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Browse our Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Proteins (NR3C1)

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Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Proteins (NR3C1)
On www.antibodies-online.com are 16 Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) Proteins from 5 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Antibodies (296) and Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Kits (60) and many more products for this protein. A total of 380 Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) products are currently listed.
Synonyms:
GCCR, GCL, GCR, gr, GR-A, GRL, Grl-1, Grl1, LOC100302444, NO, nr3c1, xGR, zgc:113038
list all proteins Gene Name GeneID UniProt
NR3C1 24413 P06536
NR3C1 14815  
NR3C1 2908 P04150

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Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Proteins (NR3C1) by Origin

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More Proteins for Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Interaction Partners

Zebrafish Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

Mouse (Murine) Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. Chronic subordinate colony housing (chronic psychosocial stressed) mice showed decreased GR mRNA and cytoplasmic protein (show BLZF1 Proteins) levels compared with single-housed control mice.

  2. Data show that agouti-related protein (AgRP (show AGRP Proteins))-glucocorticoid receptor knockout (GR-/-) mice are resistant to diet-induced obesity.

  3. show that the GR ligand binding domain (LBD) is not required for SMRT-mediated repression

  4. GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1 (show NCOR1 Proteins)-HDAC3 (show HDAC3 Proteins) repressing complex, which is indispensable for NF-kappaB (show NFKB1 Proteins)/AP1 (show JUN Proteins)-mediated GC-induced tethered indirect transrepression in vitro

  5. These findings identified aldosterone as an inducer of clonal beta-cell failure that operates through the GR-MAPK (show MAPK1 Proteins)-MafA (show MAFA Proteins) signaling pathway.

  6. NR3c1 plays an important role in the regulation of mitochondrial oxidative phosphorylation in mice on a high-fat diet.

  7. transcriptional cooperation between GR and Klf4 (show KLF4 Proteins) may determine cell-type specific gene expression regulation

  8. Data (including data from studies in transgenic/knockout mice) suggest that suppression of interleukin-12 secretion via glucocorticoid/glucocorticoid receptor-mediated signal transduction in dendritic cells is protective in endotoxin septic shock.

  9. exercise exerts a positive impact on stress resilience in single-housed mice that could be mediated by decreasing miR (show MLXIP Proteins)-124 and increasing Nr3c1 expression in the hippocampus.

  10. global and conditional gene-targeted respiratory mouse models of either GC deficiency or glucocorticoid receptor ablation, are reviewed.

Guinea Pig Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (show HSP90 Proteins) complex that favor FKBP51 (show FKBP5 Proteins) repression over FKBP52 (show FKBP4 Proteins) potentiation.

Human Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. Data, including data from in silico/molecular docking studies, suggest that high molecular weight phthalates, environmental pollutants, cause endocrine disruption by high-affinity interacts with specific ligand-binding sites on ketosteroid receptors such as AR (androgen receptor (show AR Proteins)), PR (progesterone receptor (show PGR Proteins)), and GR (glucocorticoid receptor).

  2. Logistic regression revealed that four variants in NR3C1 and SATB1 (show SATB1 Proteins) were significantly associated with lung cancer risk after false discovery rate (FDR) correction [For NR3C1, rs9324921: odds ratio (OR)=1.23, P for FDR=0.029; rs12521436: OR=0.85, P for FDR=0.040; rs4912913: OR=1.17, P for FDR=0.040; For SATB1 (show SATB1 Proteins), rs6808523: OR=1.33, P for FDR=0.040].

  3. properties of the glucocorticoid receptor contribute to the processing of emotional stimuli and influence the intensity of their processing even in the absence of acute stressors.

  4. In a Caucasian Greek multiple sclerosis population, polymorphisms in the NR3C1 gene were detected but did not reveal the presence of mutations in any patients.

  5. dysregulation of GR, MR, FKBP5 (show FKBP5 Proteins), and PTGES3 (show PTGES3 Proteins) in autistic spectrum disorder (ASD (show ARSD Proteins)) and suggest a possible role of inflammation in altered GR function in ASD (show ARSD Proteins).

  6. hyperactive hypothalamo-pituitary-adrenocortical axis in overweight diabetic subjects may be associated with downregulation of 11beta-HSD1 (show HSD11B1 Proteins), MR, and GR in the brain.

  7. Data suggest that cooperative anti-inflammatory gene regulation by glucocorticoid receptor (GR) and the p65 (show GORASP1 Proteins) subunit of NF-kappaB (show NFKB1 Proteins) contributes to glucocorticoid (GC) efficacy.

  8. Methylation of NR3C1 at exons 1D and 1F is associated with internalizing but not externalizing, behavior problems; and it mediates effects of early adversity in preschoolers.

  9. NR3C1 methylation and maternal smoking during pregnancy are independently associated with lethargic (show CACNB4 Proteins) behavior in newborns.

  10. Significant effects of maternal depressive symptoms on NR3C1 CpG 2 DNA methylation (show HELLS Proteins).

Pig (Porcine) Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Proteins) and specificity protein 1 (Sp1 (show SP1 Proteins)).

  2. Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.

  3. Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.

  4. Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).

Cow (Bovine) Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.

  2. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1. TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  3. Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement

  4. investigation of gene expression for GR, 11HSD1, and 11HSD2 (show HSD11B2 Proteins) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation

Rainbow Trout (Oncorhynchus mykiss) Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (show GARS Proteins), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.

Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) Protein Profile

Protein Summary

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

Alternative names and synonyms associated with Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1)

  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1)
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (nr3c1)
  • nuclear receptor subfamily 3, group C, member 1 (NR3C1)
  • glucocorticoid receptor (LOC100302444)
  • nuclear receptor subfamily 3, group C, member 1 (Nr3c1)
  • GCCR protein
  • GCL protein
  • GCR protein
  • gr protein
  • GR-A protein
  • GRL protein
  • Grl-1 protein
  • Grl1 protein
  • LOC100302444 protein
  • NO protein
  • nr3c1 protein
  • xGR protein
  • zgc:113038 protein

Protein level used designations for NR3C1

glucocorticoid receptor , nuclear receptor subfamily 3, group C, member 1 , glucocorticoid receptor 1 , GR , nuclear receptor subfamily 3 group C member 1 , glucocorticoid nuclear receptor variant 1 , glucocorticoid receptor alpha , glucocorticoid receptor variant P , glucocorticoid receptor variant beta , glucocorticoid receptor variant gamma

GENE ID SPECIES
100061217 Equus caballus
549721 Xenopus (Silurana) tropicalis
553740 Danio rerio
692348 Felis catus
100302444 Oryzias latipes
24413 Rattus norvegicus
14815 Mus musculus
100135583 Cavia porcellus
2908 Homo sapiens
100008890 Oryctolagus cuniculus
443412 Ovis aries
396740 Sus scrofa
281946 Bos taurus
478047 Canis lupus familiaris
416343 Gallus gallus
100136786 Oncorhynchus mykiss
100173284 Pongo abelii
100394916 Callithrix jacchus
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