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NDPK-D has an important role in the early stages of mitophagy as induced by carbonyl cyanide m-chlorophenylhydrazone as well as by PINK1-Parkin (show PARK2 ELISA Kits)-independent stimuli such as rotenone and 6-hydroxydopamine.
Mitochondrial NM23-H4/NDPK-D: a bifunctional nanoswitch for bioenergetics and lipid signaling
miR (show MLXIP ELISA Kits)-196 performed it's their function by inhibiting NME4 expression and further activating p-JNK (show MAPK8 ELISA Kits), suppressing TIMP1 (show TIMP1 ELISA Kits), and augmenting MMP1 (show MMP1 ELISA Kits)/9.
NDPK-B and NDPK-D were shown to bind efficiently to liposomes mimicking plasma membrane and mitochondrial inner membrane
findings show NDPKs (NM23-H1 (show NME1 ELISA Kits)/H2/H4) interact with and provide GTP (show AK3 ELISA Kits) to dynamins, allowing these motor proteins to work with high thermodynamic efficiency for membrane remodeling
Nm23-H4 acts as a lipid-dependent mitochondrial switch with dual function in phosphotransfer serving local GTP (show AK3 ELISA Kits) supply and cardiolipin transfer for apoptotic signaling and putative other functions
High expression of ERCC1 (show ERCC1 ELISA Kits), FLT1 (show FLT1 ELISA Kits), NME4 and PCNA (show PCNA ELISA Kits) in myelodysplastic syndrome was associated with poor prognosis and disease progression along the sequence of 5q-syndrome/RCMD/RAEB/de novo AML (show RUNX1 ELISA Kits)
The nucleoside diphosphate (NDP) kinases (EC 220.127.116.11) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997
, NDP kinase D
, NDP kinase, mitochondrial
, non-metastatic cells 4, protein expressed in
, nucleoside diphosphate kinase D
, nucleoside diphosphate kinase, mitochondrial
, expressed in non-metastatic cells 4, protein