anti-Human KAT2B antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended KAT2B Antibody (supplied by: Log in to see )

Antigen
K(lysine) Acetyltransferase 2B (KAT2B) Antibodies
  • PCAF
  • pcaf
  • si:ch211-1j13.2
  • zgc:161980
  • gb:dq017634
  • im:7156024
  • CAF
  • P
  • P/CAF
  • A930006P13Rik
  • AI461839
  • AW536563
  • Pcaf
  • p/CAF
  • K(lysine) acetyltransferase 2B
  • K(lysine) acetyltransferase 2A
  • p300/CBP-associated factor
  • KAT2B
  • kat2b
  • kat2a
  • Kat2b
  • Pcaf
Epitope
AA 460-510
19
14
13
9
9
9
7
5
4
3
2
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
106
45
31
9
7
5
3
3
3
2
2
2
1
Host
Rabbit
76
31
Clonality
Polyclonal
Conjugate
This KAT2B antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
81
42
16
12
9
6
4
4
2
1
1
Options
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Catalog No. ABIN755287
$ 295.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN755290 IF (p) Cy3 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN755291 IF (p) Cy5 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN755294 IF (p) FITC Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN755293 IF (p) Cy7 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN755292 IF (p) Cy5.5 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN903400 IF (p) Alexa Fluor 647 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN903401 IF (p) Alexa Fluor 488 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN903398 IF (p) Alexa Fluor 555 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN903399 IF (p) Alexa Fluor 350 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN2803504 IF (p) Alexa Fluor 594 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN5005736 IF (p) Alexa Fluor 750 Rabbit IgG AA 460-510 Log in to see Polyclonal
1 ABIN5005735 IF (p) Alexa Fluor 680 Rabbit IgG AA 460-510 Log in to see Polyclonal

General

Antigen K(lysine) Acetyltransferase 2B (KAT2B) Antibodies
Epitope AA 460-510
(19), (14), (13), (9), (9), (9), (7), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(106), (45), (31), (9), (7), (5), (3), (3), (3), (2), (2), (2), (1)
Host Rabbit
(76), (31)
Clonality
Polyclonal
Conjugate This KAT2B antibody is un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(81), (42), (16), (12), (9), (6), (4), (4), (2), (1), (1)
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Product Details anti-KAT2B Antibody

Target Details KAT2B Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human KAT2B
Isotype IgG

Target Details KAT2B

Product Details anti-KAT2B Antibody Application Details Handling Images back to top
Antigen
Alternative Name Kat2b (KAT2B Antibody Abstract)
Background

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2, negatively regulates CRY1 phosphorylation.

Subcellular location: Nucleus

Synonyms: HYRC, p350, DNAPK, DNPK1, HYRC1, IMD26, XRCC7, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, DNA-PK catalytic subunit, p460, PRKDC

Gene ID 5591
UniProt P78527
Pathways p53 Signaling, Regulation of Carbohydrate Metabolic Process

Application Details

Product Details anti-KAT2B Antibody Target Details KAT2B Handling Images back to top
Application Notes IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-KAT2B Antibody Target Details KAT2B Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-KAT2B Antibody Target Details KAT2B Application Details Handling back to top
Supplier Images
ELISA image for anti-K(lysine) Acetyltransferase 2B (KAT2B) (AA 460-510) antibody (ABIN755287) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:...
Immunohistochemistry (IHC) image for anti-K(lysine) Acetyltransferase 2B (KAT2B) (AA 460-510) antibody (ABIN755287) Formalin-fixed and paraffin embedded rat brain labeled with Anti-KAT2B/ GCN5/PCAF Pol...