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Guinea Pig Monoclonal NR3C1 Primary Antibody for BP, ChIP - ABIN268501
Lambert, Nordeen: CBP recruitment and histone acetylation in differential gene induction by glucocorticoids and progestins. in Molecular endocrinology (Baltimore, Md.) 2003
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Human Monoclonal NR3C1 Primary Antibody for WB - ABIN1882199
Wang, Shen, Thiyagarajan, Lin, Palm, Horvath, Klopstock, Cutler, Pique, Schrijver, Davis, Mindrinos, Speed, Scharfe: Identification of rare DNA variants in mitochondrial disorders with improved array-based sequencing. in Nucleic acids research 2011
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Human Monoclonal NR3C1 Primary Antibody for BI, IF - ABIN968431
Beato, Herrlich, Schütz: Steroid hormone receptors: many actors in search of a plot. in Cell 1996
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Human Monoclonal NR3C1 Primary Antibody for ELISA, WB - ABIN2473809
Harris, Kerns, St Clair: RNA sulfurtransferase activity in rat liver and chemically induced hepatomas. in Cancer research 1976
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Human Monoclonal NR3C1 Primary Antibody for BI, IF - ABIN968430
Hollenberg, Weinberger, Ong, Cerelli, Oro, Lebo, Thompson, Rosenfeld, Evans: Primary structure and expression of a functional human glucocorticoid receptor cDNA. in Nature 1986
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Human Monoclonal NR3C1 Primary Antibody for ICC, FACS - ABIN969321
Charmandari, Ichijo, Jubiz, Baid, Zachman, Chrousos, Kino: A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. in The Journal of clinical endocrinology and metabolism 2008
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Human Polyclonal NR3C1 Primary Antibody for FACS - ABIN2174469
Takigawa, Miyazaki, Kinoshita, Kawarabayashi, Nishiyama, Hatsuse, Ono, Saitoh, Seki, Yamamoto: Glucocorticoid receptor-dependent immunomodulatory effect of ursodeoxycholic acid on liver lymphocytes in mice. in American journal of physiology. Gastrointestinal and liver physiology 2013
Human Polyclonal NR3C1 Primary Antibody for WB - ABIN1881586
Seitz, Thoma, Schoch, Stihle, Benz, DArcy, Wiget, Ruf, Hennig, Sterner: Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. in Journal of molecular biology 2010
Human Monoclonal NR3C1 Primary Antibody for FACS - ABIN2473810
Ginouves, Baron, Bermudez, Godlewski, Allieu: [Use of a distal pedicle medial hemisoleus flap in the treatment of residual osteitis of the lower quarter of the leg]. in Annales de chirurgie plastique et esthétique 1989
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Human Monoclonal NR3C1 Primary Antibody for FACS - ABIN2473811
Berki, Kumánovics, Kumánovics, Falus, Ujhelyi, Németh: Production and flow cytometric application of a monoclonal anti-glucocorticoid receptor antibody. in Journal of immunological methods 1998
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This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha (show PPARA Antibodies) in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (show CDK5R1 Antibodies); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (show CDK5R1 Antibodies)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90 (show HSP90 Antibodies)-p23 (show CDK5R1 Antibodies) client protein, we investigated glucocorticoid signaling.
REV-ERBalpha (show NR1D1 Antibodies) binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (show HSP90AA2 Antibodies) and HSP90beta (show HSP90AB1 Antibodies), a chaperone responsible for the activation of proteins to ensure survival of a cell.
Phospho-AMPK (show PRKAA1 Antibodies) is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha (show PPARA Antibodies) at the chromatin level, a novel adaptation mechanism to prolonged fasting.
GR signaling decreases NRF2 (show NFE2L2 Antibodies) transcriptional activation through reducing the NRF2 (show NFE2L2 Antibodies)-dependent histone acetylation. Consistent with these observations, GR signaling blocked NRF2 (show NFE2L2 Antibodies)-mediated cytoprotection from oxidative stress.
GRbeta antagonizes the GC-induced signaling during fasting via GRalpha and the PPARalpha (show PPARA Antibodies)-FGF21 (show FGF21 Antibodies) axis that reduces fat burning. Furthermore, hepatic GRbeta increases inflammation, which leads to hepatic lipid accumulation.
liver-specific deletion of GR resulted in a significant increase in mRNA expression of key genes involved in gluconeogenesis and glycogen (show GYS1 Antibodies) metabolism in kidney tissue, indicating a compensatory mechanism to maintain glucose homeostasis. Liver GRKO mice demonstrated decreased fat mass and liver glycogen (show GYS1 Antibodies) content compared with WT mice administered dexamethasone for 2 weeks.
These results established a novel role for GR and KLF13 (show KLF13 Antibodies) signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.
miR (show MLXIP Antibodies)-433 helps maintain circadian rhythm in osteoblasts by regulating sensitivity to glucocorticoid receptor signaling.
this study shows that Nr3c1 regulates the formation of memory-precursor CD8 (show CD8A Antibodies)+ T cell fates
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (show HSP90 Antibodies) complex that favor FKBP51 (show FKBP5 Antibodies) repression over FKBP52 (show FKBP4 Antibodies) potentiation.
NR3C1 mean methylation was higher among women who reported childhood abuse
NR3C1 polymorphism is associated with metabolic syndrome.
The data of this study show a significant increase in DNA methylation (show HELLS Antibodies) of NR3C1 in peripheral blood mononuclear cells of major depressive disorder patients.
Polymorphisms of the glucocorticoid receptor gene influenced both the basal state of the hypothalamus-pituitary-adrenal axis as well as self-perceived stress. The mineralocorticoid receptor (show NR3C2 Antibodies) gene only associated with self-perceived stress and 5-HTT (show SLC6A4 Antibodies) only with the cortisol awakening response.
Findings suggest that posttraumatic stress disorder (PTSD) phenotypes may be characterized by differences in intracellular signaling transduction processes. The associations of expression of GRalpha and FKBP5 (show FKBP5 Antibodies) in the glucocorticoid (GC) high-sensitive PTSD subgroup may thereby reflect physiological adaptation to preserve immune-relevant GC signaling.
results reveal that liganded GR spatiotemporally controls ANGPTL4 (show ANGPTL4 Antibodies) transcription in a chromosomal context.
NR3C1 is a bona fide target of miR (show MLXIP Antibodies)-124 in acute lymphoblastic leukemia.
Numerous direct transcriptional targets of GR exist in airway smooth muscle. Genes with inducible GR occupancy included IRS2 (show IRS2 Antibodies), APPL2 (show APLP2 Antibodies), RAMP1 (show RAMP1 Antibodies), and MFGE8 (show MFGE8 Antibodies). GR occupancy occurred in the absence of supplemental ligand, including robust GR binding peaks within the IL11 (show IL11 Antibodies) and LIF (show LIF Antibodies) loci.
These results demonstrate that BCLI, N363S and ER22/23EK polymorphisms of NR3C1 do not play a pathogenetic role for Adrenal Incidentalomas.
NR3C1 is a haploinsufficient tumor suppressor in a subset of blastic plasmacytoid dendritic cell neoplasms (BPDCN).
These results indicate that myostatin (show MSTN Antibodies) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (show FOXO3 Antibodies) and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Antibodies) and specificity protein 1 (Sp1 (show SP1 Antibodies)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Antibodies) and PTGS2 (show PTGS2 Antibodies), and decreased the expression of SOD2 (show SOD2 Antibodies), GPX3 (show GPX3 Antibodies), DAB2 (show DAB2 Antibodies), and NR3C1. TNF (show TNF Antibodies) and IL6 (show IL6 Antibodies) levels were also decreased while those of NAMPT (show NAMPT Antibodies) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (show HSD11B2 Antibodies) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (show GARS Antibodies), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma