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Browse our p53 Proteins (TP53)

Full name:
Tumor Protein P53 Proteins (TP53)
On www.antibodies-online.com are 84 Tumor Protein P53 (TP53) Proteins from 17 different suppliers available. Additionally we are shipping p53 Antibodies (2238) and p53 Kits (139) and many more products for this protein. A total of 2626 p53 products are currently listed.
Synonyms:
bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, LFS1, p44, P53, Tp53, TpMs, Trp53, wu:fb40d06, Xp53, zgc:111919
list all proteins Gene Name GeneID UniProt
TP53 22059 P02340
TP53 84260 Q9BT92
Rat TP53 TP53 24842 P10361

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p53 Proteins (TP53) by Origin

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Top referenced p53 Proteins

  1. Cynomolgus p53 Protein expressed in Escherichia coli (E. coli) - ABIN2009672 : Korpelainen, Kärkkäinen, Gunji, Vikkula, Alitalo: Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. in Oncogene 1999 (PubMed)
    Show all 4 references for ABIN2009672

  2. Human p53 Protein expressed in Escherichia coli (E. coli) - ABIN1046804 : Zakut-Houri, Bienz-Tadmor, Givol, Oren: Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. in The EMBO journal 1985 (PubMed)
    Show all 3 references for ABIN1046804

  3. Human p53 Protein expressed in HEK-293 Cells - ABIN2734068 : Li, Xia, Su, Qin, Chen, Li, Dong, Ding, Li, Huang, Ge, Hou, Wang, Sun, Bai, Shen, Fang, Liu, Zhang, Zhang, Zhang, Shao: Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse. in Scientific reports 2016 (PubMed)
    Show all 2 references for ABIN2734068

  4. Human p53 Protein expressed in Wheat germ - ABIN1323380 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)
    Show all 2 references for ABIN1323380

More Proteins for p53 Interaction Partners

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

  1. These findings suggest that Mdm2 (show MDM2 Proteins) splice isoforms may play critical roles in the regulatory loop of p53/Mdm2 (show MDM2 Proteins)-Mdm4 (show MDM4 Proteins) via a RING domain-mediated biochemical mechanism.

  2. Findings revealed that fluoxetine protects against IL-1beta (show IL1B Proteins)-induced neuronal apoptosis via p38 (show CRK Proteins)-p53 dependent pathway, which give us an insight into the potential of fluoxetine in terms of opening up novel therapeutic avenues for neurological diseases including stroke

  3. APC (show APC Proteins) haploinsufficiency coupled with p53 deletion resulted in the development of a distinct type of pancreatic premalignant precursors, mucinous cystic neoplasms (MCNs)

  4. Activation of PTHrP-cyclic AMP (show TMPRSS5 Proteins)-CREB1 (show CREB1 Proteins) signaling following p53 loss is essential for osteosarcoma initiation and maintenance.

  5. Longitudinal microcomputed tomography (muCT) imaging and histopathological analyses revealed an increased rate of cyst formation, increased proportion of cysts with proliferating cells, higher frequency of atypical cysts as well as the development of neoplasms in Vhl (show VHL Proteins)/Kif3a (show KIF3A Proteins)/Trp53 mutant kidneys compared to Kif3a (show KIF3A Proteins)/Trp53 or Vhl (show VHL Proteins)/Kif3a (show KIF3A Proteins) mutant kidneys.

  6. The mutant p53-proteasome axis globally affects protein homeostasis, inhibiting multiple tumour-suppressive pathways

  7. in mouse models, both p53-dependent and p53-independent apoptosis are important to suppressing tumor formation.

  8. both MDM2 (show MDM2 Proteins) and MDMX (show MDM4 Proteins) deletion-caused pancreatic defects are completely rescued by loss of p53, verifying the crucial role of the MDM2 (show MDM2 Proteins) and/or MDMX (show MDM4 Proteins) in regulating p53 in a spatio-temporal manner during the development, functional maintenance, and related disease progress of endocrine pancreas.

  9. nuclear Ect2 (show ECT2 Proteins) GEF (show ARHGEF2 Proteins) activity is required for Kras-Trp53 lung tumorigenesis in vivo and that Ect2 (show ECT2 Proteins)-mediated transformation requires Ect2 (show ECT2 Proteins)-dependent rDNA transcription.

  10. p53 knockout reduced viral replication in the brains of mice and led to significantly reduced rates of mortality due to herpes simplex encephalitis.

Human Tumor Protein P53 (TP53) interaction partners

  1. TP53 mutations were significantly more frequent in cases with a larger deletion size (P = 0.003). The results suggest a correlation of large del(5q) with TP53 mutations and with additional chromosomal aberrations possibly contributing to more severe courses of these cases.

  2. Study identified TP53 and RET (show RET Proteins) among the most mutated oncogenes in hepatocellular carcinoma to be associated with lower overall survival.

  3. The anti-proliferative effect of silibinin on LX-2 human stellate cells is via the inhibition of the expressions of various cell cycle targets including TP53, p27 (show PAK2 Proteins), Akt (show AKT1 Proteins) and sirtuins.

  4. RASSF10 induces apoptosis in papillary thyroid carcinoma (PTC (show F9 Proteins)) cells by activating the p53 signaling pathway, indicating its role as a treatment target for PTC (show F9 Proteins).

  5. These findings suggest that Mdm2 (show MDM2 Proteins) splice isoforms may play critical roles in the regulatory loop of p53/Mdm2 (show MDM2 Proteins)-Mdm4 (show MDM4 Proteins) via a RING domain-mediated biochemical mechanism.

  6. We conclude that TP53 mutations predict sensitivity to VEGF (show VEGFA Proteins)/VEGFR (show KDR Proteins) inhibitors in the clinic. TP53 alterations may therefore be a ready biomarker for treatment with antiangiogenesis agents, a finding of seminal importance across the cancer field.

  7. Data showed elevated expression of p53 in all the megaloblastic anemia samples indicating that p53 is the primary cause for the induction of apoptosis in megaloblast cells isolated from pernicious anemia patients.

  8. Collectively, our findings present the first to elucidate that miR (show MLXIP Proteins)-29c is a direct p53 target gene, and also identify PHLDB2 as an important miR (show MLXIP Proteins)-29c target gene involved in colon cancer metastasis.

  9. knockdown of HMGI-C led to the significant induction of apoptosis via mitochondrial pathway by inducing miR34a and cell cycle arrest in MDA-MB-468 cells in vitro.

  10. These findings suggested that CNPY2 (show CNPY2 Proteins) promoted cancer cell growth in renal cell carcinoma (show MOK Proteins) cells through regulating TP53 gene expression.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

  1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

  2. SIRT1 (show SIRT1 Proteins), p53 and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

  4. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Proteins)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Proteins)).

  5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Proteins) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

  6. role of transcription factor p53 and the metabolic hormone leptin (show LEP Proteins), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

  7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

  8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Proteins) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

  9. Suppressive effect of FSH (show BRD2 Proteins) and LH on p53 expression and caspase-3 (show CASP3 Proteins) activity with parallel increase in bcl-2 (show BCL2 Proteins) expression and increased P production was observed.

  10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

  1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

  2. These results suggest that p38 MAPK (show MAPK14 Proteins) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Proteins) plays a role by way of stimulating NF-kappaB (show NFKB1 Proteins), p53 and caspase-3 (show CASP3 Proteins) activation.

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Proteins) proteins.

  4. Chronically activated, monomeric PDGFRA (show PDGFRA Proteins) induced prolonged activation of Akt (show AKT1 Proteins) and suppressed the level of p53.

  5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

  1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

  2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Proteins), regulates p53-dependent and p53-independent apoptosis during development.

  3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

  4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A (show DNMT3A Proteins) are reported.

  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

  3. PI3K/Akt (show AKT1 Proteins) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

  1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

  1. Expression of p53 and Ki67 (show MKI67 Proteins) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

  2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Zebrafish Tumor Protein P53 (TP53) interaction partners

  1. C/ebpalpha (show CEBPA Proteins) plays a role in liver growth regulation via the p53 pathway.

  2. Results demonstrate a novel role of Klf8 (show KLF8 Proteins), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

  3. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

  4. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (show MDM2 Proteins) pathway.

  5. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

  6. The crystal structure of the zebrafish p53 tetramerization domain.

  7. The identification of novel p53 isoforms with anti-apoptosis function generated due to alternative splicing of intron 8 of p53.

  8. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner.

  9. By the loss-of-function of p53.

  10. Data suggest that the co-inhibition of Tp53 activity rescued the morphological deformities but did not alleviate the erythroid aplasia indicating that ribosomal protein deficiency causes erythroid failure in a Tp53-independent manner.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

  1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

p53 (TP53) Protein Profile

Protein Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Alternative names and synonyms associated with p53 (TP53)

  • cellular tumor antigen p53 (CpipJ_CPIJ002758)
  • tumor protein p53 (TP53)
  • tumor supressor p53 (tp53)
  • p53 tumor suppressor (P53)
  • transformation related protein 53 (Trp53)
  • transformation related protein 53, pseudogene (Trp53-ps)
  • trichoplein, keratin filament binding (TCHP)
  • tumor protein p53 (Tp53)
  • tumor protein p53 (tp53)
  • Wistar clone pR53P1 p53 pseudogene (p53-ps)
  • bbl protein
  • BCC7 protein
  • bfy protein
  • bhy protein
  • brp53 protein
  • drp53 protein
  • etID22686.5 protein
  • fb40d06 protein
  • LFS1 protein
  • p44 protein
  • P53 protein
  • Tp53 protein
  • TpMs protein
  • Trp53 protein
  • wu:fb40d06 protein
  • Xp53 protein
  • zgc:111919 protein

Protein level used designations for Tumor Protein P53 Proteins (TP53)

cellular tumor antigen p53 , tumor protein p53 (Li-Fraumeni syndrome) , tumor supressor p53 , Tumor suppressor p53 , Cellular tumor antigen p53 , p53 cellular tumor antigen , tumor suppressor p53 , mitochondrial protein with oncostatic activity , mitostatin , trichoplein keratin filament-binding protein , tumor suppressor protein , antigen NY-CO-13 , p53 tumor suppressor , phosphoprotein p53 , transformation-related protein 53 , transformation related protein 53 , Li-Fraumeni syndrome , tumor suppressor protein p53 , p53 tumor suppressor phosphoprotein , tumor protein 53 , P53 , tumor suppressing protein

GENE ID SPECIES
6033952 Culex quinquefasciatus
455214 Pan troglodytes
100304476 Ictalurus punctatus
100682525 Cricetulus griseus
22059 Mus musculus
22060 Mus musculus
84260 Homo sapiens
7157 Homo sapiens
24842 Rattus norvegicus
443421 Ovis aries
403869 Canis lupus familiaris
397276 Sus scrofa
100009292 Oryctolagus cuniculus
397926 Xenopus laevis
281542 Bos taurus
100379269 Cavia porcellus
493847 Felis catus
396200 Gallus gallus
100062044 Equus caballus
716170 Macaca mulatta
30590 Danio rerio
100136737 Oncorhynchus mykiss
301300 Rattus norvegicus
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