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|Application / Reactivity||Human||Mouse (Murine)||Frog|
|Western Blotting (WB)||55 Antibodies||16 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Immunoprecipitation (IP)||11 Antibodies||6 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||10 Antibodies||7 Antibodies|
|Immunohistochemistry (IHC)||5 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||3 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||11 Antibodies|
|Immunofluorescence (IF)||26 Antibodies||14 Antibodies||2 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies||1 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies||3 Antibodies||2 Antibodies|
|Antigen||Programmed Cell Death 6 Interacting Protein (PDCD6IP) Antibodies|
|Reactivity||Frog, Human, Mouse (Murine) Alternatives|
|Conjugate||This PDCD6IP antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunofluorescence (IF)
|5 references available|
|Supplier||Log in to see|
Product Details anti-PDCD6IP AntibodyTarget Details PDCD6IP Application Details Handling References for anti-PDCD6IP Antibody (ABIN2664051) Images
|Purification||The antibody was purified by affinity chromatography.|
Target Details PDCD6IPProduct Details anti-PDCD6IP Antibody Application Details Handling References for anti-PDCD6IP Antibody (ABIN2664051) Images back to top
|Alternative Name||Alix (PDCD6IP Antibody Abstract)|
|Background||Alix (ALG-2-interacting protein X) is an adaptor protein that was first described for its capacity to bind to the calcium-binding protein ALG-2, the expression of which seemed necessary for cell death. Predicted molecular weight approximately 96 kD. Alix contains an N-terminal Bro1 domain and a C-terminal proline-rich domain (PRD). The PRD contains multiple polyproline motifs, which are potential docking sites for proteins containing SH3 domains, interactwith multiple cellular Alix-binding partners that are involvedin apoptotic induction, endosomal sorting,and endocytosis. Bro1 domain interacts with CHMP4b which is also involved in endosomal sorting.|
|Pathways||p53 Signaling, EGFR Signaling Pathway|
Application DetailsProduct Details anti-PDCD6IP Antibody Target Details PDCD6IP Handling References for anti-PDCD6IP Antibody (ABIN2664051) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PDCD6IP Antibody Target Details PDCD6IP Application Details References for anti-PDCD6IP Antibody (ABIN2664051) Images back to top
|Buffer||phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-PDCD6IP Antibody (ABIN2664051)Product Details anti-PDCD6IP Antibody Target Details PDCD6IP Application Details Handling Images back to top
Ertunc, Sikkeland, Fenaroli et al.: "Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity." in: Journal of lipid research, Vol. 56, Issue 2, pp. 423-34, 2015 (PubMed).
Morel, Regan, Higashimori et al.: "Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1." in: The Journal of biological chemistry, Vol. 288, Issue 10, pp. 7105-16, 2013 (PubMed).
Pan, Wang, Zhou et al.: "Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly." in: The EMBO journal, Vol. 27, Issue 15, pp. 2077-90, 2008 (PubMed).
Odorizzi: "The multiple personalities of Alix." in: Journal of cell science, Vol. 119, Issue Pt 15, pp. 3025-32, 2006 (PubMed).
Missotten, Nichols, Rieger et al.: "Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein." in: Cell death and differentiation, Vol. 6, Issue 2, pp. 124-9, 1999 (PubMed).
ImagesProduct Details anti-PDCD6IP Antibody Target Details PDCD6IP Application Details Handling References for anti-PDCD6IP Antibody (ABIN2664051) back to top