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anti-Human p53 antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections)

Recommended p53 Antibody (supplied by: Log in to see )

Antigen
Tumor Protein P53 (TP53) Antibodies
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
Epitope
AA 20-31
152
99
84
68
64
64
55
54
54
51
49
45
43
41
32
30
29
28
24
23
23
21
20
19
17
17
15
15
15
15
15
14
11
10
9
9
9
8
8
7
7
7
7
7
6
6
6
5
5
5
5
5
5
5
5
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
2131
480
395
169
127
94
68
64
34
23
18
17
16
16
15
11
6
4
4
4
4
3
3
2
2
1
Host
Mouse
1253
968
7
3
3
1
1
Clonality
Monoclonal
Conjugate
This p53 antibody is un-conjugated
71
68
56
47
36
35
24
24
21
21
19
18
18
18
18
17
17
17
17
16
16
15
14
14
14
14
14
12
7
4
4
4
4
4
4
4
4
3
3
2
2
1
Application
ELISA, Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
1719
715
636
580
527
466
399
265
250
179
55
41
32
31
18
17
15
15
13
9
9
4
4
3
3
3
2
2
1
1
1
1
1
1
1
Supplier
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Catalog No. ABIN4219254
$ 304.79
Plus shipping costs $45.00

Top referenced anti-p53 antibody for Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections)

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Application / Reactivity Human
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Cytometry by Time of Flight (CyTOF) 18 Antibodies
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ELISA 666 Antibodies
ELISA (Capture) 2 Antibodies
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Immunoassay (IA) 1 Antibodies
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Immunodiffusion (ID) 15 Antibodies
Immunofluorescence (IF) 507 Antibodies
Immunofluorescence (Cultured Cells) (IF (cc)) 13 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 28 Antibodies

General

Antigen Tumor Protein P53 (TP53) Antibodies
Epitope AA 20-31
(152), (99), (84), (68), (64), (64), (55), (54), (54), (51), (49), (45), (43), (41), (32), (30), (29), (28), (24), (23), (23), (21), (20), (19), (17), (17), (15), (15), (15), (15), (15), (14), (11), (10), (9), (9), (9), (8), (8), (7), (7), (7), (7), (7), (6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(2131), (480), (395), (169), (127), (94), (68), (64), (34), (23), (18), (17), (16), (16), (15), (11), (6), (4), (4), (4), (4), (3), (3), (2), (2), (1)
Host Mouse
(1253), (968), (7), (3), (3), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This p53 antibody is un-conjugated
(71), (68), (56), (47), (36), (35), (24), (24), (21), (21), (19), (18), (18), (18), (18), (17), (17), (17), (17), (16), (16), (15), (14), (14), (14), (14), (14), (12), (7), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (2), (2), (1)
Application ELISA, Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP), Western Blotting (WB)
(1719), (715), (636), (580), (527), (466), (399), (265), (250), (179), (55), (41), (32), (31), (18), (17), (15), (15), (13), (9), (9), (4), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 9 references available
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Product Details anti-p53 Antibody

Target Details p53 Application Details Handling References for anti-p53 Antibody (ABIN4219254) Images
Specificity P53
Cross-Reactivity Human
Purification Protein A affinity column
Immunogen Recombinant human p53 (transcription domain within the NH2 terminus)
Clone Bp53-11
Isotype IgG2a

Target Details p53

Product Details anti-p53 Antibody Application Details Handling References for anti-p53 Antibody (ABIN4219254) Images back to top
Antigen
Alternative Name P53 (TP53 Antibody Abstract)
Background Excellent marker for wild-type and mutant forms of human p53 antigen. The antibody stains positively approx. 60 % of investigated carcinoma of lung, breast, colon, stomach, esophagus, pancreas, urinary bladder and testis, head and neck tumors, T-cell Leuk
Gene ID 7157
UniProt P04637
Research Area Transcription Factors
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus

Application Details

Product Details anti-p53 Antibody Target Details p53 Handling References for anti-p53 Antibody (ABIN4219254) Images back to top
Application Notes IHC: 1:500, when using the APAAP method
Restrictions For Research Use only

Handling

Product Details anti-p53 Antibody Target Details p53 Application Details References for anti-p53 Antibody (ABIN4219254) Images back to top
Format Lyophilized
Reconstitution reconstitue with 1 mL deionized water
Concentration 0.025 mg/mL
Buffer PBS, pH 7.4, 0.09 % Sodium azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment 2-8°C, extended storage at -20°C, avoid repeated freeze-thaw cycles

References for anti-p53 Antibody (ABIN4219254)

Product Details anti-p53 Antibody Target Details p53 Application Details Handling Images back to top
Product cited in:

Zarka, Han, Edelson, Rosenblum: "Expression of cadherins, p53, and BCL2 in small cell carcinomas of the cervix: potential tumor suppressor role for N-cadherin." in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 13, Issue 2, pp. 240-3, 2003

Ohtaké, Cheng, Ida, Suzuki, Ohshiro, Zhang, Saku: "Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, Vol. 31, Issue 10, pp. 590-7, 2002

Homann, Nees, Conradt, Dietz, Weidauer, Maier, Bosch: "Overexpression of p53 in tumor-distant epithelia of head and neck cancer patients is associated with an increased incidence of second primary carcinoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 7, Issue 2, pp. 290-6, 2001

Andl, Kahn, Pfuhl, Nicola, Erber, Conradt, Klein, Helbig, Dietz, Weidauer, Bosch: "Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control." in: Cancer research, Vol. 58, Issue 1, pp. 5-13, 1998

Petersen, Song, Hügle-Dörr, Oldenburg, Bautz: "Mapping of linear epitopes recognized by monoclonal antibodies with gene-fragment phage display libraries." in: Molecular & general genetics : MGG, Vol. 249, Issue 4, pp. 425-31, 1996

Stephen, Helminen, Lane: "Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions." in: Journal of molecular biology, Vol. 248, Issue 1, pp. 58-78, 1995

Fisher, Gillett, Vojtĕsek, Barnes, Millis: "Problems with p53 immunohistochemical staining: the effect of fixation and variation in the methods of evaluation." in: British journal of cancer, Vol. 69, Issue 1, pp. 26-31, 1994

Bártek, Bártková, Lukás, Stasková, Vojt?sek, Lane: "Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies." in: The Journal of pathology, Vol. 169, Issue 1, pp. 27-34, 1993

Bártek, Bártková, Vojtĕsek, Stasková, Rejthar, Kovarík, Lane: "Patterns of expression of the p53 tumour suppressor in human breast tissues and tumours in situ and in vitro." in: International journal of cancer, Vol. 46, Issue 5, pp. 839-44, 1990