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Our results suggest a potential VDR (show CYP27B1 Proteins) GATG haplotype association with atherosclerotic disease in RA patients.
Vitamin D related (VDR rs2228570 and CYP2R1 rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure sustained viral response in naive CHC G4 patients treated with low cost standard therapy.
VDR (show CYP27B1 Proteins) could be a potential prognostic factor for patients with gastric cancer.
FokI polymorphism is not generally associated with Intervertebral disk degeneration (IDD (show COL9A3 Proteins)), but there is increased risk for IDD (show COL9A3 Proteins) in Hispanics and Asians carrying FokI allele T.[meta-analysis]
In the present genetic association study, authors assessed 5 Tag single nucleotide polymorphisms (SNPs) (rs11168268, rs2248098, rs1540339, rs4760648 and rs3890733), which cover most of the VDR (show CYP27B1 Proteins) gene
Data found no statistically significant association between vitamin D receptor polymorphism rs2228570 and chronic periodontitis in our population.
Vitamin D receptor single-nucleotide polymorphism is associated with cancer risk.
Despite comparable osteoprotegerin (show TNFRSF11B Proteins) concentrations, lumbar disc herniation cases express lower RANKL (show TNFSF11 Proteins) than controls. Disc herniation was strongly associated with RANKL (show TNFSF11 Proteins) and the presence of the F allele of the VDR (show CYP27B1 Proteins) gene.
investigation of NRAMP1 (show SLC11A1 Proteins), MBL (show MBL2 Proteins), MBL (show MBL2 Proteins), VDR (show CYP27B1 Proteins) gene polymorphisms and their interaction with susceptibility to pulmonary tuberculosis in a Chinese population; study suggests that genotypes of many polymorphic genes are associated with TB
In this study, we confirmed that the psoriatic patients with the VDR (show CYP27B1 Proteins) FokI CC or Cdx2 (show CDX2 Proteins) AA genotypes exhibited a significant improvement when treated with calcipotriol.
Reduced Vitamin D receptor is associated with melanoma.
Expression of TauT is differentially regulated by Vitamin D(3) and retinoic acid via formation of VDR and RXR complexes in the nuclei in a cell type-dependent manner.
The expression of TNF-alpha (show TNF Proteins) and VDR in post-angioplasty coronary artery neointimal lesions of hypercholesterolemic swine, was examined.
Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2 (show NOS2 Proteins)), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 (show NOS2 Proteins) were impacted.
Two novel SNPs identified in coding region of VDR are associated with growth traits.
Data, including data from studies in knockout mice, suggest that VDR (show CYP27B1 Proteins) regulates expression of ezrin (show EZR Proteins) in enterocytes; however, VDR (show CYP27B1 Proteins) appears not to be involved in morphology of tight junctions and absorption of large molecules in enterocytes.
These data indicate a synergistic crosstalk between 1alpha,25(OH)2D3 and BMP2 (show BMP2 Proteins) toward osteogenesis and mineral deposition, involving both VDR (show CYP27B1 Proteins) and Pdia3 (show PDIA3 Proteins).
study is the first to report an in vivo association between vitamin D, myostatin (show MSTN Proteins), and the regulation of muscle mass
The current study reveals an important and novel mechanism for VDR (show CYP27B1 Proteins) by regulation of epithelial barriers.
VitD3 reinforced physical interaction between placental VDR (show CYP27B1 Proteins) and NF-kappaB (show NFKB1 Proteins) p65 (show NFkBP65 Proteins) subunit.
1,25D3 modulates CD8 (show CD8A Proteins)+ T cell phenotype via recruitment of the VDR (show CYP27B1 Proteins) transcription factor to the promoter region of Cyp11a1 (show CYP11A1 Proteins) leading to prevention of lung allergic responses.
Data (including data from studies in knockout mice) suggest signal transduction via calcitriol/calcitriol receptor regulates expression of Elovl3 (fatty acid elongase 3) and alters fatty acid composition in subcutaneous (not visceral) adipose tissue.
Absent immune cell VDR (show CYP27B1 Proteins) expression does not impact the strength/phenotype/linetics of heart transplant rejection in mice and does not impact the graft-prolonging effects of costimulatory blockade including that induced by clinically used CTLA4Ig.
these studies delineate a protective role for vitamin D receptor signaling in Ron (show MST1R Proteins)-induced mammary tumorigenesis through disruption of beta-catenin (show CTNNB1 Proteins) activation.
These studies define mechanisms associated with hormonal regulation of the Vdr (show CYP27B1 Proteins) and hint at the differential nature of VDR (show CYP27B1 Proteins) binding activity at the Vdr (show CYP27B1 Proteins) gene in different primary target tissues in vivo.
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins.
vitamin D3 receptor
, 1,25-dihydroxyvitamin D3 receptor
, nuclear receptor subfamily 1 group I member 1
, vitamin D nuclear receptor variant 1
, vitamin D (1,25-dihydroxyvitamin D3) receptor
, vitamin D receptor
, vitamin D (1,25- dihydroxyvitamin D3) receptor