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Data show that halcinonide and clobetasol act as Smoothened (Smo) agonists to up-regulate myelin gene expression and retinoid X receptor gamma (RxRgamma) activation.
RXR-gamma plays an important role in tight control of glucose metabolism in the fasting-feeding cycle.The regulation of RXR-gamma expression in the liver by feeding or glucose.
The data of this study argued that control of NAc dopamine d2 receptor (show DRD2 Proteins) expression is critical for Retinoid x receptor gamma-mediated modulation of affective behaviors.
The ablation of all RXR (alpha, beta and gamma isotypes) in Sertoli cells does not recapitulate the phenotype generated upon ablation of all three retinoic acid receptors.
RXR/LXR up-regulates SREBP1c gene expression and FOXO1 antagonizes this effect of RXR/LXR in skeletal muscle.
genetic association studies in a population in Brazil: Data suggest that SNPs in RXRG (rs2134095) and GC (rs7041) are associated with low-density lipoprotein cholesterol levels and hypercholesterolemia in the population studied; there was no apparent association with an SNP in VDR (show CYP27B1 Proteins) (rs2228570). (RXRG = retinoid X receptor gamma; GC = vitamin D-binding protein (show GC Proteins); VDR (show CYP27B1 Proteins) = vitamin D receptor (show VDR Proteins))
Germline mutations in the RXRG gene are linked to Familial isolated pituitary adenoma in a Brazilian Family.
Data show that pregnane X receptor/retinoid X receptor PXR/RXR-[alpha], RXR-[beta], or RXR-[gamma] expression was noted in 9 (16.4%), 9 (16.4%), and 10 (18.2%) pancreatic adenocarcinoma cases, respectively.
Data show that some rexinoids display selective coactivator (CoA) recruitment by the retinoid X receptors (RXRs) homodimer and by the heterodimers nuclear receptor Nur77/RXR and Nurr1/RXR.
Differences in RAR and RXR subtype mRNA expression patterns in various PTCs may contribute to the immunochemistry data available, and may thus find exploitation in clinical oncology, particularly in the differential diagnosis of thyroid neoplasms.
loss of RXR-gamma levels appears to provide mechanistic benefits to transformed cells towards the acquisition of resistance to apoptosis hallmark of cancer
Genetic variation in RXRgamma gene may contribute to the development of HIVLD in combination antiretroviral therapy treated HIV patients.
The RXR-gamma rs3818569 single nucleotide polymorphisms is associated with diabetic retinopathy development in the Taiwanese population.
results indicate that RXR-gamma is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination.
RXRgamma and PPARgamma (show PPARG Proteins) ligands acted synergistically to inhibit proliferation and invasiveness in colon cancer cells.
Retinoic X receptor (show xpr1 Proteins)-gamma (RXRG) gene was studied as a candidate gene for the twinning trait of bovine.
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described.
nuclear receptor subfamily 2 group B member 3-B
, retinoic acid receptor RXR-gamma-B
, retinoid X receptor gamma-B
, retinoid X receptor, gamma
, retinoic acid receptor RXR-gamma
, nuclear receptor subfamily 2 group B member 1-B
, retinoic acid receptor RXR-alpha-B
, retinoid X receptor alpha-B
, retinoid x receptor, gamma
, nuclear receptor subfamily 2 group B member 3
, retinoid X receptor gamma
, retinoid X receptor alpha
, RXR gamma-1
, retinoic X receptor gamma-1