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Ataxia Telangiectasia and Rad3 Related ELISA Kits (ATR)
On www.antibodies-online.com are 0 Ataxia Telangiectasia and Rad3 Related (ATR) ELISA Kits from different suppliers available. Additionally we are shipping ATR Antibodies (11) and and many more products for this protein. A total of 12 ATR products are currently listed.
Synonyms:
ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, Ataxia telangiectasia-mutated and RAD3-related, ATR, ATRAD3, FCTCS, frp1, mec1, MHK7.5, MHK7_5, sckl, sckl1, si:dkey-231j24.1, XATR
list all ELISA KIts Gene Name GeneID UniProt
Rat ATR ATR 300942  
Human ATR ATR 545 Q13535
Mouse ATR ATR 245000  

Show all synonyms

More ELISA Kits for ATR Interaction Partners

Zebrafish Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. Findings reveal a novel role for ATR in cilia signaling distinct from its canonical function during replication and strengthen emerging links between cilia function and development.

Human Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. Authors examine how the replication stress response that is controlled by the kinase ataxia telangiectasia and Rad3-related (ATR) senses and resolves threats to DNA integrity so that the DNA remains available to read in all of our cells. They discuss the multiple data that have revealed an elegant yet increasingly complex mechanism of ATR activation. [Review]

  2. results reveal a previously unknown role for transcription factor IIH in ATR kinase activation in non-replicating, non-cycling cells

  3. Our data reveal that BETi can potentiate the cell stress and death caused by ATR inhibitors. This suggests that ATRi can be used in combination therapies of lymphomas without the use of genotoxic drugs

  4. Ultraviolet rays-induced ATR (show ANTXR1 ELISA Kits) and ATM (show ATM ELISA Kits) recruitment and activation differ in G1 and S phases due to the existence of distinct types of DNA lesions, which promote assembly of different proteins involved in the process of DNA repair and checkpoint activation.

  5. Small molecule ATR (show ANTXR1 ELISA Kits) and Chk1 (show CHEK1 ELISA Kits) inhibitors potently sensitize lymphoma cells to UVA radiation and induce a prominent apoptotic response

  6. ATR (show ANTXR1 ELISA Kits) inhibition potentiated Chk1 (show CHEK1 ELISA Kits) inhibitor induced replication stress and cytotoxicity via the abrogation of ATR (show ANTXR1 ELISA Kits)-dependent feedback activation of Chk1 (show CHEK1 ELISA Kits) induced by Chk1 (show CHEK1 ELISA Kits) inhibitor generated replication stress in tumor cell lines.

  7. Our data suggests that total cellular b-catenin levels decrease in the presence of secreted frizzled-related protein 1 (show SFRP1 ELISA Kits) and Wnt inhibitory factor 1 (show WIF1 ELISA Kits), and a significant increase in cell death after tyrosine kinase (show TXK ELISA Kits) inhibitor treatment is observed. On the contrary, when secreted frizzled-related protein 1 (show SFRP1 ELISA Kits) is suppressed, total b-catenin levels increase in the cell and the cells become resistant to tyrosine kinase (show TXK ELISA Kits) inhibitors.

  8. HPV31 regulates RRM2 (show RRM2 ELISA Kits) levels through expression of E7 and activation of the ATR (show ANTXR1 ELISA Kits)-Chk1 (show CHEK1 ELISA Kits)-E2F1 (show E2F1 ELISA Kits) DNA damage response, which is essential to combat replication stress upon entry into S-phase.

  9. disruption of IGF-1R signaling with small-molecule inhibitors or IGF-1 withdrawal partially abrogates both the phosphorylation and activation of CHK1 by ATR and the accompanying inhibition of chromosomal DNA synthesis in UVB-irradiated keratinocytes.

  10. that parallel TopBP1- and ETAA1-mediated pathways underlie ATR activation and that their combined action is essential for coping with replication stress

Xenopus laevis Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. The authors show, in live cells, that Ddx19 (show DDX19B ELISA Kits) transiently relocalizes from the nucleopore to the nucleus upon DNA damage, in an ATR/Chk1 (show CHEK1 ELISA Kits)-dependent manner, and that Ddx19 (show DDX19B ELISA Kits) nuclear relocalization is required to clear R-loops (DNA:RNA hybrids).

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. APE2 (show APEX2 ELISA Kits) associates with Chk1 (show CHEK1 ELISA Kits); a serine residue (S86) in the Chk1 (show CHEK1 ELISA Kits)-binding motif of APE2 (show APEX2 ELISA Kits) is essential for Chk1 (show CHEK1 ELISA Kits) phosphorylation, indicating a Claspin (show CLSPN ELISA Kits)-like but distinct role for APE2 (show APEX2 ELISA Kits) in ATR-Chk1 (show CHEK1 ELISA Kits) signaling.

  4. MRN (MRE11 (show MRE11A ELISA Kits)-RAD50 (show RAD50 ELISA Kits)-NBS1 (show NLRP2 ELISA Kits)) complex has role in ATR activation via TOPBP1 (show TOPBP1 ELISA Kits) recruitment.

  5. ATM (show ATM ELISA Kits) activity is required for an early step in resection, leading to ATR activation, CtIP (show RBBP8 ELISA Kits)-T818 phosphorylation, and accumulation of CtIP (show RBBP8 ELISA Kits) on chromatin.

  6. ATM (show ATM ELISA Kits) and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A ELISA Kits)/Rad50 (show RAD50 ELISA Kits)/Nbs1 (show NLRP2 ELISA Kits) dependent recovery of collapsed replication forks.

  7. Human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk and the CDC6-ATR interaction is conserved in Xenopus.

  8. ATM (show ATM ELISA Kits) and ATR phosphorylate the functionally critical replication protein Mcm2 (show MCM2 ELISA Kits) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  9. ATRIP (show ATRIP ELISA Kits) must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 (show CHEK1 ELISA Kits) effectively

  10. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

Mouse (Murine) Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)-regulated apoptosis and the p53 (show TP53 ELISA Kits)/PCNA (show PCNA ELISA Kits)- and ATM (show ATM ELISA Kits)/ATR-Chk1 (show CHEK1 ELISA Kits)/2-controlled DNA-damage response pathways.

  2. Atr deletion in cerebellar granule neuron progenitors (CGNPs) induced proliferation-associated DNA damage, p53 activation, apoptosis and cerebellar hypoplasia in mice. Genetic deletion of Atr blocked tumorigenesis in medulloblastoma-prone SmoM2 mice.

  3. ATR controls DNA damage-induced G2 checkpoint control and apoptosis in proliferating neurons.

  4. CDC25A-deficient embryonic stem cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs.

  5. These results therefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to induce an apoptotic form of cell death in non-cycling cells.

  6. RAD9 (show RAD9A ELISA Kits) has a prominent role in the ATR-Chk1 (show CHEK1 ELISA Kits) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  7. telomeres are protected from hyper-resection through the repression of the ATM (show ATM ELISA Kits) and ATR kinases by TRF2 (show TERF2 ELISA Kits) and TPP1 (show TPP1 ELISA Kits)-bound POT1a (show POT1 ELISA Kits)/b, respectively.

  8. DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

  9. ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair

  10. Observations suggest that ATR mediates a mechanical response to membrane stress that could be caused by chromatin dynamics and is important for genome integrity.

Arabidopsis thaliana Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. ATR function together with SOG1 and ALT2 (show GPT2 ELISA Kits) to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.

  2. Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation.

  3. ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other.

  4. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis

  5. TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.

  6. Short telomeres in tert mutant plants activate both ATM and ATR. Absence of telomerase elicits and ATM and ATR-dependent DNA damage response at telomeres.

  7. cooperation among DNA translesion synthesis (TLS (show FUS ELISA Kits)) polymerases (Poleta, Polzeta) and DNA-damage-activated protein kinases (ATR, ATM (show ATM ELISA Kits))

  8. Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction.

  9. The MRN complex is essential for activation of the ATM and ATR kinases in response to irradiation.

  10. Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR]

ATR Antigen Profile

Antigen Summary

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Alternative names and synonyms associated with ATR

  • ataxia telangiectasia and Rad3 related (Atr) Elisa Kit
  • ataxia telangiectasia and Rad3 related (ATR) Elisa Kit
  • ataxia telangiectasia and Rad3 related (atr) Elisa Kit
  • serine/threonine-protein kinase ATR (ATR) Elisa Kit
  • ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED Elisa Kit
  • ATATR Elisa Kit
  • Ataxia telangiectasia-mutated and RAD3-related Elisa Kit
  • ATR Elisa Kit
  • ATRAD3 Elisa Kit
  • FCTCS Elisa Kit
  • frp1 Elisa Kit
  • mec1 Elisa Kit
  • MHK7.5 Elisa Kit
  • MHK7_5 Elisa Kit
  • sckl Elisa Kit
  • sckl1 Elisa Kit
  • si:dkey-231j24.1 Elisa Kit
  • XATR Elisa Kit

Protein level used designations for ATR

ataxia telangiectasia and Rad3 related , ataxia telangiectasia and Rad3 related protein , serine/threonine-protein kinase ATR-like , FRAP-related protein 1 , FRAP-related protein-1 , MEC1, mitosis entry checkpoint 1, homolog , Rad3 related protein , ataxia telangiectasia and Rad3-related protein , protein kinase ATR , serine/threonine-protein kinase ATR , checkpoint kinase , protein kinase , serine/threonine-protein kinase atr

GENE ID SPECIES
300942 Rattus norvegicus
460745 Pan troglodytes
477101 Canis lupus familiaris
504869 Bos taurus
567770 Danio rerio
714443 Macaca mulatta
100062529 Equus caballus
100127459 Sus scrofa
100412321 Callithrix jacchus
100454403 Pongo abelii
100464897 Ailuropoda melanoleuca
100561948 Anolis carolinensis
545 Homo sapiens
398197 Xenopus laevis
245000 Mus musculus
834082 Arabidopsis thaliana
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