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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)||Monkey|
|Western Blotting (WB)||284 Antibodies||102 Antibodies||86 Antibodies||13 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Immunoprecipitation (IP)||71 Antibodies||44 Antibodies||27 Antibodies||6 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||63 Antibodies||21 Antibodies||17 Antibodies||3 Antibodies|
|Immunohistochemistry (IHC)||121 Antibodies||54 Antibodies||51 Antibodies||7 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||8 Antibodies|
|Antigen||BCL2-Associated X Protein (BAX) Antibodies|
|Reactivity||Human, Monkey, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BAX antibody is un-conjugated Alternatives|
Immunoprecipitation (IP), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-BAX AntibodyTarget Details BAX Application Details Handling References for anti-BAX Antibody (ABIN222887) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN412605|
|Specificity||The antibody detects a 20 kDa protein, corresponding to the apparent molecular weight of Bax on SDS-PAGE immunoblots.|
|Immunogen||Synthetic peptide corresponding to amino acids near the N-terminus of human Bax|
Target Details BAXProduct Details anti-BAX Antibody Application Details Handling References for anti-BAX Antibody (ABIN222887) Images back to top
|Alternative Name||Bax (BAX Antibody Abstract)|
The Bcl-2 (B-cell leukemia/lymphoma 2) family proteins function to either inhibit (Bcl-2 and Bcl-XL) or promote (Bax and Bak) apoptosis. Bax contains the conserved Bcl-2 homology 1 (BH1) and 2 (BH2) domains that allow for its homodimerization or heterodimerization with Bcl-2. When Bcl-2 is in excess, apoptosis is inhibited. However, if Bax levels increase in response to a death signal, the cell is pushed toward death.
Synonyms: 581, BAX, 600040, P55269, Bax zeta
|Research Area||Cancer, Apoptosis/Necrosis|
|Pathways||p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-BAX Antibody Target Details BAX Handling References for anti-BAX Antibody (ABIN222887) Images back to top
Western blot analysis (0.5-4 μg/mL), Immunoprecipitation (10-20 μg/mL).
However, the optimal conditions should be determined individually.
Country of Animal Origin: China
|Restrictions||For Research Use only|
HandlingProduct Details anti-BAX Antibody Target Details BAX Application Details References for anti-BAX Antibody (ABIN222887) Images back to top
|Buffer||100 μg (0.5 mg/mL) affinity purified rabbit anti-Bax polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.|
|Precaution of Use||This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
The antibody solution should be gently mixed before use.
Avoid freeze-thaw cycles.
|Storage Comment||For long-term storage, aliquot and freeze at -70 °C.|
|Expiry Date||12 months|
References for anti-BAX Antibody (ABIN222887)Product Details anti-BAX Antibody Target Details BAX Application Details Handling Images back to top
|Product cited in:||
Eslami, Sharifi, Rahimi et al.: "Protective effect of telmisartan against oxidative damage induced by high glucose in neuronal PC12 cell." in: Neuroscience letters, 2013 (PubMed).
Mousavi, Tavakkol-Afshari, Brook et al.: "Direct toxicity of Rose Bengal in MCF-7 cell line: role of apoptosis." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 47, Issue 4, pp. 855-9, 2009 (PubMed).
Jafari Anarkooli, Sankian, Vahedi et al.: "Evaluation of insulin and ascorbic acid effects on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of STZ-induced diabetic rats." in: Cellular and molecular neurobiology, Vol. 29, Issue 1, pp. 133-40, 2009 (PubMed).
Maity, Bindu, Choubey et al.: "Lansoprazole protects and heals gastric mucosa from non-steroidal anti-inflammatory drug (NSAID)-induced gastropathy by inhibiting mitochondrial as well as Fas-mediated death pathways with concurrent ..." in: The Journal of biological chemistry, Vol. 283, Issue 21, pp. 14391-401, 2008 (PubMed).
Kim, Zhang, Hitomi et al.: "Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL." in: Human molecular genetics, Vol. 15, Issue 11, pp. 1826-34, 2006 (PubMed).
ImagesProduct Details anti-BAX Antibody Target Details BAX Application Details Handling References for anti-BAX Antibody (ABIN222887) back to top