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anti-Human ATM antibody for Biochemical Assay

Recommended ATM Antibody (supplied by: Log in to see )

Antigen
Ataxia Telangiectasia Mutated (ATM) Antibodies
  • AI256621
  • at1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • atdc
  • ATE
  • Atm
  • ATM
  • atm
  • atm/tefu
  • C030026E19Rik
  • CG6535
  • dATM
  • Dmel\\CG6535
  • tef
  • Tefu
  • tel1
  • TEL1
  • TELO1
  • telo1
  • Xatm
Epitope
phosphorylated
87
41
17
15
13
13
13
7
7
7
7
5
4
4
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
330
123
62
15
7
4
1
Host
Mouse
218
86
17
8
3
Clonality
Monoclonal
Conjugate
This ATM antibody is un-conjugated
11
10
9
9
6
6
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
Application
Biochemical Assay (BCA)
206
118
100
98
84
77
60
23
22
15
11
4
4
3
1
1
1
1
1
Supplier
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Catalog No. ABIN2666313
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00088717224 ABIN2666314 BCA Mouse IgG1 kappa phosphorylated Log in to see 10H11-E12 3

Top referenced anti-ATM antibody for Biochemical Assay

Similar anti-ATM Antibodies

Application / Reactivity Human Mouse (Murine)
Western Blotting (WB) 209 Antibodies 86 Antibodies
Proximity Ligation Assay (PLA) 4 Antibodies 1 Antibodies
Immunoprecipitation (IP) 102 Antibodies 59 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 79 Antibodies 49 Antibodies
Immunohistochemistry (IHC) 121 Antibodies 61 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies 1 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies 12 Antibodies
Immunofluorescence (IF) 87 Antibodies 62 Antibodies
Immunofluorescence (Cultured Cells) (IF (cc)) 11 Antibodies 11 Antibodies
Immunocytochemistry (ICC) 62 Antibodies

General

Antigen Ataxia Telangiectasia Mutated (ATM) Antibodies
Epitope phosphorylated
(87), (41), (17), (15), (13), (13), (13), (7), (7), (7), (7), (5), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(330), (123), (62), (15), (7), (4), (1)
Host Mouse
(218), (86), (17), (8), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This ATM antibody is un-conjugated
(11), (10), (9), (9), (6), (6), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application Biochemical Assay (BCA)
(206), (118), (100), (98), (84), (77), (60), (23), (22), (15), (11), (4), (4), (3), (1), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-ATM Antibody

Target Details ATM Application Details Handling References for anti-ATM Antibody (ABIN2666313) Images
Purification The antibody was purified by affinity chromatography.
Clone 10H11-E12
Isotype IgG1 kappa

Target Details ATM

Product Details anti-ATM Antibody Application Details Handling References for anti-ATM Antibody (ABIN2666313) Images back to top
Antigen
Alternative Name ATM (ATM Antibody Abstract)
Background Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. ATM is held inactive in unirradiated cells as a dimer or higher-order multimer. Cellular irradiation induces rapid intermolecular autophosphorylation of serine 1981 that causes dimer dissociation and initiates cellular ATM kinase activity. ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. Mutations in the corresponding ATM gene result in ataxia telangiectasia (AT), an autosomal recessive disease characterized by uncoordinated muscle movement and neurodegeneration. Cells from AT patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage.
Research Area Cancer, DNA/RNA
Pathways p53 Signaling, Apoptosis, DNA Damage Repair

Application Details

Product Details anti-ATM Antibody Target Details ATM Handling References for anti-ATM Antibody (ABIN2666313) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-ATM Antibody Target Details ATM Application Details References for anti-ATM Antibody (ABIN2666313) Images back to top
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store undiluted between 2°C and 8°C.

References for anti-ATM Antibody (ABIN2666313)

Product Details anti-ATM Antibody Target Details ATM Application Details Handling Images back to top
Background publications

Tang, Hui, Cui, Garg, Kastan, Xu: "A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage." in: Molecular and cellular biology, Vol. 28, Issue 8, pp. 2559-66, 2008

Bhaskara, Dupré, Lengsfeld, Hopkins, Chan, Lee, Zhang, Gautier, Zakian, Paull: "Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes." in: Molecular cell, Vol. 25, Issue 5, pp. 647-61, 2007

McConville, Stankovic, Byrd, McGuire, Yao, Lennox, Taylor: "Mutations associated with variant phenotypes in ataxia-telangiectasia." in: American journal of human genetics, Vol. 59, Issue 2, pp. 320-30, 1996

Images

Product Details anti-ATM Antibody Target Details ATM Application Details Handling References for anti-ATM Antibody (ABIN2666313) back to top
Supplier Images
Immunofluorescence (IF) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (phosphorylated) (ABIN2666313) anti-Ataxia Telangiectasia Mutated (ATM) (phosphorylated) antibody
Western Blotting (WB) image for anti-ATM antibody (Ataxia Telangiectasia Mutated) (phosphorylated) (ABIN2666313) anti-Ataxia Telangiectasia Mutated (ATM) (phosphorylated) antibody (Image 2)