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p48.2 may represent a novel type of intracellular protein (show CKAP2 Antibodies) functioning as a negative regulator at the G0/G1 phase.
This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5.
cytokine receptor-like molecule 9
, cytokine receptor-related protein 4
, type I cytokine receptor-like factor p48
, cytokine receptor-related factor 4
, clf-3 protein