Browse our Vitamin D3 Receptor Proteins (VDR)

Full name:
Vitamin D3 Receptor Proteins (VDR)
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Synonyms:
LOC100008907, LOC100136371, Nr1i1, vdr-A, xVDR
list all proteins Gene Name GeneID UniProt
Human VDR VDR 7421 P11473
Rat VDR VDR 24873 P13053
Mouse VDR VDR 22337 P48281

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More Proteins for Vitamin D3 Receptor Interaction Partners

Human Vitamin D3 Receptor (VDR) interaction partners

  1. An alternative promoter of the vitamin D receptor (VDR) gene shows altered DNA methylation (show HELLS Proteins) levels in patients with multiple sclerosis, and it is associated with VDR (show CYP27B1 Proteins) mRNA upregulation.

  2. Genetic variability in the VDR (show CYP27B1 Proteins) region may be an important factor influencing anthropometric parameters associated with obesity, i.e. waist circumference, sum of skin fold thickness and total % of body fat in the Central-European population.

  3. Ras-induced senescent cells are hindered in their ability to recruit BRCA1 and 53BP1 (show TP53BP1 Proteins) to DNA damage sites. Whereas BRCA1 is downregulated at transcripts levels, 53BP1 (show TP53BP1 Proteins) loss is caused by activation of cathepsin L (show CTSL1 Proteins)-mediated degradation of 53BP1 (show TP53BP1 Proteins) protein. we discovered a marked downregulation of vitamin D receptor (VDR) during OIS, and a role for the vitamin D/VDR (show CYP27B1 Proteins) axis regulating the levels of these DNA repair

  4. Three SNPs, rs4516035 (A1012G; p = 0.009), rs1544410 (BsmI; p = 0.010), and rs731236 (TaqI; p = 0.038) and a 3' UTR haploblock constructed by three SNPs (Bsml-Taq1-rs10783215; p < 0.005) showed significantly associations with hand grip strength of the dominant hand.

  5. FokI polymorphism of VDR (show CYP27B1 Proteins) is potentially involved in the context of Mycosis Fungoides

  6. An association between vitamin D receptor Fokl ff genotype and multiple sclerosis susceptibility was found.

  7. SIRT1 (show SIRT1 Proteins) enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via VDR (show CYP27B1 Proteins) deacetylation.

  8. findings demonstrated associations between VDR (show CYP27B1 Proteins) polymorphisms (rs11574143, rs7975232, rs11574079, rs3819545 and rs11168287) and pulmonary tuberculosis development

  9. modulation of the expression of VDR (show CYP27B1 Proteins) can regulate the expression of IL-10 (show IL10 Proteins) in peripheral B cells of pituitary gland tumour (PGT (show SLCO2A1 Proteins))patients, which may contribute to the treatment of PGT (show SLCO2A1 Proteins).

  10. VDR (show CYP27B1 Proteins) polymorphisms play a role in calciphylaxis development in dialysis patients.

Pig (Porcine) Vitamin D3 Receptor (VDR) interaction partners

  1. Reduced Vitamin D receptor is associated with melanoma.

  2. Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.

  3. The expression of TNF-alpha (show TNF Proteins) and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.

Cow (Bovine) Vitamin D3 Receptor (VDR) interaction partners

  1. Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (show NOS2 Proteins)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (show NOS2 Proteins) were impacted.

  2. Two novel SNPs identified in coding region of VDR are associated with growth traits.

Mouse (Murine) Vitamin D3 Receptor (VDR) interaction partners

  1. Vdr (show CYP27B1 Proteins) and Casr (show CASR Proteins) are required for beta-catenin (show CTNNB1 Proteins)-regulated cell proliferation and Adherens junction formation essential for re-epithelialization after wounding. Vitamin D and calcium signaling in keratinocytes are required for a normal regenerative response of the skin to wounding.

  2. Absence of VDR (show CYP27B1 Proteins)-mediated PPARgamma (show PPARG Proteins) suppression underlies alopecia in VDR (show CYP27B1 Proteins)-/- mice.

  3. Through the VDR, vitamin D is an environmental factor that helps to maintain low serum IgE responses.

  4. VDR (show CYP27B1 Proteins) is important for the maintenance of physiological level of Axin1 (show AXIN1 Proteins)

  5. The data support the hypothesis that Vdr (show CYP27B1 Proteins) in mature adipocytes alters the metabolic response to high-fat diets and exerts anti-proliferative effects on the mammary epithelium.

  6. The data demonstrate that deficiency in the vitamin D signaling via VDR (show CYP27B1 Proteins) knockout enhances the pathological phenotype in this experimental cardiomyopathy and suggest an important role for vitamin D in modulating disease severity in common cardiovascular disorders.

  7. Absence of VDR (show CYP27B1 Proteins) or presence of an unliganded VDR (show CYP27B1 Proteins) does not affect the profile and function of ex vivo generated bone marrow-derived dendritic cells.

  8. JNK1 (show MAPK8 Proteins) physically and functionally interacted with VDR (show CYP27B1 Proteins) and positively regulated VDR (show CYP27B1 Proteins) expression at transcriptional and translational levels, which influenced calcitriol-mediated inhibition of cancer cell proliferation.

  9. Vitamin D receptor activation reduces dissecting abdominal aortic aneurysm formation induced by Ang-II (show AGT Proteins) in apoE (show APOE Proteins)(-/-) mice

  10. VDR (show CYP27B1 Proteins) may function as a selective suppressor/de-repressor of gene expression in the absence of 1,25-dihydroxyvitamin D3.

Vitamin D3 Receptor (VDR) Protein Profile

Protein Summary

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.

Alternative names and synonyms associated with Vitamin D3 Receptor (VDR)

  • vitamin D3 receptor (LOC100008907)
  • vitamin D3 receptor (LOC100136371)
  • vitamin D (1,25- dihydroxyvitamin D3) receptor (VDR)
  • vitamin D (1,25- dihydroxyvitamin D3) receptor (Vdr)
  • vitamin D (1,25- dihydroxyvitamin D3) receptor (vdr-A)
  • vitamin D receptor (Vdr)
  • LOC100008907 protein
  • LOC100136371 protein
  • Nr1i1 protein
  • vdr-A protein
  • xVDR protein

Protein level used designations for Vitamin D3 Receptor Proteins (VDR)

vitamin D3 receptor , 1,25-dihydroxyvitamin D3 receptor , nuclear receptor subfamily 1 group I member 1 , vitamin D nuclear receptor variant 1 , vitamin D (1,25-dihydroxyvitamin D3) receptor , vitamin D receptor , vitamin D (1,25- dihydroxyvitamin D3) receptor

GENE ID SPECIES
100008907 Oryctolagus cuniculus
100136371 Salmo salar
7421 Homo sapiens
24873 Rattus norvegicus
486588 Canis lupus familiaris
396628 Sus scrofa
395988 Gallus gallus
533656 Bos taurus
378575 Xenopus laevis
22337 Mus musculus
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