You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our p53 Proteins (TP53)

Full name:
Tumor Protein P53 Proteins (TP53)
On www.antibodies-online.com are 78 Tumor Protein P53 (TP53) Proteins from 18 different suppliers available. Additionally we are shipping p53 Antibodies (2173) and p53 Kits (116) and many more products for this protein. A total of 2530 p53 products are currently listed.
Synonyms:
bbl, BCC7, bfy, bhy, brp53, drp53, etID22686.5, fb40d06, LFS1, p44, P53, Tp53, TpMs, Trp53, wu:fb40d06, Xp53, zgc:111919
list all proteins Gene Name GeneID UniProt
TP53 22059 P02340
TP53 84260 Q9BT92
Rat TP53 TP53 24842 P10361

Show all synonyms

p53 Proteins (TP53) by Origin

Select your origin of interest

Top referenced p53 Proteins

  1. Cynomolgus p53 Protein expressed in Escherichia coli (E. coli) - ABIN2009672 : Korpelainen, Kärkkäinen, Gunji, Vikkula, Alitalo: Endothelial receptor tyrosine kinases activate the STAT signaling pathway: mutant Tie-2 causing venous malformations signals a distinct STAT activation response. in Oncogene 1999 (PubMed)
    Show all 4 references for ABIN2009672

  2. Human p53 Protein expressed in Escherichia coli (E. coli) - ABIN1046804 : Zakut-Houri, Bienz-Tadmor, Givol, Oren: Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. in The EMBO journal 1985 (PubMed)
    Show all 3 references for ABIN1046804

  3. Human p53 Protein expressed in Wheat germ - ABIN1323380 : Huang, Jeong, Okamura, Sook-Kim, Zhu, Guerrero-Preston, Ratovitski: Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. in Cell cycle (Georgetown, Tex.) 2012 (PubMed)
    Show all 2 references for ABIN1323380

More Proteins for p53 Interaction Partners

Mouse (Murine) Tumor Protein P53 (TP53) interaction partners

  1. Study suggests that p53 is transcriptionally active in the brains of Down syndrome individuals and is associated with an increase in apoptotic markers in the presence of Alzheimer's disease pathology

  2. MYSM1 (show MYSM1 Proteins) is a critical negative regulator of p53 transcriptional programs in hematopoiesis, and its repression of Bbc3/PUMA (show BBC3 Proteins) expression is essential for multipotent progenitor survival, and partly contributes to maintaining hematopoietic stem cell function

  3. Therapeutic response to non-genotoxic activation of p53 by Nutlin3a is driven by PUMA (show BBC3 Proteins)-mediated apoptosis in lymphoma cells.

  4. Jmjd5 (show JMJD5 Proteins) is involved in the transcriptional regulation of a subset of p53-regulated genes, possibly through the control of p53 recruitment at the gene loci.

  5. results suggest that by inducing an atypical ISR and p53-independent apoptosis, ONC201 has clinical potential in hematological malignancies.

  6. alpha-synuclein as a new transcriptional target of p53 and delineated a cellular mechanism feeding the accumulation of toxic aggregated alpha-synuclein in Parkinson's disease

  7. The novel mechanism of IL-15 (show IL15 Proteins) transfer to the surface of antigen-processing DCs may explain the enhanced potency of IL-15 (show IL15 Proteins):IL-15Ralpha-coated nanoparticles for antigen delivery.

  8. Results indicate that Rb and p53 not only function as tumor suppressors in response to carcinogenic injury, but also in response to non-carcinogenic injury.

  9. Data show that combined deletion of X-ray repair cross-complementing protein 4 (Xrcc4 (show XRCC4 Proteins)) and tumor suppressor p53 (Trp53) predisposes B cells to lymphomagenesis.

  10. Data show that the Mdm4 (show MDM4 Proteins)-p73 (show ARHGAP24 Proteins) axis cannot override the dominant role of p53 in development and tumorigenesis and that Mdm4 (show MDM4 Proteins) and p73 (show ARHGAP24 Proteins) interaction during development and tumorigenesis suggests new insight into the role of p53 family members.

Human Tumor Protein P53 (TP53) interaction partners

  1. This study demonstrated that RRP12 was crucial for cell survival during cytotoxic stress via the repression of p53 stability. Thus, targeting RRP12 may enhance chemotherapeutic effect in cancers

  2. inhibiting the expression of p53 decreased the proliferation ability and induced apoptosis/autophagy in SSC (show CYP11A1 Proteins)-4 squamous carcinoma cells..

  3. Our finding suggests that TP53 (Arg72Pro) polymorphism may play a significant role as risk factor for breast cancer in north Indian breast cancer patients

  4. TP53 mutation occurs in the early stages of colorectal cancer development from adenoma in both granular and non-granular laterally spreading tumors--but is involved at an earlier stage in non-granular laterally spreading tumors

  5. By changing Bax (show BAX Proteins)/Bcl-2 (show BCL2 Proteins) ratio (about 4-fold increase) and p53 (5-fold increase) activation.

  6. Data show that tumor supressor p53 (p53) binding to telomeric G-quadruplexes increases with the number of telomeric repeats.

  7. The repair capacity of lung cancer cell lines A549 and H1299 depends on HMGB1 (show HMGB1 Proteins) expression level and the p53 status.

  8. Findings reveal a novel mechanism by which p53 utilizes TFIIS.h (show TCEA3 Proteins) to selectively promote the transcriptional elongation of the bax (show BAX Proteins) gene, upsurging cell death in response to severe DNA damage.

  9. the role of miR (show MLXIP Proteins)-30 in the development of Gastric cancer

  10. There is no association between P53 codon 72 polymorphism and increased risk of lung cancer in patients and controls but according to results of adenocarcinoma in never-smoker patients

Pig (Porcine) Tumor Protein P53 (TP53) interaction partners

  1. SIRT1 (show SIRT1 Proteins), p53 and NF-kappaB (show NFKB1 Proteins) are involved in the control of both the proliferation and the apoptosis of ovarian cells.

  2. Taken together,these results demonstrated that Porcine parvovirus infection induced apoptosis in PK-15 cells through activation of p53 and mitochondria-mediated apoptosis pathway.

  3. Data indicate that higher hepatic glucocorticoid receptor (GR (show NR3C1 Proteins)) expression in EHL piglets attributes mainly to the enhanced transcription of GR promoter 1-9/10 from breed-specific interaction of p53 and specificity protein 1 (Sp1 (show SP1 Proteins)).

  4. Taken together, these results demonstrated that transmissible gastroenteritis virus infection promoted the activation of p38 MAPK (show MAPK14 Proteins) and p53 signalling, and p53 signalling might play a dominant role in the regulation of cell apoptosis.

  5. role of transcription factor p53 and the metabolic hormone leptin (show LEP Proteins), in controlling basic functions (proliferation, apoptosis and secretory activity) of ovarian cells

  6. differential expression of p53 pathway-related genes accounts for breed-specific skeletal muscle and meat characteristics

  7. CONCLUSION(S): (1) Apoptosis is involved in follicular atresia; (2) Bcl-2 (show BCL2 Proteins) is induced by warm ischemia; and (3) cryopreservation insult does not alter the apoptotic signals with short tissue preparation time.

  8. Suppressive effect of FSH (show BRD2 Proteins) and LH on p53 expression and caspase-3 (show CASP3 Proteins) activity with parallel increase in bcl-2 (show BCL2 Proteins) expression and increased P production was observed.

  9. p53 signaling might be a major determinant for the replicative senescence in the miniature pig fibroblast cells that have the shorter lifespan and slower growth rate compared to primary domestic pig fibroblast cells in vitro.

  10. exogenous in vivo NO treatment seems to preserve VSMC from mitochondrial-dependent apoptosis and drive cells to quiescence through p53 increase

Rabbit Tumor Protein P53 (TP53) interaction partners

  1. Suppressing expression of p53 was a required event in two assays of proliferative vitreoretinopathy.

  2. These results suggest that p38 MAPK (show MAPK14 Proteins) signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 (show MAPK14 Proteins) plays a role by way of stimulating NF-kappaB (show NFKB1 Proteins), p53 and caspase-3 (show CASP3 Proteins) activation.

  3. Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 and decrease in the antiapoptotic BCl2 (show BCL2 Proteins) proteins.

  4. Chronically activated, monomeric PDGFRA (show PDGFRA Proteins) induced prolonged activation of Akt (show AKT1 Proteins) and suppressed the level of p53.

  5. In this study evidence is provided that exogenous PGF2alpha differentially modulates luteal expression of TP53 transcripts and protein depending on luteal stage.

Xenopus laevis Tumor Protein P53 (TP53) interaction partners

  1. The stabilities of the full-length p53 orthologs were marginal and correlated with the temperature of their organism, paralleling the stability of the isolated DNA-binding domains.

  2. PP2A:B56{epsilon}, a substrate of caspase-3 (show CASP3 Proteins), regulates p53-dependent and p53-independent apoptosis during development.

  3. Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos. [SAMDC]

  4. XFDL156 actively restricts mesodermal differentiation in the presumptive ectoderm by controlling the spatiotemporal responsiveness to p53.

Cow (Bovine) Tumor Protein P53 (TP53) interaction partners

  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A (show DNMT3A Proteins) are reported.

  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes

  3. PI3K/Akt (show AKT1 Proteins) and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos.

Guinea Pig Tumor Protein P53 (TP53) interaction partners

  1. P53 may play an important role in impulse noise induced-hair cell apoptosis.

Horse (Equine) Tumor Protein P53 (TP53) interaction partners

  1. Expression of p53 and Ki67 (show MKI67 Proteins) and presence or expression of EcPV2 and EcPV3 do not appear to be important prognosticators.

  2. The allele frequency in Thoroughbred horse mares at codon 72 in exon 4 was 73.3% Arg/Pro, 17.1% Arg/Arg, 9.6% Pro/Pro. Presence of Arg/Pro was significantly associated with abortion, while Pro/Pro mares had a lower probability of abortion.

Zebrafish Tumor Protein P53 (TP53) interaction partners

  1. C/ebpalpha (show CEBPA Proteins) plays a role in liver growth regulation via the p53 pathway.

  2. Results demonstrate a novel role of Klf8 (show KLF8 Proteins), achieved via modulation of p53 and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos

  3. p53 has a limited role in eliciting the anemia phenotype of zebrafish models of Diamond-Blackfan anemia.

  4. p53 protein accumulates during tumor formation as a result of tumor-specific inactivation of the Mdm2 (show MDM2 Proteins) pathway.

  5. Apoptosis was also observed with myca expression; introduction of homozygous tp53(-/-) mutation into the myca transgenic fish reduced apoptosis and accelerated tumor progression.

  6. The crystal structure of the zebrafish p53 tetramerization domain.

  7. The identification of novel p53 isoforms with anti-apoptosis function generated due to alternative splicing of intron 8 of p53.

  8. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner.

  9. By the loss-of-function of p53.

  10. Data suggest that the co-inhibition of Tp53 activity rescued the morphological deformities but did not alleviate the erythroid aplasia indicating that ribosomal protein deficiency causes erythroid failure in a Tp53-independent manner.

Rainbow Trout (Oncorhynchus mykiss) Tumor Protein P53 (TP53) interaction partners

  1. levels of p53 in rainbow trout tissues and cell lines reported; detection of high p53 levels in gills may reflect need for elevated checkpoint readiness in a tissue that would be expected to be accessible to genotoxic compounds in the aquatic environment

p53 (TP53) Protein Profile

Protein Summary

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277).

Alternative names and synonyms associated with p53 (TP53)

  • cellular tumor antigen p53 (CpipJ_CPIJ002758)
  • tumor protein p53 (TP53)
  • tumor supressor p53 (tp53)
  • p53 tumor suppressor (P53)
  • transformation related protein 53 (Trp53)
  • transformation related protein 53, pseudogene (Trp53-ps)
  • trichoplein, keratin filament binding (TCHP)
  • tumor protein p53 (Tp53)
  • tumor protein p53 (tp53)
  • Wistar clone pR53P1 p53 pseudogene (p53-ps)
  • bbl protein
  • BCC7 protein
  • bfy protein
  • bhy protein
  • brp53 protein
  • drp53 protein
  • etID22686.5 protein
  • fb40d06 protein
  • LFS1 protein
  • p44 protein
  • P53 protein
  • Tp53 protein
  • TpMs protein
  • Trp53 protein
  • wu:fb40d06 protein
  • Xp53 protein
  • zgc:111919 protein

Protein level used designations for Tumor Protein P53 Proteins (TP53)

cellular tumor antigen p53 , tumor protein p53 (Li-Fraumeni syndrome) , tumor supressor p53 , Tumor suppressor p53 , Cellular tumor antigen p53 , p53 cellular tumor antigen , tumor suppressor p53 , mitochondrial protein with oncostatic activity , mitostatin , trichoplein keratin filament-binding protein , tumor suppressor protein , antigen NY-CO-13 , p53 tumor suppressor , phosphoprotein p53 , transformation-related protein 53 , transformation related protein 53 , Li-Fraumeni syndrome , tumor suppressor protein p53 , p53 tumor suppressor phosphoprotein , tumor protein 53 , P53 , tumor suppressing protein

GENE ID SPECIES
6033952 Culex quinquefasciatus
455214 Pan troglodytes
100304476 Ictalurus punctatus
100682525 Cricetulus griseus
22059 Mus musculus
22060 Mus musculus
84260 Homo sapiens
7157 Homo sapiens
24842 Rattus norvegicus
443421 Ovis aries
403869 Canis lupus familiaris
397276 Sus scrofa
100009292 Oryctolagus cuniculus
397926 Xenopus laevis
281542 Bos taurus
100379269 Cavia porcellus
493847 Felis catus
396200 Gallus gallus
100062044 Equus caballus
716170 Macaca mulatta
30590 Danio rerio
100136737 Oncorhynchus mykiss
301300 Rattus norvegicus
Selected quality suppliers for p53 Proteins (TP53)
Did you look for something else?