both associated wit haltered DNA methylation (show HELLS Antibodies) levels in the NR3C1 promoter region, however the location and direction of effects differ between the two exposure.s
This study presents evidence of reduced methylation of NR3C1 in association with childhood maltreatment and depressive, anxiety and substance-use disorders in adults.
These results indicate that myostatin (show MSTN Antibodies) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (show FOXO3 Antibodies) and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Antibodies) and specificity protein 1 (Sp1 (show SP1 Antibodies)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1. TNF (show TNF Antibodies) and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (show HSD11B2 Antibodies) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (show GARS Antibodies), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma