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The present study deals with the molecular modeling of the viral protein (NS3 of DENV1-4), the host protein (NRBP) and their interactions through protein-protein docking study.
Targeting this we performed homology modeling and protein-protein docking study of NS3 with NRBP (Nuclear Receptor Binding Protein) of human as it has been proved that NS3 of DENV interacts with NRBP which causes cellular trafficking in human cell.
High NRBP1 expression in prostate cancer is linked with poor clinical outcomes and increased cancer cell growth.
It was shown that NRBP1 is a tumour suppressor that plays a critical role in intestinal cell homoeostasis. NRBP1 levels are reduced in a wide variety of human tumours. Reduced NRBP1 levels in lung cancer correlates with a poor prognosis.
Interaction of the small GTPase (show RACGAP1 Proteins) Rac3 (show RAC3 Proteins) with NRBP: results suggest that NRBP functions in subcellular trafficking and may be directed to specific subcellular locations through interaction with small GTPases of the Rho family
mediates phosphorylation of the 14-3-3 (show YWHAQ Proteins) binding site of myeloid leukemia factor 1 (show MLF1 Proteins)
NS3 protein of dengue virus type 2 interacted specifically with nuclear receptor binding protein, a host cellular protein that influences trafficking between the endoplasmic reticulum and Golgi, and that interacts with Rac3
NRBP may be an important negative regulator of Jab1 (show COPS5 Proteins)-mediated functions such as gene transcription and tumor progression.
Using a novel combination of RNAi screens in worms together with detailed follow-up experiments in mouse and human cells, it was shown that NRBP1 is a tumour suppressor that plays a critical role in intestinal cell homoeostasis.
May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases (By similarity).
nuclear receptor-binding protein
, nuclear receptor binding protein 1
, nuclear receptor-binding protein-like
, multiple domain putative nuclear protein
, myeloid leukemia factor 1 adaptor molecule
, HLS7-interacting protein kinase
, MLF1 adapter molecule