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Letter: found no relationship between FOK-I vitamin D receptor gene polymorphisms and bone mineral density in patients with systemic lupus erythematosus.
Vitamin D concentration, FokI, and TaqI may be considered as the predictors for the response of chronic hepatitis C patients to a combination therapy of pegylated interferon (show IFNA Antibodies) and ribavirin.
Our findings support the hypothesis that inherited common variation in VDR (show CYP27B1 Antibodies) binding sites affects the development of basal cell carcinoma .
High levels of PAI-1 (show SERPINE1 Antibodies) and low levels of VDR (show CYP27B1 Antibodies) expression were significantly associated with an increased risk for keloid disease in Chinese patients.
Study showed a considerable association between ApaI, BsmI and TaqI single nucleotide polymorphisms of VDR (show CYP27B1 Antibodies) gene with multiple sclerosis while FokI polymorphic variant did not reveal any correlation with susceptibility to the disease
no evidence of association is apparent between polymorphisms of vitamin D receptor genes and osteoporosis risk in the Han Chinese population.
We demonstrated that VDR (show CYP27B1 Antibodies)/miRNA155-modulated SOCS1 (show SOCS1 Antibodies) expression is decreased in PBC (show DLAT Antibodies) which may lead to insufficient negative regulation of cytokine signaling. These findings suggest that the decreased VDR (show CYP27B1 Antibodies) signaling in PBC (show DLAT Antibodies) could be of importance in the pathogenesis of PBC (show DLAT Antibodies).
We performed a meta-analysis to determine if there was an association between the Vitamin D Receptor polymorphisms and Intervertebral Disc Degeneration. We investigated associations of the FokI (rs2228570, rs10735810), and ApaI (rs7975253) polymorphisms of the VDR (show CYP27B1 Antibodies) gene with DD. This meta-analysis confirmed the protective role of the ApaI polymorphism.
Our study revealed that there is no significant difference in the allele and genotype frequencies of the VDR (show CYP27B1 Antibodies) polymorphisms (Bsm1 and Fok1) between the patients and controls.
VDR Bsm I polymorphisms may be predisposition factors of adolescent idiopathic scoliosis and the efficacy of brace treatment.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha (show TNF Antibodies) and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (show NOS2 Antibodies)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (show NOS2 Antibodies) were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
Vitamin D and its receptor might be involved in the progression of diabetic nephropathy by regulating transforming growth factor-beta, angiotensinogen (show AGT Antibodies) expression and apoptosis of podocytes.
suggest that VD3/VDR (show CYP27B1 Antibodies) inhibits weight gain by activating UCP3 (show UCP3 Antibodies) in the muscles.
The major finding of this study is that large intestine VDR (show CYP27B1 Antibodies) significantly contributes to whole-body Ca metabolism but that duodenal compensation may prevent the consequences of VDR (show CYP27B1 Antibodies) deletion from large intestine and kidney in growing mice.
The present study investigated whether the vitamin D/vitamin D receptor (VDR) pathway may ameliorate lipopolysaccharide (LPS (show TLR4 Antibodies))induced ALI through maintaining the integrity of the alveolar epithelial barrier.
Data, including data from studies in knockout mice, suggest that VDR (show CYP27B1 Antibodies) regulates expression of ezrin (show EZR Antibodies) in enterocytes; however, VDR (show CYP27B1 Antibodies) appears not to be involved in morphology of tight junctions and absorption of large molecules in enterocytes.
These data indicate a synergistic crosstalk between 1alpha,25(OH)2D3 and BMP2 (show BMP2 Antibodies) toward osteogenesis and mineral deposition, involving both VDR (show CYP27B1 Antibodies) and Pdia3 (show PDIA3 Antibodies).
study is the first to report an in vivo association between vitamin D, myostatin (show MSTN Antibodies), and the regulation of muscle mass
The current study reveals an important and novel mechanism for VDR (show CYP27B1 Antibodies) by regulation of epithelial barriers.
VitD3 reinforced physical interaction between placental VDR (show CYP27B1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) subunit.
1,25D3 modulates CD8 (show CD8A Antibodies)+ T cell phenotype via recruitment of the VDR (show CYP27B1 Antibodies) transcription factor to the promoter region of Cyp11a1 (show CYP11A1 Antibodies) leading to prevention of lung allergic responses.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D nuclear receptor variant 1
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D receptor
, vitamin D (1,25- dihydroxyvitamin D3) receptor