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The studies identify a P/CAF-PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) signalling node that promotes oncogenesis and may contribute to MyoD (show MYOD1 Proteins) dysfunction in Alveolar rhabdomyosarcoma (ARMS).
results strongly support our hypothesis that PCAF is induced and activated by ATRA, and the subsequent acetylation of PCAF substrates promotes granulocytic differentiation in leukemia cells
Our findings demonstrated a novel epigenetic mechanism of IL-10 (show IL10 Proteins) dysregulation in inflammatory bowel disease. Down-regulation of KAT2B may disrupt the innate and adaptive inflammatory responses due to the suppression of this crucial anti-inflammatory cytokine.
Acetyltransferase p300/CBP-associated factor (PCAF) interacts with and acetylates HOXB9 (show HOXB9 Proteins) both in vivo and in vitro.
Results suggest that increase in nuclear expression of p300 (show EP300 Proteins), as well as the presence of cytoplasmic but loss of nuclear expression of p300/CBP-associated factor (PCAF), could play an important role in the development and progression of cutaneous squamous cell carcinomas (SCC (show CYP11A1 Proteins)).
Loss of p300 (show EP300 Proteins) reduced repair of mismatches in DNA mismatch repair-deficient cells, but did not have evident effects on Base Excision Repair (BER) mechanisms, including the long patch BER pathway.
Kat2b is a crucial transcriptional regulator for adaptive betaeta cell function during metabolic stress by controlling Unfolded Protein Response and represents a promising target for type 2 diabetes prevention and treatment.
data define an essential motif cNM in N-terminal E1A as an acetyl-CoA entry blocker that directly associates with the entrance of acetyl-CoA binding pocket to block the HAT domain access to its cofactor
PCAF protein and mRNA were not expressed in normal brain, but were expressed in pediatric astrocytoma in levels decreasing with tumor grade.
Notch (show NOTCH1 Proteins) signaling was altered in almost half of the clear-cell renal cell carcinoma (show MOK Proteins) patients and copy number variances in MAML1 (show MAML1 Proteins) and KAT2B were predominant changes.
This study demonstrated that pcaf increase in skeletal muscle in muscle atrophy.
Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 (show NOTCH1 Proteins) and PCAF to the NKX2.5 (show NKX2-5 Proteins), beta-MHC (show MYH7 Proteins), Cx43 (show GJA1 Proteins) promoters and attenuated H3K9 hyperacetylation.
Gcn5 (show KAT2A Proteins) and PCAF repress IFN-beta (show IFNB1 Proteins) production in an enzymatic activity-independent and non-transcriptional manner: by inhibiting the innate immune signaling kinase TBK1 (show TBK1 Proteins) in the cytoplasm.
PCAF acetylates two lysine residues K328 and K450 in PGC-1alpha. PCAF in the obese mouse liver greatly represses gluconeogenic enzyme activation and glucose production and improves glucose homeostasis and insulin (show INS Proteins) sensitivity.
Study reveals that Gcn5 (show KAT2A Proteins)/PCAF facilitate adipogenesis through regulation of PPARgamma (show PPARG Proteins) expression and regulate brown adipogenesis by influencing Prdm16 (show PRDM16 Proteins) expression.
KLF10, functions as a toggle to integrate antagonistic signals regulating FOXP3 (show FOXP3 Proteins) via Sin3-HDAC (show HDAC3 Proteins)/PCAF pathway and, thus, immune activation.
PCAF is necessary for axonal regeneration and also promotes regeneration after spinal cord injury.
These data unveil a p53 (show TP53 Proteins)/PCAF/Gli1 (show GLI1 Proteins) circuitry centered on PCAF that limits Gli1 (show GLI1 Proteins)-enhanced mitogenic and prosurvival response.
PCAF is an important regulator for promoting osteoblast differentiation via acetylation modification of Runx2 (show RUNX2 Proteins).
CSB (show ERCC6 Proteins) and PCAF play cooperative roles to establish the active state of rRNA genes by histone acetylation
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
, histone acetyltransferase KAT2B
, CREBBP-associated factor
, histone acetylase PCAF
, histone acetyltransferase PCAF
, lysine acetyltransferase 2B
, K(lysine) acetyltransferase 2B