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anti-Human Checkpoint Kinase 2 antibody for Immunocytochemistry

Recommended Checkpoint Kinase 2 Antibody (supplied by: Log in to see )

Antigen
Checkpoint Kinase 2 (CHEK2) Antibodies
  • Cds1
  • CDS1
  • CHK-2
  • Chk2
  • CHK2
  • fa66f08
  • hCds1
  • HuCds1
  • HUCDS1
  • LFS2
  • PP1425
  • Rad53
  • RAD53
  • wu:fa66f08
  • zgc:55865
Epitope
AA 481-531
44
42
40
32
24
15
13
13
12
11
10
9
9
6
6
6
5
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
454
186
167
10
9
8
8
7
5
1
1
1
Host
Mouse
333
127
8
1
Clonality
Monoclonal
Conjugate
Un-conjugated
8
8
8
7
7
5
5
5
5
5
5
5
4
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
372
126
123
82
75
56
44
40
25
6
5
2
1
1
Supplier
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Catalog No. ABIN1724714
$ 466.40
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.65836227 ABIN2156174 ICC ELISA WB Rabbit N-Term Log in to see Polyclonal
0.65836227 ABIN1843154 ICC IF IHC ELISA WB Mouse IgG2b AA 481-531 Log in to see
0.0010194078 ABIN213921 ICC IHC (p) WB Rabbit N-Term Log in to see Polyclonal
0.0010194078 ABIN1871829 ICC IP IHC WB Rabbit IgG Log in to see Polyclonal
0.0010194078 ABIN219984 ICC FACS IF IP ELISA WB Rabbit IgG pThr68 Log in to see Polyclonal
0.0010194078 ABIN151943 ICC IF WB Mouse IgG Log in to see 8F12
0.0010194078 ABIN210859 ICC IP WB Mouse IgG1 Log in to see
0.0010194078 ABIN2883631 ICC ELISA WB Rabbit IgG pThr383 Log in to see Polyclonal
0.0010194078 ABIN1733039 ICC IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal
0.0010194078 ABIN1031318 ICC ELISA WB Rabbit N-Term Log in to see Polyclonal
0.0010194078 ABIN2594908 ICC Rabbit N-Term Log in to see Polyclonal
0.0010194078 ABIN2619241 ICC Rabbit pThr383 Log in to see Polyclonal
0.0010194078 ABIN1975320 ICC IHC ELISA WB PE Mouse IgG2a AA 1-544 Log in to see
0.0010194078 ABIN1970738 ICC IHC ELISA WB FITC Mouse IgG2a AA 1-544 Log in to see
0.0010194078 ABIN1888227 ICC ELISA WB Rabbit N-Term Log in to see Polyclonal
0.0010194078 ABIN1964302 ICC IHC ELISA WB APC Mouse IgG2a AA 1-544 Log in to see
0.0010194078 ABIN1961923 ICC IHC ELISA WB Alkaline Phosphatase (AP) Mouse IgG2a AA 1-544 Log in to see
0.0010194078 ABIN2405164 ICC IF IP IHC WB Rabbit IgG Log in to see Polyclonal
0.0010194078 ABIN4297968 FACS ICC IF IHC IHC (p) IP WB Mouse IgG1 Transcript Variant 1 Log in to see 5C4
0.0010194078 ABIN1844022 ICC IF WB Rabbit pThr383 Log in to see Polyclonal

Top referenced anti-Checkpoint Kinase 2 antibody for Immunocytochemistry

Similar anti-Checkpoint Kinase 2 Antibodies

Application / Reactivity Human
ELISA 113 Antibodies
Enzyme Immunoassay (EIA) 5 Antibodies
Flow Cytometry (FACS) 25 Antibodies
Immunochromatography (IC) 6 Antibodies
Immunocytochemistry (ICC) 46 Antibodies
Immunofluorescence (IF) 83 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 56 Antibodies
Immunohistochemistry (IHC) 127 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 75 Antibodies
Immunoprecipitation (IP) 39 Antibodies
Luminex Assay (LMNX) 2 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Western Blotting (WB) 362 Antibodies

General

Antigen Checkpoint Kinase 2 (CHEK2) Antibodies
Epitope AA 481-531
(44), (42), (40), (32), (24), (15), (13), (13), (12), (11), (10), (9), (9), (6), (6), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(454), (186), (167), (10), (9), (8), (8), (7), (5), (1), (1), (1)
Host Mouse
(333), (127), (8), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate Un-conjugated
(8), (8), (8), (7), (7), (5), (5), (5), (5), (5), (5), (5), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(372), (126), (123), (82), (75), (56), (44), (40), (25), (6), (5), (2), (1), (1)
Pubmed 3 references available
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Product details

Target details Application Details Handling References Images
Immunogen Purified recombinant fragment of human CHK2 (aa481-531) expressed in E. Coli.
Clone 1C12B8
Isotype IgG2b

Target details

Product details Application Details Handling References Images back to top
Antigen
Alternative Name CHK2 (CHEK2 Antibody Abstract)
Background CHK2: CHK2 checkpoint homolog (S. pombe). In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.
Molecular Weight 61 kDa
Gene ID 11200
HGNC 11200
Pathways p53 Signaling, Apoptosis, Cell Division Cycle

Application Details

Product details Target details Handling References Images back to top
Application Notes Recommended Dilution:
ELISA: 1/10000
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
ICC: 1/200 - 1/1000
Restrictions For Research Use only

Handling

Product details Target details Application Details References Images back to top
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.

References

Product details Target details Application Details Handling Images back to top
Product cited in:

Cybulski, Masojc, Oszutowska, Jaworowska, Grodzki, Waloszczyk, Serwatowski, Pankowski, Huzarski, Byrski, Górski, Jakubowska, Debniak, Wokolorczyk, Gronwald, Tarnowska, Serrano-Fernández, Lubinski et al.: "Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers. ..." in: Carcinogenesis, Vol. 29, Issue 4, pp. 762-5, 2008

Antoni, Sodha, Collins, Garrett: "CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?" in: Nature reviews. Cancer, Vol. 7, Issue 12, pp. 925-36, 2007

Bell, Kim, Godwin, Schiripo, Harris, Haserlat, Wahrer, Haiman, Daly, Niendorf, Smith, Sgroi, Garber, Olopade, Le Marchand, Henderson, Altshuler, Haber, Freedman: "Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts." in: International journal of cancer. Journal international du cancer, Vol. 121, Issue 12, pp. 2661-7, 2007

Images

Product details Target details Application Details Handling References back to top
Supplier Images
Immunocytochemistry (ICC) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (ABIN1724714) anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody
Immunohistochemistry (IHC) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (ABIN1724714) anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (Image 2)
Western Blotting (WB) image for anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (ABIN1724714) anti-Checkpoint Kinase 2 (CHEK2) (AA 481-531) antibody (Image 3)