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This study identifies an endocrine developmental axis in which fetal GR primes the activity of PPARalpha (show PPARA Proteins) in anticipation of the sudden shifts in postnatal nutrient source and metabolic demands.
Skin differentiation is impaired, and both apoptosis and cell proliferation are augmented in the absence of p23 (show CDK5R1 Proteins); the consequences are a severe thinning of the stratum corneum and reduced numbers of hair follicles. Since the phenotype of p23 (show CDK5R1 Proteins)-null embryos is strikingly similar to that of embryos lacking the glucocorticoid receptor, a paradigmatic Hsp90 (show HSP90 Proteins)-p23 (show CDK5R1 Proteins) client protein, we investigated glucocorticoid signaling.
REV-ERBalpha (show NR1D1 Proteins) binds to the C-terminal portion and GR to the N-terminal portion of HSP90alpha (show HSP90AA2 Proteins) and HSP90beta (show HSP90AB1 Proteins), a chaperone responsible for the activation of proteins to ensure survival of a cell.
Phospho-AMPK (show PRKAA1 Proteins) is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha (show PPARA Proteins) at the chromatin level, a novel adaptation mechanism to prolonged fasting.
GR signaling decreases NRF2 (show NFE2L2 Proteins) transcriptional activation through reducing the NRF2 (show NFE2L2 Proteins)-dependent histone acetylation. Consistent with these observations, GR signaling blocked NRF2 (show NFE2L2 Proteins)-mediated cytoprotection from oxidative stress.
GRbeta antagonizes the GC-induced signaling during fasting via GRalpha and the PPARalpha (show PPARA Proteins)-FGF21 (show FGF21 Proteins) axis that reduces fat burning. Furthermore, hepatic GRbeta increases inflammation, which leads to hepatic lipid accumulation.
liver-specific deletion of GR resulted in a significant increase in mRNA expression of key genes involved in gluconeogenesis and glycogen (show GYS1 Proteins) metabolism in kidney tissue, indicating a compensatory mechanism to maintain glucose homeostasis. Liver GRKO mice demonstrated decreased fat mass and liver glycogen (show GYS1 Proteins) content compared with WT mice administered dexamethasone for 2 weeks.
These results established a novel role for GR and KLF13 (show KLF13 Proteins) signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.
miR (show MLXIP Proteins)-433 helps maintain circadian rhythm in osteoblasts by regulating sensitivity to glucocorticoid receptor signaling.
this study shows that Nr3c1 regulates the formation of memory-precursor CD8 (show CD8A Proteins)+ T cell fates
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (show HSP90 Proteins) complex that favor FKBP51 (show FKBP5 Proteins) repression over FKBP52 (show FKBP4 Proteins) potentiation.
Glucocorticoid receptor (GR) is recruited to activator protein-1 (AP-1) target genes in a DNA-binding-dependent manner.
NR3C1 mean methylation was higher among women who reported childhood abuse
NR3C1 polymorphism is associated with metabolic syndrome.
The data of this study show a significant increase in DNA methylation (show HELLS Proteins) of NR3C1 in peripheral blood mononuclear cells of major depressive disorder patients.
Polymorphisms of the glucocorticoid receptor gene influenced both the basal state of the hypothalamus-pituitary-adrenal axis as well as self-perceived stress. The mineralocorticoid receptor (show NR3C2 Proteins) gene only associated with self-perceived stress and 5-HTT (show SLC6A4 Proteins) only with the cortisol awakening response.
Findings suggest that posttraumatic stress disorder (PTSD) phenotypes may be characterized by differences in intracellular signaling transduction processes. The associations of expression of GRalpha and FKBP5 (show FKBP5 Proteins) in the glucocorticoid (GC) high-sensitive PTSD subgroup may thereby reflect physiological adaptation to preserve immune-relevant GC signaling.
results reveal that liganded GR spatiotemporally controls ANGPTL4 (show ANGPTL4 Proteins) transcription in a chromosomal context.
NR3C1 is a bona fide target of miR (show MLXIP Proteins)-124 in acute lymphoblastic leukemia.
Numerous direct transcriptional targets of GR exist in airway smooth muscle. Genes with inducible GR occupancy included IRS2 (show IRS2 Proteins), APPL2 (show APLP2 Proteins), RAMP1 (show RAMP1 Proteins), and MFGE8 (show MFGE8 Proteins). GR occupancy occurred in the absence of supplemental ligand, including robust GR binding peaks within the IL11 (show IL11 Proteins) and LIF (show LIF Proteins) loci.
These results demonstrate that BCLI, N363S and ER22/23EK polymorphisms of NR3C1 do not play a pathogenetic role for Adrenal Incidentalomas.
These results indicate that myostatin (show MSTN Proteins) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (show FOXO3 Proteins) and glucocorticoid receptor binding to its promoter.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Proteins) and specificity protein 1 (Sp1 (show SP1 Proteins)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1. TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (show HSD11B2 Proteins) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (show GARS Proteins), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma