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Vitamin D related (VDR (show CYP27B1 Antibodies) rs2228570 and CYP2R1 (show CYP2R1 Antibodies) rs10741657) and IL28B (show IL28B Antibodies) rs12979860 genes polymorphisms accurately assure sustained viral response in naive CHC (show CLTC Antibodies) G4 patients treated with low cost standard therapy.
VDR (show CYP27B1 Antibodies) could be a potential prognostic factor for patients with gastric cancer.
FokI polymorphism is not generally associated with Intervertebral disk degeneration (IDD (show COL9A3 Antibodies)), but there is increased risk for IDD (show COL9A3 Antibodies) in Hispanics and Asians carrying FokI allele T.[meta-analysis]
In the present genetic association study, authors assessed 5 Tag single nucleotide polymorphisms (SNPs) (rs11168268, rs2248098, rs1540339, rs4760648 and rs3890733), which cover most of the VDR (show CYP27B1 Antibodies) gene
Data found no statistically significant association between vitamin D receptor polymorphism rs2228570 and chronic periodontitis in our population.
Vitamin D receptor single-nucleotide polymorphism is associated with cancer risk.
Despite comparable osteoprotegerin (show TNFRSF11B Antibodies) concentrations, lumbar disc herniation cases express lower RANKL (show TNFSF11 Antibodies) than controls. Disc herniation was strongly associated with RANKL (show TNFSF11 Antibodies) and the presence of the F allele of the VDR (show CYP27B1 Antibodies) gene.
investigation of NRAMP1 (show SLC11A1 Antibodies), MBL (show MBL2 Antibodies), MBL (show MBL2 Antibodies), VDR (show CYP27B1 Antibodies) gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis in a Chinese population; study suggests that genotypes of many polymorphic genes are associated with TB
In this study, we confirmed that the psoriatic patients with the VDR (show CYP27B1 Antibodies) FokI CC or Cdx2 (show CDX2 Antibodies) AA genotypes exhibited a significant improvement when treated with calcipotriol.
The VDR (show CYP27B1 Antibodies) BsmI B allele may be considered as a genetic determinant for heart disease.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha (show TNF Antibodies) and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (show NOS2 Antibodies)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (show NOS2 Antibodies) were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
These data indicate a synergistic crosstalk between 1alpha,25(OH)2D3 and BMP2 (show BMP2 Antibodies) toward osteogenesis and mineral deposition, involving both VDR (show CYP27B1 Antibodies) and Pdia3 (show PDIA3 Antibodies).
study is the first to report an in vivo association between vitamin D, myostatin (show MSTN Antibodies), and the regulation of muscle mass
The current study reveals an important and novel mechanism for VDR (show CYP27B1 Antibodies) by regulation of epithelial barriers.
VitD3 reinforced physical interaction between placental VDR (show CYP27B1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) p65 (show NFkBP65 Antibodies) subunit.
1,25D3 modulates CD8 (show CD8A Antibodies)+ T cell phenotype via recruitment of the VDR (show CYP27B1 Antibodies) transcription factor to the promoter region of Cyp11a1 (show CYP11A1 Antibodies) leading to prevention of lung allergic responses.
Data (including data from studies in knockout mice) suggest signal transduction via calcitriol/calcitriol receptor regulates expression of Elovl3 (show ELOVL3 Antibodies) (fatty acid elongase 3) and alters fatty acid composition in subcutaneous (not visceral) adipose tissue.
Absent immune cell VDR (show CYP27B1 Antibodies) expression does not impact the strength/phenotype/linetics of heart transplant rejection in mice and does not impact the graft-prolonging effects of costimulatory blockade including that induced by clinically used CTLA4Ig.
these studies delineate a protective role for vitamin D receptor signaling in Ron (show MST1R Antibodies)-induced mammary tumorigenesis through disruption of beta-catenin (show CTNNB1 Antibodies) activation.
These studies define mechanisms associated with hormonal regulation of the Vdr (show CYP27B1 Antibodies) and hint at the differential nature of VDR (show CYP27B1 Antibodies) binding activity at the Vdr (show CYP27B1 Antibodies) gene in different primary target tissues in vivo.
VDR (show CYP27B1 Antibodies) expression is lost in the majority of the colon tumor cells.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D nuclear receptor variant 1
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D receptor
, vitamin D (1,25- dihydroxyvitamin D3) receptor