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Browse our NR4A2 Proteins (NR4A2)

Full name:
Nuclear Receptor Subfamily 4, Group A, Member 2 Proteins (NR4A2)
On www.antibodies-online.com are 5 Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) Proteins from 4 different suppliers available. Additionally we are shipping NR4A2 Antibodies (67) and NR4A2 Kits (7) and many more products for this protein. A total of 87 NR4A2 products are currently listed.
Synonyms:
HZF-3, ngf1b, NGFI-B, NOT, nr4a2, nr41/42/43, Nurr1, RNR-1, RNR1, TINOR, TINUR, zgc:92696
list all proteins Gene Name GeneID UniProt
NR4A2 4929 P43354
Rat NR4A2 NR4A2 54278 Q07917
NR4A2 18227 Q06219

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NR4A2 Proteins (NR4A2) by Origin

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More Proteins for NR4A2 Interaction Partners

Human Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) interaction partners

  1. decreased expression levels of Nurr1 were associated with chronic inflammation and insulin (show INS Proteins) resistance in patients with T2D.

  2. The immunohistochemical, qRT-PCR and western blot analyses revealed that Nurr1 expression was increased in gastric cancer tissues compared with normal gastric tissue.

  3. NR4A2 is a key factor in multiple diseases, such as inflammation, cancer and cardiovascular diseases.

  4. A2M (show A2M Proteins) is expressed in the vasculature and NR4A receptors modulate VSMC MMP2 (show MMP2 Proteins)/9 activity by several mechanisms including the up-regulation of A2M (show A2M Proteins).

  5. In this review, a concise overview of the current understanding of the important metabolic roles governed by NR4A members NR4A1 (show NR4A1 Proteins), NR4A2 and NR4A3 (show NR4A3 Proteins) including their participation in a number of diseases shall be provided

  6. Data show that some rexinoids display selective coactivator (CoA) recruitment by the retinoid X receptors (RXRs) homodimer and by the heterodimers nuclear receptor Nur77/RXR and Nurr1/RXR.

  7. Thus our data identify a previously unknown role for Nr4a2 in the regulation of macrophage polarization.

  8. The results failed to reveal significant link between NR4A2 polymorphism and schizophrenia risk. [META-ANALYSIS]

  9. Because the phosphorylation site mutants of NR4A2 cannot rescue the cell death-promoting activity, ASK1 (show MAP3K5 Proteins)-p38 (show CRK Proteins) pathway-dependent phosphorylation and subsequent cytoplasmic translocation of NR4A2 may be required for oxidative stress-induced (show SQSTM1 Proteins) cell death.

  10. NURR1 upregulation by tissue-type plasminogen activator (show PLAT Proteins) during ischemic stroke is associated with endothelial dysfunction and inflammation.

Mouse (Murine) Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) interaction partners

  1. Nurr1 defect induces early experimental autoimmune encephalomyelitis (EAE) onset and increases inflammatory infiltrates in spinal cord suggesting a Nurr1 role in the early phase of EAE

  2. Nr4a2 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions.

  3. Results indicate that Nurr1 overexpression in olfactory bulb stem cells induces the formation of two populations of mature dopaminergic neurons with features of the ventral mesencephalon or of the olfactory bulb

  4. Nurr1 +/- genotype predisposes mice to T. gondii-induced alterations in behaviors that involve dopamine neurotransmission

  5. The authors show herein that Nurr1 and Foxa2 (show FOXA2 Proteins) interact to protect midbrain dopaminergic neurons against various toxic insults, but their expression is lost during aging and degenerative processes.

  6. Because the phosphorylation site mutants of NR4A2 cannot rescue the cell death-promoting activity, ASK1 (show MAP3K5 Proteins)-p38 (show CRK Proteins) pathway-dependent phosphorylation and subsequent cytoplasmic translocation of NR4A2 may be required for oxidative stress-induced (show SQSTM1 Proteins) cell death.

  7. Nurr1 protein is prominently expressed in brain areas with Abeta (show APP Proteins) accumulation, that is, the subiculum and the frontal cortex, in the 5XFAD mouse and that Nurr1 is highly co-expressed with Abeta (show APP Proteins) at early stages.

  8. This study showed that nurr1 has a similar mRNA expression pattern and low levels of expression at rest.

  9. Induction of Nurr1 expression is mediated by voltage-dependent calcium channels.

  10. The interplay of Nurr1 and Foxa2 (show FOXA2 Proteins) is the crucial determinant for dopamine phenotype acquisition during midbrain dopaminergic neuron development.

Zebrafish Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2) interaction partners

  1. data indicate a conserved evolutionary role of Nr4a2 proteins in specification of the neurotransmitter phenotype

  2. Results shed new light on NR4A2 function in the dopamine differentiation pathway, and stress the effect of dopamine dysregulation on the control of locomotor activity.

NR4A2 Protein Profile

Protein Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Alternative names and synonyms associated with NR4A2

  • nuclear receptor subfamily 4, group A, member 2 (NR4A2)
  • nuclear receptor (nr41/42/43)
  • nuclear receptor related 1 (nurr1)
  • nuclear receptor subfamily 4, group A, member 2 (nr4a2)
  • nuclear receptor subfamily 4, group A, member 2 (Nr4a2)
  • nuclear receptor subfamily 4, group A, member 2b (nr4a2b)
  • HZF-3 protein
  • ngf1b protein
  • NGFI-B protein
  • NOT protein
  • nr4a2 protein
  • nr41/42/43 protein
  • Nurr1 protein
  • RNR-1 protein
  • RNR1 protein
  • TINOR protein
  • TINUR protein
  • zgc:92696 protein

Protein level used designations for NR4A2

nuclear receptor subfamily 4, group A, member 2 , nuclear receptor , nuclear receptor related 1 , nuclear receptor subfamily 4 group A member 2 , Nuclear receptor subfamily 4 group A member 2 , NGFI-B/nur77 beta-type transcription factor homolog , T-cell nuclear receptor NOT , immediate-early response protein NOT , intermediate-early receptor protein , nur related protein-1, human homolog of , orphan nuclear receptor NR4A2 , orphan nuclear receptor NURR1 , transcriptionally inducible nuclear receptor related 1 , transcriptionally-inducible nuclear receptor , NUR-related factor 1 , RNR-1 , SL-322 , nuclear orphan receptor HZF-3 , nuclear receptor subfamily 4 group A member 2 variant TINUR , nuclear receptor subfamily 4 group A member 2 variant NURR1a , nuclear receptor subfamily 4 group A member 2 variant NURR1b , nuclear receptor subfamily 4 group A member 2 variant NURR1c , nuclear receptor subfamily 4 group A member 2 variant NURR2c , nur related protein 1 , regenerating liver nuclear receptor 1 , nerve growth factor 1b , neural orphan nuclear receptor

GENE ID SPECIES
459669 Pan troglodytes
697077 Macaca mulatta
778703 Ciona intestinalis
100049370 Oryzias latipes
100050666 Equus caballus
100101682 Xenopus (Silurana) tropicalis
100190832 Pongo abelii
100409975 Callithrix jacchus
100482377 Ailuropoda melanoleuca
100589731 Nomascus leucogenys
4929 Homo sapiens
54278 Rattus norvegicus
424320 Gallus gallus
100157120 Sus scrofa
540245 Bos taurus
18227 Mus musculus
436679 Danio rerio
478754 Canis lupus familiaris
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