Browse our anti-CHEK2 (CHEK2) Antibodies

Full name:
anti-Checkpoint Kinase 2 Antibodies (CHEK2)
On www.antibodies-online.com are 483 Checkpoint Kinase 2 (CHEK2) Antibodies from 34 different suppliers available. Additionally we are shipping CHEK2 Kits (15) and CHEK2 Proteins (13) and many more products for this protein. A total of 534 CHEK2 products are currently listed.
Synonyms:
Cds1, CHK-2, Chk2, fa66f08, hCds1, HUCDS1, LFS2, PP1425, Rad53, wu:fa66f08, zgc:55865
list all antibodies Gene Name GeneID UniProt
CHEK2 11200 O96017
CHEK2 50883 Q9Z265
CHEK2 114212  

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Top referenced anti-CHEK2 Antibodies

  1. Human Monoclonal CHEK2 Primary Antibody for IHC (p), WB - ABIN302248 : Lukas, Bartkova, Latella, Falck, Mailand, Schroeder, Sehested, Lukas, Bartek: DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. in Cancer research 2001 (PubMed)
    Show all 6 references for 302248

  2. Human Monoclonal CHEK2 Primary Antibody for IHC (p), IP - ABIN487312 : Yoda, Xu, Onishi, Toyoshima, Fujimoto, Kato, Oishi, Kondo, Minami: Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1. in The Journal of biological chemistry 2006 (PubMed)
    Show all 4 references for 487312

  3. Human Polyclonal CHEK2 Primary Antibody for IHC, WB - ABIN2779312 : Kobayashi, Lin: Antiangiogenic and radiotherapy for cancer treatment. in Histology and histopathology 2006 (PubMed)
    Show all 3 references for 2779312

  4. Human Monoclonal CHEK2 Primary Antibody for IF, WB - ABIN968596 : Matsuoka, Huang, Elledge: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 2 references for 968596

  5. Human Polyclonal CHEK2 Primary Antibody for IF (p), IHC (p) - ABIN703165 : Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum. in Oncotarget 2016 (PubMed)
    Show all 2 references for 703165

  6. Human Monoclonal CHEK2 Primary Antibody for ICC, IF - ABIN151943 : Chen, Chang, Hsieh, Cheng, Hsieh, Tsai, Lin, Wu, Yuan: A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. in Free radical biology & medicine 2011 (PubMed)
    Show all 2 references for 151943

  7. Human Polyclonal CHEK2 Primary Antibody for WB - ABIN616051 : Melchionna, Chen, Blasina, McGowan: Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. in Nature cell biology 2000 (PubMed)
    Show all 2 references for 616051

  8. Human Polyclonal CHEK2 Primary Antibody for ELISA, WB - ABIN129576 : Lu, Lou, Peng, Xie, Nghiem, Conney: Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice. in Cancer research 2008 (PubMed)

  9. Human Polyclonal CHEK2 Primary Antibody for IF (p), IHC (p) - ABIN685867 : Wei, Zhang, Ren, Zhang, Liu, Duan, Yu, Li, Peng, Zhou, Sun: Endosulfan induces cell dysfunction through cycle arrest resulting from DNA damage and DNA damage response signaling pathways. in The Science of the total environment 2017 (PubMed)

  10. Human Polyclonal CHEK2 Primary Antibody for WB - ABIN2779326 : Li, Baskaran, Krisky, Bein, Grandi, Cohen, Glorioso: Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth. in Virology 2008 (PubMed)

More Antibodies against CHEK2 Interaction Partners

Human Checkpoint Kinase 2 (CHEK2) interaction partners

  1. In this paper, we describe an extension to the BOADICEA model to incorporate the effects of intermediate risk variants for breast cancer, specifically loss of function mutations in the three genes for which the evidence for association is clearest and the risk estimates most precise: PALB2 (show PALB2 Antibodies), CHEK2 and ATM (show ATM Antibodies)

  2. SIAH2 (show SIAH2 Antibodies) regulates CHK2 basal turnover, with important consequences on cell-cycle control and on the ability of hypoxia to alter the DNA damage-response pathway in cancer cells.

  3. MCM2 (show MCM2 Antibodies)-MCM6 (show MCM6 Antibodies) complex is required for CHK2 chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.

  4. On the basis of analyses of approximately 87,000 controls and patients with breast cancer from population- and hospital-based studies, our best estimate for the relative risk of invasive breast cancer for carriers of the 1100delC mutation in CHEK2, compared with noncarriers, was 2.26 (95% CI, 1.90 to 2.69).

  5. the G2 damage checkpoint prevents stable recruitment of the chromosome-packaging-machinery components condensin complex (show SMC4 Antibodies) I and II onto the chromatin even in the presence of an active Cdk1 (show CDK1 Antibodies).

  6. data suggest that cancer risks reported for founder mutations may be generalizable to all CHEK2 + s, particularly for breast cancer

  7. K373E mutation of CHK2 in tumorigenesis

  8. Checkpoint kinase 1 (show CHEK1 Antibodies) and 2 signaling is important for apoptin regulation.

  9. High CHEK2 expression is associated with Lung Adenocarcinoma.

  10. Our study reports the first case of Li-Fraumeni syndrome (show TP53 Antibodies)-like in Chinese patients and demonstrates the important contribution of de novo mutations in this type of rare disease.

Mouse (Murine) Checkpoint Kinase 2 (CHEK2) interaction partners

  1. work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF (show TRAF1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)-regulated apoptosis and the p53 (show TP53 Antibodies)/PCNA (show PCNA Antibodies)- and ATM (show ATM Antibodies)/ATR (show ATR Antibodies)-Chk1 (show CHEK1 Antibodies)/2-controlled DNA-damage response pathways.

  2. Together, this study described the regulation of Chk2 expression through promoter methylation by Dnmt3b (show DNMT3B Antibodies) and also presented a novel role of Chk2 during neuronal differentiation, which is independent of its previously known function in DNA damage response.

  3. We conclude that Chk2 regulates renal 25-hydroxyvitamin D 1alpha-hydroxylase expression thereby impacting on calcium and phosphate metabolism.

  4. TRIP13 (show TRIP13 Antibodies)-deficient spermatocytes also progress to an H1t (show HIST1H1T Antibodies)-positive stage if ATM (show ATM Antibodies) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A Antibodies) or Nbs1 (show NBN Antibodies) or by elimination of the ATM (show ATM Antibodies)-effector kinase CHK2

  5. Results represent the first demonstration of a role for CHK2 in the in vivo signaling of dysfunctional telomeres.

  6. DNA-PK/Chk2 signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

  7. Results demonstrate that Chk2 plays important roles in regulating cell cycle progression during female meiosis and early embryo development.

  8. These data establish CHK2 as essential for DNA damage surveillance in female meiosis and indicate that the oocyte DNA double-strand breaks damage response primarily involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, which then activates p53 and p63.

  9. Findings indicate that PIRH2 (show RCHY1 Antibodies) has central roles in the ubiquitylation of Chk2 and its turnover and in the regulation of its function.

  10. Chk2 deficiency in Myc (show MYC Antibodies) overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP (show PARP1 Antibodies) inhibition.

CHEK2 Antigen Profile

Antigen Summary

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CHEK2

  • checkpoint kinase 2 (CHEK2) antibody
  • CHK2 checkpoint homolog (S. pombe) (chek2) antibody
  • checkpoint kinase 2 (Chek2) antibody
  • CHK2 checkpoint homolog (S. pombe) (CHEK2) antibody
  • serine/threonine-protein kinase chk2 (MCYG_07308) antibody
  • blue sensitive cone opsin (LOC396525) antibody
  • Cds1 antibody
  • CHK-2 antibody
  • Chk2 antibody
  • fa66f08 antibody
  • hCds1 antibody
  • HUCDS1 antibody
  • LFS2 antibody
  • PP1425 antibody
  • Rad53 antibody
  • wu:fa66f08 antibody
  • zgc:55865 antibody

Protein level used designations for CHEK2

CHK2 checkpoint homolog , cds1 homolog , checkpoint-like protein CHK2 , serine/threonine-protein kinase Chk2 , protein kinase CHK2 , checkpoint and tumor suppressor protein 2 , Cds1 homolog , Rad53 homolog , protein kinase Chk2 , CHK2 checkpoint homolog (S. pombe) , serine/threonine-protein kinase Chk2-like , serine/threonine-protein kinase chk2 , blue cone photoreceptor pigment , blue-sensitive opsin , opsin CHK-2

GENE ID SPECIES
11200 Homo sapiens
486338 Canis lupus familiaris
458733 Pan troglodytes
100192447 Sus scrofa
336998 Danio rerio
768913 Gallus gallus
50883 Mus musculus
114212 Rattus norvegicus
100059288 Equus caballus
100404949 Callithrix jacchus
100467146 Ailuropoda melanoleuca
100594542 Nomascus leucogenys
9226831 Arthroderma otae CBS 113480
396525 Gallus gallus
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