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Browse our CHEK1 (CHEK1) ELISA Kits

Full name:
Checkpoint Kinase 1 ELISA Kits (CHEK1)
On www.antibodies-online.com are 24 Checkpoint Kinase 1 (CHEK1) ELISA Kits from 9 different suppliers available. Additionally we are shipping CHEK1 Antibodies (480) and CHEK1 Proteins (16) and many more products for this protein. A total of 560 CHEK1 products are currently listed.
Synonyms:
An08g10320, AO090003000441, C85740, CHEK1, Chk1, id:ibd2720, rad27, zgc:56093
list all ELISA KIts Gene Name GeneID UniProt
CHEK1 1111 O14757
CHEK1 12649 O35280
CHEK1 140583 Q91ZN7

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More ELISA Kits for CHEK1 Interaction Partners

Human Checkpoint Kinase 1 (CHEK1) interaction partners

  1. CHEK1 loss-of-function mutations have not been found in human tumors, and transgenic expression of Chek1 in mice promotes oncogene (show RAB1A ELISA Kits)-induced transformation. [review]

  2. persistence of CHK1 levels in response to DNA damage in p53 (show TP53 ELISA Kits)-deficient cancer cells, leads to CHK1-mediated activation of NF-kappaB (show NFKB1 ELISA Kits) and induction of NF-kappaB (show NFKB1 ELISA Kits)-regulated genes in cells and in associated tumor-derived microvesicles, both of which are abrogated by loss or inhibition of CHK1.

  3. Chk1's expression is controlled by p53 (show TP53 ELISA Kits) and RB/E2F1 (show E2F1 ELISA Kits) at the transcriptional level.

  4. High CHK1 expression correlates with urinary bladder cancer.

  5. Inappropriate activation of CDK2 (show CDK2 ELISA Kits) in S phase underlies the sensitivity of a subset of cell lines to Chk1 inhibitors.

  6. In conclusion, this study exemplifies cancer-specific synthetic lethality between two proteins in the same pathway and raises the prospect of combining ATR (show ANTXR1 ELISA Kits) and CHK1 inhibitors as promising cancer therapy.

  7. This study shows that Chk1 indeed maintains a closed conformation in the absence of DNA damage through an intramolecular interaction between a region (residues 31-87) at the N-terminal kinase domain and the distal C terminus. A highly conserved Leu-449 at the C terminus is important for this intramolecular interaction.

  8. Avoiding damage formation through invalidation of Mus81 (show MUS81 ELISA Kits)-Eme2 (show EME2 ELISA Kits) and Mre11 (show MRE11A ELISA Kits), or preventing damage signaling by turning off the ATM (show ATM ELISA Kits) pathway, suppresses the replication phenotypes of Chk1-deficient cells.

  9. Chk1 is a predictive biomarker of radiotherapy resistance and early local recurrence.

  10. A new pathway of proliferation restriction for tetraploid untransformed cells that seems to be specific for loss of adhesion dependent cytokinesis failure involves Chk1 and p53 (show TP53 ELISA Kits) activation during G2.

Xenopus laevis Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The study analyzes the role of Chk1 in the replication program in sperm nuclei replicating in Xenopus egg extracts by a combination of experimental and modelling approaches.

  2. ATR-Chk1 DDR pathway appears to be dispensable for the preferential association of REV1 to MMC-damaged chromatin.

  3. Results show that Chk1 negatively regulates the Treslin-mediated loading of Cdc45 onto chromatin and thereby serves to antagonize the initiation of replication.

  4. The MRN complex, in particular the nuclease (show DCLRE1C ELISA Kits) activity of Mre11 (show MRE11A ELISA Kits), plays an important role in the activation of Chk1 in response to stalled replication forks.

  5. DNA polymerase kappa (show POLK ELISA Kits)-dependent DNA synthesis at stalled replication forks is important for CHK1 activation.

  6. APE2 (show APEX2 ELISA Kits) associates with Chk1; a serine residue (S86) in the Chk1-binding motif of APE2 (show APEX2 ELISA Kits) is essential for Chk1 phosphorylation, indicating a Claspin (show CLSPN ELISA Kits)-like but distinct role for APE2 (show APEX2 ELISA Kits) in ATR (show ATR ELISA Kits)-Chk1 signaling.

  7. Data show that the death pathway is independent of ERK (show MAPK1 ELISA Kits) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (show CDK1 ELISA Kits) and JNK (show MAPK8 ELISA Kits).

  8. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (show TRH ELISA Kits)(16) by Chk1.

  9. mechanism of Chk1 activation at the DNA replication checkpoint

  10. Cdc25A (show CDC25A ELISA Kits) is essential for the Chk1-induced cell cycle arrest and the DNA replication checkpoint in early embryos

Mouse (Murine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. RAD9 (show RAD9A ELISA Kits) has a prominent role in the ATR (show ATR ELISA Kits)-Chk1 pathway that is necessary for successful formation of the damage-sensing complex and DNA damage checkpoint signaling.

  2. Acute inactivation of E4F1 (show E4F1 ELISA Kits) in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (show ROS1 ELISA Kits) production, energy stress, and inhibition of de novo pyrimidine synthesis

  3. Altogether, our results classify E4F1 (show E4F1 ELISA Kits) as a master regulator of CHK1 activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  4. Heterozygous loss of Chk1 in a Wnt (show WNT2 ELISA Kits)-driven background resulted in an increase in DNA damage and apoptosis and accelerated both tumour development and progression.

  5. PAR, supplied by PARP1, interacts with Chk1 via a novel PAR-binding regulatory (PbR) motif in Chk1, independent of ATR and its activity

  6. ATM (show ATM ELISA Kits) (pSer-1981)-Chk1 (pSer-345) cascade might have mediated G2/M cell cycle arrest to allowed time to facilitate sperm-derived DNA damage repair in mouse zygotes fertilized with oxygen-stressed sperm.

  7. High level of phospho-Chk1 is associated with skin tumors.

  8. Chk1 is essential for the developmental formation of murine epidermal melanocytes but hemizygosity has little permanent developmental consequence in this cell type

  9. activated Akt1 (show AKT1 ELISA Kits) in Brca1 (show BRCA1 ELISA Kits)-deficient cells impairs Chk1 nuclear localization and subsequently disrupts interaction of Chk1 and Rad51 (show RAD51 ELISA Kits) leading to homologous recombination defects.

  10. Our results uncover a novel p53 (show TP53 ELISA Kits)-independent function for p21 in protecting cells from the lethal effects of DNA damage followed by Chk1 inhibition

Cow (Bovine) Checkpoint Kinase 1 (CHEK1) interaction partners

  1. The Chk1 directly phosphorylates eNOS (show NOS3 ELISA Kits) Ser (show SIGLEC1 ELISA Kits)(1179) in response to UV irradiation, which is dependent on Hsp90 (show HSP90 ELISA Kits) interaction.

CHEK1 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with CHEK1

  • checkpoint kinase 1 (CHEK1) Elisa Kit
  • serine/threonine-protein kinase chk1 (ANI_1_2436074) Elisa Kit
  • serine/threonine-protein kinase chk1 (AOR_1_768154) Elisa Kit
  • serine/threonine-protein kinase Chk1 (PTRG_04183) Elisa Kit
  • serine/threonine-protein kinase chk1 (SJAG_01680) Elisa Kit
  • serine/threonine-protein kinase chk1 (PAAG_04978) Elisa Kit
  • serine/threonine-protein kinase chk1 (MCYG_03290) Elisa Kit
  • serine/threonine-protein kinase chk1 (VDBG_03742) Elisa Kit
  • checkpoint kinase 1 (chek1) Elisa Kit
  • checkpoint kinase 1 (Chek1) Elisa Kit
  • CHK1 checkpoint homolog (S. pombe) (chek1) Elisa Kit
  • CHK1 checkpoint homolog (S. pombe) (CHEK1) Elisa Kit
  • STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) (STT3A) Elisa Kit
  • An08g10320 Elisa Kit
  • AO090003000441 Elisa Kit
  • C85740 Elisa Kit
  • CHEK1 Elisa Kit
  • Chk1 Elisa Kit
  • id:ibd2720 Elisa Kit
  • rad27 Elisa Kit
  • zgc:56093 Elisa Kit

Protein level used designations for Checkpoint Kinase 1 (CHEK1) ELISA Kits

CHK1 checkpoint homolog , Serine/threonine-protein kinase Chk1-like protein , serine/threonine-protein kinase Chk1 , serine/threonine-protein kinase chk1 , Checkpoint, S. pombe, homolog of, 1 , Chk1-S , cell cycle checkpoint kinase , checkpoint kinase-1 , Chk1 checkpoint kinase , xChk1 , checkpoint kinase 1 homolog , rad27 homolog , 2720 , integral membrane protein 1

GENE ID SPECIES
100064353 Equus caballus
4983346 Aspergillus niger CBS 513.88
5991605 Aspergillus oryzae RIB40
6342420 Pyrenophora tritici-repentis Pt-1C-BFP
7049849 Schizosaccharomyces japonicus yFS275
9096078 Paracoccidioides sp. 'lutzii' Pb01
9230546 Arthroderma otae CBS 113480
9532482 Verticillium alfalfae VaMs.102
1111 Homo sapiens
398191 Xenopus laevis
609767 Canis lupus familiaris
12649 Mus musculus
140583 Rattus norvegicus
100511709 Sus scrofa
393162 Danio rerio
513678 Bos taurus
374260 Gallus gallus
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