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Gadd45a and Gadd45g (show GADD45G Proteins) regulate neural development and exit from pluripotency in Xenopus.
Results provide evidence for a coupled mechanism of 5-methylcytosine (5-meC (show CCL28 Proteins)) demethylation, whereby 5-meC (show CCL28 Proteins) deaminase (AID) deaminates 5-meC (show CCL28 Proteins), followed by thymine base excision by G:T mismatch-specific thymine glycosylase (Mbd4 (show MBD4 Proteins)), promoted by Gadd45.
GADD45A gene variants are associated with meat quality in pigs.
identifed Gadd45a as a chromatin relaxer in embryonic fibroblasts, which also enhances somatic cell reprogramming efficiency; showed that residue glycine 39 in Gadd45a is essential for interacting with core histones, opening chromatin and enhancing reprogramming. demonstrateed that Gadd45a destabilizes histone-DNA interactions and facilitates binding of Yamanaka factors to their targets for activation
Data show that loss of growth arrest and DNA-damage-inducible 45 alpha protein (Gadd45a) accelerates the onset of BCR-ABL driven leukemia in bone marrow recipient mice.
by forming a complex with MEKK4 (show MAP3K4 Proteins) in skeletal muscle fibers, Gadd45a increases MEKK4 (show MAP3K4 Proteins) protein kinase (show CDK7 Proteins) activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a-mediated skeletal muscle fiber atrophy.
Gadd45a may counteract hepatic fi brosis by regulating the activation of hepatic stellate cells via the inhibition of TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling.
These data indicate that genotoxic stress-induced GADD45A expression in HSCs prevents their fatal transformation by directing them into differentiation and thereby clearing them from the system
provide the novel evidence that GADD45A inhibits autophagy via impairing the BECN1 (show BECN1 Proteins)-PIK3C3 (show PIK3C3 Proteins) complex formation
Results suggest the possibility that differential Gadd45a, Gadd45b (show GADD45B Proteins) and Gadd45g (show GADD45G Proteins) expression during development affects neurons, contributing cortical evolution and diversity
GADD45a promoter regulation by a functional genetic variant is associated with acute mechanical lung injury.
In SOD1 (show SOD1 Proteins) and Neurotomized mice the results of this studysuggest LC3 (show MAP1LC3A Proteins), Fn14 (show TNFRSF12A Proteins), Bcl3 (show BCL3 Proteins) and Gadd45a as candidate genes involved in the maintenance of the severe atrophic state.
results for the first time demonstrate that nucleolin (show NCL Proteins)-SUMO at K294R plays a critical role in its nucleus sequestration and gadd45alpha mRNA binding activity.
Stimulation of ribosomal RNA gene promoter by transcription factor Sp1 (show SP1 Proteins) involves active DNA demethylation by Gadd45-NER (show NR1H2 Proteins) pathway.
The findings indicate that p38alpha (show MAPK14 Proteins) and GADD45alpha are involved in an enhanced vitamin D signaling on TRPV6 (show TRPV6 Proteins) expression.
the enhancement of GADD45A-mediated base excision repair modulated by ATF2 (show ATF2 Proteins) might be a potential protective mechanism of visible red light.
Data show that growth arrest and DNA-damage-inducible 45 alpha protein (Gadd45a) expression is up-regulated in chronic phase myelocytic leukemia, chronic (CML) patient samples but down-regulated in accelerated and blast crisis phase samples.
These data revealed that Riboflavin plus ultraviolet (UV) pathogen reduction technology effectively inhibited proliferation and induced apoptosis of lymphocytes by promoting GADD45alpha expression, which subsequently activates p38 (show CRK Proteins) and JNK (show MAPK8 Proteins) signaling pathways.
data suggest GADD45 proteins play a role in controlling HIV-1 transcription and in regulating HIV-1 latency
Taken together, our results suggest that ROS (show ROS1 Proteins) generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 (show XAF1 Proteins) and GADD45alpha expression by MAPK (show MAPK1 Proteins) and functional p53 (show TP53 Proteins).
Collective results lead us to conclude that GADD45alpha modulates curcumin sensitivity through activation of c-Abl (show ABL1 Proteins) > JNK (show MAPK8 Proteins) signaling in a mismatch repair-dependent manner
BRCA1 may act as an important negative regulator in cell cycle progression and tumorigenesis through regulating the stability of Smad4 (show SMAD4 Proteins); this defines a novel link that connects BRCA1 to TGF-beta1 (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) pathway.
MiR (show MLXIP Proteins)-362-5p promotes the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45alpha
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
growth arrest and DNA-damage-inducible, alpha
, growth arrest and DNA damage-inducible protein GADD45 alpha
, growth arrest and DNA-damage-inducible protein 45 alpha
, growth arrest and DNA-damage-inducible protein alpha
, growth arrest and DNA damage-inducible protein 45
, Growth arrest and DNA-damage-inducible protein GADD45 alpha
, DNA damage-inducible transcript 1 protein
, DNA-damage inducible transcript 1
, DNA-damage-inducible transcript 1
, growth arrest and DNA-damage-inducible protein GADD45 alpha
, DNA damage-inducible transcript-1
, growth arrest and DNA-damage-inducible 45 alpha