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Browse our MDM2 (MDM2) ELISA Kits

Full name:
Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) ELISA Kits (MDM2)
On www.antibodies-online.com are 10 Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) ELISA Kits from 6 different suppliers available. Additionally we are shipping MDM2 Antibodies (376) and MDM2 Proteins (21) and many more products for this protein. A total of 443 MDM2 products are currently listed.
Synonyms:
1700007J15Rik, AA415488, ACTFS, hdm2, HDMX, Mdm-2, zgc:109834
list all ELISA KIts Gene Name GeneID UniProt
MDM2 4193 Q00987
Rat MDM2 MDM2 314856  
MDM2 17246 P23804

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MDM2 (MDM2) ELISA Kits by Reactivity

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Top referenced MDM2 ELISA Kits

  1. Human MDM2 ELISA Kit for Sandwich ELISA - ABIN422415 : Seipel, Marques, Bozzini, Meinken, Mueller, Pabst: Inactivation of the p53-KLF4-CEBPA Axis in Acute Myeloid Leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2016 (PubMed)

More ELISA Kits for MDM2 Interaction Partners

Human Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 ELISA Kits)/Mdm2-Mdm4 (show MDM4 ELISA Kits) via a RING domain-mediated biochemical mechanism.

  2. Tat (show TAT ELISA Kits) exploited the cellular HDM2 (human double minute 2 protein) ubiquitin ligase to accelerate IRF-1 (show IRF1 ELISA Kits) proteasome-mediated degradation, resulting in a quenching of IRF-1 (show IRF1 ELISA Kits) transcriptional activity during HIV-1 infection.

  3. Data show that long noncoding RNAs lnc00462717 direct target MDM2 protein and regulate MAPK (show MAPK1 ELISA Kits) relevant pathway expression.

  4. TLP (show TBPL1 ELISA Kits) Prevents p53 (show TP53 ELISA Kits) Degradation through Disrupting the p53 (show TP53 ELISA Kits)-MDM2 Interaction.

  5. MDM2 T309G polymorphism is associated with risk and prognosis of lung cancer. TT or T genotype may be associated with the reduced risk of lung cancer, especially in Asians (Meta-Analysis)

  6. NF2 (show NF2 ELISA Kits) regulates the interaction of FAK (show PTK2 ELISA Kits)-p53 (show TP53 ELISA Kits) and MDM2-p53 (show TP53 ELISA Kits).

  7. Report up-regulation of TP53 (show TP53 ELISA Kits)/MDM2 signaling pathway in breast carcinomas.

  8. Expressions of COX-2 (show COX2 ELISA Kits), p53 (show TP53 ELISA Kits), and MDM2 increased with oral submucous fibrosis progression.

  9. LRRC8A (show LRRC8A ELISA Kits) is an essential regulator of cisplatin induced p53 (show TP53 ELISA Kits) protein activity and its downstream signaling involving increased expression of p21Waf1/Cip1 and MDM2, as well as activation of caspase-9 (show CASP9 ELISA Kits) and -3 in tumor cell lines.

  10. These results indicate that p53 (show TP53 ELISA Kits)-independent upregulation of MDM2 by increasing selected clones may lead to oncogenesis.

Cow (Bovine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. results suggest overexpression of MDM2 is closely linked to inhibition of p53 (show TP53 ELISA Kits)-dependent apoptosis of Theileria parva (show PARVA ELISA Kits)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (show PARVA ELISA Kits), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (show PARVA ELISA Kits)-infected lymphocytes

Zebrafish Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. Data indicate that knockdown of the Mdm2 and Mdm4 (show MDM4 ELISA Kits) caused dramatic accumulation of mutant p53 protein (show TP53 ELISA Kits).

  2. Together with p53 (show TP53 ELISA Kits), provides an experimental model for characterizing drugs and genes that affect p53 (show TP53 ELISA Kits) signaling.

  3. Data show that liver-specific expression of p53 (show TP53 ELISA Kits)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.

Mouse (Murine) Mdm2, p53 E3 Ubiquitin Protein Ligase Homolog (Mouse) (MDM2) interaction partners

  1. These findings suggest that Mdm2 splice isoforms may play critical roles in the regulatory loop of p53 (show TP53 ELISA Kits)/Mdm2-Mdm4 (show MDM4 ELISA Kits) via a RING domain-mediated biochemical mechanism.

  2. both MDM2 and MDMX (show MDM4 ELISA Kits) deletion-caused pancreatic defects are completely rescued by loss of p53 (show TP53 ELISA Kits), verifying the crucial role of the MDM2 and/or MDMX (show MDM4 ELISA Kits) in regulating p53 (show TP53 ELISA Kits) in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  3. Vif (show BTG1 ELISA Kits) stabilization by CBFbeta (show CBFB ELISA Kits) is mainly caused by impairing MDM2-mediated degradation.

  4. These results demonstrated a critical prosurvival role for MDM2 in the oocytes

  5. we failed to detect any increase in p53 (show TP53 ELISA Kits) level in mutant oocytes, nor any other apoptotic marker, introgression of this targeted invalidation in p53 (show TP53 ELISA Kits)-/- mice restored the fertility of females. This study is the first to show that Mdm2, but not Mdm4 (show MDM4 ELISA Kits), has a critical role in oocyte survival and would be involved in premature ovarian insufficiency phenotype.

  6. Inhibition of MDM2 re-sensitizes rapamycin resistant renal cancer cells via the activation of p53 (show TP53 ELISA Kits).

  7. Inactivation of Mdm2 in sertoli cells triggers p53 (show TP53 ELISA Kits) activation and apoptosis as early as 15.5 days post conception with a significant increase in apoptosis.

  8. These findings elucidate a critical role of Mdm2-p53-Nedd4-2 signaling underlying the regulation of neural network synchrony and seizure susceptibility.

  9. These studies demonstrate that Mdm2 holds promise as a therapeutic target in combination with conventional therapy and may lead to new clinical therapies for Triple-negative breast cancers .

  10. there is a fine tuned balance in the interaction of ribosomal proteins with the MDM2/p53 (show TP53 ELISA Kits) axis which is important in normal hematopoiesis.

MDM2 Antigen Profile

Antigen Summary

This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.

Alternative names and synonyms associated with MDM2

  • MDM2 oncogene, E3 ubiquitin protein ligase (MDM2) Elisa Kit
  • MDM2 oncogene, E3 ubiquitin protein ligase (mdm2) Elisa Kit
  • MDM2 oncogene, E3 ubiquitin protein ligase (Mdm2) Elisa Kit
  • Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (MDM2) Elisa Kit
  • p53 E3 ubiquitin protein ligase (Mdm2) Elisa Kit
  • transformed 3T3 cell double minute 2 homolog (mouse) (mdm2) Elisa Kit
  • transformed mouse 3T3 cell double minute 2 (Mdm2) Elisa Kit
  • 1700007J15Rik Elisa Kit
  • AA415488 Elisa Kit
  • ACTFS Elisa Kit
  • hdm2 Elisa Kit
  • HDMX Elisa Kit
  • Mdm-2 Elisa Kit
  • zgc:109834 Elisa Kit

Protein level used designations for MDM2

E3 ubiquitin-protein ligase Mdm2 , Mdm2, p53 E3 ubiquitin protein ligase homolog , Mdm2, transformed 3T3 cell double minute 2, p53 binding protein , double minute 2, human homolog of; p53-binding protein , oncoprotein Mdm2 , Mdm2 p53 binding protein homolog , double minute 2 protein , p53-binding protein Mdm2 , xdm2 , MDM2 alpha , cdm2 , double minute 2 homolog , double minute 2 , MDM2-like protein , edm2 , transformed mouse 3T3 cell double minute 2 , etID309863.4 , murine double minute 2 homolog

GENE ID SPECIES
4193 Homo sapiens
444499 Xenopus laevis
100724684 Cavia porcellus
403693 Canis lupus familiaris
493939 Felis catus
100125959 Sus scrofa
540378 Bos taurus
100033891 Equus caballus
395609 Gallus gallus
742141 Pan troglodytes
314856 Rattus norvegicus
30637 Danio rerio
17246 Mus musculus
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