Browse our anti-Checkpoint Kinase 2 (CHEK2) Antibodies

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anti-Checkpoint Kinase 2 Antibodies (CHEK2)
On are 470 Checkpoint Kinase 2 (CHEK2) Antibodies from 34 different suppliers available. Additionally we are shipping Checkpoint Kinase 2 Kits (15) and Checkpoint Kinase 2 Proteins (12) and many more products for this protein. A total of 520 Checkpoint Kinase 2 products are currently listed.
Cds1, CHK-2, Chk2, fa66f08, hCds1, HUCDS1, LFS2, PP1425, Rad53, wu:fa66f08, zgc:55865
list all antibodies Gene Name GeneID UniProt
CHEK2 11200 O96017
CHEK2 50883 Q9Z265
CHEK2 114212  

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All available anti-Checkpoint Kinase 2 Antibodies

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Top referenced anti-Checkpoint Kinase 2 Antibodies

  1. Human Polyclonal CHEK2 Primary Antibody for IHC (p), IHC - ABIN408359 : Velimezi, Liontos, Vougas, Roumeliotis, Bartkova, Sideridou, Dereli-Oz, Kocylowski, Pateras, Evangelou, Kotsinas, Orsolic, Bursac, Cokaric-Brdovcak, Zoumpourlis, Kletsas, Papafotiou, Klinakis et al.: Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. ... in Nature cell biology 2013 (PubMed)
    Show all 7 references for 408359

  2. Human Monoclonal CHEK2 Primary Antibody for IHC (p), WB - ABIN302248 : Lukas, Bartkova, Latella, Falck, Mailand, Schroeder, Sehested, Lukas, Bartek: DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. in Cancer research 2001 (PubMed)
    Show all 6 references for 302248

  3. Human Monoclonal CHEK2 Primary Antibody for IHC (p), IP - ABIN487312 : Yoda, Xu, Onishi, Toyoshima, Fujimoto, Kato, Oishi, Kondo, Minami: Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1. in The Journal of biological chemistry 2006 (PubMed)
    Show all 4 references for 487312

  4. Human Polyclonal CHEK2 Primary Antibody for EIA, IF - ABIN499619 : Matsuoka, Huang, Elledge: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. in Science (New York, N.Y.) 1998 (PubMed)
    Show all 4 references for 499619

  5. Human Polyclonal CHEK2 Primary Antibody for IHC, WB - ABIN2779312 : Kobayashi, Lin: Antiangiogenic and radiotherapy for cancer treatment. in Histology and histopathology 2006 (PubMed)
    Show all 3 references for 2779312

  6. Human Monoclonal CHEK2 Primary Antibody for ICC, IF - ABIN151943 : Chen, Chang, Hsieh, Cheng, Hsieh, Tsai, Lin, Wu, Yuan: A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. in Free radical biology & medicine 2011 (PubMed)
    Show all 2 references for 151943

  7. Human Monoclonal CHEK2 Primary Antibody for IF, WB - ABIN968596 : Tominaga, Morisaki, Kaneko, Fujimoto, Tanaka, Ohtsubo, Hirai, Okayama, Ikeda, Nakanishi: Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. in The Journal of biological chemistry 1999 (PubMed)
    Show all 2 references for 968596

  8. Human Polyclonal CHEK2 Primary Antibody for WB - ABIN616051 : Melchionna, Chen, Blasina, McGowan: Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1. in Nature cell biology 2000 (PubMed)
    Show all 2 references for 616051

  9. Human Polyclonal CHEK2 Primary Antibody for WB - ABIN2779326 : Li, Baskaran, Krisky, Bein, Grandi, Cohen, Glorioso: Chk2 is required for HSV-1 ICP0-mediated G2/M arrest and enhancement of virus growth. in Virology 2008 (PubMed)

  10. Human Polyclonal CHEK2 Primary Antibody for ELISA, WB - ABIN129576 : Lu, Lou, Peng, Xie, Nghiem, Conney: Effect of caffeine on the ATR/Chk1 pathway in the epidermis of UVB-irradiated mice. in Cancer research 2008 (PubMed)

More Antibodies against Checkpoint Kinase 2 Interaction Partners

Human Checkpoint Kinase 2 (CHEK2) interaction partners

  1. MCM2 (show MCM2 Antibodies)-MCM6 (show MCM6 Antibodies) complex is required for CHK2 chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.

  2. On the basis of analyses of approximately 87,000 controls and patients with breast cancer from population- and hospital-based studies, our best estimate for the relative risk of invasive breast cancer for carriers of the 1100delC mutation in CHEK2, compared with noncarriers, was 2.26 (95% CI, 1.90 to 2.69).

  3. the G2 damage checkpoint prevents stable recruitment of the chromosome-packaging-machinery components condensin complex (show SMC4 Antibodies) I and II onto the chromatin even in the presence of an active Cdk1 (show CDK1 Antibodies).

  4. data suggest that cancer risks reported for founder mutations may be generalizable to all CHEK2 + s, particularly for breast cancer

  5. K373E mutation of CHK2 in tumorigenesis

  6. Checkpoint kinase 1 (show CHEK1 Antibodies) and 2 signaling is important for apoptin regulation.

  7. High CHEK2 expression is associated with Lung Adenocarcinoma.

  8. Our study reports the first case of Li-Fraumeni syndrome (show TP53 Antibodies)-like in Chinese patients and demonstrates the important contribution of de novo mutations in this type of rare disease.

  9. hese findings confirmed that 53BP1 (show TP53BP1 Antibodies) loss might be a negative factor for chemotherapy efficacy, promoting cell proliferation and inhibiting apoptosis by suppressing ATM (show ATM Antibodies)-CHK2-P53 (show TP53 Antibodies) signaling, and finally inducing 5-FU resistance.

  10. All 14 exons of CHEK2 were amplified and sequenced.

Mouse (Murine) Checkpoint Kinase 2 (CHEK2) interaction partners

  1. Together, this study described the regulation of Chk2 expression through promoter methylation by Dnmt3b (show DNMT3B Antibodies) and also presented a novel role of Chk2 during neuronal differentiation, which is independent of its previously known function in DNA damage response.

  2. We conclude that Chk2 regulates renal 25-hydroxyvitamin D 1alpha-hydroxylase expression thereby impacting on calcium and phosphate metabolism.

  3. TRIP13 (show TRIP13 Antibodies)-deficient spermatocytes also progress to an H1t (show HIST1H1T Antibodies)-positive stage if ATM (show ATM Antibodies) activity is attenuated by hypomorphic mutations in Mre11 (show MRE11A Antibodies) or Nbs1 (show NBN Antibodies) or by elimination of the ATM (show ATM Antibodies)-effector kinase CHK2

  4. Results represent the first demonstration of a role for CHK2 in the in vivo signaling of dysfunctional telomeres.

  5. DNA-PK/Chk2 signaling induces centrosome amplification upon long-term HU treatment, therefore increasing our insight into tumor recurrence after initial chemotherapy.

  6. Results demonstrate that Chk2 plays important roles in regulating cell cycle progression during female meiosis and early embryo development.

  7. These data establish CHK2 as essential for DNA damage surveillance in female meiosis and indicate that the oocyte DNA double-strand breaks damage response primarily involves a pathway hierarchy in which ataxia telangiectasia and Rad3-related (ATR) signals to CHK2, which then activates p53 and p63.

  8. Findings indicate that PIRH2 (show RCHY1 Antibodies) has central roles in the ubiquitylation of Chk2 and its turnover and in the regulation of its function.

  9. Chk2 deficiency in Myc (show MYC Antibodies) overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP (show PARP1 Antibodies) inhibition.

  10. Point mutation at the Nbs1 (show NBN Antibodies) Threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 (show SMC1A Antibodies) phosphorylation after DNA damage.

Checkpoint Kinase 2 (CHEK2) Antigen Profile

Antigen Summary

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with Checkpoint Kinase 2 (CHEK2)

  • serine/threonine-protein kinase chk2 (MCYG_07308) antibody
  • blue sensitive cone opsin (LOC396525) antibody
  • checkpoint kinase 2 (CHEK2) antibody
  • checkpoint kinase 2 (Chek2) antibody
  • CHK2 checkpoint homolog (S. pombe) (chek2) antibody
  • Cds1 antibody
  • CHK-2 antibody
  • Chk2 antibody
  • fa66f08 antibody
  • hCds1 antibody
  • HUCDS1 antibody
  • LFS2 antibody
  • PP1425 antibody
  • Rad53 antibody
  • wu:fa66f08 antibody
  • zgc:55865 antibody

Protein level used designations for CHEK2

serine/threonine-protein kinase chk2 , blue cone photoreceptor pigment , blue-sensitive opsin , opsin CHK-2 , CHK2 checkpoint homolog , cds1 homolog , checkpoint-like protein CHK2 , serine/threonine-protein kinase Chk2 , Cds1 homolog , Rad53 homolog , protein kinase Chk2

9226831 Arthroderma otae CBS 113480
396525 Gallus gallus
11200 Homo sapiens
50883 Mus musculus
114212 Rattus norvegicus
486338 Canis lupus familiaris
336998 Danio rerio
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