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The "f" allele of VDR (show CYP27B1 Antibodies) FokI polymorphism is associated with a higher risk of UBC (show RPS27A Antibodies) in Tunisians, especially in smokers as well as subjects with occupational exposition and subjects without vitamin D deficiency.
VDR (show CYP27B1 Antibodies) polymorphisms contribute to growth after very premature birth.
VDR (show CYP27B1 Antibodies) polymorphisms may contribute to susceptibility to aplastic anemia and influence the severity and prognosis of aplastic anemia in a Chinese population.
The ApaI and TaqI VDR (show CYP27B1 Antibodies) gene restriction fragment length polymorphisms have a significant association with Behcet disease in Egyptian patients.
The TT genotype of TaqI VDR (show CYP27B1 Antibodies) gene polymorphism was correlated with low levels of osteocalcin (show BGLAP Antibodies) in overweight and obese subjects.
The vitamin D receptor R BsmI gene polymorphisms may contribute to susceptibility to systemic lupus erythematosus in Egyptian children and adolescents. Moreover, we found that the BB genotype constituted a risk factor for the development of nephropathy among studied patients with systemic lupus erythematosus .
We conclude that Claudin-2 (show CLDN2 Antibodies) expression is significantly associated with bile acid receptors VDR (show CYP27B1 Antibodies) and TGR5 (show GPBAR1 Antibodies) expression. Our studies identify a novel role of a tight junction protein (show OCLN Antibodies) in the development and progression of esophageal mucosal metaplasia, dysplasia and carcinoma.
VDR (show CYP27B1 Antibodies) regulates hundreds of myeloid cell genes and that the molecular pathways controlled by VDR (show CYP27B1 Antibodies) in these cells are important in maintaining tolerance.
Association of VDR (show CYP27B1 Antibodies) polymorphisms with the susceptibility to Hepatitis C virus infection
No association was observed between GC or VDR (show CYP27B1 Antibodies) polymorphisms and breast cancer risk. associations between vitamin D-related genetic variants and breast cancer were not observed overall, although the relationships between vitamin D pathway polymorphisms and breast cancer may be modified by menopausal status and breast tumour subtype
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha (show TNF Antibodies) and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (show NOS2 Antibodies)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (show NOS2 Antibodies) were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
Vitamin D and its receptor might be involved in the progression of diabetic nephropathy by regulating transforming growth factor-beta, angiotensinogen (show AGT Antibodies) expression and apoptosis of podocytes.
suggest that VD3/VDR (show CYP27B1 Antibodies) inhibits weight gain by activating UCP3 (show UCP3 Antibodies) in the muscles.
The major finding of this study is that large intestine VDR (show CYP27B1 Antibodies) significantly contributes to whole-body Ca metabolism but that duodenal compensation may prevent the consequences of VDR (show CYP27B1 Antibodies) deletion from large intestine and kidney in growing mice.
The present study investigated whether the vitamin D/vitamin D receptor (VDR) pathway may ameliorate lipopolysaccharide (LPS (show TLR4 Antibodies))induced ALI through maintaining the integrity of the alveolar epithelial barrier.
Data, including data from studies in knockout mice, suggest that VDR (show CYP27B1 Antibodies) regulates expression of ezrin (show EZR Antibodies) in enterocytes; however, VDR (show CYP27B1 Antibodies) appears not to be involved in morphology of tight junctions and absorption of large molecules in enterocytes.
These data indicate a synergistic crosstalk between 1alpha,25(OH)2D3 and BMP2 (show BMP2 Antibodies) toward osteogenesis and mineral deposition, involving both VDR (show CYP27B1 Antibodies) and Pdia3 (show PDIA3 Antibodies).
study is the first to report an in vivo association between vitamin D, myostatin (show MSTN Antibodies), and the regulation of muscle mass
The current study reveals an important and novel mechanism for VDR (show CYP27B1 Antibodies) by regulation of epithelial barriers.
VitD3 reinforced physical interaction between placental VDR (show CYP27B1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) subunit.
1,25D3 modulates CD8 (show CD8A Antibodies)+ T cell phenotype via recruitment of the VDR (show CYP27B1 Antibodies) transcription factor to the promoter region of Cyp11a1 (show CYP11A1 Antibodies) leading to prevention of lung allergic responses.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D nuclear receptor variant 1
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D receptor
, vitamin D (1,25- dihydroxyvitamin D3) receptor