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|Application / Reactivity||Human|
|Activation (Act)||3 Antibodies|
|Apoptosis Blocking (AB)||3 Antibodies|
|Apoptosis Induction (AI)||2 Antibodies|
|Biochemical Assay (BCA)||1 Antibodies|
|Blocking Antibody (Inhibition)||5 Antibodies|
|Blocking Reagent (BR)||1 Antibodies|
|Dot Blot (DB)||13 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Enzyme Immunoassay (EIA)||12 Antibodies|
|Flow Cytometry (FACS)||328 Antibodies|
|Fluorescence Microscopy (FM)||1 Antibodies|
|Functional Studies (Func)||50 Antibodies|
|Immunochromatography (IC)||4 Antibodies|
|Immunocytochemistry (ICC)||14 Antibodies|
|Immunofluorescence (IF)||49 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||33 Antibodies|
|Immunohistochemistry (IHC)||130 Antibodies|
|Antigen||Fas (TNF Receptor Superfamily, Member 6) (FAS) Antibodies|
|Conjugate||This FAS antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Neutralization (Neut), Western Blotting (WB)
|11 references available|
|Supplier||Log in to see|
Product Details anti-FAS AntibodyTarget Details FAS Application Details Handling References for anti-FAS Antibody (ABIN1106613) Images
|Specificity||This antibody reacts with Fas.|
|No Cross-Reactivity||Mouse (Murine)|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Purification||Protein A agarose|
|Immunogen||Recombinant human Fas|
Target Details FASProduct Details anti-FAS Antibody Application Details Handling References for anti-FAS Antibody (ABIN1106613) Images back to top
|Alternative Name||CD95 / FAS (FAS Antibody Abstract)|
|Background||It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas (also known as CD95/APO-1) is a cell surface protein belonging to the tumor necrosis factor receptor superfamily, which is expressed in a variety of normal and neoplastic cells. Binding of FasL to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies results in rapid induction of apoptosis in Fas expressing cells. Clone ZB4 is known as Fas blocking, Fas neutralizing or Fas antagonistic antibody, whereas anti-human Fas antibody (clone CH-11) is known as the agonistic antibody.Synonyms: APT1, Apo-1 antigen, FAS1, FASLG receptor, TNFRSF6, Tumor necrosis factor receptor superfamily member 6|
|Pathways||p53 Signaling, Apoptosis, TCR Signaling|
Application DetailsProduct Details anti-FAS Antibody Target Details FAS Handling References for anti-FAS Antibody (ABIN1106613) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-FAS Antibody Target Details FAS Application Details References for anti-FAS Antibody (ABIN1106613) Images back to top
|Buffer||PBS containing 50 % glycerol, pH 7.2|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage Comment||Store (in aliquots) at -20 °C.|
References for anti-FAS Antibody (ABIN1106613)Product Details anti-FAS Antibody Target Details FAS Application Details Handling Images back to top
Schumann, Maedler, Franklin et al.: "The Fas pathway is involved in pancreatic beta cell secretory function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 8, pp. 2861-6, 2007 (PubMed).
Maedler, Schumann, Sauter et al.: "Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets." in: Diabetes, Vol. 55, Issue 10, pp. 2713-22, 2006 (PubMed).
Gilhar, Yaniv, Assy et al.: "Fas pulls the trigger on psoriasis." in: The American journal of pathology, Vol. 168, Issue 1, pp. 170-5, 2006 (PubMed).
Ito, Nakazato, Xian et al.: "1'-acetoxychavicol acetate is a novel nuclear factor kappaB inhibitor with significant activity against multiple myeloma in vitro and in vivo." in: Cancer research, Vol. 65, Issue 10, pp. 4417-24, 2005 (PubMed).
Ahmed, Ings, Pizzey et al.: "Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model." in: Blood, Vol. 103, Issue 6, pp. 2079-87, 2004 (PubMed).
Holler, Tardivel, Kovacsovics-Bankowski et al.: "Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex." in: Molecular and cellular biology, Vol. 23, Issue 4, pp. 1428-40, 2003 (PubMed).
Maedler, Spinas, Lehmann et al.: "Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets." in: Diabetes, Vol. 50, Issue 8, pp. 1683-90, 2001 (PubMed).
Jiang, Wu, Sternberg et al.: "Fas mediates apoptosis and oxidant-induced cell death in cultured hRPE cells." in: Investigative ophthalmology & visual science, Vol. 41, Issue 3, pp. 645-55, 2000 (PubMed).
Agrawal, Marquet, Delfau-Larue et al.: "CD3 hyporesponsiveness and in vitro apoptosis are features of T cells from both malignant and nonmalignant secondary lymphoid organs." in: The Journal of clinical investigation, Vol. 102, Issue 9, pp. 1715-23, 1998 (PubMed).
Giordano, Stassi, De Maria et al.: "Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis." in: Science (New York, N.Y.), Vol. 275, Issue 5302, pp. 960-3, 1997 (PubMed).
Boirivant, Pica, DeMaria et al.: "Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis." in: The Journal of clinical investigation, Vol. 98, Issue 11, pp. 2616-22, 1997 (PubMed).
ImagesProduct Details anti-FAS Antibody Target Details FAS Application Details Handling References for anti-FAS Antibody (ABIN1106613) back to top