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Human Retinoic Acid Receptor alpha Protein expressed in Wheat germ - ABIN1317431
Schulz, Paus, Frey, Schmid, Kohl, Mennerich, Winkler, Gillardon: Leucine-rich repeat kinase 2 modulates retinoic acid-induced neuronal differentiation of murine embryonic stem cells. in PLoS ONE 2011
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High RARA expression is associated with acute myeloid leukemia (show BCL11A Proteins).
Data suggest that the binding of Z-10 to RXRalpha (show RXRA Proteins) inhibited the interaction of RXRalpha (show RXRA Proteins) with PML (show PML Proteins)-RARalpha, leading to Z-10's selective induction of PML (show PML Proteins)-RARalpha degradation.
PML (show PML Proteins)-RARa bcr1 (show BCR Proteins) fusion is not responsible for colorectal tumor development.
overexpression of NLS (show ALDH1A2 Proteins)-RARalpha promoted the proliferation of APL (show FASL Proteins) cells and inhibited their differentiation via the PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling pathway.
r study demonstrated that ATRA cound promote differentiation while inhibit proliferation of acute promyelocytic leukemia (show PML Proteins) NB4 cells via activating p38a (show MAPK14 Proteins) protein after recruiting p38a (show MAPK14 Proteins)-combinded NLS (show ALDH1A2 Proteins)-RARa, while NLS (show ALDH1A2 Proteins)-RARa could inhibit the effects of ATRA in the process.
Low expression of RARalpha was independently associated with worse progression-free survival following platinum-based chemotherapy of advanced Non-small cell lung cancer.
The classical counterpart of RARalpha, retinoid X receptor alpha (RXRalpha (show RXRA Proteins)), was down-regulated in both cytoplasm and nucleus of A549 cells upon atRA addition.
RAI1 (show DOM3Z Proteins) polymorphisms rs4925102 and rs9907986 are predicted to disrupt the binding of retinoic acid RXR-RAR receptors and the transcription factor DEAF1 (show DEAF1 Proteins), respectively, in Smith-Magenis and Potocki-Lupski syndromes patients.
Data suggest that hematopoietically expressed homeobox protein (HHEX (show HHEX Proteins)) downmodulation by promyelocytic leukemia (show PML Proteins)-retinoic acid receptor alpha fusion oncoprotein (PML (show PML Proteins)-RARalpha) is a key event during acute promyelocytic leukemia (show PML Proteins) (APL (show FASL Proteins)) pathogenesis.
ATRA dramatically down regulated RARalpha protein levels and led to more DNA damage and ultimately resulted in the synergism of these two agents
These data suggest that impairment of cardiac RARalpha signaling may be a novel mechanism that is directly linked to pathological stimuli-induced diastolic dysfunction.
Retinoic acid receptor alpha agonist all trans retinoic acid can protect the liver from ischemia reperfusion injury by promoting autophagy, which is dependent on Foxo3 (show FOXO3 Proteins)/p-Akt (show AKT1 Proteins)/Foxo1 (show FOXO1 Proteins) signaling.
both the PML (show PML Proteins)-RARA-driven competitive transplantation advantage and development of acute promyelocytic leukemia (show PML Proteins) (APL (show FASL Proteins)) required DNMT3A (show DNMT3A Proteins)
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (show WNT2 Proteins) signalling through physical interactions of RARs (show RARS Proteins) with beta-catenin (show CTNNB1 Proteins).
our findings challenge the predominant model in the field and we propose that PML (show PML Proteins)/RARA initiates leukemia by subtly shifting cell fate decisions within the promyelocyte compartment.
DNA-binding-defective PML (show PML Proteins)/RARA mutants could not repress the transcription of retinoic acid regulated genes.
although X-RARA fusion proteins have been suggested to act by blocking retinoid-dependent transcriptional programs , we observed a surprising paucity of natural retinoids capable of transactivating Gal4 (show LGALS4 Proteins)-RARA in primary mouse bone marrow cells
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha and RARgamma in bone structure regulation.
Data suggest that retinoic acid and GM-CSF (show CSF2 Proteins)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Proteins)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (show SP1 Proteins) via the RA receptor/retinoid X receptor (show RXRB Proteins) complex to the Aldh1a2 (show ALDH1A1 Proteins) promoter.
Retinoic acid-RARalpha as a key component of the regulatory network governing maintenance and plasticity of Th1 (show HAND1 Proteins)-cell fate.
Increased expression of mammary TRbeta1 (show THRB Proteins) and DIO2 (show DIO2 Proteins), and decreased RXRalpha (show RXRA Proteins), provide a mechanism to increase thyroid hormone (show PTH Proteins) activity within the mammary gland during lactation.
results show role for retinoic acid receptor (show RARB Proteins) as a regulator of spatial patterning of the pre-placodal ectoderm (PPE)through Tbx1 and RIPPLY3; demonstrate that Ripply3, acting downstream of RAR (show RAB40B Proteins) signaling, is key player in establishing boundaries in the PPE
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
retinoic acid receptor alpha
, retinoic acid receptor, alpha
, retinoic acid receptor alpha-like
, nuclear receptor subfamily 1 group B member 1
, nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form
, retinoic acid nuclear receptor alpha variant 1
, retinoic acid nuclear receptor alpha variant 2
, retinoic acid receptor, alpha polypeptide
, RAR alpha 1
, rar alpha
, xRAR alpha
, retinoic acid receptor alpha 1 isoform