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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)|
|ELISA||42 Antibodies||43 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||1 Antibodies|
|Flow Cytometry (FACS)||8 Antibodies||14 Antibodies|
|Immunochromatography (IC)||1 Antibodies||1 Antibodies|
|Immunocytochemistry (ICC)||8 Antibodies||8 Antibodies|
|Immunofluorescence (IF)||15 Antibodies||18 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||11 Antibodies|
|Immunohistochemistry (IHC)||27 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||18 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Western Blotting (WB)||76 Antibodies|
|Antigen||High-Mobility Group Box 1 (HMGB1) Antibodies|
|Epitope||AA 60-110 Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This HMGB1 antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
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Product Details anti-HMGB1 AntibodyTarget Details HMGB1 Application Details Handling References for anti-HMGB1 Antibody (ABIN671616) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human HMGB1|
Target Details HMGB1Product Details anti-HMGB1 Antibody Application Details Handling References for anti-HMGB1 Antibody (ABIN671616) Images back to top
|Alternative Name||HMGB1 (HMGB1 Antibody Abstract)|
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells (By similarity).
Subcellular location: Nucleus
Synonyms: HMG1, HMG3, SBP-1, High mobility group protein B1, High mobility group protein 1, HMG-1, HMGB1
|Research Area||Chromatin and Nuclear Signaling, Transcription Factors, Chromatin Binding Proteins, Neurology|
Application DetailsProduct Details anti-HMGB1 Antibody Target Details HMGB1 Handling References for anti-HMGB1 Antibody (ABIN671616) Images back to top
|Application Notes||WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)|
|Restrictions||For Research Use only|
HandlingProduct Details anti-HMGB1 Antibody Target Details HMGB1 Application Details References for anti-HMGB1 Antibody (ABIN671616) Images back to top
|Buffer||Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-HMGB1 Antibody (ABIN671616)Product Details anti-HMGB1 Antibody Target Details HMGB1 Application Details Handling Images back to top
|Product cited in:||
Sun, Zhang, Cui et al.: "High mobility group box-1 and its clinical value in breast cancer." in: OncoTargets and therapy, Vol. 8, pp. 413-9, 2015 (PubMed).
Zhang, He, Wang et al.: "Omega-3 polyunsaturated fatty acids inhibit the increase in cytokines and chemotactic factors induced in vitro by lymph fluid from an intestinal ischemia-reperfusion injury model." in: Nutrition (Burbank, Los Angeles County, Calif.), Vol. 31, Issue 3, pp. 508-14, 2015 (PubMed).
Luan, Kan, Xu et al.: "Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response." in: Journal of neuroinflammation, Vol. 10, pp. 28, 2013 (PubMed). Method employed by authors: Western Blotting (WB)
Jiang, Fu, Tian et al.: "Curculigoside A attenuates experimental cerebral ischemia injury in vitro and vivo." in: Neuroscience, Vol. 192, pp. 572-9, 2011 (PubMed).
Zhao, Hu, Sun et al.: "The high mobility group box 1 protein of Sciaenops ocellatus is a secreted cytokine that stimulates macrophage activation." in: Developmental and comparative immunology, Vol. 35, Issue 10, pp. 1052-8, 2011 (PubMed).
ImagesProduct Details anti-HMGB1 Antibody Target Details HMGB1 Application Details Handling References for anti-HMGB1 Antibody (ABIN671616) back to top