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Chronic subordinate colony housing (chronic psychosocial stressed) mice showed decreased GR mRNA and cytoplasmic protein (show BLZF1 Proteins) levels compared with single-housed control mice.
Data show that agouti-related protein (AgRP (show AGRP Proteins))-glucocorticoid receptor knockout (GR-/-) mice are resistant to diet-induced obesity.
show that the GR ligand binding domain (LBD) is not required for SMRT-mediated repression
GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT/NCoR1 (show NCOR1 Proteins)-HDAC3 (show HDAC3 Proteins) repressing complex, which is indispensable for NF-kappaB (show NFKB1 Proteins)/AP1 (show JUN Proteins)-mediated GC-induced tethered indirect transrepression in vitro
These findings identified aldosterone as an inducer of clonal beta-cell failure that operates through the GR-MAPK (show MAPK1 Proteins)-MafA (show MAFA Proteins) signaling pathway.
NR3c1 plays an important role in the regulation of mitochondrial oxidative phosphorylation in mice on a high-fat diet.
transcriptional cooperation between GR and Klf4 (show KLF4 Proteins) may determine cell-type specific gene expression regulation
Data (including data from studies in transgenic/knockout mice) suggest that suppression of interleukin-12 secretion via glucocorticoid/glucocorticoid receptor-mediated signal transduction in dendritic cells is protective in endotoxin septic shock.
exercise exerts a positive impact on stress resilience in single-housed mice that could be mediated by decreasing miR (show MLXIP Proteins)-124 and increasing Nr3c1 expression in the hippocampus.
global and conditional gene-targeted respiratory mouse models of either GC deficiency or glucocorticoid receptor ablation, are reviewed.
The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (show HSP90 Proteins) complex that favor FKBP51 (show FKBP5 Proteins) repression over FKBP52 (show FKBP4 Proteins) potentiation.
Infants with the high-risk neurobehavioral profile showed more methylation than infants with the low-risk neurobehavioral profile at CpG3 for NR3C1 and less methylation of CpG3 for HSD11B2 (show HSD11B2 Proteins).
The hypothalamus-pituitary-adrenal axis is sensitive to changes in the early-life environment that associate with DNA methylation (show HELLS Proteins) of a neuron-specific exon 17 promoter of the glucocorticoid receptor (GR) (Nr3c1). [review]
Data show that glucocorticoid response genes NR3C1, ADCYAP1R1 (show ADCYAP1R1 Proteins) and HSD11B2 (show HSD11B2 Proteins) were relatively hypomethylated whereas FKBP5 (show FKBP5 Proteins) was hypermethylated.
GRbeta bound to the N-terminus domain of TCF-4 (show TCF4 Proteins) its influence on Wnt (show WNT2 Proteins) signaling required both ligand- and DNA-binding domains. This is enough to maintain the TCF (show HNF4A Proteins)/LEF activity at a high level in the absence of beta-catenin (show CTNNB1 Proteins) stabilization.
relationship between depression, early trauma, the HPA (show HPSE Proteins) axis and the DNA methylation (show HELLS Proteins) status of the NR3C1 gene [review]
This result supports the proposed association between a specific CpG site located at the NR3C1 promoter and prenatal stress.
This study found sex-specific NR3C1 associations with the muscle strength and size response to resistance training.
No evidence of an additional effect of childhood trauma on CFS via alterations in NR3C1 methylation.
This study does not confirm a role for genetic variants in the MYOC (show MYOC Proteins), NR3C1 and FKBP5 (show FKBP5 Proteins) genes in the pathogenesis of corticosteroid-induced ocular hypertension.
Epigenetic modifications of the glucocorticoid receptor gene (NR3C1) have been associated with early-life experiences.
Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Proteins) and specificity protein 1 (Sp1 (show SP1 Proteins)).
Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.
Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.
Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).
Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1. TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.
Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement
investigation of gene expression for GR, 11HSD1, and 11HSD2 (show HSD11B2 Proteins) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation
The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (show GARS Proteins), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
, nuclear receptor subfamily 3, group C, member 1
, glucocorticoid receptor 1
, nuclear receptor subfamily 3 group C member 1
, glucocorticoid nuclear receptor variant 1
, glucocorticoid receptor alpha
, glucocorticoid receptor variant P
, glucocorticoid receptor variant beta
, glucocorticoid receptor variant gamma