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PM2.5 exposure strongly induced the activation of the ATR (ATR (show ANTXR1 ELISA Kits) serine/threonine kinase (show TLK2 ELISA Kits))-CHEK1/CHK1 (checkpoint kinase 1) axis, which subsequently triggered TP53 (show TP53 ELISA Kits)-dependent autophagy and VEGFA (show VEGFA ELISA Kits) production in Beas-2B cells.
BRCA1 downregulation combined with CHK1 inhibition induced excessive amounts of DNA damage, resulting in an inability to complete the S-phase. Therefore, we suggest CHK1 inhibition as a strategy for targeting BRCA1- or CDK12 (show CRKRS ELISA Kits)-deficient tumors.
PLAUR (show PLAUR ELISA Kits) to be essential for activation of Checkpoint kinase 1 (CHK1); maintenance of cell cycle arrest after DNA damage in a TP53 (show TP53 ELISA Kits)-dependent manner; expression, nuclear import and recruitment to DNA-damage foci of RAD51 (show RAD51 ELISA Kits) recombinase (show RAG1 ELISA Kits), the principal protein involved in the homologous recombination repair pathway.
Results unveil a new aspect of PERK (show EIF2AK3 ELISA Kits) function and previously unknown roles for Claspin (show CLSPN ELISA Kits) and Chk1 as negative regulators of DNA replication in the absence of genotoxic stress.
The findings reveal ATXN3 (show ATXN3 ELISA Kits) to be a novel deubiquitinase of Chk1, providing a new mechanism of Chk1 stabilization in genome integrity maintenance.
Small molecule ATR (show ANTXR1 ELISA Kits) and Chk1 inhibitors potently sensitize lymphoma cells to UVA radiation and induce a prominent apoptotic response
These findings demonstrate an unsuspected requirement for a balanced nucleotide pool for optimal Chk1 activation both in unchallenged cells and in response to genotoxic stress.
ATR (show ANTXR1 ELISA Kits) inhibition potentiated Chk1 inhibitor induced replication stress and cytotoxicity via the abrogation of ATR (show ANTXR1 ELISA Kits)-dependent feedback activation of Chk1 induced by Chk1 inhibitor generated replication stress in tumor cell lines.
CHK1 overexpression is associated with T-cell and Hodgkin Lymphoma.
Date show that when Wee1 (show WEE1 ELISA Kits) alone is inhibited, Chk1 suppresses CDC45 loading and thereby limits the extent of unscheduled replication initiation and subsequent S-phase DNA damage, despite very high CDK (show CDK4 ELISA Kits)-activity.
Inhibition of Drf1 is the primary mechanism by which Chk1 blocks cell-cycle progression in the early embryo and is an essential function of Chk1 at the blastula-to-gastrula stage of development.
The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.
ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.
Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 onto chromatin and thereby serves to antagonize the initiation of replication.
The MRN complex, in particular the nuclease (show DCLRE1C ELISA Kits) activity of Mre11 (show MRE11A ELISA Kits), plays an important role in the activation of Chk1 in response to stalled replication forks.
DNA polymerase kappa (show POLK ELISA Kits)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.
APE2 (show APEX2 ELISA Kits) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (show APEX2 ELISA Kits) is essential for Chk1 phosphorylation, indicating a Claspin (show CLSPN ELISA Kits)-like but distinct role for APE2 (show APEX2 ELISA Kits) in ATR (show ATR ELISA Kits)-Chk1 signaling.
Data show that the death pathway is independent of ERK (show MAPK1 ELISA Kits) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 ELISA Kits) and JNK (show MAPK8 ELISA Kits).
Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH ELISA Kits)(16) by Chk1.
mechanism of Chk1 activation at the DNA replication checkpoint
During neurogenesis, cortical neurons became protected from S-phase Chk1 pathway activation by the DNA methyltransferase (show DNMT1 ELISA Kits) Dnmt1 (show DNMT1 ELISA Kits), and underwent cell death after S-phase progression.
work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)-regulated apoptosis and the p53 (show TP53 ELISA Kits)/PCNA (show PCNA ELISA Kits)- and ATM (show ATM ELISA Kits)/ATR (show ATR ELISA Kits)-Chk1/2-controlled DNA-damage response pathways.
Chk1(-/-) MEFs exhibited the absence of double-strand breaks, yet cells showed delayed DNA damage recovery with pan-nuclear immunostaining pattern of Histone H2AX.
RAD9 (show RAD9A ELISA Kits) has a prominent role in the ATR (show ATR ELISA Kits)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.
Acute inactivation of E4F1 (show E4F1 ELISA Kits) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (show ROS1 ELISA Kits) production, energy stress, and inhibition of de novo pyrimidine synthesis
Altogether, our results classify E4F1 (show E4F1 ELISA Kits) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.
Heterozygous loss of Chk1 in a Wnt (show WNT2 ELISA Kits)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.
PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity
ATM (show ATM ELISA Kits) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.
High level of phospho-Chk1 is associated with skin tumors.
The Chk1 directly phosphorylates eNOS (show NOS3 ELISA Kits) Ser (show SIGLEC1 ELISA Kits)(1179) in response to UV irradiation, which is dependent on Hsp90 (show HSP90 ELISA Kits) interaction.
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
CHK1 checkpoint homolog
, Serine/threonine-protein kinase Chk1-like protein
, serine/threonine-protein kinase Chk1
, serine/threonine-protein kinase chk1
, Checkpoint, S. pombe, homolog of, 1
, cell cycle checkpoint kinase
, checkpoint kinase-1
, Chk1 checkpoint kinase
, checkpoint kinase 1 homolog
, rad27 homolog
, integral membrane protein 1