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Browse our anti-Checkpoint Kinase 2 (CHEK2) Antibodies

Full name:
anti-Checkpoint Kinase 2 Antibodies (CHEK2)
On www.antibodies-online.com are 420 Checkpoint Kinase 2 (CHEK2) Antibodies from 34 different suppliers available. Additionally we are shipping Checkpoint Kinase 2 Kits (13) and Checkpoint Kinase 2 Proteins (10) and many more products for this protein. A total of 467 Checkpoint Kinase 2 products are currently listed.
Synonyms:
Cds1, CHK-2, Chk2, fa66f08, hCds1, HUCDS1, LFS2, PP1425, Rad53, wu:fa66f08, zgc:55865
list all antibodies Gene Name GeneID UniProt
CHEK2 11200 O96017
CHEK2 50883 Q9Z265
CHEK2 114212  

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All available anti-Checkpoint Kinase 2 Antibodies

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Top referenced anti-Checkpoint Kinase 2 Antibodies

  1. Human Monoclonal CHEK2 Primary Antibody for IHC (p), WB - ABIN302248 : Lukas, Bartkova, Latella, Falck, Mailand, Schroeder, Sehested, Lukas, Bartek: DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. in Cancer research 2001 (PubMed)
    Show all 6 references for ABIN302248

  2. Human Monoclonal CHEK2 Primary Antibody for IF, WB - ABIN393759 : Guénard, Pedneault, Ouellette, Labrie, Simard, , Durocher: Evaluation of the contribution of the three breast cancer susceptibility genes CHEK2, STK11, and PALB2 in non-BRCA1/2 French Canadian families with high risk of breast cancer. in Genetic testing and molecular biomarkers 2010 (PubMed)
    Show all 5 references for ABIN393759

  3. Human Monoclonal CHEK2 Primary Antibody for IHC (p), IP - ABIN487312 : Yoda, Xu, Onishi, Toyoshima, Fujimoto, Kato, Oishi, Kondo, Minami: Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1. in The Journal of biological chemistry 2006 (PubMed)
    Show all 4 references for ABIN487312

  4. Human Polyclonal CHEK2 Primary Antibody for EIA, IF - ABIN499619 : Matsuoka, Huang, Elledge: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 4 references for ABIN499619

  5. Human Polyclonal CHEK2 Primary Antibody for EIA, WB - ABIN117975 : Blasina, de Weyer, Laus, Luyten, Parker, McGowan: A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. in Current biology : CB 1999 (PubMed)
    Show all 3 references for ABIN117975

  6. Human Polyclonal CHEK2 Primary Antibody for IHC, WB - ABIN2779312 : Kobayashi, Lin: Antiangiogenic and radiotherapy for cancer treatment. in Histology and histopathology 2006 (PubMed)
    Show all 3 references for ABIN2779312

  7. Human Monoclonal CHEK2 Primary Antibody for IF, WB - ABIN968596 : Tominaga, Morisaki, Kaneko, Fujimoto, Tanaka, Ohtsubo, Hirai, Okayama, Ikeda, Nakanishi: Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. in The Journal of biological chemistry 1999 (PubMed)
    Show all 2 references for ABIN968596

  8. Human Polyclonal CHEK2 Primary Antibody for WB - ABIN616051 : Melchionna, Chen, Blasina, McGowan: Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. in Nature cell biology 2000 (PubMed)
    Show all 2 references for ABIN616051

  9. Human Polyclonal CHEK2 Primary Antibody for WB - ABIN2779326 : Li, Baskaran, Krisky, Bein, Grandi, Cohen, Glorioso: Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth. in Virology 2008 (PubMed)

  10. Human Polyclonal CHEK2 Primary Antibody for ELISA, WB - ABIN129576 : Lu, Lou, Peng, Xie, Nghiem, Conney: Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice. in Cancer research 2008 (PubMed)

More Antibodies against Checkpoint Kinase 2 Interaction Partners

Human Checkpoint Kinase 2 (CHEK2) interaction partners

  1. The germline mutations of the CHEK2 gene are associated with an increased risk of polycythaemia vera (show IGF2BP3 Antibodies).

  2. loss of CHK2 or PP6C-SAPS3 promotes Aurora-A activity associated with BRCA1 in mitosis

  3. we observed a great degree of heterogeneity amongst the CHEK2*1100delC breast cancers, comparable to the BRCAX breast cancers. copy number aberrations were mostly seen at low frequencies in both the CHEK2*1100delC and BRCAX group of breast cancers.

  4. The aim of this study was to determine the frequency and spectrum of germline mutations in BRCA1, BRCA2 and PALB2 and to evaluate the presence of the CHEK2 c.1100delC allele in these patients.

  5. germ-line CHEK2 mutations affecting protein coding sequence confer a moderately-increased risk of NHL (show RTEL1 Antibodies), they are associated with an unfavorable NHL (show RTEL1 Antibodies) prognosis, and they may represent a valuable predictive biomarker for patients with DLBCL.

  6. Mutations in CHEK2 were most frequent in patients with hereditary non-triple-negative breast cancers.

  7. Authors propose that CHK2 is a negative regulator of androgen sensitivity and prostate cancer growth, and that CHK2 signaling is lost during prostate cancer progression to castration resistance.

  8. These data provide a rationale for further evaluation of the combination of Wee1 (show WEE1 Antibodies) and Chk1 (show CHEK1 Antibodies)/2 inhibitors in malignant melanoma.

  9. Variants at the CHEK2 locus are associated with risk of invasive epithelial ovarian cancer. [meta-analysis]

  10. CHEK2 H371Y mutation carriers are more likely to respond to neoadjuvant chemotherapy than are non-carriers

Mouse (Murine) Checkpoint Kinase 2 (CHEK2) interaction partners

  1. We conclude that Chk2 regulates renal 25-hydroxyvitamin D 1alpha-hydroxylase expression thereby impacting on calcium and phosphate metabolism.

  2. TRIP13 (show TRIP13 Antibodies)-deficient spermatocytes also progress to an H1t (show HIST1H1T Antibodies)-positive stage if ATM (show ATM Antibodies) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A Antibodies) or Nbs1 (show NBN Antibodies) or by elimination of the ATM (show ATM Antibodies)-effector kinase CHK2

  3. Results represent the first demonstration of a role for CHK2 in the in vivo signaling of dysfunctional telomeres.

  4. DNA-PK/Chk2 signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

  5. Results demonstrate that Chk2 plays important roles in regulating cell cycle progression during female meiosis and early embryo development.

  6. These data establish CHK2 as essential for DNA damage surveillance in female meiosis and indicate that the oocyte DNA double-strand breaks damage response primarily involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, which then activates p53 and p63.

  7. Findings indicate that PIRH2 (show RCHY1 Antibodies) has central roles in the ubiquitylation of Chk2 and its turnover and in the regulation of its function.

  8. Chk2 deficiency in Myc (show MYC Antibodies) overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP (show PARP1 Antibodies) inhibition.

  9. Point mutation at the Nbs1 (show NBN Antibodies) Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 (show SMC1A Antibodies) phosphorylation after DNA damage.

  10. data indicate that an important role for Chk2 is maintaining lymphocyte development and that dual inactivation of Chk2 and Mus81 (show MUS81 Antibodies) remarkably inhibits cancer

Checkpoint Kinase 2 (CHEK2) Antigen Profile

Antigen Summary

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Checkpoint Kinase 2 (CHEK2)

  • serine/threonine-protein kinase chk2 (MCYG_07308) antibody
  • blue sensitive cone opsin (LOC396525) antibody
  • checkpoint kinase 2 (CHEK2) antibody
  • checkpoint kinase 2 (Chek2) antibody
  • CHK2 checkpoint homolog (S. pombe) (chek2) antibody
  • Cds1 antibody
  • CHK-2 antibody
  • Chk2 antibody
  • fa66f08 antibody
  • hCds1 antibody
  • HUCDS1 antibody
  • LFS2 antibody
  • PP1425 antibody
  • Rad53 antibody
  • wu:fa66f08 antibody
  • zgc:55865 antibody

Protein level used designations for CHEK2

serine/threonine-protein kinase chk2 , blue cone photoreceptor pigment , blue-sensitive opsin , opsin CHK-2 , CHK2 checkpoint homolog , cds1 homolog , checkpoint-like protein CHK2 , serine/threonine-protein kinase Chk2 , Cds1 homolog , Rad53 homolog , protein kinase Chk2

GENE ID SPECIES
9226831 Arthroderma otae CBS 113480
396525 Gallus gallus
11200 Homo sapiens
50883 Mus musculus
114212 Rattus norvegicus
486338 Canis lupus familiaris
336998 Danio rerio
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