anti-Human FAS antibody for Neutralization

Recommended FAS Antibody (supplied by: Log in to see )

Antigen
Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
  • AI196731
  • APO1
  • APT1
  • CD95
  • TNFR6
  • Tnfrsf6
  • lpr
  • TNFRSF6
  • ALPS1A
  • APO-1
  • FAS1
  • FASTM
  • A630082H08Rik
  • FAS
  • Fas (TNF receptor superfamily member 6)
  • Fas (TNF receptor superfamily, member 6)
  • Fas cell surface death receptor
  • fatty acid synthase
  • Fas
  • FAS
  • Fasn
Reactivity
Human
640
112
99
15
11
10
6
6
3
3
3
3
2
1
Host
Mouse
413
298
23
5
4
3
3
Clonality
Monoclonal
Conjugate
This FAS antibody is un-conjugated
73
63
51
29
15
8
7
7
5
5
5
4
4
4
4
4
4
2
2
2
2
2
2
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
333
310
207
145
112
84
60
52
52
46
23
18
12
7
6
6
5
4
4
3
3
3
2
2
2
2
2
1
1
1
1
1
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Catalog No. ABIN1106613
$ 423.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1817958 FACS Neut ELISA FITC Hamster IgG Log in to see 4H9
1 ABIN1817959 FACS Neut PE Hamster IgG Log in to see 4H9
1 ABIN2962722 FACS IP Neut WB Mouse IgG3 Log in to see APO-1-3
1 ABIN1817957 FACS Neut ELISA Hamster IgG Log in to see 4H9
1 ABIN1818527 FACS Neut WB Mouse IgG1 Log in to see ZB4
1 ABIN2264888 FACS Neut WB Mouse IgG1 Log in to see 0-T-46

Top referenced anti-FAS antibody for Neutralization

  • Human Monoclonal FAS Primary Antibody for FACS, Neut - ABIN1106613 (11 Publications): Holler, Tardivel, Kovacsovics-Bankowski, Hertig, Gaide, Martinon, Tinel, Deperthes, Calderara, Schulthess, Engel, Schneider, Tschopp: Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. in Molecular and cellular biology 2003 (PubMed)

Similar anti-FAS Antibodies

Application / Reactivity Human
Activation (Act) 3 Antibodies
Apoptosis Blocking (AB) 3 Antibodies
Apoptosis Induction (AI) 2 Antibodies
Biochemical Assay (BCA) 1 Antibodies
Blocking Antibody (Inhibition) 5 Antibodies
Blocking Reagent (BR) 1 Antibodies
Cell Culture (CC) 1 Antibodies
Cytometry by Time of Flight (CyTOF) 1 Antibodies
Dot Blot (DB) 18 Antibodies
ELISA 181 Antibodies
ELISA (Capture) 1 Antibodies
ELISA (Detection) 1 Antibodies
Enzyme Immunoassay (EIA) 12 Antibodies
Flow Cytometry (FACS) 299 Antibodies
Fluorescence Microscopy (FM) 1 Antibodies
Functional Studies (Func) 46 Antibodies
Immunochromatography (IC) 4 Antibodies
Immunocytochemistry (ICC) 11 Antibodies

General

Antigen Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies
Reactivity Human
(640), (112), (99), (15), (11), (10), (6), (6), (3), (3), (3), (3), (2), (1)
Host Mouse
(413), (298), (23), (5), (4), (3), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This FAS antibody is un-conjugated
(73), (63), (51), (29), (15), (8), (7), (7), (5), (5), (5), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
(333), (310), (207), (145), (112), (84), (60), (52), (52), (46), (23), (18), (12), (7), (6), (6), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 11 references available
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Product Details anti-FAS Antibody

Target Details FAS Application Details Handling ProductDetails: References for anti-FAS antibody (ABIN1106613) Images
Specificity This antibody reacts with Fas.
No Cross-Reactivity Mouse (Murine)
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Protein A agarose
Immunogen Recombinant human Fas
Clone ZB4
Isotype IgG1

Target Details FAS

Product Details anti-FAS Antibody Application Details Handling ProductDetails: References for anti-FAS antibody (ABIN1106613) Images back to top
Antigen
Alternative Name CD95 / FAS (FAS Antibody Abstract)
Background It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas (also known as CD95/APO-1) is a cell surface protein belonging to the tumor necrosis factor receptor superfamily, which is expressed in a variety of normal and neoplastic cells. Binding of FasL to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies results in rapid induction of apoptosis in Fas expressing cells. Clone ZB4 is known as Fas blocking, Fas neutralizing or Fas antagonistic antibody, whereas anti-human Fas antibody (clone CH-11) is known as the agonistic antibody.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6
Gene ID 355
NCBI Accession NP_000034
UniProt P25445
Pathways p53 Signaling, Apoptosis, TCR Signaling, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity

Application Details

Product Details anti-FAS Antibody Target Details FAS Handling ProductDetails: References for anti-FAS antibody (ABIN1106613) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-FAS Antibody Target Details FAS Application Details ProductDetails: References for anti-FAS antibody (ABIN1106613) Images back to top
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2
Preservative Azide free
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.

ProductDetails: References for anti-FAS antibody (ABIN1106613)

Product Details anti-FAS Antibody Target Details FAS Application Details Handling Images back to top
Background publications

Schumann, Maedler, Franklin, Konrad, Størling, Böni-Schnetzler, Gjinovci, Kurrer, Gauthier, Bosco, Andres, Berney, Greter, Becher, Chervonsky, Halban, Mandrup-Poulsen, Wollheim, Donath: "The Fas pathway is involved in pancreatic beta cell secretory function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 8, pp. 2861-6, 2007

Maedler, Schumann, Sauter, Ellingsgaard, Bosco, Baertschiger, Iwakura, Oberholzer, Wollheim, Gauthier, Donath: "Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets." in: Diabetes, Vol. 55, Issue 10, pp. 2713-22, 2006

Gilhar, Yaniv, Assy, Serafimovich, Ullmann, Kalish: "Fas pulls the trigger on psoriasis." in: The American journal of pathology, Vol. 168, Issue 1, pp. 170-5, 2006

Ito, Nakazato, Xian, Yamada, Hozumi, Murakami, Ohigashi, Ikeda, Kizaki: "1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo." in: Cancer research, Vol. 65, Issue 10, pp. 4417-24, 2005

Ahmed, Ings, Pizzey, Blundell, Thrasher, Ye, Fahey, Linch, Yong: "Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model." in: Blood, Vol. 103, Issue 6, pp. 2079-87, 2004

Holler, Tardivel, Kovacsovics-Bankowski, Hertig, Gaide, Martinon, Tinel, Deperthes, Calderara, Schulthess, Engel, Schneider, Tschopp: "Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex." in: Molecular and cellular biology, Vol. 23, Issue 4, pp. 1428-40, 2003

Maedler, Spinas, Lehmann, Sergeev, Weber, Fontana, Kaiser, Donath: "Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets." in: Diabetes, Vol. 50, Issue 8, pp. 1683-90, 2001

Jiang, Wu, Sternberg, Jones: "Fas mediates apoptosis and oxidant-induced cell death in cultured hRPE cells." in: Investigative ophthalmology & visual science, Vol. 41, Issue 3, pp. 645-55, 2000

Agrawal, Marquet, Delfau-Larue, Copie-Bergman, Jouault, Reyes, Bensussan, Farcet: "CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs." in: The Journal of clinical investigation, Vol. 102, Issue 9, pp. 1715-23, 1998

Giordano, Stassi, De Maria, Todaro, Richiusa, Papoff, Ruberti, Bagnasco, Testi, Galluzzo: "Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis." in: Science (New York, N.Y.), Vol. 275, Issue 5302, pp. 960-3, 1997

Boirivant, Pica, DeMaria, Testi, Pallone, Strober: "Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis." in: The Journal of clinical investigation, Vol. 98, Issue 11, pp. 2616-22, 1997

Images

Product Details anti-FAS Antibody Target Details FAS Application Details Handling ProductDetails: References for anti-FAS antibody (ABIN1106613) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (ABIN1106613) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody
Western Blotting (WB) image for anti-FAS antibody (Fas (TNF Receptor Superfamily, Member 6)) (ABIN1106613) anti-Fas (TNF Receptor Superfamily, Member 6) (FAS) antibody (Image 2)