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anti-Non-Human Primate p53 antibody for Intracellular Flow Cytometry

Recommended p53 Antibody (supplied by: Log in to see )

Antigen
Tumor Protein P53 (TP53) Antibodies
  • tp53
  • p53
  • TP53
  • Tp53
  • bbl
  • bfy
  • bhy
  • p44
  • TpMs
  • BCC7
  • LFS1
  • P53
  • TRP53
  • Trp53
  • Xp53
  • brp53
  • drp53
  • etID22686.5
  • fb40d06
  • wu:fb40d06
  • zgc:111919
  • cellular tumor antigen p53
  • tumor protein p53
  • tumor supressor p53
  • p53 tumor suppressor
  • transformation related protein 53
  • transformation related protein 53, pseudogene
  • trichoplein, keratin filament binding
  • Wistar clone pR53P1 p53 pseudogene
  • CpipJ_CPIJ002758
  • TP53
  • tp53
  • P53
  • Trp53
  • Trp53-ps
  • TCHP
  • Tp53
  • p53-ps
Reactivity
Human, Non Human Primates, Non-Human Primate
2212
496
410
170
130
94
69
64
35
23
18
17
17
16
16
11
5
4
4
4
3
3
3
3
1
1
Host
Mouse
1310
994
7
4
3
1
1
Clonality
Monoclonal
Conjugate
This p53 antibody is un-conjugated
75
70
57
48
36
35
24
24
21
21
19
18
18
18
18
17
17
17
17
16
16
15
14
14
14
14
14
12
7
4
4
4
4
4
4
4
4
3
3
2
2
1
Application
Intracellular Flow Cytometry (ICFC)
1783
751
660
587
535
473
412
267
259
179
55
41
34
31
18
17
15
15
13
12
11
9
9
4
3
3
3
2
2
2
1
1
1
1
1
1
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Catalog No. ABIN2664003
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2664004 ICFC Mouse IgG2a kappa Log in to see BP53-12 6

Top referenced anti-p53 antibody for Intracellular Flow Cytometry

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Application / Reactivity Human Non-Human Primate Non Human Primates
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Simple Western (SimWes) 9 Antibodies
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Radioimmunoassay (RIA) 55 Antibodies
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Intracellular Staining (ICS) 3 Antibodies
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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 583 Antibodies 2 Antibodies

General

Antigen Tumor Protein P53 (TP53) Antibodies
Reactivity Human, Non Human Primates, Non-Human Primate
(2212), (496), (410), (170), (130), (94), (69), (64), (35), (23), (18), (17), (17), (16), (16), (11), (5), (4), (4), (4), (3), (3), (3), (3), (1), (1)
Host Mouse
(1310), (994), (7), (4), (3), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This p53 antibody is un-conjugated
(75), (70), (57), (48), (36), (35), (24), (24), (21), (21), (19), (18), (18), (18), (18), (17), (17), (17), (17), (16), (16), (15), (14), (14), (14), (14), (14), (12), (7), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (2), (2), (1)
Application Intracellular Flow Cytometry (ICFC)
(1783), (751), (660), (587), (535), (473), (412), (267), (259), (179), (55), (41), (34), (31), (18), (17), (15), (15), (13), (12), (11), (9), (9), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-p53 Antibody

Target Details p53 Application Details Handling References for anti-p53 Antibody (ABIN2664003) Images
Purification This antibody was purified by affinity chromatography.
Clone BP53-12
Isotype IgG2a kappa

Target Details p53

Product Details anti-p53 Antibody Application Details Handling References for anti-p53 Antibody (ABIN2664003) Images back to top
Antigen
Alternative Name P53 (TP53 Antibody Abstract)
Background P53 is a 53 kD protein that forms tetramers and functions as a tumor suppressor and transcriptional activator of genes that inhibit growth and/or invasion, cell cycle checkpoint after irradiation, DNA repair, apoptotic induction, signal transduction, and cell adhesion. This protein is localized to the nucleus when activated and can be upregulated by genotoxic or other cellular stresses. p53 is modified by phosphorylation, acetylation, ribosylation, ubiquitination, and sumoylation, ubiquination targets p53 for degradation via mdm2. This protein interacts with a variety of proteins including mdm2, mdmx, topoisomerase I, PML3, Bcl-XL, Bcl-2, Chk1, JNK, p38, HIPK2, CK2, DNA-PK, p300/CBP, PCAF, PARP1, and HDAC1-3. Mutant p53 associates with p63 and p73.
Research Area Transcription Factors
Pathways p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding

Application Details

Product Details anti-p53 Antibody Target Details p53 Handling References for anti-p53 Antibody (ABIN2664003) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-p53 Antibody Target Details p53 Application Details References for anti-p53 Antibody (ABIN2664003) Images back to top
Concentration 0.5 mg/mL
Buffer Tris-buffered solution, pH 8.0, containing 0.09 % sodium azide at 0.5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-p53 Antibody (ABIN2664003)

Product Details anti-p53 Antibody Target Details p53 Application Details Handling Images back to top
Background publications

Lanoix, Lacasse, Reiter, Vaillancourt: "Melatonin: the watchdog of villous trophoblast homeostasis against hypoxia/reoxygenation-induced oxidative stress and apoptosis." in: Molecular and cellular endocrinology, Vol. 381, Issue 1-2, pp. 35-45, 2013

Mihara, Erster, Zaika, Petrenko, Chittenden, Pancoska, Moll: "p53 has a direct apoptogenic role at the mitochondria." in: Molecular cell, Vol. 11, Issue 3, pp. 577-90, 2003

Saito, Yamaguchi, Higashimoto, Chao, Xu, Fornace, Appella, Anderson: "Phosphorylation site interdependence of human p53 post-translational modifications in response to stress." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37536-44, 2003

Shieh, Ikeda, Taya, Prives: "DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2." in: Cell, Vol. 91, Issue 3, pp. 325-34, 1997

Terada, Shimizu, Izumi, Nakanuma et al.: "Methods in pathology. p53 expression in formalin-fixed, paraffin-embedded archival specimens of intrahepatic cholangiocarcinoma: retrieval of p53 antigenicity by microwave oven heating of tissue ..." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 7, Issue 2, pp. 249-52, 1994

Vogelstein, Kinzler: "p53 function and dysfunction." in: Cell, Vol. 70, Issue 4, pp. 523-6, 1992

Images

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Supplier Images
Western Blotting (WB) image for anti-p53 antibody (Tumor Protein P53) (ABIN2664003) anti-Tumor Protein P53 (TP53) antibody