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Dual small interfering RNA (siRNA) silencing of RARalpha (show RARA ELISA Kits) and RARgamma reversed RA blockade of P4-induced CK5 (show KRT5 ELISA Kits). Using promoter deletion analysis, we identified a region 1.1 kb upstream of the CK5 (show KRT5 ELISA Kits) transcriptional start site that is necessary for P4 activation and contains a putative progesterone response element (PRE
Loss of RARG expression is associated with Colorectal Tumorigenesis and Metastasis.
A nonsynonymous variant in RARG is highly associated with anthracycline-induced cardiotoxicity in childhood cancers.
deregulation of the retinoid/rexinoid signaling pathway has a major role and may represent a potential therapeutic target for NUP98 (show NUP98 ELISA Kits)-RARG-mediated transformation
The current status of knowledge indicates that there might be inter- or overlapping actions between PPARg (show PPARG ELISA Kits) and RARs (show RARS ELISA Kits), and there might be an association of PPARg (show PPARG ELISA Kits)/RARs (show RARS ELISA Kits)(RARa (show RARA ELISA Kits), RARb (show RARB ELISA Kits), and RARg) with renal diseases
RARgamma in concert with ATRA regulates protein levels of CDK1 (show CDK1 ELISA Kits) and its subcellular localization.
RARG plays an important role in the proliferation, metastasis, and chemoresistance of cholangiocarcinoma through simultaneous activation of the Akt (show AKT1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits) and Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathways.
Evidence that the retinoic acid receptor gamma plays a major role in the regulation of the human prostatic transglutaminase gene.
findings demonstrate that signaling through RARs (show RARS ELISA Kits) has critical roles in molecular reprogramming and that the synergistic interaction between Rarg and Lrh1 (show NR5A2 ELISA Kits) directs reprogramming toward ground-state pluripotency
results suggest that a RARgamma-dependent functional crosstalk is present between the retinoic acid and BMP2 (show BMP2 ELISA Kits) signaling to induce osteogenic transdifferentiation in myoblastic C2C12 cells
the reprogramming of epiblast stem cells into embryonic stem cell-like cells also requires low levels of retinoic acid (RA), which can modulate Wnt (show WNT2 ELISA Kits) signalling through physical interactions of RARs (show RARS ELISA Kits) with beta-catenin (show CTNNB1 ELISA Kits).
Data show that retinoic acid receptor gamma (RARgamma)-proto-oncogene protein c-fos (c-Fos)-PPARgamma2 (PPARgamma2 (show PPARG ELISA Kits)) signaling rather than reactive oxygen species generation is critical for all-trans retinoic acid (ATRA)-inhibited adipocyte differentiation.
RARgamma plays key roles in the differentiation competence of NGN3 (show NEUROG3 ELISA Kits)+ cells in response to retinoic acid during mouse spermatogenesis.
The results indicate a physiological role for RARgamma as a negative regulator of osteoclastogenesis in vivo and in vitro, and reveal distinct influences of RARalpha (show RARA ELISA Kits) and RARgamma in bone structure regulation.
this study shows that the combination of Rarg and Nr5a2 (show NR5A2 ELISA Kits) rapidly promote the iN cell maturation within 1 week and greatly facilitate the conversion with neuronal purities of approximately 50% and yields of >130%.
Data indicate that all three retinoic acid receptor (show RARA ELISA Kits) isoforms RARalha, RARbeta (show RARB ELISA Kits) and RARgamma are expressed in naive CD8 (show CD8A ELISA Kits)+ T cells, as well as CD8 (show CD8A ELISA Kits)+ T cells activated for 48 or 72 h.
erythroid-specific RAR (show RARA ELISA Kits) function is dispensable for erythropoiesis and RARgamma plays an erythroid extrinsic role in erythropoiesis.
Data indicate that male germ cell specific miR (show MLXIP ELISA Kits)-34c might be pivotal in embryonic stem cells (ESCs (show NR2E3 ELISA Kits)) differentiation into male germ cells through its target retinoic acid receptor gamma (RARg).
RARG cell-autonomously transduces, in undifferentiated spermatogonia of adult testes, a RA signal critical for spermatogenesis.
This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
retinoic acid receptor, gamma
, retinoic acid receptor gamma-like
, retinoic acid receptor gamma
, nuclear receptor subfamily 1 group B member 3
, retinoic acid nuclear receptor gamma variant 1
, retinoic acid nuclear receptor gamma variant 2
, RAR gamma 2
, RAR-gamma 2.1
, rar gamma
, retinoic acid receptor gamma isoform 2.1