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anti-Human p53 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended p53 Antibody (supplied by: Log in to see )

Antigen
Tumor Protein P53 (TP53) Antibodies
  • bbl
  • BCC7
  • bfy
  • bhy
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • LFS1
  • p44
  • P53
  • p53
  • tp53
  • TP53
  • Tp53
  • TpMs
  • Trp53
  • TRP53
  • wu:fb40d06
  • Xp53
  • zgc:111919
Epitope
AA 345-390, Wild Type
156
103
87
67
66
65
56
52
52
52
47
46
42
40
31
30
28
25
25
22
22
21
20
17
16
14
14
14
14
14
12
11
11
10
10
9
9
8
8
8
7
7
7
7
7
7
6
6
6
6
6
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rabbit, Rat (Rattus)
2086
393
327
120
101
89
56
54
29
23
19
15
13
10
10
5
5
4
4
3
3
3
3
2
2
Host
Rabbit
1253
931
7
4
3
1
1
Clonality
Polyclonal
Conjugate
This p53 antibody is un-conjugated
68
61
49
45
31
31
30
23
23
17
17
16
16
14
14
14
14
14
14
13
13
13
13
13
12
12
6
4
4
4
4
4
4
4
4
4
3
3
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1658
732
564
491
442
421
397
230
194
169
53
38
35
17
16
12
12
11
11
9
9
4
3
3
3
2
2
2
1
1
1
1
1
Supplier
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Catalog No. ABIN677408
$ 269.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008853478 ABIN723935 IF (cc) IF (p) IHC (p) WB Rabbit IgG AA 240-290, Wild Type Log in to see Polyclonal 3
0.0008853478 ABIN702925 IF (p) IHC (p) WB Rabbit IgG AA 20-70, pSer33 Log in to see Polyclonal
0.0008853478 ABIN702895 IF (p) IHC (p) WB Rabbit IgG AA 5-55, pSer20 Log in to see Polyclonal
0.0008853478 ABIN723366 IF (p) IHC (p) WB Mouse IgG Log in to see D2F7 1
0.0008853478 ABIN732518 IF (p) IHC (p) WB Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
0.0008853478 ABIN702910 IF (p) IHC (p) WB Rabbit IgG AA 280-330, pSer315 Log in to see Polyclonal
0.0008853478 ABIN729673 IF (p) IHC (p) WB Rabbit IgG acLys382, AA 350-393 Log in to see Polyclonal
0.0008853478 ABIN2804968 IF (p) Alexa Fluor 594 Rabbit IgG AA 382-393, pSer392 Log in to see Polyclonal
0.0008853478 ABIN2804972 IF (p) Alexa Fluor 594 Rabbit IgG AA 20-70, pSer33 Log in to see Polyclonal
0.0008853478 ABIN2804970 IF (p) Alexa Fluor 594 Rabbit IgG AA 5-55, pSer20 Log in to see Polyclonal
0.0008853478 ABIN2804971 IF (p) Alexa Fluor 594 Rabbit IgG AA 280-330, pSer315 Log in to see Polyclonal
0.0008853478 ABIN2808148 IF (cc) IF (p) Alexa Fluor 594 Rabbit IgG AA 240-290 Log in to see Polyclonal
0.0008853478 ABIN2804977 IF (p) Alexa Fluor 594 Rabbit IgG pThr18 Log in to see Polyclonal
0.0008853478 ABIN2804976 IF (p) Alexa Fluor 594 Rabbit IgG pSer9 Log in to see Polyclonal
0.0008853478 ABIN2804979 IF (p) Alexa Fluor 594 Rabbit IgG pThr55 Log in to see Polyclonal
0.0008853478 ABIN2804974 IF (p) Alexa Fluor 594 Rabbit IgG pSer46 Log in to see Polyclonal
0.0008853478 ABIN2804973 IF (p) Alexa Fluor 594 Rabbit IgG pSer37 Log in to see Polyclonal
0.0008853478 ABIN2804978 IF (p) Alexa Fluor 594 Rabbit IgG pThr81 Log in to see Polyclonal
0.0008853478 ABIN2804980 IF (p) Alexa Fluor 594 Rabbit IgG pSer376 Log in to see Polyclonal
0.0008853478 ABIN875496 IF (p) Alexa Fluor 350 Rabbit IgG AA 280-330, pSer315 Log in to see Polyclonal

Top referenced anti-p53 antibody for Immunofluorescence (Paraffin-embedded Sections)

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General

Antigen Tumor Protein P53 (TP53) Antibodies
Epitope AA 345-390, Wild Type
(156), (103), (87), (67), (66), (65), (56), (52), (52), (52), (47), (46), (42), (40), (31), (30), (28), (25), (25), (22), (22), (21), (20), (17), (16), (14), (14), (14), (14), (14), (12), (11), (11), (10), (10), (9), (9), (8), (8), (8), (7), (7), (7), (7), (7), (7), (6), (6), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rabbit, Rat (Rattus)
(2086), (393), (327), (120), (101), (89), (56), (54), (29), (23), (19), (15), (13), (10), (10), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2)
Host Rabbit
(1253), (931), (7), (4), (3), (1), (1)
Clonality
Polyclonal
Conjugate This p53 antibody is un-conjugated
(68), (61), (49), (45), (31), (31), (30), (23), (23), (17), (17), (16), (16), (14), (14), (14), (14), (14), (14), (13), (13), (13), (13), (13), (12), (12), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(1658), (732), (564), (491), (442), (421), (397), (230), (194), (169), (53), (38), (35), (17), (16), (12), (12), (11), (11), (9), (9), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-p53 Antibody

Target Details p53 Application Details Handling References for anti-p53 Antibody (ABIN677408) Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human P53
Isotype IgG

Target Details p53

Product Details anti-p53 Antibody Application Details Handling References for anti-p53 Antibody (ABIN677408) Images back to top
Antigen
Alternative Name P53 (TP53 Antibody Abstract)
Background

Acts as a tumor suppressor in many tumor types,induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis,the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.


Synonyms: P53,BCC7,LFS1,TRP53,Cellular tumor antigen p53,Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53,TP53
Gene ID 7157
UniProt P04637
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling

Application Details

Product Details anti-p53 Antibody Target Details p53 Handling References for anti-p53 Antibody (ABIN677408) Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-p53 Antibody Target Details p53 Application Details References for anti-p53 Antibody (ABIN677408) Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

References for anti-p53 Antibody (ABIN677408)

Product Details anti-p53 Antibody Target Details p53 Application Details Handling Images back to top
Product cited in:

Zhang, Zhang, Liu, Huang, Zhang, Yi, Yao, Hu: "Therapeutic efficacy of paclitaxel and carboplatin via arterial or venous perfusion in rabbits with VX-2 tongue cancer." in: International journal of clinical and experimental medicine, Vol. 8, Issue 4, pp. 4979-88, 2015

Images

Product Details anti-p53 Antibody Target Details p53 Application Details Handling References for anti-p53 Antibody (ABIN677408) back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-p53 antibody (Tumor Protein P53) (AA 345-390) (ABIN677408) Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-P53(wt-p5...
Immunohistochemistry (IHC) image for anti-p53 antibody (Tumor Protein P53) (AA 345-390) (ABIN677408) Formalin-fixed and paraffin embedded rat brain labeled with Anti-P53(wt-p53) Polyclon...