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VDR (show CYP27B1 Antibodies) polymorphism, FOK1, associated with greater vitamin D3-dependent growth inhibition of plasmablastic lymphoma and myeloma cells
Allelic variations in CYP2R1 (show CYP2R1 Antibodies) and GC affect vitamin D levels, but variant alleles on VDR (show CYP27B1 Antibodies) and DHCR7 (show DHCR7 Antibodies) were not correlated with vitamin D deficiency.
We also report that VDR (show CYP27B1 Antibodies) gene polymorphisms may be a risk for the development of vitiligo (show MITF Antibodies) in an Egyptian population.
VDR (show CYP27B1 Antibodies) receptor genes polymorphism was found in patients, diagnosed with dermatomyositis or systemic lupus erythematosus.
VDR (show CYP27B1 Antibodies) association with the susceptibility of esophageal squamous cell carcinoma in a Northern Chinese population.
PU.1 is an important modulator of VDR (show CYP27B1 Antibodies) signaling in monocytes.
Overexpression of the human VDR (show CYP27B1 Antibodies) gene in mature osteoblasts of C57Bl6/J mice increases cortical and trabecular bone volumes.
JNK1 (show MAPK8 Antibodies) physically and functionally interacted with VDR (show CYP27B1 Antibodies) and positively regulated VDR (show CYP27B1 Antibodies) expression at transcriptional and translational levels, which influenced calcitriol-mediated inhibition of cancer cell proliferation.
Our study showed no significant association of the FokI polymorphism in the vitamin D receptor gene with type 2 diabetes mellitus in Tunisian population
It was determined that high glucose-induced VDR (show CYP27B1 Antibodies) expression, increased inflammatory cytokine expression, including transforming growth factor beta (TGFbeta (show TGFB1 Antibodies)) and interleukin6 (IL6 (show IL6 Antibodies)) and phosphorylatedSMAD family member 3 (pSmad3) expression.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha (show TNF Antibodies) and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (show NOS2 Antibodies)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (show NOS2 Antibodies) were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
The data support the hypothesis that Vdr (show CYP27B1 Antibodies) in mature adipocytes alters the metabolic response to high-fat diets and exerts anti-proliferative effects on the mammary epithelium.
The data demonstrate that deficiency in the vitamin D signaling via VDR (show CYP27B1 Antibodies) knockout enhances the pathological phenotype in this experimental cardiomyopathy and suggest an important role for vitamin D in modulating disease severity in common cardiovascular disorders.
Absence of VDR (show CYP27B1 Antibodies) or presence of an unliganded VDR (show CYP27B1 Antibodies) does not affect the profile and function of ex vivo generated bone marrow-derived dendritic cells.
Vitamin D receptor activation reduces dissecting abdominal aortic aneurysm formation induced by Ang-II (show AGT Antibodies) in apoE (show APOE Antibodies)(-/-) mice
VDR (show CYP27B1 Antibodies) may function as a selective suppressor/de-repressor of gene expression in the absence of 1,25-dihydroxyvitamin D3.
In the presence of normocalcemia, absence of VDR (show CYP27B1 Antibodies) or its ligand-activated transcription of genes has no direct regulatory effect on murine glucose homeostasis or gene expression in islets of Langerhans.
The Vdr (show CYP27B1 Antibodies)-/- mouse model displays sex- and site-specific differences in skeletal structures with long-term feeding of a rescue diet.
The endothelial cell VDR (show CYP27B1 Antibodies) plays a tonic inhibitory role in regulating glucose disposal and could prove to be a factor in controlling glucose homeostasis in the intact organism.
Cyp27b1 (show CYP27B1 Antibodies)(-/-) mice exhibited hypocalcemia, growth defects, and skeletogenesis dysfunction, similar to Vdr (show CYP27B1 Antibodies)(-/-) mice, but do not display alopecia
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D nuclear receptor variant 1
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D receptor
, vitamin D (1,25- dihydroxyvitamin D3) receptor