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|Antigen||Tumor Protein P53 (TP53) Antibodies|
|Epitope||AA 240-290, Wild Type Alternatives|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This p53 antibody is un-conjugated Alternatives|
Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|4 references available|
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Product Details anti-p53 AntibodyTarget Details p53 Application Details Handling References for anti-p53 antibody (ABIN723935) Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human P53|
Target Details p53Product Details anti-p53 Antibody Application Details Handling References for anti-p53 antibody (ABIN723935) Images back to top
|Alternative Name||P53 Protein (TP53 Antibody Abstract)|
Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Subcellular location: Cytoplasm, Nucleus
Synonyms: P53, BCC7, LFS1, TRP53, Cellular tumor antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53
|Pathways||p53 Signaling, MAPK Signaling, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy|
Application DetailsProduct Details anti-p53 Antibody Target Details p53 Handling References for anti-p53 antibody (ABIN723935) Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-p53 Antibody Target Details p53 Application Details References for anti-p53 antibody (ABIN723935) Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
References for anti-p53 antibody (ABIN723935)Product Details anti-p53 Antibody Target Details p53 Application Details Handling Images back to top
|Product cited in:||
Wang, Liu, Liu, Chen, Liu, Kuang: "Hypoxia Inhibits Myogenic Differentiation through p53 Protein-dependent Induction of Bhlhe40 Protein." in: The Journal of biological chemistry, Vol. 290, Issue 50, pp. 29707-16, 2015
Hong, Shen, Liu, Li, Huang, Shi: "Developmental toxicity of three hexabromocyclododecane diastereoisomers in embryos of the marine medaka Oryzias melastigma." in: Marine pollution bulletin, Vol. 101, Issue 1, pp. 110-8, 2015
Chen, Shi, Liu, Fang, Zhang, Zhao: "Targeting SPARC by lentivirus-mediated RNA interference inhibits cervical cancer cell growth and metastasis." in: BMC cancer, Vol. 12, pp. 464, 2012 (1:1000).
Carry, Banssillon: "[Intra-abdominal pressure]." in: Annales francaises d'anesthesie et de reanimation, Vol. 13, Issue 3, pp. 381-99, 1995 Method employed by authors: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (Sample species: Rat (Rattus)).
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