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Browse our Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Proteins (NR3C1)

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Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Proteins (NR3C1)
On www.antibodies-online.com are 17 Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) Proteins from 5 different suppliers available. Additionally we are shipping Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Antibodies (289) and Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Kits (73) and many more products for this protein. A total of 387 Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) products are currently listed.
Synonyms:
GCCR, GCL, GCR, gr, GR-A, GRL, Grl-1, Grl1, LOC100302444, NO, nr3c1, xGR, zgc:113038
list all proteins Gene Name GeneID UniProt
NR3C1 24413 P06536
NR3C1 14815  
NR3C1 2908 P04150

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Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Proteins (NR3C1) by Origin

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More Proteins for Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Interaction Partners

Zebrafish Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

Mouse (Murine) Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. Phospho-AMPK (show PRKAA1 Proteins) is a molecular switch able to cooperate with glucocorticoid receptors and Ppar-alpha (show PPARA Proteins) at the chromatin level, a novel adaptation mechanism to prolonged fasting.

  2. GR signaling decreases NRF2 (show NFE2L2 Proteins) transcriptional activation through reducing the NRF2 (show NFE2L2 Proteins)-dependent histone acetylation. Consistent with these observations, GR signaling blocked NRF2 (show NFE2L2 Proteins)-mediated cytoprotection from oxidative stress.

  3. GRbeta antagonizes the GC-induced signaling during fasting via GRalpha and the PPARalpha (show PPARA Proteins)-FGF21 (show FGF21 Proteins) axis that reduces fat burning. Furthermore, hepatic GRbeta increases inflammation, which leads to hepatic lipid accumulation.

  4. liver-specific deletion of GR resulted in a significant increase in mRNA expression of key genes involved in gluconeogenesis and glycogen (show GYS1 Proteins) metabolism in kidney tissue, indicating a compensatory mechanism to maintain glucose homeostasis. Liver GRKO mice demonstrated decreased fat mass and liver glycogen (show GYS1 Proteins) content compared with WT mice administered dexamethasone for 2 weeks.

  5. These results established a novel role for GR and KLF13 (show KLF13 Proteins) signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure.

  6. miR (show MLXIP Proteins)-433 helps maintain circadian rhythm in osteoblasts by regulating sensitivity to glucocorticoid receptor signaling.

  7. this study shows that Nr3c1 regulates the formation of memory-precursor CD8 (show CD8A Proteins)+ T cell fates

  8. Chronic subordinate colony housing (chronic psychosocial stressed) mice showed decreased GR mRNA and cytoplasmic protein (show BLZF1 Proteins) levels compared with single-housed control mice.

  9. Data show that agouti-related protein (AgRP (show AGRP Proteins))-glucocorticoid receptor knockout (GR-/-) mice are resistant to diet-induced obesity.

  10. show that the GR ligand binding domain (LBD) is not required for SMRT-mediated repression

Guinea Pig Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 (show HSP90 Proteins) complex that favor FKBP51 (show FKBP5 Proteins) repression over FKBP52 (show FKBP4 Proteins) potentiation.

Human Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. TR4 (show NR2C2 Proteins) binds GR to play an important role in glucocorticoid-directed corticotroph tumor POMC (show POMC Proteins) regulation in addition to modulating glucocorticoid actions on other GR targets.

  2. individuals carrying the ADHD risk haplotype 9beta of NR3C1 showed significantly more positive relation between stress exposure and ADHD severity than non-carriers.

  3. The structure and conformational dynamics of glucocorticoid receptor in complex with small heterodimer partner (show NR0B2 Proteins) is described.

  4. our studies suggest that the joint influence of positive and negative sequence signals partition the genome into regions where glucocorticoid receptor can bind and those where it cannot.

  5. Hic-5 (show TGFB1I1 Proteins) regulates GR binding site selection by a novel mechanism, exploiting gene-specific requirements for chromatin remodeling enzymes to selectively influence DNA occupancy and gene regulation by a transcription factor.

  6. SERPINE1 (show SERPINE1 Proteins), ANGPLT4, CCL20 (show CCL20 Proteins), and SAA1 (show SAA1 Proteins) as well as the NF-kappaB (show NFKB1 Proteins) (p65 (show GORASP1 Proteins)) binding sites on GR-transrepressed promoters such as IL-1beta (show IL1B Proteins), IL-6 (show IL6 Proteins), and IL-8 (show IL8 Proteins) Taken together, our data establish ACTN4 (show ACTN4 Proteins) as a transcriptional co-regulator that modulates both dexamethasone-transactivated and -transrepressed genes in podocytes.

  7. GR directly represses the MDFIC (show MDFIC Proteins) gene, revealing a negative feedback loop by which glucocorticoids limit MDFIC (show MDFIC Proteins) activity. These findings identify a new binding partner for cytoplasmic GR that modulates the receptor transcriptome and contributes to the tissue-specific actions of glucocorticoids.

  8. this study shows that children with moderate-to-severe asthma exacerbations who are homozygous for the G allele at the rs41423247 locus in the NR3C1 gene may have a better response to inhaled corticosteroid treatment

  9. The authors examined maternal distress and salivary cortisol in relation to fetal movement and heart rate ("coupling") and DNA methylation (show HELLS Proteins) of three glucocorticoid pathway genes-HSD11B2 (show HSD11B2 Proteins), NR3C1, and FKBP5 (show FKBP5 Proteins)-in term placentas.

  10. this paper shows that glutathione peroxidase 3 (show GPX3 Proteins) expression can be regulated independently via epigenetic or glucocorticoid receptor-mediated mechanisms in lung cancer cells

Pig (Porcine) Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. These results indicate that myostatin (show MSTN Proteins) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 (show FOXO3 Proteins) and glucocorticoid receptor binding to its promoter.

  2. Data indicate that higher hepatic glucocorticoid receptor (GR) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 (show TP53 Proteins) and specificity protein 1 (Sp1 (show SP1 Proteins)).

  3. Tissue specificities, gene expression and induction responsiveness of the porcine NR3C1 gene.

  4. Cloning and dna sequence analysis of the upstream flanking region of the NR3C1 gene in the domestic pig.

  5. Effects of age, weaning and/or social isolation on the expression of genes regulating glucocorticoid response [glucocorticoid receptor).

Cow (Bovine) Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. Glucocorticoid Receptor protein expression in granulosa cells was higher in cysts from animals with spontaneous cystic ovarian disease and adrenocorticotropic hormone-induced cystic ovarian disease than in tertiary follicles from control animals.

  2. Exposure to follicular fluid transiently increased the transcript levels of IL8 (show IL8 Proteins) and PTGS2 (show PTGS2 Proteins), and decreased the expression of SOD2 (show SOD2 Proteins), GPX3 (show GPX3 Proteins), DAB2 (show DAB2 Proteins), and NR3C1. TNF (show TNF Proteins) and IL6 (show IL6 Proteins) levels were also decreased while those of NAMPT (show NAMPT Proteins) were unaffected.

  3. Bayesian image analysis of dexamethasone and shear stress-induced glucocorticoid receptor intracellular movement

  4. investigation of gene expression for GR, 11HSD1, and 11HSD2 (show HSD11B2 Proteins) in granulosa cells and theca interna layers during follicular maturation and atresia: expression of GR was largely unchanged during follicular maturation

Rainbow Trout (Oncorhynchus mykiss) Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) interaction partners

  1. The E domain of the trout receptors are not involved in the nucleocytoplasmic localization of naive trout GRs (show GARS Proteins), but the A/B domain, especially if linked to the corresponding trout CD region, plays a pivotal role in the cellular distribution pattern.

Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1) Protein Profile

Protein Summary

This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).

Alternative names and synonyms associated with Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) (NR3C1)

  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1)
  • nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (nr3c1)
  • nuclear receptor subfamily 3, group C, member 1 (NR3C1)
  • glucocorticoid receptor (LOC100302444)
  • nuclear receptor subfamily 3, group C, member 1 (Nr3c1)
  • GCCR protein
  • GCL protein
  • GCR protein
  • gr protein
  • GR-A protein
  • GRL protein
  • Grl-1 protein
  • Grl1 protein
  • LOC100302444 protein
  • NO protein
  • nr3c1 protein
  • xGR protein
  • zgc:113038 protein

Protein level used designations for NR3C1

glucocorticoid receptor , nuclear receptor subfamily 3, group C, member 1 , glucocorticoid receptor 1 , GR , nuclear receptor subfamily 3 group C member 1 , glucocorticoid nuclear receptor variant 1 , glucocorticoid receptor alpha , glucocorticoid receptor variant P , glucocorticoid receptor variant beta , glucocorticoid receptor variant gamma

GENE ID SPECIES
100061217 Equus caballus
549721 Xenopus (Silurana) tropicalis
553740 Danio rerio
692348 Felis catus
100302444 Oryzias latipes
24413 Rattus norvegicus
14815 Mus musculus
100135583 Cavia porcellus
2908 Homo sapiens
100008890 Oryctolagus cuniculus
443412 Ovis aries
396740 Sus scrofa
281946 Bos taurus
478047 Canis lupus familiaris
416343 Gallus gallus
100136786 Oncorhynchus mykiss
100173284 Pongo abelii
100394916 Callithrix jacchus
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