Browse our p53 Proteins (TP53)

Full name:
Tumor Protein P53 Proteins (TP53)
On www.antibodies-online.com are 84 Tumor Protein P53 (TP53) Proteins from 17 different suppliers available. Additionally we are shipping p53 Antibodies (2362) and p53 Kits (139) and many more products for this protein. A total of 2750 p53 products are currently listed.
Synonyms:
bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, LFS1, p44, P53, Tp53, TpMs, Trp53, wu:fb40d06, Xp53, zgc:111919
list all proteins Gene Name GeneID UniProt
TP53 22059 P02340
TP53 84260 Q9BT92
Rat TP53 TP53 24842 P10361

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p53 Proteins (TP53) by Origin

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Top referenced p53 Proteins

  1. Cynomolgus p53 Protein expressed in Escherichia coli (E. coli) - ABIN2009672 : Korpelainen, Kärkkäinen, Gunji, Vikkula, Alitalo: Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. in Oncogene 1999 (PubMed)
    Show all 4 references for 2009672

  2. Human p53 Protein expressed in Escherichia coli (E. coli) - ABIN1046804 : Zakut-Houri, Bienz-Tadmor, Givol, Oren: Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. in The EMBO journal 1985 (PubMed)
    Show all 3 references for 1046804

  3. Human p53 Protein expressed in HEK-293 Cells - ABIN2734068 : Li, Xia, Su, Qin, Chen, Li, Dong, Ding, Li, Huang, Ge, Hou, Wang, Sun, Bai, Shen, Fang, Liu, Zhang, Zhang, Zhang, Shao: Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse. in Scientific reports 2016 (PubMed)
    Show all 2 references for 2734068

  4. Human p53 Protein expressed in Wheat germ - ABIN1323380 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)
    Show all 2 references for 1323380

More Proteins for p53 Interaction Partners

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

  1. p53(-/-) synergizes with enhanced oncogenic Nras (show NRAS Proteins) signaling to transform megakaryocyte-erythroid progenitors and drive AML (show RUNX1 Proteins) development

  2. Exercise activates p53 protein in skin epidermis.

  3. findings position p53 as a novel molecular determinant of thymic epithelium function throughout life.

  4. pancreatic ductal cells, whereas exhibiting relative resistance to oncogenic Kras alone, can serve as an effective cell of origin for pancreatic ductal adenocarcinoma in the setting of gain-of-function mutations in p53

  5. USP7 (show USP7 Proteins) inhibition is selectively cytotoxic to CLL cells independently of ATM (show ATM Proteins) and p53 and synergizes with chemotherapy.

  6. Fractionated exposure to low doses of X-rays resulted in accumulation of DNA damage in the murine spleen and induction of apoptotic response in p53/Atm (show ATM Proteins)-independent manner. Further studies are needed to understand the outcomes and molecular mechanisms underlying cellular responses and early induction of p38 (show CRK Proteins) in response to prolonged exposure to IR.

  7. these studies define mechanisms by which p53 regulates thrombus resolution by increasing inflammatory vascular remodeling of venous thrombi in vivo, and the potential therapeutic application of a p53 agonist as a treatment to accelerate this process in patients with DVT.

  8. Data suggest that tumor suppressor protein p53 has a limited contribution to the development of injury in the immature/juvenile brain following hypoxia-ischemia (HI).

  9. an intricate link between caveolin-1 (show CAV1 Proteins) and Src kinase (show CSK Proteins)-mediated cell signaling and alveolar epithelial cell apoptosis due to loss of SP-C (show SFTPC Proteins) expression through p53 and uPA (show PLAU Proteins) system-mediated cross-talk, is reported.

  10. loss of the BH3-only (show BBC3 Proteins) protein BIM (show BCL2L11 Proteins) accelerated lymphoma development in p53-deficient mice. This process was negated by concomitant loss of RAG1 (show RAG1 Proteins)/2-mediated antigen receptor gene rearrangement.

Human Tumor Protein P53 (TP53) interaction partners

  1. p53 could be altered in benign-appearing breast glands in patients with high-grade breast carcinomas.

  2. Although TP53 and BAX (show BAX Proteins) immunoreactivity levels were associated with some clinicopathological parameters of the patients, the expression of EP300 (show EP300 Proteins), TP53 and BAX (show BAX Proteins) did not reveal any prognostic significance in ccRCC

  3. Patients with esophageal adenocarcinoma and TP53 gene mutations have reduced overall survival compared with patients without these mutations, and this effect is independent of tumor stage (Meta -Analysis)

  4. TRIB3 (show TRIB3 Proteins) promotes acute promyelocytic leukemia (show PML Proteins) progression through stabilization of the oncoprotein PML (show PML Proteins)-RARalpha (show RARA Proteins) and inhibition of p53-mediated senescence.

  5. these findings indicate that reduced levels of HSPA9 (show HSPA9 Proteins) may contribute to TP53 activation and increased apoptosis observed in del(5q)-associated MDS (show PAFAH1B1 Proteins).

  6. Results indicate a pathway via which microRNA miR-17-5p inhibits STAT3 (show STAT3 Proteins) and increases p53 expression to promote apoptosis in breast cancer cells.

  7. TP53 Mutations are associated with Head and Neck Squamous Cell Carcinoma.

  8. the genotype Pro/Pro in p53 might be associated with a major risk for developing pre-senile cataract

  9. Dmp1 (show DMP1 Proteins) (Dmp1alpha) physically interacts with p53, stabilizes p53's binding to its target genes, and increases the transcriptional activity of p53.

  10. Chromatin-bound MDM2 (show MDM2 Proteins) regulates serine metabolism and redox homeostasis independently of p53 status in tumor cells.

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

  1. This study demonstrated that various expression levels of p53 in porcine fibroblasts could be achieved by gene targeting and RNA interference.

  2. SIRT1 (show SIRT1 Proteins), p53 and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  3. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

  4. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Proteins)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Proteins)).

  5. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Proteins) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

  6. role of transcription factor p53 and the metabolic hormone leptin (show LEP Proteins), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

  7. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

  8. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Proteins) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

  9. Suppressive effect of FSH (show BRD2 Proteins) and LH on p53 expression and caspase-3 (show CASP3 Proteins) activity with parallel increase in bcl-2 (show BCL2 Proteins) expression and increased P production was observed.

  10. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

Rabbit Tumor Protein P53 (TP53) interaction partners

  1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

  2. These results suggest that p38 MAPK (show MAPK14 Proteins) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Proteins) plays a role by way of stimulating NF-kappaB (show NFKB1 Proteins), p53 and caspase-3 (show CASP3 Proteins) activation.

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Proteins) proteins.

  4. Chronically activated, monomeric PDGFRA (show PDGFRA Proteins) induced prolonged activation of Akt (show AKT1 Proteins) and suppressed the level of p53.

  5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

  1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

  2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Proteins), regulates p53-dependent and p53-independent apoptosis during development.

  3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

  4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A (show DNMT3A Proteins) are reported.

  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

  3. PI3K/Akt (show AKT1 Proteins) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

  1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

  1. Expression of p53 and Ki67 (show MKI67 Proteins) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

  2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Zebrafish Tumor Protein P53 (TP53) interaction partners

  1. C/ebpalpha (show CEBPA Proteins) plays a role in liver growth regulation via the p53 pathway.

  2. Results demonstrate a novel role of Klf8 (show KLF8 Proteins), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

  3. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

  4. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (show MDM2 Proteins) pathway.

  5. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

  6. The crystal structure of the zebrafish p53 tetramerization domain.

  7. The identification of novel p53 isoforms with anti-apoptosis function generated due to alternative splicing of intron 8 of p53.

  8. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner.

  9. By the loss-of-function of p53.

  10. Data suggest that the co-inhibition of Tp53 activity rescued the morphological deformities but did not alleviate the erythroid aplasia indicating that ribosomal protein deficiency causes erythroid failure in a Tp53-independent manner.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

  1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

p53 (TP53) Protein Profile

Protein Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Alternative names and synonyms associated with p53 (TP53)

  • cellular tumor antigen p53 (CpipJ_CPIJ002758)
  • tumor protein p53 (TP53)
  • tumor supressor p53 (tp53)
  • p53 tumor suppressor (P53)
  • transformation related protein 53 (Trp53)
  • transformation related protein 53, pseudogene (Trp53-ps)
  • trichoplein, keratin filament binding (TCHP)
  • tumor protein p53 (Tp53)
  • tumor protein p53 (tp53)
  • Wistar clone pR53P1 p53 pseudogene (p53-ps)
  • bbl protein
  • BCC7 protein
  • bfy protein
  • bhy protein
  • brp53 protein
  • drp53 protein
  • etID22686.5 protein
  • fb40d06 protein
  • LFS1 protein
  • p44 protein
  • P53 protein
  • Tp53 protein
  • TpMs protein
  • Trp53 protein
  • wu:fb40d06 protein
  • Xp53 protein
  • zgc:111919 protein

Protein level used designations for Tumor Protein P53 Proteins (TP53)

cellular tumor antigen p53 , tumor protein p53 (Li-Fraumeni syndrome) , tumor supressor p53 , Tumor suppressor p53 , Cellular tumor antigen p53 , p53 cellular tumor antigen , tumor suppressor p53 , mitochondrial protein with oncostatic activity , mitostatin , trichoplein keratin filament-binding protein , tumor suppressor protein , antigen NY-CO-13 , p53 tumor suppressor , phosphoprotein p53 , transformation-related protein 53 , transformation related protein 53 , Li-Fraumeni syndrome , tumor suppressor protein p53 , p53 tumor suppressor phosphoprotein , tumor protein 53 , P53 , tumor suppressing protein

GENE ID SPECIES
6033952 Culex quinquefasciatus
455214 Pan troglodytes
100304476 Ictalurus punctatus
100682525 Cricetulus griseus
22059 Mus musculus
22060 Mus musculus
84260 Homo sapiens
7157 Homo sapiens
24842 Rattus norvegicus
443421 Ovis aries
403869 Canis lupus familiaris
397276 Sus scrofa
100009292 Oryctolagus cuniculus
397926 Xenopus laevis
281542 Bos taurus
100379269 Cavia porcellus
493847 Felis catus
396200 Gallus gallus
100062044 Equus caballus
716170 Macaca mulatta
30590 Danio rerio
100136737 Oncorhynchus mykiss
301300 Rattus norvegicus
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