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provide evidence that PPARD G32E is the variation underlying the ear size QTL
study provides evidence for an association between PPARD and backfat thickness.
PPAR profiles in bladder smooth muscle (BSM) may contribute to the susceptibility of BSM to lipotoxicity in the metabolic syndrome.
Overexpression of PPARdelta inhibits myotube formation and also enhances adipocyte differentiation in cultured mouse myoblasts.
data suggested that PPARbeta-regulated PDK1 (show PDPK1 ELISA Kits)/Akt (show AKT1 ELISA Kits) and E2f (show E2F1 ELISA Kits) signaling that controls metabolism and proliferation is involved in the normal progression of liver regeneration
Since the R6/2 mice represent a 'truncated' huntingtin (Htt (show HTT ELISA Kits)) mouse model of Huntington's disease (HD), we tested the efficacy of bezafibrate in a 'full-length' Htt (show HTT ELISA Kits) mouse model, the BACHD mice. Bezafibrate treatment restored the impaired PPARg (show PPARG ELISA Kits), PPARd, PGC (show PGC ELISA Kits)-1a signaling pathway, enhanced mitochondrial biogenesis and improved antioxidant defense in the striatum of BACHD mice
we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 (show MFN2 ELISA Kits) and mitochondrial Ca2 (show CA2 ELISA Kits)+, PPAR-b took an important role in neuronal differentiation induced by flavonoid compound 4a
PPAR-delta activation prevents in-stent restenosis and stent thrombosis.
The results demonstrate that PPARdelta-mediated inhibition of ER stress contributes to the vascular benefits of exercise.
this study shows that PPARbeta/delta is an important regulator of mast cell phenotype
findings identify LPCAT3 (show LPCAT3 ELISA Kits) as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3 (show LPCAT3 ELISA Kits).
Taken together, we provide crucial evidence that miR (show MLXIP ELISA Kits)-132 plays a key role in regulating osteogenic differentiation through Sirt1 (show SIRT1 ELISA Kits) in a PPARbeta/delta-dependent manner, indicating that miR (show MLXIP ELISA Kits)-132 and Sirt1 (show SIRT1 ELISA Kits)-PPARbeta/delta may act as potential therapeutic targets for T2DM-induced osteoporosis.
results from the present study demonstrate a novel regulatory role of PPARbeta/delta in modulating CYP2B10 that may contribute to the etiology of alcoholic liver disease.
PPARbeta/PPARgamma (show PPARG ELISA Kits) activation restored the LPS (show TLR4 ELISA Kits)-induced endothelial dysfunction by upregulation of UCP2 (show UCP2 ELISA Kits), with the subsequent alleviation of ER stress and NADPH oxidase (show NOX1 ELISA Kits) activity, thus reducing intracellular reactive oxygen species production and increasing nitric oxide bioavailability.
findings suggest that PPARdelta conditions CLL cells to survive in harsh microenvironmental conditions by reducing oxidative stress and increasing metabolic efficiency.
Here, theauthors describe a novel PPARbeta/delta-dependent molecular cascade involving TGFbeta1 (show TGFB1 ELISA Kits) and miR (show MLXIP ELISA Kits)-21-3p, which is activated in the epidermis in response to UV exposure.
findings identified previously unrecognized role of IP-PPARdelta signal transduction pathway in the production of sAPPalpha in cerebral microvasculature.
The minor allele of rs2016520 and rs9794 in PPAR-delta and interaction between rs2016520 and non-smoking were associated with decreased risk of CVD.
a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL (show HSD11B1 ELISA Kits)-C levels in the Singaporean Chinese population.
Results indicate that PPARdelta-mediated downregulation of Nox4 (show NOX4 ELISA Kits) modulates cellular redox status, which in turn plays a critical role in extracellular matrix homeostasis through ROS (show ROS1 ELISA Kits)-dependent regulation of MMP-2 (show MMP2 ELISA Kits) activity.
The PPAR delta role in neuroblastoma (show ARHGEF16 ELISA Kits) cell tumorigenesis and differentiation
PPARdelta activation may be a potential risk of atherosclerosis through enhancing activity of SMS2 (show SGMS2 ELISA Kits)
Gene expression of the carnitine transporter OCTN2 (show SLC22A5 ELISA Kits) and carnitine transport are regulated by PPARbeta/delta in bovine cells.
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants.
, nuclear hormone receptor 1
, nuclear receptor subfamily 1 group C member 2
, peroxisome proliferator-activated nuclear receptor beta/delta variant 2
, peroxisome proliferator-activated receptor beta
, Peroxisome proliferator-activated receptor beta
, peroxisome proliferator-activated receptor delta
, peroxisome proliferative activated receptor, delta
, peroxisome proliferator-activated receptor delta-like
, peroxisome proliferator activated receptor delta
, peroxisome proliferator activator receptor beta
, peroxisome proliferator activator receptor, delta
, peroxisome proliferator activator receptor delta