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Browse our APAF1 Proteins (APAF1)

Full name:
Apoptotic Peptidase Activating Factor 1 Proteins (APAF1)
On www.antibodies-online.com are 7 Apoptotic Peptidase Activating Factor 1 (APAF1) Proteins from 5 different suppliers available. Additionally we are shipping APAF1 Antibodies (214) and APAF1 Kits (48) and many more products for this protein. A total of 277 APAF1 products are currently listed.
Synonyms:
6230400I06Rik, anon-53Fa, APAF-1, apaf1, Apaf1l, arc, ark, CED4, CG6829, D-Apaf-1, dapaf, dapaf-1, dApaf-1/DARK/HAC-1, Dapaf-1/HAC-1, dapaf-1L, dapaf-1S, dApaf1, dark, Dark/Apaf-I, dark/dapaf-1/hac-1, Dark/Dapaf-1/HAC1, dark/hac-1/dapaf-1, Dark/Hac-1/dApaf1, Dmel\\CG6829, fog, hac-1, Hac-1/Dark, hac1, l(2)SH0173, mKIAA0413, T1, zgc:136543
list all proteins Gene Name GeneID UniProt
APAF1 317 O14727
APAF1 11783 O88879
Rat APAF1 APAF1 78963 Q9EPV5

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APAF1 Proteins (APAF1) by Origin

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More Proteins for APAF1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. polyglutamine-induced cell death was dramatically suppressed in flies lacking Dark, the fly homolog of human Apaf-1, a key regulator of apoptosis

  2. structural analysis of Apaf-1 in the auto-inhibited form demonstrates the critical role of ADP [review]

  3. ARK is essential for apoptosis during D. melanogaster development, and for radiation-induced apoptosis. Ark mutant embryos have extra cells, and tissues such as brain lobes and wing discs are enlarged.

  4. Daxx (show DAXX Proteins)-like protein of Drosophila interacts with Dmp53 and affects longevity and Ark mRNA level

Human Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Different selenium concentrations had varying effects on BAK1 (show BAK1 Proteins) and APAF1 levels. APAF1 may play an important role in the pathogenesis of KBD

  2. miR21 is transferred from cancer-associated adipocytes (CAAs) and fibroblasts (CAFs (show TBX1 Proteins)) to the cancer cells, where it suppresses ovarian cancer apoptosis and confers chemoresistance by binding to its direct novel target, APAF1.

  3. HDAC (show HDAC3 Proteins) inhibitors can induce p53 (show TP53 Proteins) acetylation at lysine 120, which in turn enhances mitochondrion-mediated apoptosis through transcriptional up-regulation of Apaf-1.

  4. Renal APAF1 expression is increased in diabetes and diabetic nephropathy.

  5. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  6. These results suggest that CED-4 forms a complex with ced-3 mRNA and delivers it to ribosomes for translation.

  7. The auto-assembly of truncated Apaf1 molecules disappeared after several hours without any enzyme activation.

  8. cytochrome c (show CYCS Proteins) and the WD domains of Apaf-1 interact, with bifurcated salt bridges involved in apoptosome assembly

  9. NF-kappaB (show NFKB1 Proteins) response element, located close to the p53RE#1, mediates APAF1 transcriptional repression by affecting interaction between KAISO (show ZBTB33 Proteins) and p53 (show TP53 Proteins)

  10. This study suggested that miR (show MLXIP Proteins)-23a, acting as an oncogenic regulator by directly targeting APAF1 in pancreatic cancer, is a useful potential biomarker in diagnosis and treatment of pancreatic cancer.

Mouse (Murine) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Apaf1's pivotal role during embryonic development as has been demonstrated to be in regulation of neuronal cell death

  2. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells.

  3. Apaf1 is required for proper cortical neuron differentiation since its deletion specifically impairs axonal outgrowth.

  4. study demonstrates that MMP-3 (show MMP3 Proteins) leads to caspase-9 (show CASP9 Proteins) activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1

  5. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

  6. Study reports experimental evidence suggesting the likely participation of the Apaf1 protein in the aggregation of polyQ stretches; Apaf1 may enhance polyglutamine aggregation by reducing the cellular protein levels of available functional Hsp70 (show HSP70 Proteins)

  7. miR (show MLXIP Proteins)-23a/b and miR (show MLXIP Proteins)-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis.

  8. a role for Apaf1 at the mitochondria

  9. The Apaf-1-independent caspase (show CASP3 Proteins) activation was not inhibited by Bcl-2 (show BCL2 Proteins), and occurred without the release of cytochrome c (show CYCS Proteins) from mitochondria, suggesting that the mitochondrial pathway was not involved in this death process.

  10. These data are consistent with a model in which alterations of GH signaling and/or insulin (show INS Proteins) sensitivity lead to increased lifespan mediated by decreased renal expression of pro-apoptotic genes.

Pig (Porcine) Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. Counterpulsation could protect vascular endothelial cells from apoptosis, delaying early atherosclerotic lesions possibly through transcriptional down-regulation of pro-apoptotic gene Apaf-1, and up-regulation of anti-apoptotic gene BIRC2 (show BIRC2 Proteins).

Zebrafish Apoptotic Peptidase Activating Factor 1 (APAF1) interaction partners

  1. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases.

APAF1 Protein Profile

Protein Summary

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.

Alternative names and synonyms associated with APAF1

  • Apaf-1-related-killer (Ark)
  • apoptotic peptidase activating factor 1 (apaf1)
  • apoptotic peptidase activating factor 1 (APAF1)
  • apoptotic peptidase activating factor 1 (Apaf1)
  • apoptotic protease activating factor 1 (apaf1)
  • 6230400I06Rik protein
  • anon-53Fa protein
  • APAF-1 protein
  • apaf1 protein
  • Apaf1l protein
  • arc protein
  • ark protein
  • CED4 protein
  • CG6829 protein
  • D-Apaf-1 protein
  • dapaf protein
  • dapaf-1 protein
  • dApaf-1/DARK/HAC-1 protein
  • Dapaf-1/HAC-1 protein
  • dapaf-1L protein
  • dapaf-1S protein
  • dApaf1 protein
  • dark protein
  • Dark/Apaf-I protein
  • dark/dapaf-1/hac-1 protein
  • Dark/Dapaf-1/HAC1 protein
  • dark/hac-1/dapaf-1 protein
  • Dark/Hac-1/dApaf1 protein
  • Dmel\\CG6829 protein
  • fog protein
  • hac-1 protein
  • Hac-1/Dark protein
  • hac1 protein
  • l(2)SH0173 protein
  • mKIAA0413 protein
  • T1 protein
  • zgc:136543 protein

Protein level used designations for APAF1

Apaf-1 related , Apaf-1 related killer , Apaf-1-related killer , Ark-PA , Ark-PB , CG6829-PA , CG6829-PB , apaf1-related killer , dark , drosophila Apaf-1-related killer , lethal (2) SH0173 , transcription unit 1 , apoptotic peptidase activating factor 1 , apoptotic protease-activating factor 1-like , apoptotic protease-activating factor 1 , apoptotic protease activating factor 1 , forebrain overgrowth , apaf-1

GENE ID SPECIES
36914 Drosophila melanogaster
444261 Xenopus laevis
100127738 Xenopus (Silurana) tropicalis
452153 Pan troglodytes
694164 Macaca mulatta
768257 Felis catus
100013051 Monodelphis domestica
100459074 Pongo abelii
100464163 Ailuropoda melanoleuca
100549497 Meleagris gallopavo
100556318 Anolis carolinensis
100590369 Nomascus leucogenys
317 Homo sapiens
11783 Mus musculus
78963 Rattus norvegicus
537782 Bos taurus
482620 Canis lupus familiaris
417926 Gallus gallus
100719903 Cavia porcellus
100513283 Sus scrofa
100052552 Equus caballus
100135699 Ovis aries
58131 Danio rerio
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