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Browse our anti-CHEK1 (CHEK1) Antibodies

Full name:
anti-Checkpoint Kinase 1 Antibodies (CHEK1)
On www.antibodies-online.com are 469 Checkpoint Kinase 1 (CHEK1) Antibodies from 30 different suppliers available. Additionally we are shipping CHEK1 Kits (23) and CHEK1 Proteins (16) and many more products for this protein. A total of 548 CHEK1 products are currently listed.
Synonyms:
An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093
list all antibodies Gene Name GeneID UniProt
CHEK1 1111 O14757
CHEK1 12649 O35280
CHEK1 140583 Q91ZN7

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Most Popular Reactivities for anti-CHEK1 (CHEK1) Antibodies

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anti-Human CHEK1 Antibodies:

anti-Mouse (Murine) CHEK1 Antibodies:

anti-Rat (Rattus) CHEK1 Antibodies:

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Top referenced anti-CHEK1 Antibodies

  1. Human Polyclonal CHEK1 Primary Antibody for EIA, IHC (p) - ABIN358109 : Krämer, Mailand, Lukas, Syljuåsen, Wilkinson, Nigg, Bartek, Lukas: Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. in Nature cell biology 2004 (PubMed)
    Show all 5 references for ABIN358109

  2. Human Polyclonal CHEK1 Primary Antibody for EIA, WB - ABIN357628 : Chen, Ryan, Piwnica-Worms: Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. in Molecular and cellular biology 2003 (PubMed)
    Show all 5 references for ABIN357628

  3. Human Polyclonal CHEK1 Primary Antibody for EIA, IHC (p) - ABIN358108 : Xu, Lee, Stern: Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for ABIN358108

  4. Human Polyclonal CHEK1 Primary Antibody for IF, ELISA - ABIN1532570 : Sanchez, Wong, Thoma, Richman, Wu, Piwnica-Worms, Elledge: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. in Science (New York, N.Y.) 1997 (PubMed)
    Show all 2 references for ABIN1532570

  5. Human Polyclonal CHEK1 Primary Antibody for IF, ELISA - ABIN1531554 : Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. in Science (New York, N.Y.) 2007 (PubMed)
    Show all 2 references for ABIN1531554

  6. Chicken Polyclonal CHEK1 Primary Antibody for WB - ABIN2779737 : Bennett, Larkin, Gillespie, Clarke: Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against CHEK1 Interaction Partners

Human Checkpoint Kinase 1 (CHEK1) interaction partners

  1. Chk1 is a predictive biomarker of radiotherapy resistance and early local recurrence.

  2. A new pathway of proliferation restriction for tetraploid untransformed cells that seems to be specific for loss of adhesion dependent cytokinesis failure involves Chk1 and p53 (show TP53 Antibodies) activation during G2.

  3. Human induced pluripotent stem cells fail to activate CHK1 when exposed to DNA replication inhibitors and commit to apoptosis instead.

  4. RAD9 (show RAD9A Antibodies) has a prominent role in the ATR (show ANTXR1 Antibodies)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  5. Isolate/characterize mantle cell lymphoma cell line resistance to Chk1 inhibitor PF-00477736.

  6. Results support the inhibition of checkpoint kinase 1 (Chk1) as a new therapeutic strategy in acute lymphoblastic leukemia.

  7. these results demonstrate a positive feedback loop involving Rad9A (show RAD9A Antibodies)-dependend activation of Chk1.

  8. DNA damage induces Chk1 phosphorylation on chromatin followed by releasing phospho-Chk1 from the chromatin into soluble nucleus and the cytoplasm where Chk1 activates the cell cycle checkpoints; and Chk1 is degraded and checkpoint signaling is terminated.

  9. We suggest that MNNG-stimulated ATR (show ANTXR1 Antibodies)/CHK1 signaling stabilizes E2F3 by S124 phosphorylation, and then E2F3 together with NFY co-transactivate RRM2 (show RRM2 Antibodies) expression for DNA repair.

  10. nasopharyngeal carcinoma cells depend on CHK1 and WEE1 (show WEE1 Antibodies) activity for growth

Xenopus laevis Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (show CDC45 Antibodies) onto chromatin and thereby serves to antagonize the initiation of replication.

  4. The MRN complex, in particular the nuclease (show DCLRE1C Antibodies) activity of Mre11 (show MRE11A Antibodies), plays an important role in the activation of Chk1 in response to stalled replication forks.

  5. DNA polymerase kappa (show POLK Antibodies)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

  6. APE2 (show APEX2 Antibodies) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (show APEX2 Antibodies) is essential for Chk1 phosphorylation, indicating a Claspin (show CLSPN Antibodies)-like but distinct role for APE2 (show APEX2 Antibodies) in ATR (show ATR Antibodies)-Chk1 signaling.

  7. Data show that the death pathway is independent of ERK (show MAPK1 Antibodies) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Antibodies) and JNK (show MAPK8 Antibodies).

  8. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH Antibodies)(16) by Chk1.

  9. mechanism of Chk1 activation at the DNA replication checkpoint

  10. Cdc25A (show CDC25A Antibodies) is essential for the Chk1-induced cell cycle arrest and the DNA replication checkpoint in early embryos

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. RAD9 (show RAD9A Antibodies) has a prominent role in the ATR (show ATR Antibodies)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  2. Acute inactivation of E4F1 (show E4F1 Antibodies) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (show ROS1 Antibodies) production, energy stress, and inhibition of de novo pyrimidine synthesis

  3. Altogether, our results classify E4F1 (show E4F1 Antibodies) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  4. Heterozygous loss of Chk1 in a Wnt (show WNT2 Antibodies)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.

  5. PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity

  6. ATM (show ATM Antibodies) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.

  7. High level of phospho-Chk1 is associated with skin tumors.

  8. Chk1 is essential for the developmental formation of murine epidermal melanocytes but hemizygosity has little permanent developmental consequence in this cell type

  9. activated Akt1 (show AKT1 Antibodies) in Brca1 (show BRCA1 Antibodies)-deficient cells impairs Chk1 nuclear localization and subsequently disrupts interaction of Chk1 and Rad51 (show RAD51 Antibodies) leading to homologous recombination defects.

  10. Our results uncover a novel p53 (show TP53 Antibodies)-independent function for p21 (show D4S234E Antibodies) in protecting cells from the lethal effects of DNA damage followed by Chk1 inhibition

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The Chk1 directly phosphorylates eNOS (show NOS3 Antibodies) Ser (show SIGLEC1 Antibodies)(1179) in response to UV irradiation, which is dependent on Hsp90 (show HSP90 Antibodies) interaction.

CHEK1 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

  • checkpoint kinase 1 (CHEK1) antibody
  • serine/threonine-protein kinase chk1 (ANI_1_2436074) antibody
  • serine/threonine-protein kinase chk1 (AOR_1_768154) antibody
  • serine/threonine-protein kinase Chk1 (PTRG_04183) antibody
  • serine/threonine-protein kinase chk1 (SJAG_01680) antibody
  • serine/threonine-protein kinase chk1 (PAAG_04978) antibody
  • serine/threonine-protein kinase chk1 (MCYG_03290) antibody
  • serine/threonine-protein kinase chk1 (VDBG_03742) antibody
  • checkpoint kinase 1 (chek1) antibody
  • checkpoint kinase 1 (Chek1) antibody
  • CHK1 checkpoint homolog (S. pombe) (chek1) antibody
  • CHK1 checkpoint homolog (S. pombe) (CHEK1) antibody
  • STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A) antibody
  • An08g10320 antibody
  • AO090003000441 antibody
  • C85740 antibody
  • CHEK1 antibody
  • Chk1 antibody
  • id:ibd2720 antibody
  • rad27 antibody
  • zgc:56093 antibody

Protein level used designations for CHEK1

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

GENE ID SPECIES
100064353 Equus caballus
4983346 Aspergillus niger CBS 513.88
5991605 Aspergillus oryzae RIB40
6342420 Pyrenophora tritici-repentis Pt-1C-BFP
7049849 Schizosaccharomyces japonicus yFS275
9096078 Paracoccidioides sp. 'lutzii' Pb01
9230546 Arthroderma otae CBS 113480
9532482 Verticillium alfalfae VaMs.102
1111 Homo sapiens
398191 Xenopus laevis
609767 Canis lupus familiaris
12649 Mus musculus
140583 Rattus norvegicus
100511709 Sus scrofa
393162 Danio rerio
513678 Bos taurus
374260 Gallus gallus
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