anti-Human ATM antibody for Immunofluorescence (Cultured Cells)

Recommended ATM Antibody (supplied by: Log in to see )

Antigen
Ataxia Telangiectasia Mutated (ATM) Antibodies
  • ATM
  • Atm
  • CG6535
  • Dmel\\CG6535
  • Tefu
  • atm
  • atm/tefu
  • dATM
  • tef
  • Xatm
  • at1
  • atdc
  • tel1
  • telo1
  • AT1
  • ATA
  • ATC
  • ATD
  • ATDC
  • ATE
  • TEL1
  • TELO1
  • AI256621
  • C030026E19Rik
  • telomere fusion
  • ataxia telangiectasia mutated
  • ataxia telangiectasia mutated (atm)
  • ataxia telangiectasia mutated homolog (human)
  • tefu
  • atm
  • ATM
  • EDI_100660
  • CpipJ_CPIJ001772
  • BDBG_08252
  • PAAG_02532
  • MCYG_05088
  • VDBG_06833
  • ACLA_015700
  • AaeL_AAEL014900
  • MGYG_07634
  • PGTG_14279
  • Atm
  • LOC100349299
Epitope
AA 2700-2750
89
40
17
16
15
15
8
8
6
6
6
6
4
4
4
4
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
359
157
77
27
8
1
1
1
1
Host
Rabbit
233
99
17
9
3
Clonality
Polyclonal
Conjugate
This ATM antibody is un-conjugated
12
11
10
9
6
6
5
5
5
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
220
126
110
87
86
72
59
44
26
21
12
6
4
4
2
2
2
1
1
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Catalog No. ABIN685582
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2808094 FACS IF (cc) IF (p) Alexa Fluor 594 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN685585 FACS IF (cc) IF (p) Cy3 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN685586 FACS IF (cc) IF (p) Cy5 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN685587 FACS IF (cc) IF (p) Cy5.5 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN685589 FACS IF (cc) IF (p) FITC Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN685588 FACS IF (cc) IF (p) Cy7 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN884036 FACS IF (cc) IF (p) Alexa Fluor 555 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN884039 FACS IF (cc) IF (p) Alexa Fluor 647 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN884037 FACS IF (cc) IF (p) Alexa Fluor 350 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN884038 FACS IF (cc) IF (p) Alexa Fluor 488 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN4997012 FACS IF (cc) IF (p) Alexa Fluor 680 Rabbit IgG AA 2700-2750 Log in to see Polyclonal
1 ABIN4997013 FACS IF (cc) IF (p) Alexa Fluor 750 Rabbit IgG AA 2700-2750 Log in to see Polyclonal

General

Antigen Ataxia Telangiectasia Mutated (ATM) Antibodies
Epitope AA 2700-2750
(89), (40), (17), (16), (15), (15), (8), (8), (6), (6), (6), (6), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(359), (157), (77), (27), (8), (1), (1), (1), (1)
Host Rabbit
(233), (99), (17), (9), (3)
Clonality
Polyclonal
Conjugate This ATM antibody is un-conjugated
(12), (11), (10), (9), (6), (6), (5), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(220), (126), (110), (87), (86), (72), (59), (44), (26), (21), (12), (6), (4), (4), (2), (2), (2), (1), (1)
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Product Details anti-ATM Antibody

Target Details ATM Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from mouse ATM
Isotype IgG

Target Details ATM

Product Details anti-ATM Antibody Application Details Handling Images back to top
Antigen
Alternative Name Atm (ATM Antibody Abstract)
Background

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.

Subcellular location: Cytoplasm, Nucleus

Synonyms: AI256621, C030026E19Rik, Serine-protein kinase ATM, Ataxia telangiectasia mutated homolog, A-T mutated homolog, Atm

Gene ID 11920
UniProt Q62388
Research Area Cancer, DNA/RNA
Pathways p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus

Application Details

Product Details anti-ATM Antibody Target Details ATM Handling Images back to top
Application Notes FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-ATM Antibody Target Details ATM Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-ATM Antibody Target Details ATM Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-ATM Polyc...
Immunohistochemistry (IHC) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Formalin-fixed and paraffin embedded human cervical cancer labeled with Anti-ATM Poly...
Immunofluorescence (Cultured Cells) (IF (cc)) image for anti-Ataxia Telangiectasia Mutated (ATM) (AA 2700-2750) antibody (ABIN685582) Image provided by One World Lab validation program. A549 cells probed with Rabbit Ant...