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Browse our GADD45A Proteins (GADD45A)

Full name:
Growth Arrest and DNA-Damage-Inducible, alpha Proteins (GADD45A)
On www.antibodies-online.com are 19 Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) Proteins from 9 different suppliers available. Additionally we are shipping GADD45A Antibodies (84) and GADD45A Kits (11) and many more products for this protein. A total of 121 GADD45A products are currently listed.
Synonyms:
AA545191, DDIT1, Gadd45, GADD45A, MGC53491, zgc:91795
list all proteins Gene Name GeneID UniProt
GADD45A 13197 P48316
GADD45A 1647 P24522
GADD45A 25112  

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GADD45A Proteins (GADD45A) by Origin

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Top referenced GADD45A Proteins

  1. Human GADD45A Protein expressed in Escherichia coli (E. coli) - ABIN666990 : Hollander, Alamo, Jackman, Wang, McBride, Fornace: Analysis of the mammalian gadd45 gene and its response to DNA damage. in The Journal of biological chemistry 1993 (PubMed)
    Show all 2 references for ABIN666990

  2. Human GADD45A Protein expressed in Baculovirus infected Insect Cells - ABIN2004026 : Rosemary Siafakas, Richardson: Growth arrest and DNA damage-45 alpha (GADD45alpha). in The international journal of biochemistry & cell biology 2009 (PubMed)

More Proteins for GADD45A Interaction Partners

Xenopus laevis Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) interaction partners

  1. Gadd45a and Gadd45g (show GADD45G Proteins) regulate neural development and exit from pluripotency in Xenopus.

Zebrafish Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) interaction partners

  1. Results provide evidence for a coupled mechanism of 5-methylcytosine (5-meC (show CCL28 Proteins)) demethylation, whereby 5-meC (show CCL28 Proteins) deaminase (AID) deaminates 5-meC (show CCL28 Proteins), followed by thymine base excision by G:T mismatch-specific thymine glycosylase (Mbd4 (show MBD4 Proteins)), promoted by Gadd45.

Pig (Porcine) Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) interaction partners

  1. GADD45A gene variants are associated with meat quality in pigs.

Mouse (Murine) Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) interaction partners

  1. by forming a complex with MEKK4 (show MAP3K4 Proteins) in skeletal muscle fibers, Gadd45a increases MEKK4 (show MAP3K4 Proteins) protein kinase (show CDK7 Proteins) activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a-mediated skeletal muscle fiber atrophy.

  2. Gadd45a may counteract hepatic fi brosis by regulating the activation of hepatic stellate cells via the inhibition of TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling.

  3. These data indicate that genotoxic stress-induced GADD45A expression in HSCs prevents their fatal transformation by directing them into differentiation and thereby clearing them from the system

  4. provide the novel evidence that GADD45A inhibits autophagy via impairing the BECN1 (show BECN1 Proteins)-PIK3C3 (show PIK3C3 Proteins) complex formation

  5. Results suggest the possibility that differential Gadd45a, Gadd45b (show GADD45B Proteins) and Gadd45g (show GADD45G Proteins) expression during development affects neurons, contributing cortical evolution and diversity

  6. GADD45a promoter regulation by a functional genetic variant is associated with acute mechanical lung injury.

  7. In SOD1 (show SOD1 Proteins) and Neurotomized mice the results of this studysuggest LC3 (show MAP1LC3A Proteins), Fn14 (show TNFRSF12A Proteins), Bcl3 (show BCL3 Proteins) and Gadd45a as candidate genes involved in the maintenance of the severe atrophic state.

  8. results for the first time demonstrate that nucleolin (show NCL Proteins)-SUMO at K294R plays a critical role in its nucleus sequestration and gadd45alpha mRNA binding activity.

  9. Dendrin is dispensable for the function of the normal glomerular filtration barrier, and it interacts with Wtip (show WTIP Proteins) and Gadd45a.

  10. Loss of Gadd45a leads to more DNA damage accumulation and increased sensitivity to ionizing radiation.

Human Growth Arrest and DNA-Damage-Inducible, alpha (GADD45A) interaction partners

  1. These data revealed that Riboflavin plus ultraviolet (UV) pathogen reduction technology effectively inhibited proliferation and induced apoptosis of lymphocytes by promoting GADD45alpha expression, which subsequently activates p38 (show CRK Proteins) and JNK (show MAPK8 Proteins) signaling pathways.

  2. data suggest GADD45 proteins play a role in controlling HIV-1 transcription and in regulating HIV-1 latency

  3. Taken together, our results suggest that ROS (show ROS1 Proteins) generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 (show XAF1 Proteins) and GADD45alpha expression by MAPK (show MAPK1 Proteins) and functional p53 (show TP53 Proteins).

  4. Collective results lead us to conclude that GADD45alpha modulates curcumin sensitivity through activation of c-Abl (show ABL1 Proteins) > JNK (show MAPK8 Proteins) signaling in a mismatch repair-dependent manner

  5. BRCA1 may act as an important negative regulator in cell cycle progression and tumorigenesis through regulating the stability of Smad4 (show SMAD4 Proteins); this defines a novel link that connects BRCA1 to TGF-beta1 (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) pathway.

  6. MiR (show MLXIP Proteins)-362-5p promotes the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45alpha

  7. these data suggest a dual function of GADD45a in oxidative DNA demethylation, to promote directly or indirectly TET1 (show TET1 Proteins) activity and to enhance subsequent 5-formylcytosine/5-carboxylcytosine removal.

  8. These data suggest that GADD45A (1506T>C) is a new tumor susceptibility gene and could be a useful molecular marker for assessing ovarian cancer risk and for predicting ovarian cancer patient prognosis.

  9. Data show that heterogeneous nuclear ribonucleoprotein A0 (hnRNPA0 (show HNRNPA0 Proteins)) drives chemo-resistance of p53 (show TP53 Proteins)-mutant tumor cells via p27Kip1 (show CDKN1B Proteins)/Gadd45alpha mRNAs.

  10. GADD45A mRNA expression was significantly greater in patients with SLE compared to controls.

GADD45A Protein Profile

Protein Summary

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Alternative names and synonyms associated with GADD45A

  • growth arrest and DNA-damage-inducible, alpha (gadd45a)
  • growth arrest and DNA-damage-inducible, alpha, b (gadd45ab)
  • growth arrest and DNA-damage-inducible, alpha (GADD45A)
  • growth arrest and DNA damage-inducible protein 45 (GADD45)
  • growth arrest and DNA-damage-inducible 45 alpha (Gadd45a)
  • growth arrest and DNA-damage-inducible, alpha (Gadd45a)
  • AA545191 protein
  • DDIT1 protein
  • Gadd45 protein
  • GADD45A protein
  • MGC53491 protein
  • zgc:91795 protein

Protein level used designations for GADD45A

growth arrest and DNA-damage-inducible, alpha , growth arrest and DNA damage-inducible protein GADD45 alpha , growth arrest and DNA-damage-inducible protein 45 alpha , growth arrest and DNA-damage-inducible protein alpha , growth arrest and DNA damage-inducible protein 45 , Growth arrest and DNA-damage-inducible protein GADD45 alpha , DDIT-1 , DNA damage-inducible transcript 1 protein , DNA-damage inducible transcript 1 , DNA-damage-inducible transcript 1 , Gadd45alpha , growth arrest and DNA-damage-inducible protein GADD45 alpha , DNA damage-inducible transcript-1 , growth arrest and DNA-damage-inducible 45 alpha

GENE ID SPECIES
379224 Xenopus laevis
431763 Danio rerio
456929 Pan troglodytes
548905 Xenopus (Silurana) tropicalis
693255 Gallus gallus
701054 Macaca mulatta
733669 Sus scrofa
493656 Felis catus
13197 Mus musculus
1647 Homo sapiens
25112 Rattus norvegicus
505463 Bos taurus
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