anti-Human p53 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended p53 Antibody (supplied by: Log in to see )

Antigen
Tumor Protein P53 (TP53) Antibodies
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
Epitope
AA 345-390, Wild Type
175
125
91
84
74
71
70
62
59
55
50
49
48
45
42
38
32
31
28
24
22
20
16
16
15
15
15
15
15
15
14
11
10
10
10
9
9
8
8
7
7
7
7
6
6
6
6
6
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rabbit, Rat (Rattus)
2387
516
423
186
127
94
85
82
35
23
20
18
16
16
15
14
6
4
4
4
4
3
3
3
2
2
1
1
Host
Rabbit
1364
1134
7
3
3
1
1
1
Clonality
Polyclonal
Conjugate
This p53 antibody is un-conjugated
81
78
65
54
46
45
31
31
26
25
25
25
25
25
25
24
24
24
22
20
19
18
14
14
14
14
14
12
7
5
5
5
5
5
5
5
5
4
3
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1915
768
747
732
626
615
432
346
314
178
72
41
32
31
21
17
17
15
13
9
9
4
4
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
Options
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Catalog No. ABIN677408
$ 307.45
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN723935 IF (cc) IF (p) IHC (p) WB Rabbit IgG AA 240-290, Wild Type Log in to see Polyclonal 4
1 ABIN1386190 IF (p) IHC (p) WB Rabbit IgG Log in to see Polyclonal 1
1 ABIN732518 IF (p) IHC (p) WB Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
1 ABIN702910 IF (p) IHC (p) WB Rabbit IgG AA 280-330, pSer315 Log in to see Polyclonal
1 ABIN702925 IF (p) IHC (p) WB Rabbit IgG AA 20-70, pSer33 Log in to see Polyclonal
1 ABIN702895 IF (p) IHC (p) WB Rabbit IgG AA 5-55, pSer20 Log in to see Polyclonal
1 ABIN711911 IF (p) IHC (p) WB Rabbit IgG pThr55 Log in to see Polyclonal
1 ABIN729673 IF (p) IHC (p) WB Rabbit IgG acLys382, AA 350-393 Log in to see Polyclonal
1 ABIN2804968 IF (p) Alexa Fluor 594 Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
1 ABIN2804971 IF (p) Alexa Fluor 594 Rabbit IgG AA 280-330, pSer315 Log in to see Polyclonal
1 ABIN732521 IF (p) Cy3 Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
1 ABIN732524 IF (p) Cy7 Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
1 ABIN732523 IF (p) Cy5.5 Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
1 ABIN732522 IF (p) Cy5 Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
1 ABIN732525 IF (p) FITC Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
1 ABIN702913 IF (p) Cy3 Rabbit IgG AA 280-330, pSer315 Log in to see Polyclonal
1 ABIN702932 IF (p) FITC Rabbit IgG AA 20-70, pSer33 Log in to see Polyclonal
1 ABIN702917 IF (p) FITC Rabbit IgG AA 280-330, pSer315 Log in to see Polyclonal
1 ABIN702928 IF (p) Cy3 Rabbit IgG AA 20-70, pSer33 Log in to see Polyclonal
1 ABIN702931 IF (p) Cy7 Rabbit IgG AA 20-70, pSer33 Log in to see Polyclonal

General

Antigen Tumor Protein P53 (TP53) Antibodies
Epitope AA 345-390, Wild Type
(175), (125), (91), (84), (74), (71), (70), (62), (59), (55), (50), (49), (48), (45), (42), (38), (32), (31), (28), (24), (22), (20), (16), (16), (15), (15), (15), (15), (15), (15), (14), (11), (10), (10), (10), (9), (9), (8), (8), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rabbit, Rat (Rattus)
(2387), (516), (423), (186), (127), (94), (85), (82), (35), (23), (20), (18), (16), (16), (15), (14), (6), (4), (4), (4), (4), (3), (3), (3), (2), (2), (1), (1)
Host Rabbit
(1364), (1134), (7), (3), (3), (1), (1), (1)
Clonality
Polyclonal
Conjugate This p53 antibody is un-conjugated
(81), (78), (65), (54), (46), (45), (31), (31), (26), (25), (25), (25), (25), (25), (25), (24), (24), (24), (22), (20), (19), (18), (14), (14), (14), (14), (14), (12), (7), (5), (5), (5), (5), (5), (5), (5), (5), (4), (3), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(1915), (768), (747), (732), (626), (615), (432), (346), (314), (178), (72), (41), (32), (31), (21), (17), (17), (15), (13), (9), (9), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-p53 Antibody

Target Details p53 Application Details Handling References for anti-p53 antibody (ABIN677408) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human P53
Isotype IgG

Target Details p53

Product Details anti-p53 Antibody Application Details Handling References for anti-p53 antibody (ABIN677408) Images back to top
Antigen
Alternative Name P53 (TP53 Antibody Abstract)
Background

Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

Synonyms: P53, BCC7, LFS1, TRP53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53

Gene ID 7157
UniProt P04637
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy

Application Details

Product Details anti-p53 Antibody Target Details p53 Handling References for anti-p53 antibody (ABIN677408) Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-p53 Antibody Target Details p53 Application Details References for anti-p53 antibody (ABIN677408) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-p53 antibody (ABIN677408)

Product Details anti-p53 Antibody Target Details p53 Application Details Handling Images back to top
Product cited in:

Zhang, Zhang, Liu, Huang, Zhang, Yi, Yao, Hu: "Therapeutic efficacy of paclitaxel and carboplatin via arterial or venous perfusion in rabbits with VX-2 tongue cancer." in: International journal of clinical and experimental medicine, Vol. 8, Issue 4, pp. 4979-88, 2015

Images

Product Details anti-p53 Antibody Target Details p53 Application Details Handling References for anti-p53 antibody (ABIN677408) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) (AA 345-390), (Wild Type) antibody (ABIN677408) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-P53(wt-p5...
Immunohistochemistry (IHC) image for anti-Tumor Protein P53 (TP53) (AA 345-390), (Wild Type) antibody (ABIN677408) Formalin-fixed and paraffin embedded rat brain labeled with Anti-P53(wt-p53) Polyclon...