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These data suggest that RXRs may be of crucial importance in the mechanism of allergic asthma and that the novel RXR partial agonist NEt-4IB may be a promising candidate for the treatment of allergic airway inflammation and airway hyperresponsiveness in a model of allergic asthma.
The study shows that FXR (show NR1H4 Proteins)/RXR regulates Chop (show DDIT3 Proteins) expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
These results suggest a mechanism to establish RXR therapeutic targets with significance in neurodegeneration.
The optimal PPARalpha (show PPARA Proteins)/RXRalpha heterodimer binding sequence was WAWVTRGGBBAHRGKTYA. The single nucleotide substitution, which reduces binding of RXRalpha to DNA, attenuated PPARalpha (show PPARA Proteins)-induced transcriptional activation, but this is not always true for PPARalpha (show PPARA Proteins).
A change in the heterodimeric partner of Peroxisome Proliferator Activated Receptor-alpha (show PPARA Proteins) from retinoid X receptor (show RXRB Proteins) to Silent information regulator 1 is responsible for the impaired fatty acid metabolism and cardiac dysfunction in the failing heart.
interaction of Wnt and RXR-alpha pathways in hepatocyte development and hepatocellular carcinoma
a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN
This uncovered a novel RXR-dependent innate immune regulatory pathway, suggesting that downregulation of RXR expression or RXR antagonist treatment benefits host antiviral response, whereas RXR agonist treatment may increase risk of viral infections.
Data suggest that retinoic acid and GM-CSF (show CSF2 Proteins)-induced retinal dehydrogenase 2 (RALDH2 (show ALDH1A2 Proteins)) expression in dendritic cells requires cooperative binding of transcription factor Sp1 (show SP1 Proteins) via the RA receptor/retinoid X receptor (show RXRB Proteins) complex to the Aldh1a2 (show ALDH1A1 Proteins) promoter.
The expression and binding of RXRalpha to CYP3A genes in liver was sex-dependent and regulated by growth hormone secretion.
Immune cell-infiltration is controlled by activated peroxisome proliferator activated receptor gamma (PPARgamma (show PPARG Proteins))/retinoid X receptor alpha (RXRalpha) that inhibits expression/secretion of inflammatory cytokines.
Data suggest that the binding of Z-10 to RXRalpha inhibited the interaction of RXRalpha with PML (show PML Proteins)-RARalpha (show RARA Proteins), leading to Z-10's selective induction of PML (show PML Proteins)-RARalpha (show RARA Proteins) degradation.
This suggests that hRXRalpha phosphorylation significantly disrupts its nuclear localization, interaction with VDR, intra-nuclear trafficking, and binding to chromatin of the hVDR-hRXR complex.
the expression of CAMP, vitamin D receptor (VDR), and the retinoid X receptor (RXR) isoforms in human skin and gingival tissue biopsies and investigated the signaling pathways involved in 1alpha,25-dihydroxyvitamin D3-induced upregulation of CAMP.
data show that RXRalpha expression is increased in miscarriage in endometrial glands and correlation analysis showed that negative correlation between RXRalpha and PPARgamma (show PPARG Proteins) disappears in miscarriage. This shift is supposable responsible for the loss of regular function in trophoblast and embryonic tissue.
IL-1beta (show IL1B Proteins) upregulated RXRalpha through activation of NF-kappaB (show NFKB1 Proteins) signaling.
RXRA rs10776909 allele T is specifically involved in the pathogenesis of ChGN (show CSGALNACT1 Proteins). This risk allele may be also associated with worse clinical course of ChGN (show CSGALNACT1 Proteins).
Results suggest that retinoid X receptor (show RXRB Proteins) (RXR) activation protects retinal pigment epithelium (RPE (show RPE Proteins)) cells from oxidative stress-induced (show SQSTM1 Proteins) apoptosis.
Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.
Retinoid X receptor alpha plays an important role in proliferation of cholangiocarcinoma
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators.
retinoid X receptor, alpha
, retinoid X receptor alpha
, RXR alpha 1
, nuclear receptor subfamily 2 group B member 1
, retinoic acid receptor RXR-alpha
, retinoid X nuclear receptor alpha
, retinoic acid receptor
, retinoid x receptor alpha
, retinoid X receptor alpha protein
, nuclear receptor subfamily 2 group B member 2-A
, retinoic acid receptor RXR-beta-A
, retinoid X receptor beta-A
, retinoid receptor-epsilon
, retinoid x receptor, epsilon