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Browse our ATR (ATR) ELISA Kits

Full name:
Ataxia Telangiectasia and Rad3 Related ELISA Kits (ATR)
On www.antibodies-online.com are 0 Ataxia Telangiectasia and Rad3 Related (ATR) ELISA Kits from different suppliers available. Additionally we are shipping ATR Antibodies (10) and many more products for this protein. A total of 10 ATR products are currently listed.
Synonyms:
ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED, ATATR, Ataxia telangiectasia-mutated and RAD3-related, ATR, ATRAD3, FCTCS, frp1, mec1, MHK7.5, MHK7_5, sckl, sckl1, si:dkey-231j24.1, XATR
list all ELISA KIts Gene Name GeneID UniProt
Rat ATR ATR 300942  
Human ATR ATR 545 Q13535
Mouse ATR ATR 245000  

Show all synonyms

More ELISA Kits for ATR Interaction Partners

Zebrafish Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. Findings reveal a novel role for ATR in cilia signaling distinct from its canonical function during replication and strengthen emerging links between cilia function and development.

Human Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. High ATR expression is associated with colorectal cancer.

  2. The ATM (show ATM ELISA Kits)- and ATR (show ANTXR1 ELISA Kits)-related SCD (show SCD ELISA Kits) domain is over-represented in proteins involved in nervous system development.

  3. High ATR expression correlates with urinary bladder cancer.

  4. ATRIP deacetylation by SIRT2 promotes ATR-ATRIP binding to replication protein A-single-stranded DNA to drive ATR activation and thus facilitate recovery from replication stress.

  5. Findings reveal a novel role for ATR in cilia signaling distinct from its canonical function during replication and strengthen emerging links between cilia function and development.

  6. The kinase domains in the Mec1.Ddc2 dimer are located in close proximity to each other. However, in the Tel1 (show ATM ELISA Kits) dimer they are fully separated, providing potential access of substrates to this kinase, even in its dimeric form.

  7. The combination of cisplatin and ATR (show ANTXR1 ELISA Kits) inhibitor AZD6738 resolves ATM (show ATM ELISA Kits)-deficient lung cancer xenografts.

  8. In conclusion, this study exemplifies cancer-specific synthetic lethality between two proteins in the same pathway and raises the prospect of combining ATR (show ANTXR1 ELISA Kits) and CHK1 (show CHEK1 ELISA Kits) inhibitors as promising cancer therapy.

  9. These results therefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to induce an apoptotic form of cell death in non-cycling cells.

  10. ATR inhibition rewires cellular signaling networks induced by replication stress.

Xenopus laevis Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  2. APE2 (show APEX2 ELISA Kits) associates with Chk1 (show CHEK1 ELISA Kits); a serine residue (S86) in the Chk1 (show CHEK1 ELISA Kits)-binding motif of APE2 (show APEX2 ELISA Kits) is essential for Chk1 (show CHEK1 ELISA Kits) phosphorylation, indicating a Claspin (show CLSPN ELISA Kits)-like but distinct role for APE2 (show APEX2 ELISA Kits) in ATR-Chk1 (show CHEK1 ELISA Kits) signaling.

  3. MRN (MRE11 (show MRE11A ELISA Kits)-RAD50 (show RAD50 ELISA Kits)-NBS1 (show NLRP2 ELISA Kits)) complex has role in ATR activation via TOPBP1 (show TOPBP1 ELISA Kits) recruitment.

  4. ATM (show ATM ELISA Kits) activity is required for an early step in resection, leading to ATR activation, CtIP (show RBBP8 ELISA Kits)-T818 phosphorylation, and accumulation of CtIP (show RBBP8 ELISA Kits) on chromatin.

  5. ATM (show ATM ELISA Kits) and ATR prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A ELISA Kits)/Rad50 (show RAD50 ELISA Kits)/Nbs1 (show NLRP2 ELISA Kits) dependent recovery of collapsed replication forks.

  6. Human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner that is stimulated by phosphorylation by Cdk and the CDC6-ATR interaction is conserved in Xenopus.

  7. ATM (show ATM ELISA Kits) and ATR phosphorylate the functionally critical replication protein Mcm2 (show MCM2 ELISA Kits) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

  8. ATRIP (show ATRIP ELISA Kits) must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 (show CHEK1 ELISA Kits) effectively

  9. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

  10. Data show that recombinant TopBP1 (show TOPBP1 ELISA Kits) induces a large increase in the kinase activity of both Xenopus and human ATR-ATRIP (show ATRIP ELISA Kits).

Mouse (Murine) Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. These results therefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to protect cell viability and prevent apoptosis, the stalling of RNA polymerases instead activates ATR to induce an apoptotic form of cell death in non-cycling cells.

  2. RAD9 (show RAD9A ELISA Kits) has a prominent role in the ATR-Chk1 (show CHEK1 ELISA Kits) pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  3. telomeres are protected from hyper-resection through the repression of the ATM (show ATM ELISA Kits) and ATR kinases by TRF2 (show TERF2 ELISA Kits) and TPP1 (show TPP1 ELISA Kits)-bound POT1a (show POT1 ELISA Kits)/b, respectively.

  4. DNA double-strand breaks by Cr(VI) are targeted to euchromatin and cause ATR-dependent phosphorylation of histone H2AX and its ubiquitination.

  5. ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair

  6. Observations suggest that ATR mediates a mechanical response to membrane stress that could be caused by chromatin dynamics and is important for genome integrity.

  7. These results suggest that minute virus of mice infection disables the ATR cellular signaling pathway.

  8. Our data suggest that, unlike the yeast models, the TopBP1-AAD is the major activator of ATR, sustaining cell proliferation and embryonic development.

  9. A new localization of ATR in the cilia of photoreceptors and the fact that mutant mice have shorter cilia suggests that the photoreceptor degeneration here described results from a ciliary defect.

  10. a role for ATR in the epigenetic regulation of gene expression

Arabidopsis thaliana Ataxia Telangiectasia and Rad3 Related (ATR) interaction partners

  1. ATR function together with SOG1 and ALT2 (show GPT2 ELISA Kits) to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure.

  2. Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation.

  3. ATR and MKP1 play distinct roles in response to UV-B stress.MKP1-regulated and ATR-mediated DNA damage pathways operate independently of each other.

  4. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis

  5. TANMEI/ALT2 works in conjunction with ATR to detect Al-dependent DNA damage and actively halt root growth to allow for repair of this damage.

  6. Short telomeres in tert mutant plants activate both ATM and ATR. Absence of telomerase elicits and ATM and ATR-dependent DNA damage response at telomeres.

  7. cooperation among DNA translesion synthesis (TLS (show FUS ELISA Kits)) polymerases (Poleta, Polzeta) and DNA-damage-activated protein kinases (ATR, ATM (show ATM ELISA Kits))

  8. Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction.

  9. The MRN complex is essential for activation of the ATM and ATR kinases in response to irradiation.

  10. Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR]

ATR Antigen Profile

Antigen Summary

The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist.

Alternative names and synonyms associated with ATR

  • ataxia telangiectasia and Rad3 related (Atr) Elisa Kit
  • ataxia telangiectasia and Rad3 related (ATR) Elisa Kit
  • ataxia telangiectasia and Rad3 related (atr) Elisa Kit
  • serine/threonine-protein kinase ATR (ATR) Elisa Kit
  • ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED Elisa Kit
  • ATATR Elisa Kit
  • Ataxia telangiectasia-mutated and RAD3-related Elisa Kit
  • ATR Elisa Kit
  • ATRAD3 Elisa Kit
  • FCTCS Elisa Kit
  • frp1 Elisa Kit
  • mec1 Elisa Kit
  • MHK7.5 Elisa Kit
  • MHK7_5 Elisa Kit
  • sckl Elisa Kit
  • sckl1 Elisa Kit
  • si:dkey-231j24.1 Elisa Kit
  • XATR Elisa Kit

Protein level used designations for ATR

ataxia telangiectasia and Rad3 related , ataxia telangiectasia and Rad3 related protein , serine/threonine-protein kinase ATR-like , FRAP-related protein 1 , FRAP-related protein-1 , MEC1, mitosis entry checkpoint 1, homolog , Rad3 related protein , ataxia telangiectasia and Rad3-related protein , protein kinase ATR , serine/threonine-protein kinase ATR , checkpoint kinase , protein kinase , serine/threonine-protein kinase atr

GENE ID SPECIES
300942 Rattus norvegicus
460745 Pan troglodytes
477101 Canis lupus familiaris
504869 Bos taurus
567770 Danio rerio
714443 Macaca mulatta
100062529 Equus caballus
100127459 Sus scrofa
100412321 Callithrix jacchus
100454403 Pongo abelii
100464897 Ailuropoda melanoleuca
100561948 Anolis carolinensis
545 Homo sapiens
398197 Xenopus laevis
245000 Mus musculus
834082 Arabidopsis thaliana
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