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Browse our p53 Proteins (TP53)

Full name:
Tumor Protein P53 Proteins (TP53)
On are 78 Tumor Protein P53 (TP53) Proteins from 18 different suppliers available. Additionally we are shipping p53 Antibodies (1863) and p53 Kits (128) and many more products for this protein. A total of 2232 p53 products are currently listed.
bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, LFS1, p44, P53, Tp53, TpMs, Trp53, wu:fb40d06, Xp53, zgc:111919
list all proteins Gene Name GeneID UniProt
TP53 22059 P02340
TP53 84260 Q9BT92
Rat TP53 TP53 24842 P10361

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p53 Proteins (TP53) by Origin

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Top referenced p53 Proteins

  1. Cynomolgus p53 Protein expressed in Escherichia coli (E. coli) - ABIN2009672 : Korpelainen, Kärkkäinen, Gunji, Vikkula, Alitalo: Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. in Oncogene 1999 (PubMed)
    Show all 4 references for ABIN2009672

  2. Human p53 Protein expressed in Escherichia coli (E. coli) - ABIN1046804 : Zakut-Houri, Bienz-Tadmor, Givol, Oren: Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. in The EMBO journal 1985 (PubMed)
    Show all 3 references for ABIN1046804

  3. Human p53 Protein expressed in Wheat germ - ABIN1323380 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)
    Show all 2 references for ABIN1323380

More Proteins for p53 Interaction Partners

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

  1. Microwave radiation leads to oxidative/nitrosative stress induced p53-dependent/independent activation of hippocampal neuronal and nonneuronal apoptosis associated with spatial memory loss.

  2. These studies support a direct relationship between p53 mutations and GLDC (show GLDC Proteins) expression in B cell lymphoma.

  3. ISCU (show ISCU Proteins) expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 mutation.

  4. Hyperactive mTOR (show FRAP1 Proteins) signaling combined with loss of p53 in mice induces tumors similar to human acinar cell carcinoma.

  5. gene deletion in Bcl-2 (show BCL2 Proteins)-/- mice inhibits apoptosis induction in spleen and hair follicle melanocytes and keratinocytes, but not in kidney

  6. The expression of Trp53 was increased in tumor transplants undergoing oncogene (show RAB1A Proteins)-induced senescence. Trp53 inactivation reversed this.

  7. Mild p53 activation in the myeloid linage attenuates tumor development and suppresses alternative macrophage polarization together with c-MYC (show MYC Proteins) downregulation.

  8. A nonsynonymous single-nucleotide polymorphism at codon 47 in TP53 (S47) exhibits a modest decrease in apoptosis in response to most genotoxic stresses compared with wild-type p53 but exhibits a significant defect in cell death induced by cisplatin.

  9. inhibition of UBF (show UBTF Proteins) function is a major factor in the cytotoxicity of cisplatin; its depletion selectively induces p53-independent apoptotic death in transformed cells

  10. There is a p53 dependent downregulation of Fanc genes in Fanconi Anaemia.

Human Tumor Protein P53 (TP53) interaction partners

  1. Findings suggest that silibinin's efficacy against UVB-induced photodamage is primarily by inhibiting nucleotide excision repair (NER (show NR1H2 Proteins)) and tumor protein p53.

  2. TRIM65 is a potential oncogenic protein, highly likely through p53 inactivation

  3. loss of Che-1 (show BCHE Proteins) inhibits proliferation and promotes apoptosis in MG-63 cells by decreasing the level of mutant p53

  4. that miR-4516 mediated down-regulation of UBE2N promotes p53 nuclear translocation and pro-apoptotic activity of PUVA is independent of IRF3 but is mediated by the RIG-I in a p53 and NFkappaB dependent manner

  5. Point mutations in TP53 but not in p15(Ink4b (show CDKN2B Proteins)) and p16(Ink4a) genes represent poor prognosis factors in acute adult T cell leukemia/lymphoma

  6. p53 level is diminished during replicative senescence and oncogene (show RAB1A Proteins)-induced senescence, and that such diminution is associated with H3 deacetylation at the p53 promoter. The reduced intracellular p53 level in keratinocytes of the elderly could be a contributing factor for more frequent development of epithelial cancer in the elderly because of the loss of genomic integrity of cells

  7. ATRX (show ATRX Proteins) loss may predict better clinical outcome in astrocytoma patients with p53 overexpression as compared to patients with wild-type ATRX (show ATRX Proteins)

  8. R337H mutation of the TP53 gene has significant predictive and prognostic value and is associated with tumorigenesis of the adrenal cortex.

  9. DNA damage induced necrosis through a PARP1 (show PARP1 Proteins)-dependent and p53-independent pathway.

  10. Studies indicate that Programmed Cell Death 5 (PDCD5 (show PDCD5 Proteins)) interacts with the tumor protein p53 (p53) pathway to promote cell apoptosis.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

  1. SIRT1 (show SIRT1 Proteins), p53 and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  2. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

  3. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Proteins)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Proteins)).

  4. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Proteins) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

  5. role of transcription factor p53 and the metabolic hormone leptin (show LEP Proteins), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

  6. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

  7. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Proteins) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

  8. Suppressive effect of FSH (show BRD2 Proteins) and LH on p53 expression and caspase-3 (show CASP3 Proteins) activity with parallel increase in bcl-2 (show BCL2 Proteins) expression and increased P production was observed.

  9. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

  10. exogenous in vivo NO treatment seems to preserve VSMC from mitochondrial-dependent apoptosis and drive cells to quiescence through p53 increase

Rabbit Tumor Protein P53 (TP53) interaction partners

  1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

  2. These results suggest that p38 MAPK (show MAPK14 Proteins) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Proteins) plays a role by way of stimulating NF-kappaB (show NFKB1 Proteins), p53 and caspase-3 (show CASP3 Proteins) activation.

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Proteins) proteins.

  4. Chronically activated, monomeric PDGFRA (show PDGFRA Proteins) induced prolonged activation of Akt (show AKT1 Proteins) and suppressed the level of p53.

  5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

  1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

  2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Proteins), regulates p53-dependent and p53-independent apoptosis during development.

  3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

  4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A (show DNMT3A Proteins) are reported.

  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

  3. PI3K/Akt (show AKT1 Proteins) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

  1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

  1. Expression of p53 and Ki67 (show MKI67 Proteins) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

  2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Zebrafish Tumor Protein P53 (TP53) interaction partners

  1. C/ebpalpha (show CEBPA Proteins) plays a role in liver growth regulation via the p53 pathway.

  2. Results demonstrate a novel role of Klf8 (show KLF8 Proteins), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

  3. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

  4. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (show MDM2 Proteins) pathway.

  5. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

  6. The crystal structure of the zebrafish p53 tetramerization domain.

  7. The identification of novel p53 isoforms with anti-apoptosis function generated due to alternative splicing of intron 8 of p53.

  8. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner.

  9. By the loss-of-function of p53.

  10. Data suggest that the co-inhibition of Tp53 activity rescued the morphological deformities but did not alleviate the erythroid aplasia indicating that ribosomal protein deficiency causes erythroid failure in a Tp53-independent manner.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

  1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

p53 (TP53) Protein Profile

Protein Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Alternative names and synonyms associated with p53 (TP53)

  • cellular tumor antigen p53 (CpipJ_CPIJ002758)
  • tumor protein p53 (TP53)
  • tumor supressor p53 (tp53)
  • p53 tumor suppressor (P53)
  • transformation related protein 53 (Trp53)
  • transformation related protein 53, pseudogene (Trp53-ps)
  • trichoplein, keratin filament binding (TCHP)
  • tumor protein p53 (Tp53)
  • tumor protein p53 (tp53)
  • Wistar clone pR53P1 p53 pseudogene (p53-ps)
  • bbl protein
  • BCC7 protein
  • bfy protein
  • bhy protein
  • brp53 protein
  • drp53 protein
  • etID22686.5 protein
  • fb40d06 protein
  • LFS1 protein
  • p44 protein
  • P53 protein
  • Tp53 protein
  • TpMs protein
  • Trp53 protein
  • wu:fb40d06 protein
  • Xp53 protein
  • zgc:111919 protein

Protein level used designations for Tumor Protein P53 Proteins (TP53)

cellular tumor antigen p53 , tumor protein p53 (Li-Fraumeni syndrome) , tumor supressor p53 , Tumor suppressor p53 , Cellular tumor antigen p53 , p53 cellular tumor antigen , tumor suppressor p53 , mitochondrial protein with oncostatic activity , mitostatin , trichoplein keratin filament-binding protein , tumor suppressor protein , antigen NY-CO-13 , p53 tumor suppressor , phosphoprotein p53 , transformation-related protein 53 , transformation related protein 53 , Li-Fraumeni syndrome , tumor suppressor protein p53 , p53 tumor suppressor phosphoprotein , tumor protein 53 , P53 , tumor suppressing protein

6033952 Culex quinquefasciatus
455214 Pan troglodytes
100304476 Ictalurus punctatus
100682525 Cricetulus griseus
22059 Mus musculus
22060 Mus musculus
84260 Homo sapiens
7157 Homo sapiens
24842 Rattus norvegicus
443421 Ovis aries
403869 Canis lupus familiaris
397276 Sus scrofa
100009292 Oryctolagus cuniculus
397926 Xenopus laevis
281542 Bos taurus
100379269 Cavia porcellus
493847 Felis catus
396200 Gallus gallus
100062044 Equus caballus
716170 Macaca mulatta
30590 Danio rerio
100136737 Oncorhynchus mykiss
301300 Rattus norvegicus
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