Browse our anti-CHEK1 (CHEK1) Antibodies

Full name:
anti-Checkpoint Kinase 1 Antibodies (CHEK1)
On www.antibodies-online.com are 488 Checkpoint Kinase 1 (CHEK1) Antibodies from 31 different suppliers available. Additionally we are shipping CHEK1 Kits (26) and CHEK1 Proteins (21) and many more products for this protein. A total of 575 CHEK1 products are currently listed.
Synonyms:
An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093
list all antibodies Gene Name GeneID UniProt
CHEK1 1111 O14757
CHEK1 12649 O35280
CHEK1 140583 Q91ZN7

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Most Popular Reactivities for anti-CHEK1 (CHEK1) Antibodies

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anti-Human CHEK1 Antibodies:

anti-Mouse (Murine) CHEK1 Antibodies:

anti-Rat (Rattus) CHEK1 Antibodies:

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Top referenced anti-CHEK1 Antibodies

  1. Human Polyclonal CHEK1 Primary Antibody for EIA, IHC (p) - ABIN358108 : Xu, Lee, Stern: Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358108

  2. Human Polyclonal CHEK1 Primary Antibody for EIA, IHC (p) - ABIN358109 : Krämer, Mailand, Lukas, Syljuåsen, Wilkinson, Nigg, Bartek, Lukas: Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. in Nature cell biology 2004 (PubMed)
    Show all 5 references for 358109

  3. Human Polyclonal CHEK1 Primary Antibody for EIA, WB - ABIN357628 : Chen, Ryan, Piwnica-Worms: Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. in Molecular and cellular biology 2003 (PubMed)
    Show all 5 references for 357628

  4. Human Polyclonal CHEK1 Primary Antibody for IF, ELISA - ABIN1531555 : Sanchez, Wong, Thoma, Richman, Wu, Piwnica-Worms, Elledge: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. in Science (New York, N.Y.) 1997 (PubMed)
    Show all 2 references for 1531555

  5. Human Polyclonal CHEK1 Primary Antibody for IF, ELISA - ABIN1531554 : Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. in Science (New York, N.Y.) 2007 (PubMed)
    Show all 2 references for 1531554

  6. Human Polyclonal CHEK1 Primary Antibody for IF (p), IHC (p) - ABIN757072 : Guo, Cui, Peng, Fang, Zuo, Deng, Wang, Wu, Chen, Deng: Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney. in Oncotarget 2015 (PubMed)

  7. Cow (Bovine) Polyclonal CHEK1 Primary Antibody for IHC, WB - ABIN2779737 : Bennett, Larkin, Gillespie, Clarke: Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against CHEK1 Interaction Partners

Human Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The findings reveal ATXN3 (show ATXN3 Antibodies) to be a novel deubiquitinase of Chk1, providing a new mechanism of Chk1 stabilization in genome integrity maintenance.

  2. Small molecule ATR (show ANTXR1 Antibodies) and Chk1 inhibitors potently sensitize lymphoma cells to UVA radiation and induce a prominent apoptotic response

  3. These findings demonstrate an unsuspected requirement for a balanced nucleotide pool for optimal Chk1 activation both in unchallenged cells and in response to genotoxic stress.

  4. ATR (show ANTXR1 Antibodies) inhibition potentiated Chk1 inhibitor induced replication stress and cytotoxicity via the abrogation of ATR (show ANTXR1 Antibodies)-dependent feedback activation of Chk1 induced by Chk1 inhibitor generated replication stress in tumor cell lines.

  5. CHK1 overexpression is associated with T-cell and Hodgkin Lymphoma.

  6. Date show that when Wee1 (show WEE1 Antibodies) alone is inhibited, Chk1 suppresses CDC45 (show CDC45 Antibodies) loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (show CDK4 Antibodies)-activity.

  7. HPV31 regulates RRM2 (show RRM2 Antibodies) levels through expression of E7 and activation of the ATR (show ANTXR1 Antibodies)-Chk1-E2F1 (show E2F1 Antibodies) DNA damage response, which is essential to combat replication stress upon entry into S-phase.

  8. disruption of IGF-1R signaling with small-molecule inhibitors or IGF-1 withdrawal partially abrogates both the phosphorylation and activation of CHK1 by ATR and the accompanying inhibition of chromosomal DNA synthesis in UVB-irradiated keratinocytes.

  9. revealed more than 170 NFAT (show NFATC1 Antibodies)-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 (show NFATC1 Antibodies) and NFATc2 (show NFAT1 Antibodies) in T cells, such as Raptor (show RPTOR Antibodies), CHEK1, CREB1 (show CREB1 Antibodies), RUNX1 (show RUNX1 Antibodies), SATB1 (show SATB1 Antibodies), Ikaros (show IKZF1 Antibodies), and Helios (show ZNFN1A2 Antibodies).

  10. Checkpoint kinase 1 and 2 signaling is important for apoptin regulation.

Xenopus laevis Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 (show CDC45 Antibodies) onto chromatin and thereby serves to antagonize the initiation of replication.

  4. The MRN complex, in particular the nuclease (show DCLRE1C Antibodies) activity of Mre11 (show MRE11A Antibodies), plays an important role in the activation of Chk1 in response to stalled replication forks.

  5. DNA polymerase kappa (show POLK Antibodies)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

  6. APE2 (show APEX2 Antibodies) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (show APEX2 Antibodies) is essential for Chk1 phosphorylation, indicating a Claspin (show CLSPN Antibodies)-like but distinct role for APE2 (show APEX2 Antibodies) in ATR (show ATR Antibodies)-Chk1 signaling.

  7. Data show that the death pathway is independent of ERK (show MAPK1 Antibodies) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 Antibodies) and JNK (show MAPK8 Antibodies).

  8. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH Antibodies)(16) by Chk1.

  9. mechanism of Chk1 activation at the DNA replication checkpoint

  10. Cdc25A (show CDC25A Antibodies) is essential for the Chk1-induced cell cycle arrest and the DNA replication checkpoint in early embryos

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR (show ATR Antibodies)-Chk1/2-controlled DNA-damage response pathways.

  2. Chk1(-/-) MEFs exhibited the absence of double-strand breaks, yet cells showed delayed DNA damage recovery with pan (show SUPT6H Antibodies)-nuclear immunostaining pattern of Histone H2AX.

  3. RAD9 (show RAD9A Antibodies) has a prominent role in the ATR (show ATR Antibodies)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  4. Acute inactivation of E4F1 (show E4F1 Antibodies) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (show ROS1 Antibodies) production, energy stress, and inhibition of de novo pyrimidine synthesis

  5. Altogether, our results classify E4F1 (show E4F1 Antibodies) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  6. Heterozygous loss of Chk1 in a Wnt (show WNT2 Antibodies)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.

  7. PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity

  8. ATM (show ATM Antibodies) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.

  9. High level of phospho-Chk1 is associated with skin tumors.

  10. Chk1 is essential for the developmental formation of murine epidermal melanocytes but hemizygosity has little permanent developmental consequence in this cell type

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The Chk1 directly phosphorylates eNOS (show NOS3 Antibodies) Ser (show SIGLEC1 Antibodies)(1179) in response to UV irradiation, which is dependent on Hsp90 (show HSP90 Antibodies) interaction.

CHEK1 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

  • checkpoint kinase 1 (CHEK1) antibody
  • serine/threonine-protein kinase chk1 (ANI_1_2436074) antibody
  • serine/threonine-protein kinase chk1 (AOR_1_768154) antibody
  • serine/threonine-protein kinase Chk1 (PTRG_04183) antibody
  • serine/threonine-protein kinase chk1 (SJAG_01680) antibody
  • serine/threonine-protein kinase chk1 (PAAG_04978) antibody
  • serine/threonine-protein kinase chk1 (MCYG_03290) antibody
  • serine/threonine-protein kinase chk1 (VDBG_03742) antibody
  • checkpoint kinase 1 (chek1) antibody
  • checkpoint kinase 1 (Chek1) antibody
  • CHK1 checkpoint homolog (S. pombe) (chek1) antibody
  • CHK1 checkpoint homolog (S. pombe) (CHEK1) antibody
  • STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A) antibody
  • An08g10320 antibody
  • AO090003000441 antibody
  • C85740 antibody
  • CHEK1 antibody
  • Chk1 antibody
  • id:ibd2720 antibody
  • rad27 antibody
  • zgc:56093 antibody

Protein level used designations for CHEK1

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

GENE ID SPECIES
100064353 Equus caballus
4983346 Aspergillus niger CBS 513.88
5991605 Aspergillus oryzae RIB40
6342420 Pyrenophora tritici-repentis Pt-1C-BFP
7049849 Schizosaccharomyces japonicus yFS275
9096078 Paracoccidioides sp. 'lutzii' Pb01
9230546 Arthroderma otae CBS 113480
9532482 Verticillium alfalfae VaMs.102
1111 Homo sapiens
398191 Xenopus laevis
609767 Canis lupus familiaris
12649 Mus musculus
140583 Rattus norvegicus
100511709 Sus scrofa
393162 Danio rerio
513678 Bos taurus
374260 Gallus gallus
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