You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Human ATR antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended ATR Antibody (supplied by: Log in to see )

Antigen
Ataxia Telangiectasia and Rad3 Related (ATR) Antibodies
  • ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED
  • ATATR
  • Ataxia telangiectasia-mutated and RAD3-related
  • ATR
  • ATRAD3
  • FCTCS
  • frp1
  • FRP1
  • MEC1
  • mec1
  • MHK7.5
  • MHK7_5
  • SCKL
  • sckl
  • SCKL1
  • sckl1
  • si:dkey-231j24.1
  • XATR
Epitope
Ser428
1
1
1
1
1
Reactivity
Human
8
5
2
1
1
1
1
1
1
Host
Rabbit
6
2
Clonality
Polyclonal
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
6
2
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Catalog No. ABIN319379
$ 308.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00089485606 ABIN614390 EIA IHC (p) Mouse IgG2a AA 2545-2645 Log in to see 1-00E-009

Top referenced anti-ATR antibody for Immunohistochemistry (Paraffin-embedded Sections)

Similar anti-ATR Antibodies

Application / Reactivity Human
Enzyme Immunoassay (EIA) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 2 Antibodies
Western Blotting (WB) 7 Antibodies

General

Antigen Ataxia Telangiectasia and Rad3 Related (ATR) Antibodies
Epitope Ser428
(1), (1), (1), (1), (1)
Reactivity Human
(8), (5), (2), (1), (1), (1), (1), (1), (1)
Host Rabbit
(6), (2)
Clonality
Polyclonal
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(6), (2), (1)
Pubmed 4 references available
Supplier Log in to see

Product Details anti-ATR Antibody

Target Details ATR Application Details Handling References for anti-ATR Antibody (ABIN319379) Images
Specificity This antibody detects endogenous levels of total ATR protein.
Purification Immunoaffinity Chromatography.
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human ATR around the phosphorylation site of Serine 428 (G-I-SP-P-K).

Target Details ATR

Product Details anti-ATR Antibody Application Details Handling References for anti-ATR Antibody (ABIN319379) Images back to top
Antigen
Alternative Name ATR / FRP1 (ATR Antibody Abstract)
Background Ataxia Telangiectasia Mutated (ATM) and Rad 3-related protein (ATR) is a phosphatidylinositol kinase (PK)-related kinase which functions in response to DNA damage and repair as well as at DNA replication checkpoints during the cell cycle. ATR is a member of the DNA-PK kinases closely related to ATM and DNA-PK for which DNA stimulates the observed kinase activity. Chromosomal remodeling proteins have also been reported to associate with ATR complexes. Several known components of the NuRD complex including histone deacetylase 1 (HDAC1), HDAC2, and CHD4.Synonyms: Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1, Serine/threonine-protein kinase ATR
Gene ID 545
NCBI Accession NP_001175
UniProt Q13535
Pathways p53 Signaling, Apoptosis, DNA Damage Repair

Application Details

Product Details anti-ATR Antibody Target Details ATR Handling References for anti-ATR Antibody (ABIN319379) Images back to top
Application Notes Immunohistochemistry (1/50-1/100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-ATR Antibody Target Details ATR Application Details References for anti-ATR Antibody (ABIN319379) Images back to top
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at-20 °C.

References for anti-ATR Antibody (ABIN319379)

Product Details anti-ATR Antibody Target Details ATR Application Details Handling Images back to top
Background publications

Boiteux, Guillet: "Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae." in: DNA repair, Vol. 3, Issue 1, pp. 1-12, 2003

Brooksbank: "Pocket the difference." in: Nature reviews. Molecular cell biology, Vol. 1, Issue 1, pp. 9, 2001

Zhou, Lu, Wulf, Lu: "Phosphorylation-dependent prolyl isomerization: a novel signaling regulatory mechanism." in: Cellular and molecular life sciences : CMLS, Vol. 56, Issue 9-10, pp. 788-806, 2001

Vostal, Shafer, Mondoro, Fratantoni: "Endogenous ADP prevents PGE1-induced tyrosine dephosphorylation of focal adhesion kinase in thrombin-activated platelets." in: Biochimica et biophysica acta, Vol. 1314, Issue 1-2, pp. 1-12, 1997

Images

Product Details anti-ATR Antibody Target Details ATR Application Details Handling References for anti-ATR Antibody (ABIN319379) back to top
Supplier Images
 image for anti-ATR antibody (Ataxia Telangiectasia and Rad3 Related) (Ser428) (ABIN319379) anti-Ataxia Telangiectasia and Rad3 Related (ATR) (Ser428) antibody