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Kat2b is a crucial transcriptional regulator for adaptive betaeta cell function during metabolic stress by controlling Unfolded Protein Response and represents a promising target for type 2 diabetes prevention and treatment.
data define an essential motif cNM in N-terminal E1A as an acetyl-CoA entry blocker that directly associates with the entrance of acetyl-CoA binding pocket to block the HAT domain access to its cofactor
PCAF protein and mRNA were not expressed in normal brain, but were expressed in pediatric astrocytoma in levels decreasing with tumor grade.
Notch (show NOTCH1 Proteins) signaling was altered in almost half of the clear-cell renal cell carcinoma (show MOK Proteins) patients and copy number variances in MAML1 (show MAML1 Proteins) and KAT2B were predominant changes.
Results show that PCAF can induce cell apoptosis by modulating a GLI1 (show GLI1 Proteins)/Bcl-2 (show BCL2 Proteins)/BAX (show BAX Proteins) axis that in turn suppresses HCC (show FAM126A Proteins) progression.
low expression of PCAF in hepatocellular carcinoma tissues facilitates tumor cells migration and invasion which is achieved via Gli1 (show GLI1 Proteins)-driven epithelial-mesenchymal transition phenotypes.
p300HAT activated by p38MAPK (show MAPK14 Proteins) plays a pivotal role in regulating the expression of prosurvival molecules following photodynamic therapy.
The Gcn5 (show KAT2A Proteins) is important for turning on genes in cancers that overexpress Myc (show MYC Proteins).
CBP (show CREBBP Proteins) and p300 (show EP300 Proteins) as lysine acetyltransferases responsible for the regulation of MR
our results represent the first work demonstrating that GCN5 (show KAT2A Proteins) and PCAF exhibit different functions and antagonistically regulate the XBP-1S-mediated transcription.
This study demonstrated that pcaf increase in skeletal muscle in muscle atrophy.
Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 (show NOTCH1 Proteins) and PCAF to the NKX2.5 (show NKX2-5 Proteins), beta-MHC (show MYH7 Proteins), Cx43 (show GJA1 Proteins) promoters and attenuated H3K9 hyperacetylation.
Gcn5 (show KAT2A Proteins) and PCAF repress IFN-beta (show IFNB1 Proteins) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (show TBK1 Proteins) in the cytoplasm.
PCAF acetylates two lysine residues K328 and K450 in PGC-1alpha. PCAF in the obese mouse liver greatly represses gluconeogenic enzyme activation and glucose production and improves glucose homeostasis and insulin (show INS Proteins) sensitivity.
Study reveals that Gcn5 (show KAT2A Proteins)/PCAF facilitate adipogenesis through regulation of PPARgamma (show PPARG Proteins) expression and regulate brown adipogenesis by influencing Prdm16 (show PRDM16 Proteins) expression.
KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 (show FOXP3 Proteins) via Sin3-HDAC (show HDAC3 Proteins)/PCAF pathway and, thus, immune activation.
PCAF is necessary for axonal regeneration and also promotes regeneration after spinal cord injury.
These data unveil a p53 (show TP53 Proteins)/PCAF/Gli1 (show GLI1 Proteins) circuitry centered on PCAF that limits Gli1 (show GLI1 Proteins)-enhanced mitogenic and prosurvival response.
PCAF is an important regulator for promoting osteoblast differentiation via acetylation modification of Runx2 (show RUNX2 Proteins).
CSB (show ERCC6 Proteins) and PCAF play cooperative roles to establish the active state of rRNA genes by histone acetylation
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
, histone acetyltransferase KAT2B
, CREBBP-associated factor
, histone acetylase PCAF
, histone acetyltransferase PCAF
, lysine acetyltransferase 2B
, K(lysine) acetyltransferase 2B