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Human NFKB1 Protein expressed in Wheat germ - ABIN1312483
Park, Hong, Park, Yoon, Seo, Hyun, Han, Ham, Hwang, Hong: Anticancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression. in Molecular cancer 2015
TRIM5alpha (show TRIM5 Proteins) represses HIV-1 LTR promoter activity by negatively regulating TAK1 (show NR2C2 Proteins)/TAB1 (show TAB1 Proteins)/TAB2 (show TAB2 Proteins)/TAB3 (show TAB3 Proteins)-complex-mediated NF-kappaB activation.
Prostaglandin E receptor subtype 2 (EP2 (show SPAG11A Proteins); Ptger2 (show PTGER2 Proteins)) deficiency suppressed nuclear factor kappaB (NF-kappaB) activation in intracranial arteries 4 and 8 weeks after intracranial aneurysm induction.
Loss of HDAC (show HDAC3 Proteins)-mediated repression and gain of NF-kappaB activation underlie cytokine induction in ARID1A- and PIK3CA (show PIK3CA Proteins)-mutation-driven ovarian cancer.
Absence of Musashi2 (show MSI2 Proteins) in osteoclast precursors promotes apoptosis and inhibits RANKL (show TNFSF11 Proteins)-induced NF-kappaB activation, which is essential for osteoclast survival.
NF-kappaB-mediated miR (show MLXIP Proteins)-130a modulation is critical in lung vascular remodeling.
Inflammasome-derived exosomes activate NF-kappaB signaling in macrophages.
Genetic reduction of the P65 (show NFkBP65 Proteins) subunit of NF-kappaB diminished chronic inflammation in dystrophic muscle.
selective knockdown of TNFR5 ameliorates glucolipotoxic induction of STAT1 (show STAT1 Proteins) expression and NF-kappaB activity.
c-REL (show NFkBP65 Proteins), but not IkappaBNS (show NFKBID Proteins), controlled the generation of classical CD25 (show IL2RA Proteins)(+)Foxp3 (show FOXP3 Proteins)(-) precursors via direct binding to the Cd25 (show IL2RA Proteins) locus; propose that CD4 (show CD4 Proteins)(+)GITR (show TNFRSF18 Proteins)(+)CD122 (show IL2RB Proteins)(+)CD25 (show IL2RA Proteins)(-)Foxp3 (show FOXP3 Proteins)(-) cells represent a Treg pre-precursor population, whose transition into Treg precursors is mediated via c-REL (show NFkBP65 Proteins)
The results presented in this study represent the first demonstration that NF-kappaB activation acts cell autonomously to protect oligodendrocytes against inflammation in animal models of MS.
proposed that TLR9 (show TLR9 Proteins) regulates the NF-kappaB-NLRP3 (show NLRP3 Proteins)-IL-1beta (show IL1B Proteins) pathway negatively in Salmonella-induced NKG2D (show KLRK1 Proteins)-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity
Using iterative experimental and computational analyses, the authors show physical and functional interactions between NF-kappaB and the E2 Factor 1 (E2F-1 (show E2F1 Proteins)) and E2 Factor 4 (E2F-4 (show E2F4 Proteins)) cell cycle regulators.
Smad7 (show SMAD7 Proteins) expression in necrotizing enterocolitis macrophages interrupts TGF-beta (show TGFB1 Proteins) signaling and promotes NF-kappaB-mediated inflammatory signaling in these cells through increased expression of IKK-beta (show IKBKB Proteins)
The activation of GPER can inhibit the epithelial mesenchymal transition and metastasis of triple negative breast cancer cells via NF-kappaB.
Sam68 (show KHDRBS1 Proteins) deletion diminishes gamma-irradiation-triggered PAR (show JTB Proteins) synthesis and NF-kappaB activation in colon epithelial cells (CECs), thus hampering the expression of anti-apoptotic molecules in situ and facilitating CECs to undergo apoptosis in mice post whole-body gamma-irradiation (WBIR).
The results suggest that TWEAK (show TNFSF12 Proteins)/Fn14 (show TNFRSF12A Proteins) interaction directly favors inorganic phosphate-induced vascular smooth muscle cells calcification by activation of both canonical and non-canonical NF-kappaB pathways.
Low doses of IL1B (show IL1B Proteins) activate the BMP/Smad (show SMAD1 Proteins) signaling pathway to promote the osteogenesis of periodontal ligament stem cells, but higher doses of IL1B (show IL1B Proteins) inhibit BMP/Smad (show SMAD1 Proteins) signaling through the activation of NF-kappaB and MAPK (show MAPK1 Proteins) signaling, inhibiting osteogenesis.
Our data propose an additional novel mechanism to explain the known NF-kappaB inhibitory effects of A20: by affecting p105 ubiquitination and subsequently its degradation and limited processing.
IL-18 (show IL18 Proteins) cooperates with IL-15 (show IL15 Proteins) to promote group 3 innate lymphoid cell (ILC3) proliferation and IL-22 (show IL22 Proteins) production; describe an IL-18 (show IL18 Proteins)-induced, NF-kappaB-mediated mechanism that regulates IL-22 (show IL22 Proteins) in ILC3s; at steady-state, IL-18 (show IL18 Proteins) produced by dendritic cells mediates IL-22 (show IL22 Proteins) production by ILC3s to help maintain normal tissue integrity
These data indicate that RAGE (show AGER Proteins) plays a central role in maintaining inflammatory signaling in PDAC that benefits tumor growth.
HBx activates NF-kappaB to promote the expression of miR1269b, which augments CDC40 (show CDC40 Proteins) expression, contributing to malignancy in hepatocellular cancer.
Study indicate an essential role of NF-kappaB in gonadal differentiation.
This study showed that porcine epidemic diarrhea virus inhibited NF-kappaB activity and nsp1 was a potent NF-kappaB antagonist for suppression of both interferon (show IFNA Proteins) and early production of pro-inflammatory cytokines.
inhibition of NF-kappaB increases autophagy via JNK (show MAPK8 Proteins) signaling, and promotes steroidogenesis in porcine granulosa cells
SIRT1 (show SIRT1 Proteins), p53 (show TP53 Proteins) and NF-kappaB are involved in the control of both the proliferation and the apoptosis of ovarian cells.
porcine CD74 (show CD74 Proteins) significantly enhanced the inflammatory response by regulating the NF-kappaB signalling pathway during PCV2 infection, which suggests that porcine CD74 (show CD74 Proteins) may be implicated in the pathogenesis of PCV2 infection.
These results suggest that trans-10, cis (show CISH Proteins)-12-conjugated linoleic acid can modulate TNF-alpha (show TNF Proteins) production and NF-kappa B expression by a PPARgamma (show PPARG Proteins)-dependent pathway in porcine peripheral blood mononuclear cells.
These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma (show PPARG Proteins) activation.
Taken together, Staphylococcus aureus induces TGF-beta1 (show TGFB1 Proteins) and bFGF (show FGF2 Proteins) expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB in bovine mammary gland fibroblasts.
Data indicate the involvement of PKC-alpha (show PKCa Proteins) in proMMP-2 activation and inhibition of TIMP-2 (show TIMP2 Proteins) expression by NF-kappaB-MT1-MMP (show MMP14 Proteins)-dependent and -independent pathway.
MMP-1 (show MMP1 Proteins) promotes VEGFR2 (show KDR Proteins) expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R Proteins) and activation of NF-kappaB
dynamic compression stimulates cell proliferation and proteoglycan (show Vcan Proteins) synthesis in the presence of IL-1beta (show IL1B Proteins) and/or inhibitors of the MAPKs and NFkappaB and AP-1 (show JUN Proteins) signalling pathways
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
DNA binding factor KBF1
, DNA-binding factor KBF1
, nuclear factor NF-kappa-B p105 subunit
, nuclear factor NF-kappa-B p50 subunit
, nuclear factor kappa-B DNA binding subunit
, nuclear factor of kappa light chain gene enhancer in B-cells 1, p105
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
, NF-kB p50 subunit
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
, nuclear factor kappa-B, subunit 1
, nuclear factor of kappa light polypeptide enhancer in B-cells 1
, nuclear factor kappa-B 1
, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
, nuclear factor NF-kappa-B p105 subunit-like
, NF kappaB1
, NF-kappa-B1 p84/NF-kappa-B1 p98
, NF-kappaB p50
, nuclear factor kappaB p50
, nuclear factor-kappaB p50
, p50 subunit of NF kappaB
, p50 subunit of NF-kappaB
, BICD-related protein 1
, NF-kB1 precursor protein
, bicaudal D-related protein 1
, coiled-coil domain-containing protein 64A